{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T19:47:02Z","timestamp":1773344822390,"version":"3.50.1"},"reference-count":157,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Malignant pleural mesothelioma (MPM) is a rare malignancy, with extremely poor survival rates. At present, treatment options are limited, with no second line chemotherapy for those who fail first line therapy. Extensive efforts are ongoing in a bid to characterise the underlying molecular mechanisms of mesothelioma. Recent research has determined that between 70\u201390% of our genome is transcribed. As only 2% of our genome is protein coding, the roles of the remaining proportion of non-coding RNA in biological processes has many applications, including roles in carcinogenesis and epithelial\u2013mesenchymal transition (EMT), a process thought to play important roles in MPM pathogenesis. Non-coding RNAs can be separated loosely into two subtypes, short non-coding RNAs (&lt;200 nucleotides) or long (&gt;200 nucleotides). A significant body of evidence has emerged for the roles of short non-coding RNAs in MPM. Less is known about the roles of long non-coding RNAs (lncRNAs) in this disease setting. LncRNAs have been shown to play diverse roles in EMT, and it has been suggested that EMT may play a role in the aggressiveness of MPM histological subsets. In this report, using both in vitro analyses on mesothelioma patient material and in silico analyses of existing RNA datasets, we posit that various lncRNAs may play important roles in EMT within MPM, and we review the current literature regarding these lncRNAs with respect to both EMT and MPM.<\/jats:p>","DOI":"10.3390\/ijms19051297","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T06:52:23Z","timestamp":1524811943000},"page":"1297","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["In Silico and In Vitro Analyses of LncRNAs as Potential Regulators in the Transition from the Epithelioid to Sarcomatoid Histotype of Malignant Pleural Mesothelioma (MPM)"],"prefix":"10.3390","volume":"19","author":[{"given":"Anand","family":"Singh","sequence":"first","affiliation":[{"name":"Thoracic Oncology Research Group, Trinity Translational Medical Institute, St. James\u2019s Hospital, Dublin D08 W9RT, Ireland"},{"name":"MSc in Translational Oncology Program, Trinity College Dublin, Dublin 2, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Heery","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Research Group, Trinity Translational Medical Institute, St. James\u2019s Hospital, Dublin D08 W9RT, Ireland"},{"name":"MSc in Translational Oncology Program, Trinity College Dublin, Dublin 2, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5850-6392","authenticated-orcid":false,"given":"Steven","family":"Gray","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Research Group, Trinity Translational Medical Institute, St. James\u2019s Hospital, Dublin D08 W9RT, Ireland"},{"name":"HOPE Directorate, St. James\u2019s Hospital, Dublin 8, Ireland"},{"name":"Department of Clinical Medicine, Trinity College Dublin, Dublin 8, Ireland"},{"name":"Labmed Directorate, St. James\u2019s Hospital, Dublin 8, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"key":"ref_1","first-page":"260","article-title":"Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province","volume":"17","author":"Wagner","year":"1960","journal-title":"Br. J. Ind. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ctrv.2014.10.007","article-title":"Malignant pleural mesothelioma: New hope in the horizon with novel therapeutic strategies","volume":"41","author":"Remon","year":"2015","journal-title":"Cancer Treat. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/oemed-2017-104298","article-title":"Estimation of the global burden of mesothelioma deaths from incomplete national mortality data","volume":"74","author":"Odgerel","year":"2017","journal-title":"Occup. Environ. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S1470-2045(17)30169-9","article-title":"Clinical safety and activity of pembrolizumab in patients with malignant pleural mesothelioma (KEYNOTE-028): Preliminary results from a non-randomised, open-label, phase 1b trial","volume":"18","author":"Alley","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_5","first-page":"S292","article-title":"OA13.01 A Phase II Study of Nivolumab in Malignant Pleural Mesothelioma (NivoMes): With Translational Research (TR) Biopies","volume":"12","author":"Zago","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"v31","DOI":"10.1093\/annonc\/mdv199","article-title":"Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"26","author":"Baas","year":"2015","journal-title":"Ann. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Kindler, H.L., Ismaila, N., Armato, S.G., Bueno, R., Hesdorffer, M., Jahan, T., Jones, C.M., Miettinen, M., Pass, H., and Rimner, A. (2018). Treatment of Malignant Pleural Mesothelioma: American Society of Clinical Oncology Clinical Practice Guideline. J. Clin. Oncol.","DOI":"10.1200\/JCO.2017.76.6394"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","article-title":"Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma","volume":"21","author":"Vogelzang","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nrc.2017.118","article-title":"EMT in cancer","volume":"18","author":"Brabletz","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5858\/arpa.2017-0124-RA","article-title":"Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group","volume":"142","author":"Husain","year":"2018","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"244","DOI":"10.21037\/atm.2017.06.60","article-title":"Diagnosis and prognosis-review of biomarkers for mesothelioma","volume":"5","author":"Sun","year":"2017","journal-title":"Ann. Transl. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ctrv.2015.05.001","article-title":"The established and future biomarkers of malignant pleural mesothelioma","volume":"41","author":"Panou","year":"2015","journal-title":"Cancer Treat. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.ejcts.2009.08.027","article-title":"Prognostic significance of epithelial-mesenchymal transition in malignant pleural mesothelioma","volume":"37","author":"Schramm","year":"2010","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Thies, S., Friess, M., Frischknecht, L., Korol, D., Felley-Bosco, E., Stahel, R., Vrugt, B., Weder, W., Opitz, I., and Soltermann, A. (2015). Expression of the Stem Cell Factor Nestin in Malignant Pleural Mesothelioma Is Associated with Poor Prognosis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139312"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1158\/1078-0432.CCR-13-2429","article-title":"Molecular classification of malignant pleural mesothelioma: Identification of a poor prognosis subgroup linked to the epithelial-to-mesenchymal transition","volume":"20","author":"Jaurand","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Legras, A., Pecuchet, N., Imbeaud, S., Pallier, K., Didelot, A., Roussel, H., Gibault, L., Fabre, E., Le Pimpec-Barthes, F., and Laurent-Puig, P. (2017). Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer. Cancers, 9.","DOI":"10.3390\/cancers9080101"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.semcancer.2017.02.004","article-title":"Role of miRNAs in human cancer metastasis: Implications for therapeutic intervention","volume":"44","author":"Jafri","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.lungcan.2015.11.002","article-title":"Non-coding RNA repertoires in malignant pleural mesothelioma","volume":"90","author":"Quinn","year":"2015","journal-title":"Lung Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Martinez-Rivera, V., Negrete-Garcia, M.C., Avila-Moreno, F., and Ortiz-Quintero, B. (2018). Secreted and Tissue miRNAs as Diagnosis Biomarkers of Malignant Pleural Mesothelioma. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020595"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"12472","DOI":"10.18632\/oncotarget.13957","article-title":"The crosstalk between lncRNA and microRNA in cancer metastasis: Orchestrating the epithelial-mesenchymal plasticity","volume":"8","author":"Cao","year":"2017","journal-title":"Oncotarget"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Heery, R., Finn, S.P., Cuffe, S., and Gray, S.G. (2017). Long Non-Coding RNAs: Key Regulators of Epithelial-Mesenchymal Transition, Tumour Drug Resistance and Cancer Stem Cells. Cancers, 9.","DOI":"10.3390\/cancers9040038"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1159\/000485766","article-title":"Missing Links in Epithelial-Mesenchymal Transition: Long Non-Coding RNAs Enter the Arena","volume":"44","author":"Wang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fonc.2018.00040","article-title":"Live-Cell Mesothelioma Biobank to Explore Mechanisms of Tumor Progression","volume":"8","author":"Oehl","year":"2018","journal-title":"Front. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1097\/JTO.0000000000000202","article-title":"Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma","volume":"9","author":"Riquelme","year":"2014","journal-title":"J. Thorac. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1476-4598-13-119","article-title":"GAS5 long non-coding RNA in malignant pleural mesothelioma","volume":"13","author":"Renganathan","year":"2014","journal-title":"Mol. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Wright, C.M., Kirschner, M.B., Cheng, Y.Y., O\u2019Byrne, K.J., Gray, S.G., Schelch, K., Hoda, M.A., Klebe, S., McCaughan, B., and van Zandwijk, N. (2013). Long non coding RNAs (lncRNAs) are dysregulated in Malignant Pleural Mesothelioma (MPM). PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0070940"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng.3520","article-title":"Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations","volume":"48","author":"Bueno","year":"2016","journal-title":"Nat. Genet."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3892\/or.2013.2850","article-title":"Role of long non-coding RNA HULC in cell proliferation, apoptosis and tumor metastasis of gastric cancer: A clinical and in vitro investigation","volume":"31","author":"Zhao","year":"2014","journal-title":"Oncol. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"42431","DOI":"10.18632\/oncotarget.9883","article-title":"LncRNA HULC enhances epithelial-mesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR-200a-3p\/ZEB1 signaling pathway","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"key":"ref_30","first-page":"2070","article-title":"MiR-488 suppresses cell proliferation and invasion by targeting ADAM9 and lncRNA HULC in hepatocellular carcinoma","volume":"7","author":"Hu","year":"2017","journal-title":"Am. J. Cancer Res."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Zhang, Q., Li, X., and Chen, Z. (2017). LncRNA H19 promotes epithelial-mesenchymal transition (EMT) by targeting miR-484 in human lung cancer cells. J. Cell. Biochem.","DOI":"10.1002\/jcb.26537"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1080\/09168451.2018.1431518","article-title":"Silencing of lncRNA ZFAS1 inhibits malignancies by blocking Wnt\/beta-catenin signaling in gastric cancer cells","volume":"82","author":"Xu","year":"2018","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.18632\/aging.101048","article-title":"Increased expression of long-noncoding RNA ZFAS1 is associated with epithelial-mesenchymal transition of gastric cancer","volume":"8","author":"Zhou","year":"2016","journal-title":"Aging"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1111\/jgh.13646","article-title":"Long non-coding ribonucleic acid zinc finger antisense 1 promotes the progression of colonic cancer by modulating ZEB1 expression","volume":"32","author":"Fang","year":"2017","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3892\/etm.2017.4535","article-title":"Overexpression of long non-coding RNA zinc finger antisense 1 in acute myeloid leukemia cell lines influences cell growth and apoptosis","volume":"14","author":"Guo","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s00432-017-2361-2","article-title":"Exosomes-mediated transfer of long noncoding RNA ZFAS1 promotes gastric cancer progression","volume":"143","author":"Pan","year":"2017","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_37","first-page":"4584","article-title":"Long noncoding RNA CASC2 inhibits metastasis and epithelial to mesenchymal transition of lung adenocarcinoma via suppressing SOX4","volume":"21","author":"Wang","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.lungcan.2006.08.012","article-title":"EGFR expression: Associations with outcome and clinicopathological variables in malignant pleural mesothelioma","volume":"54","author":"Edwards","year":"2006","journal-title":"Lung Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1200\/JCO.2006.09.7634","article-title":"Phase II study of erlotinib in patients with malignant pleural mesothelioma: A Southwest Oncology Group Study","volume":"25","author":"Garland","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1158\/1078-0432.CCR-04-1940","article-title":"Gefitinib in patients with malignant mesothelioma: A phase II study by the Cancer and Leukemia Group B","volume":"11","author":"Govindan","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1586\/17476348.2015.1081066","article-title":"Latest developments in our understanding of the pathogenesis of mesothelioma and the design of targeted therapies","volume":"9","author":"Bononi","year":"2015","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/S1470-2045(17)30621-6","article-title":"Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: A first-in-man, phase 1, open-label, dose-escalation study","volume":"18","author":"Pavlakis","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e141","DOI":"10.1016\/j.jtho.2017.04.028","article-title":"Malignant Pleural Mesothelioma Harboring Both G719C and S768I Mutations of EGFR Successfully Treated with Afatinib","volume":"12","author":"Agatsuma","year":"2017","journal-title":"J. Thorac. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s13277-015-3887-z","article-title":"The long noncoding RNA, EGFR-AS1, a target of GHR, increases the expression of EGFR in hepatocellular carcinoma","volume":"37","author":"Qi","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/nm.4401","article-title":"Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma","volume":"23","author":"Tan","year":"2017","journal-title":"Nat. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s10585-007-9121-7","article-title":"Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions","volume":"25","author":"Barr","year":"2008","journal-title":"Clin. Exp. Metast."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"12723","DOI":"10.18632\/oncotarget.3713","article-title":"JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN\/AKT signaling in hepatocellular carcinoma cells","volume":"6","author":"Tang","year":"2015","journal-title":"Oncotarget"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3389\/fonc.2014.00344","article-title":"Altered Transcriptional Control Networks with Trans-Differentiation of Isogenic Mutant-KRas NSCLC Models","volume":"4","author":"Haley","year":"2014","journal-title":"Front. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.4161\/cc.25142","article-title":"KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family","volume":"12","author":"Enkhbaatar","year":"2013","journal-title":"Cell Cycle"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3727\/096504016X14618564639178","article-title":"Knockdown of Long Noncoding RNA PCAT6 Inhibits Proliferation and Invasion in Lung Cancer Cells","volume":"24","author":"Wan","year":"2016","journal-title":"Oncol. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"5695","DOI":"10.2147\/OTT.S149314","article-title":"Diagnostic significance of circulating long noncoding RNA PCAT6 in patients with non-small cell lung cancer","volume":"10","author":"Wan","year":"2017","journal-title":"Onco Targets Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/S0002-9440(10)62492-3","article-title":"Identification of novel candidate oncogenes and tumor suppressors in malignant pleural mesothelioma using large-scale transcriptional profiling","volume":"166","author":"Gordon","year":"2005","journal-title":"Am. J. Pathol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1101\/gad.455708","article-title":"A natural antisense transcript regulates ZEB2\/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition","volume":"22","author":"Beltran","year":"2008","journal-title":"Genes Dev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"11924","DOI":"10.1038\/srep11924","article-title":"TGFbeta1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT","volume":"5","author":"Zhuang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.3892\/mmr.2016.5836","article-title":"Downregulation of ZEB2-AS1 decreased tumor growth and metastasis in hepatocellular carcinoma","volume":"14","author":"Lan","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1158\/0008-5472.CAN-05-3907","article-title":"Global gene expression profiling of pleural mesotheliomas: Overexpression of aurora kinases and P16\/CDKN2A deletion as prognostic factors and critical evaluation of microarray-based prognostic prediction","volume":"66","author":"Chuai","year":"2006","journal-title":"Cancer Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"113174","DOI":"10.18632\/oncotarget.22830","article-title":"Prognostic value of long non-coding RNA PVT1 as a novel biomarker in various cancers: A meta-analysis","volume":"8","author":"Zhu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.bbrc.2017.09.005","article-title":"Upregulation of SOX2 activated LncRNA PVT1 expression promotes breast cancer cell growth and invasion","volume":"493","author":"Wang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Wu, B.Q., Jiang, Y., Zhu, F., Sun, D.L., and He, X.Z. (2017). Long Noncoding RNA PVT1 Promotes EMT and Cell Proliferation and Migration through Downregulating p21 in Pancreatic Cancer Cells. Technol. Cancer Res. Treat.","DOI":"10.1177\/1533034617700559"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"85353","DOI":"10.18632\/oncotarget.19743","article-title":"lncRNA PVT1 and its splicing variant function as competing endogenous RNA to regulate clear cell renal cell carcinoma progression","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1016\/j.bbrc.2017.12.114","article-title":"Long non-coding RNA PVT1\u20135 promotes cell proliferation by regulating miR-126\/SLC7A5 axis in lung cancer","volume":"495","author":"Li","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_62","first-page":"1105","article-title":"LncRNA PVT1 regulate expression of HIF1alpha via functioning as ceRNA for miR199a5p in nonsmall cell lung cancer under hypoxia","volume":"17","author":"Wang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.3727\/096504017X14881559833562","article-title":"Long Noncoding RNA PVT1 Facilitates Cervical Cancer Progression via Negative Regulating of miR-424","volume":"25","author":"Gao","year":"2017","journal-title":"Oncol. Res."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Conte, F., Fiscon, G., Chiara, M., Colombo, T., Farina, L., and Paci, P. (2017). Role of the long non-coding RNA PVT1 in the dysregulation of the ceRNA-ceRNA network in human breast cancer. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0171661"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"85728","DOI":"10.18632\/oncotarget.13828","article-title":"Construction of differential mRNA-lncRNA crosstalk networks based on ceRNA hypothesis uncover key roles of lncRNAs implicated in esophageal squamous cell carcinoma","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Lan, T., Yan, X., Li, Z., Xu, X., Mao, Q., Ma, W., Hong, Z., Chen, X., and Yuan, Y. (2017). Long non-coding RNA PVT1 serves as a competing endogenous RNA for miR-186\u20135p to promote the tumorigenesis and metastasis of hepatocellular carcinoma. Tumour Biol., 39.","DOI":"10.1177\/1010428317705338"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.gene.2018.02.036","article-title":"Long noncoding RNA PVT1 promotes EMT via mediating microRNA-186 targeting of Twist1 in prostate cancer","volume":"654","author":"Chang","year":"2018","journal-title":"Gene"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1080\/1061186X.2017.1307379","article-title":"LncRNA PVT1 epigenetically silences miR-195 and modulates EMT and chemoresistance in cervical cancer cells","volume":"25","author":"Shen","year":"2017","journal-title":"J. Drug Target."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/apm.12555","article-title":"Long noncoding RNA PVT1 promotes cervical cancer progression through epigenetically silencing miR-200b","volume":"124","author":"Zhang","year":"2016","journal-title":"APMIS"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1158\/1535-7163.MCT-15-0707","article-title":"Long Noncoding RNA PVT1 Promotes Non-Small Cell Lung Cancer Cell Proliferation through Epigenetically Regulating LATS2 Expression","volume":"15","author":"Wan","year":"2016","journal-title":"Mol. Cancer Ther."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12943-015-0355-8","article-title":"Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16","volume":"14","author":"Kong","year":"2015","journal-title":"Mol. Cancer"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1007\/s13277-015-4149-9","article-title":"Long noncoding RNA PVT1 modulates thyroid cancer cell proliferation by recruiting EZH2 and regulating thyroid-stimulating hormone receptor (TSHR)","volume":"37","author":"Zhou","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3233\/CBM-170331","article-title":"Long noncoding RNA PVT1 promotes hepatocellular carcinoma progression through regulating miR-214","volume":"20","author":"Gou","year":"2017","journal-title":"Cancer Biomark."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Yang, A., Wang, H., and Yang, X. (2017). Long non-coding RNA PVT1 indicates a poor prognosis of glioma and promotes cell proliferation and invasion via target EZH2. Biosci. Rep., 37.","DOI":"10.1042\/BSR20170871"},{"key":"ref_75","first-page":"1275","article-title":"Effect of long non-coding RNA PVT1 on cell proliferation and migration in melanoma","volume":"41","author":"Chen","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/nature13311","article-title":"PVT1 dependence in cancer with MYC copy-number increase","volume":"512","author":"Tseng","year":"2014","journal-title":"Nature"},{"key":"ref_77","first-page":"1020","article-title":"lncRNA NEAT1 is closely related with progression of breast cancer via promoting proliferation and EMT","volume":"21","author":"Zhang","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2016.12.011","article-title":"The long non-coding RNA NEAT1 interacted with miR-101 modulates breast cancer growth by targeting EZH2","volume":"615","author":"Qian","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1158\/1078-0432.CCR-17-0605","article-title":"Long Noncoding RNA NEAT1, Regulated by the EGFR Pathway, Contributes to Glioblastoma Progression Through the WNT\/beta-Catenin Pathway by Scaffolding EZH2","volume":"24","author":"Chen","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12943-017-0587-x","article-title":"BAP1 dependent expression of long non-coding RNA NEAT-1 contributes to sensitivity to gemcitabine in cholangiocarcinoma","volume":"16","author":"Parasramka","year":"2017","journal-title":"Mol. Cancer"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nrc.2017.42","article-title":"Novel insights into mesothelioma biology and implications for therapy","volume":"17","author":"Yap","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1091\/mbc.e03-05-0279","article-title":"Gene expression patterns in ovarian carcinomas","volume":"14","author":"Schaner","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Di Palma, T., Lucci, V., de Cristofaro, T., Filippone, M.G., and Zannini, M. (2014). A role for PAX8 in the tumorigenic phenotype of ovarian cancer cells. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-292"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1158\/1078-0432.CCR-13-2063","article-title":"Discrete molecular classes of ovarian cancer suggestive of unique mechanisms of transformation and metastases","volume":"20","author":"Gardi","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1097\/PAS.0000000000000935","article-title":"PAX8 Expression in a Subset of Malignant Peritoneal Mesotheliomas and Benign Mesothelium has Diagnostic Implications in the Differential Diagnosis of Ovarian Serous Carcinoma","volume":"41","author":"Chapel","year":"2017","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/PAS.0b013e3181da7687","article-title":"PAX8 reliably distinguishes ovarian serous tumors from malignant mesothelioma","volume":"34","author":"Laury","year":"2010","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13045-015-0140-6","article-title":"The long non-coding RNA, GAS5, enhances gefitinib-induced cell death in innate EGFR tyrosine kinase inhibitor-resistant lung adenocarcinoma cells with wide-type EGFR via downregulation of the IGF-1R expression","volume":"8","author":"Dong","year":"2015","journal-title":"J. Hematol. Oncol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Xue, D., Zhou, C., Lu, H., Xu, R., Xu, X., and He, X. (2016). LncRNA GAS5 inhibits proliferation and progression of prostate cancer by targeting miR-103 through AKT\/mTOR signaling pathway. Tumour Biol.","DOI":"10.1007\/s13277-016-5429-8"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1002\/jcb.26145","article-title":"Long Noncoding RNA GAS5 Suppresses Cell Growth and Epithelial-Mesenchymal Transition in Osteosarcoma by Regulating the miR-221\/ARHI Pathway","volume":"118","author":"Ye","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cell.2007.05.022","article-title":"Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs","volume":"129","author":"Rinn","year":"2007","journal-title":"Cell"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.1192002","article-title":"Long noncoding RNA as modular scaffold of histone modification complexes","volume":"329","author":"Tsai","year":"2010","journal-title":"Science"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.3892\/ijo.2015.2976","article-title":"Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma","volume":"46","author":"Wu","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/onc.2016.260","article-title":"The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition","volume":"36","author":"Battistelli","year":"2017","journal-title":"Oncogene"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"19795","DOI":"10.18632\/oncotarget.15047","article-title":"Long noncoding RNA HOTAIR promotes metastasis of renal cell carcinoma by up-regulating histone H3K27 demethylase JMJD3","volume":"8","author":"Xia","year":"2017","journal-title":"Oncotarget"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e1802","DOI":"10.1038\/cddis.2015.150","article-title":"LincHOTAIR epigenetically silences miR34a by binding to PRC2 to promote the epithelial-to-mesenchymal transition in human gastric cancer","volume":"6","author":"Liu","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1186\/s13058-014-0454-2","article-title":"Nuclear factor of activated T cells 5 maintained by Hotair suppression of miR-568 upregulates S100 calcium binding protein A4 to promote breast cancer metastasis","volume":"16","author":"Li","year":"2014","journal-title":"Breast Cancer Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1002\/stem.1795","article-title":"MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway","volume":"32","author":"Zhang","year":"2014","journal-title":"Stem Cells"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"8031","DOI":"10.1038\/sj.onc.1206928","article-title":"MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer","volume":"22","author":"Ji","year":"2003","journal-title":"Oncogene"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"102291","DOI":"10.18632\/oncotarget.21013","article-title":"Diagnostic efficacy of long non-coding RNA MALAT-1 in human cancers: A meta-analysis study","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Cheng, Y., Imanirad, P., Jutooru, I., Hedrick, E., Jin, U.H., Rodrigues Hoffman, A., Leal de Araujo, J., Morpurgo, B., Golovko, A., and Safe, S. (2018). Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0192264"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.bbrc.2016.02.102","article-title":"MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42","volume":"472","author":"Chou","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_102","first-page":"4881","article-title":"Downregulation of long noncoding RNA MALAT1 induces epithelial-to-mesenchymal transition via the PI3K-AKT pathway in breast cancer","volume":"8","author":"Xu","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_103","first-page":"1099","article-title":"LncRNA MALAT1 exerts oncogenic functions in lung adenocarcinoma by targeting miR-204","volume":"6","author":"Li","year":"2016","journal-title":"Am. J. Cancer Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"7383","DOI":"10.1007\/s13277-015-4605-6","article-title":"Reciprocal regulation of Hsa-miR-1 and long noncoding RNA MALAT1 promotes triple-negative breast cancer development","volume":"37","author":"Jin","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1158\/0008-5472.CAN-14-2931","article-title":"Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205","volume":"75","author":"Hirata","year":"2015","journal-title":"Cancer Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.canlet.2016.09.019","article-title":"Disrupting MALAT1\/miR-200c sponge decreases invasion and migration in endometrioid endometrial carcinoma","volume":"383","author":"Li","year":"2016","journal-title":"Cancer Lett."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1158\/1078-0432.CCR-13-1455","article-title":"TGF-beta-induced upregulation of malat1 promotes bladder cancer metastasis by associating with suz12","volume":"20","author":"Fan","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"71","DOI":"10.7150\/jca.22113","article-title":"Targeting LncRNA-MALAT1 suppresses the progression of osteosarcoma by altering the expression and localization of beta-catenin","volume":"9","author":"Zhang","year":"2018","journal-title":"J. Cancer"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"25668","DOI":"10.18632\/oncotarget.8257","article-title":"Long noncoding RNA MALAT1 promotes malignant development of esophageal squamous cell carcinoma by targeting beta-catenin via Ezh2","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"806","DOI":"10.4161\/cbt.28584","article-title":"MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK\/MAPK pathway","volume":"15","author":"Wu","year":"2014","journal-title":"Cancer Biol. Ther."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e2123","DOI":"10.1038\/cddis.2015.407","article-title":"Tumor-suppressive function of long noncoding RNA MALAT1 in glioma cells by downregulation of MMP2 and inactivation of ERK\/MAPK signaling","volume":"7","author":"Han","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s13277-014-2631-4","article-title":"MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K\/Akt pathway","volume":"36","author":"Dong","year":"2015","journal-title":"Tumour Biol."},{"key":"ref_113","first-page":"3176","article-title":"LncRNA MALAT1 promotes proliferation and metastasis in epithelial ovarian cancer via the PI3K-AKT pathway","volume":"21","author":"Jin","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"11313","DOI":"10.1038\/s41598-017-11904-8","article-title":"MiR-503 modulates epithelial-mesenchymal transition in silica-induced pulmonary fibrosis by targeting PI3K p85 and is sponged by lncRNA MALAT1","volume":"7","author":"Yan","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1111\/jcmm.13522","article-title":"Crosstalk between long non-coding RNAs and Wnt\/beta-catenin signalling in cancer","volume":"22","author":"Yang","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_116","first-page":"98","article-title":"MALAT1 induces tongue cancer cells\u2019 EMT and inhibits apoptosis through Wnt\/beta-catenin signaling pathway","volume":"48","author":"Liang","year":"2016","journal-title":"J. Oral Pathol. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1158\/0008-5472.CAN-14-0427","article-title":"A novel wnt regulatory axis in endometrioid endometrial cancer","volume":"74","author":"Zhao","year":"2014","journal-title":"Cancer Res."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Liu, S., Yan, G., Zhang, J., and Yu, L. Knockdown of Long Noncoding RNA (lncRNA) Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Inhibits Proliferation, Migration, and Invasion and Promoted Apoptosis By Targeting miR-124 in Retinoblastoma. Oncol. Res., 2017.","DOI":"10.3727\/096504017X14953948675403"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/onc.2015.61","article-title":"WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1","volume":"35","author":"Vassallo","year":"2016","journal-title":"Oncogene"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1158\/2159-8290.CD-17-0273","article-title":"The Expanding World of N-MYC-Driven Tumors","volume":"8","author":"Rickman","year":"2018","journal-title":"Cancer Discov."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/ncb2024","article-title":"miR-9, a MYC\/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis","volume":"12","author":"Ma","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1080\/15476286.2015.1063773","article-title":"MYCNOS functions as an antisense RNA regulating MYCN","volume":"12","author":"Vadie","year":"2015","journal-title":"RNA Biol."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Jacobs, J.F., van Bokhoven, H., van Leeuwen, F.N., Hulsbergen-van de Kaa, C.A., de Vries, I.J., Adema, G.J., Hoogerbrugge, P.M., and de Brouwer, A.P. (2009). Regulation of MYCN expression in human neuroblastoma cells. BMC Cancer, 9.","DOI":"10.1186\/1471-2407-9-239"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1038\/onc.2015.422","article-title":"CTCF cooperates with noncoding RNA MYCNOS to promote neuroblastoma progression through facilitating MYCN expression","volume":"35","author":"Zhao","year":"2016","journal-title":"Oncogene"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s12943-015-0458-2","article-title":"The H19 Long non-coding RNA in cancer initiation, progression and metastasis\u2014A proposed unifying theory","volume":"14","author":"Raveh","year":"2015","journal-title":"Mol. Cancer"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.18632\/oncotarget.6387","article-title":"The role of the oncofetal H19 lncRNA in tumor metastasis: Orchestrating the EMT-MET decision","volume":"7","author":"Matouk","year":"2016","journal-title":"Oncotarget"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1053\/j.gastro.2006.08.026","article-title":"Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA","volume":"132","author":"Panzitt","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/jcmm.12956","article-title":"HULC: An oncogenic long non-coding RNA in human cancer","volume":"21","author":"Yu","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.gene.2017.01.004","article-title":"Long noncoding RNA HULC promotes cell proliferation by regulating PI3K\/AKT signaling pathway in chronic myeloid leukemia","volume":"607","author":"Lu","year":"2017","journal-title":"Gene"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3233\/CBM-170188","article-title":"Long non-coding RNA HULC promotes bladder cancer cells proliferation but inhibits apoptosis via regulation of ZIC2 and PI3K\/AKT signaling pathway","volume":"20","author":"Wang","year":"2017","journal-title":"Cancer Biomark."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"36045","DOI":"10.1038\/srep36045","article-title":"HULC cooperates with MALAT1 to aggravate liver cancer stem cells growth through telomere repeat-binding factor 2","volume":"6","author":"Wu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.gene.2016.08.002","article-title":"Long noncoding RNA HULC promotes colorectal carcinoma progression through epigenetically repressing NKD2 expression","volume":"592","author":"Yang","year":"2016","journal-title":"Gene"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"5366","DOI":"10.1093\/nar\/gkq285","article-title":"CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/jcb.26273","article-title":"Knockdown of lncRNA HULC inhibits proliferation, migration, invasion, and promotes apoptosis by sponging miR-122 in osteosarcoma","volume":"119","author":"Kong","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"ref_135","first-page":"12956","article-title":"Molecular mechanism of HEIH and HULC in the proliferation and invasion of hepatoma cells","volume":"8","author":"Zhang","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12943-017-0702-z","article-title":"Long non-coding RNA CASC2 suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells through CASC2\/miR-367\/FBXW7 axis","volume":"16","author":"Wang","year":"2017","journal-title":"Mol. Cancer"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Zhao, L., and Zhang, Y. Long noncoding RNA CASC2 regulates hepatocellular carcinoma cell oncogenesis through miR-362\u20135p\/Nf-kappaB axis. J. Cell. Physiol., 2018.","DOI":"10.1002\/jcp.26446"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1261\/rna.2528811","article-title":"SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer","volume":"17","author":"Crawford","year":"2011","journal-title":"RNA"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.biopha.2017.01.014","article-title":"Long non-coding RNA ZFAS1 is an unfavourable prognostic factor and promotes glioma cell progression by activation of the Notch signaling pathway","volume":"87","author":"Gao","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1158\/0008-5472.CAN-14-3721","article-title":"Amplification of Long Noncoding RNA ZFAS1 Promotes Metastasis in Hepatocellular Carcinoma","volume":"75","author":"Li","year":"2015","journal-title":"Cancer Res."},{"key":"ref_141","first-page":"1450","article-title":"LncRNA ZFAS1 promotes growth and metastasis by regulating BMI1 and ZEB2 in osteosarcoma","volume":"7","author":"Liu","year":"2017","journal-title":"Am. J. Cancer Res."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Lv, Q.L., Chen, S.H., Zhang, X., Sun, B., Hu, L., Qu, Q., Huang, Y.T., Wang, G.H., Liu, Y.L., and Zhang, Y.Y. (2017). Upregulation of long noncoding RNA zinc finger antisense 1 enhances epithelial-mesenchymal transition in vitro and predicts poor prognosis in glioma. Tumour Biol., 39.","DOI":"10.1177\/1010428317695022"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"38227","DOI":"10.18632\/oncotarget.9611","article-title":"Long noncoding RNA ZFAS1 promotes gastric cancer cells proliferation by epigenetically repressing KLF2 and NKD2 expression","volume":"8","author":"Nie","year":"2017","journal-title":"Oncotarget"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"622","DOI":"10.18632\/oncotarget.5807","article-title":"Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer","volume":"7","author":"Thorenoor","year":"2016","journal-title":"Oncotarget"},{"key":"ref_145","first-page":"5126","article-title":"Overexpression of long-noncoding RNA ZFAS1 decreases survival in human NSCLC patients","volume":"20","author":"Tian","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.prp.2016.05.003","article-title":"Upregulation of long noncoding RNA ZFAS1 predicts poor prognosis and prompts invasion and metastasis in colorectal cancer","volume":"212","author":"Wang","year":"2016","journal-title":"Pathol. Res. Pract."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"19534","DOI":"10.18632\/oncotarget.14663","article-title":"Long non-coding RNA ZFAS1 interacts with miR-150\u20135p to regulate Sp1 expression and ovarian cancer cell malignancy","volume":"8","author":"Xia","year":"2017","journal-title":"Oncotarget"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1080\/15384101.2017.1407895","article-title":"Long non-coding RNA ZFAS1 sponges miR-484 to promote cell proliferation and invasion in colorectal cancer","volume":"17","author":"Xie","year":"2018","journal-title":"Cell Cycle"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.3892\/ijo.2017.3870","article-title":"Kdm6a and Kdm6b: Altered expression in malignant pleural mesothelioma","volume":"50","author":"Cregan","year":"2017","journal-title":"Int. J. Oncol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1593\/neo.07112","article-title":"Oncomine 3.0: Genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles","volume":"9","author":"Rhodes","year":"2007","journal-title":"Neoplasia"},{"key":"ref_151","unstructured":"(2018, April 02). Oncomine. Available online: www.oncomine.org."},{"key":"ref_152","unstructured":"(2018, April 02). cBioportal. Available online: www.cbioportal.org."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Goswami, C.P., and Nakshatri, H. (2014). PROGgeneV2: Enhancements on the existing database. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-970"},{"key":"ref_156","unstructured":"(2018, April 02). PROGgene. Available online: http:\/\/watson.compbio.iupui.edu\/chirayu\/proggene\/database\/?url=proggene."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2217\/imt-2017-0144","article-title":"Immunotherapy in relapsed mesothelioma","volume":"10","author":"Brosseau","year":"2018","journal-title":"Immunotherapy"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/5\/1297\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:02:18Z","timestamp":1760194938000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/5\/1297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,26]]},"references-count":157,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,5]]}},"alternative-id":["ijms19051297"],"URL":"https:\/\/doi.org\/10.3390\/ijms19051297","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,26]]}}}