{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:11:26Z","timestamp":1792894286681,"version":"4.5.0"},"reference-count":161,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:00:00Z","timestamp":1526515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Preeclampsia is a persistent hypertensive gestational disease characterized by high blood pressure and proteinuria, which presents from the second trimester of pregnancy. At the cellular level, preeclampsia has largely been associated with the release of free radicals by the placenta. Placenta-borne oxidative and nitrosative stresses are even sometimes considered as the major molecular determinants of the maternal disease. In this review, we present the recent literature evaluating free radical production in both normal and pathological placentas (including preeclampsia and other major pregnancy diseases), in humans and animal models. We then assess the putative effects of these free radicals on the placenta and maternal endothelium. This analysis was conducted with regard to recent papers and possible therapeutic avenues.<\/jats:p>","DOI":"10.3390\/ijms19051496","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T03:49:29Z","timestamp":1526528969000},"page":"1496","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":562,"title":["Oxidative Stress in Preeclampsia and Placental Diseases"],"prefix":"10.3390","volume":"19","author":[{"given":"Rajaa","family":"Aouache","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, U1016, Institut Cochin, 75014 Paris, France"},{"name":"Centre National de la Recherche Scientifique, UMR8104, 75014 Paris, France"},{"name":"D\u00e9partement D\u00e9veloppement, G\u00e9n\u00e9tique, Neurobiologie, Reproduction et Vieillissement, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, 75014 Paris, France"},{"name":"D\u00e9partement Hospitalo-Universitaire Risques et Grossesse, PRES Sorbonne, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Biquard","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, U1016, Institut Cochin, 75014 Paris, France"},{"name":"Centre National de la Recherche Scientifique, UMR8104, 75014 Paris, France"},{"name":"D\u00e9partement D\u00e9veloppement, G\u00e9n\u00e9tique, Neurobiologie, Reproduction et Vieillissement, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, 75014 Paris, France"},{"name":"D\u00e9partement Hospitalo-Universitaire Risques et Grossesse, PRES Sorbonne, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1915-0717","authenticated-orcid":false,"given":"Daniel","family":"Vaiman","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, U1016, Institut Cochin, 75014 Paris, France"},{"name":"Centre National de la Recherche Scientifique, UMR8104, 75014 Paris, France"},{"name":"D\u00e9partement D\u00e9veloppement, G\u00e9n\u00e9tique, Neurobiologie, Reproduction et Vieillissement, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, 75014 Paris, France"},{"name":"D\u00e9partement Hospitalo-Universitaire Risques et Grossesse, PRES Sorbonne, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Miralles","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, U1016, Institut Cochin, 75014 Paris, France"},{"name":"Centre National de la Recherche Scientifique, UMR8104, 75014 Paris, France"},{"name":"D\u00e9partement D\u00e9veloppement, G\u00e9n\u00e9tique, Neurobiologie, Reproduction et Vieillissement, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, 75014 Paris, France"},{"name":"D\u00e9partement Hospitalo-Universitaire Risques et Grossesse, PRES Sorbonne, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"13043","DOI":"10.3390\/ijms160613043","article-title":"A proposed molecular mechanism of high-dose vitamin d3 supplementation in prevention and treatment of preeclampsia","volume":"16","author":"Zabul","year":"2015","journal-title":"Int. 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