{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:56:37Z","timestamp":1778673397205,"version":"3.51.4"},"reference-count":103,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T00:00:00Z","timestamp":1527465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>It is recognized that the properties of liquid water can be markedly different from those of bulk one when it is in contact with hydrophobic surfaces or is confined in nano-environments. Because our knowledge regarding water structure on the molecular level of dynamic equilibrium within a picosecond time scale is far from completeness all of water\u2019s conventionally known properties are based on inert \u201cbulk liquid water\u201d with a tetrahedral hydrogen-bonded structure. Actually, the strength of water\u2019s hydrogen bonds (HBs) decides its properties and activities. In this review, an innovative idea on preparation of metastable plasmon-activated water (PAW) with intrinsically reduced HBs, by letting deionized (DI) water flow through gold-supported nanoparticles (AuNPs) under resonant illumination at room temperature, is reported. Compared to DI water, the created stable PAW can scavenge free hydroxyl and 2,2-diphenyl-1-picrylhydrazyl radicals and effectively reduce NO release from lipopolysaccharide-induced inflammatory cells. Moreover, PAW can dramatically induce a major antioxidative Nrf2 gene in human gingival fibroblasts. This further confirms its cellular antioxidative and anti-inflammatory properties. In addition, innovatively therapeutic strategy of daily drinking PAW on inflammatory-related diseases based on animal disease models is demonstrated, examples being chronic kidney disease (CKD), chronic sleep deprivation (CSD), and lung cancer.<\/jats:p>","DOI":"10.3390\/ijms19061589","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T02:58:18Z","timestamp":1527562698000},"page":"1589","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Therapeutics for Inflammatory-Related Diseases Based on Plasmon-Activated Water: A Review"],"prefix":"10.3390","volume":"19","author":[{"given":"Chih-Ping","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wuxing St., Taipei 11031, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2111-8991","authenticated-orcid":false,"given":"Yu-Chuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wuxing St., Taipei 11031, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nature08907","article-title":"Shell-isolated nanoparticle-enhanced Raman spectroscopy","volume":"464","author":"Li","year":"2010","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nnano.2011.79","article-title":"Highly uniform and reproducible surface-enhanced Raman scattering from DNA-tailorable nanoparticles with 1-nm interior gap","volume":"6","author":"Lim","year":"2011","journal-title":"Nat. Nanotechnol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"38222","DOI":"10.1021\/acsami.7b10409","article-title":"Click-functionalized SERS nanoprobes with improved labeling efficiency and capability for cancer cell imaging","volume":"9","author":"Liu","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1021\/nl070610y","article-title":"Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy","volume":"7","author":"Gobin","year":"2007","journal-title":"Nano Lett."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1021\/acs.nanolett.7b04162","article-title":"Resonance energy transfer-promoted photothermal and photodynamic performance of gold\u2013copper sulfide yolk\u2013shell nanoparticles for chemophototherapy of cancer","volume":"18","author":"Chang","year":"2018","journal-title":"Nano Lett."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/s41467-018-03473-9","article-title":"Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer","volume":"9","author":"Nam","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1021\/acs.chemmater.6b05164","article-title":"Gold nanoparticle\/graphene oxide hybrid sheets attached on mesenchymal stem cells for effective photothermal cancer therapy","volume":"29","author":"Kang","year":"2017","journal-title":"Chem. Mater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1021\/acs.nanolett.7b04183","article-title":"Atom transfer radical polymerization of multishelled cationic corona for the systemic delivery of siRNA","volume":"18","author":"Kim","year":"2018","journal-title":"Nano Lett."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1601453","DOI":"10.1002\/adhm.201601453","article-title":"Au nanoclusters and photosensitizer dual loaded spatiotemporal controllable liposomal nanocomposites enhance tumor photodynamic therapy effect by inhibiting thioredoxin reductase","volume":"6","author":"Gao","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"10636","DOI":"10.1021\/acsnano.6b02231","article-title":"Gold nanoparticle reprograms pancreatic tumor microenvironment and inhibits tumor growth","volume":"10","author":"Saha","year":"2016","journal-title":"ACS Nano"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10631","DOI":"10.1021\/acsnano.6b07673","article-title":"Using Gold nanoparticles to disrupt the tumor microenvironment: An emerging therapeutic strategy","volume":"10","author":"Melamed","year":"2016","journal-title":"ACS Nano"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1021\/acsnano.6b08345","article-title":"Nuclear membrane-targeted gold nanoparticles inhibit cancer cell migration and invasion","volume":"11","author":"Ali","year":"2017","journal-title":"ACS Nano"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nm1577","article-title":"Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals","volume":"13","author":"Ohsawa","year":"2007","journal-title":"Nat. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1111\/jcmm.13569","article-title":"Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision","volume":"22","author":"Franceschelli","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bbrc.2017.08.035","article-title":"Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice","volume":"492","author":"Suzuki","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/SHK.0000000000000810","article-title":"Preadministration of Hydrogen-rich water protects against lipopolysaccharide-induced sepsis and attenuates liver injury","volume":"48","author":"Iketani","year":"2017","journal-title":"Shock"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1248\/bpb.b16-00832","article-title":"Hydrogen rich water attenuates renal injury and fibrosis byregulation transforming growth factor-\u03b2 induced Sirt1","volume":"40","author":"Xing","year":"2017","journal-title":"Biol. Pharm. Bull."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cbi.2015.07.013","article-title":"Hydrogen-rich water attenuates amyloid b-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells","volume":"240","author":"Lin","year":"2015","journal-title":"Chem.-Biol. Interact."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.3390\/ijms13055952","article-title":"Biological properties of acidic cosmetic water from seawater","volume":"13","author":"Liao","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/sj.ejcn.1602892","article-title":"Antioxidative effects of sulfurous mineral water: Protection against lipid and protein oxidation","volume":"63","author":"Benedetti","year":"2009","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/01902148.2011.641668","article-title":"Free radical\u2013scavenging activity of sulfurous water investigated by electron paramagnetic resonance (EPR) spectroscopy","volume":"38","author":"Braga","year":"2012","journal-title":"Exp. Lung Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1021\/ar200064z","article-title":"Water: A responsive small molecule","volume":"45","author":"Shultz","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1021\/nn406403c","article-title":"Active and stable liquid water innovatively prepared using resonantly illuminated gold nanoparticles","volume":"8","author":"Chen","year":"2014","journal-title":"ACS Nano"},{"key":"ref_24","first-page":"2065","article-title":"Hydrogen-bond structure dynamics in bulk water: Insights from ab initio simulations with coupled cluster theory","volume":"9","author":"Liu","year":"2018","journal-title":"ACS Nano"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"14171","DOI":"10.1073\/pnas.0506899102","article-title":"Unified description of temperature-dependent hydrogen-bond rearrangements in liquid water","volume":"102","author":"Smith","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"075502","DOI":"10.1103\/PhysRevLett.90.075502","article-title":"Temperature-dependent hydrogen-bond geometry in liquid water","volume":"90","author":"Modig","year":"2003","journal-title":"Phys. Rev. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/anie.201004501","article-title":"Specific ion effects on water structure and dynamics beyond the first hydration shell","volume":"50","author":"Paschek","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"13847","DOI":"10.1021\/ja071933z","article-title":"The effects of dissolved halide anions on hydrogen bonding in liquid water","volume":"129","author":"Smith","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"16731","DOI":"10.1073\/pnas.0707824104","article-title":"Hydrogen bond dynamics in aqueous NaBr solutions","volume":"104","author":"Park","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8037","DOI":"10.1021\/ja000459t","article-title":"The strength of hydrogen bonds in liquid water and around nonpolar solutes","volume":"122","author":"Silverstein","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.molstruc.2009.08.037","article-title":"The effects of magnetic fields on water molecular hydrogen bonds","volume":"938","author":"Cai","year":"2009","journal-title":"J. Mol. Struct."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/ar2000088","article-title":"Dynamics of water interacting with interfaces, molecules, and ions","volume":"45","author":"Fayer","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"15243","DOI":"10.1073\/pnas.0907875106","article-title":"Water dynamics at neutral and ionic interfaces","volume":"106","author":"Fenn","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nchem.1716","article-title":"On the cooperative formation of non-hydrogen-bonded water at molecular hydrophobic interfaces","volume":"5","author":"Davis","year":"2013","journal-title":"Nat. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1126\/science.1131536","article-title":"Ultrafast vibrational dynamics at water interfaces","volume":"313","author":"McGuire","year":"2006","journal-title":"Science"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1021\/ja068120f","article-title":"On the theory of organic catalysis \u201con water\u201d","volume":"129","author":"Jung","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/35102535","article-title":"Water conduction through the hydrophobic channel of a carbon nanotube","volume":"414","author":"Hummer","year":"2001","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1126\/science.aan2438","article-title":"Enhanced water permeability and tunable ion selectivity in subnanometer carbon nanotube porins","volume":"6353","author":"Tunuguntla","year":"2017","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1021\/nn3002533","article-title":"Confinement by carbon nanotubes drastically alters the boiling and critical behavior of water droplets","volume":"6","author":"Chaban","year":"2012","journal-title":"ACS Nano"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1021\/nn201277a","article-title":"Water boiling inside carbon nanotubes: Toward efficient drug release","volume":"5","author":"Chaban","year":"2011","journal-title":"ACS Nano"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1021\/acs.accounts.6b00617","article-title":"Confined water: Structure, dynamics, and thermodynamics","volume":"50","author":"Chakraborty","year":"2017","journal-title":"Acc. Chem. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1021\/es505868a","article-title":"Inactivation of foodborne microorganisms using engineered water nanostructures (EWNS)","volume":"49","author":"Pyrgiotakis","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1039\/C3EN00007A","article-title":"A chemical free, nanotechnology-based method for airborne bacterial inactivation using engineered water nanostructures","volume":"1","author":"Pyrgiotakis","year":"2014","journal-title":"Environ. Sci. Nano"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"21073","DOI":"10.1038\/srep21073","article-title":"Optimization of a nanotechnology based antimicrobial platform for food safety applications using engineered water nanostructures (EWNS)","volume":"6","author":"Pyrgiotakis","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1016\/j.physb.2008.05.032","article-title":"The changes of macroscopic features and microscopic structures of water under influence of magnetic field","volume":"403","author":"Pang","year":"2008","journal-title":"Physica B"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1250069","DOI":"10.1142\/S0217984912500698","article-title":"Influences of magnetic field on macroscopic properties of water","volume":"26","author":"Pang","year":"2012","journal-title":"Mod. Phys. Lett. B"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/nnano.2017.133","article-title":"Electromagnetized gold nanoparticles mediate direct lineage reprogramming into induced dopamine neurons in vivo for Parkinson\u2019s disease therapy","volume":"12","author":"Yoo","year":"2017","journal-title":"Nat. Nanotechnol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0304-4165(02)00209-X","article-title":"The effect of guar galactomannan and water availability during hydrothermal processing on the hydrolysis of starch catalysed by pancreatic \u00e1-amylase","volume":"1571","author":"Slaughter","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bej.2003.08.002","article-title":"Hydrolysis of disaccharides containing glucose residue in subcritical water","volume":"18","author":"Oomori","year":"2004","journal-title":"Biochem. Eng. J."},{"key":"ref_50","first-page":"639","article-title":"Effect of food shortage on growth, energetic reserves mobilization, and water quality in juveniles of the redclaw crayfish, cherax quadricarinatus, reared in groups","volume":"35","author":"Valenti","year":"2014","journal-title":"J. Crustac. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"11774","DOI":"10.1021\/jp035538g","article-title":"ATP Hydrolysis in water\u2014A density functional study","volume":"107","author":"Akola","year":"2003","journal-title":"J. Phys. Chem. B"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1021\/jz501378d","article-title":"Donor\u2013bridge\u2013acceptor proton transfer in aqueous solution","volume":"5","author":"Rivard","year":"2014","journal-title":"J. Phys. Chem. Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1038\/ncomms4145","article-title":"Photobiocatalytic chemistry of oxidoreductases using water as the electron donor","volume":"5","author":"Mifsud","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1038\/ncomms5400","article-title":"Water-induced correlation between single ions imaged at the solid\u2013liquid interface","volume":"5","author":"Ricci","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1002\/jcc.23296","article-title":"Dynamics and structural changes of small water clusters on ionization","volume":"34","author":"Lee","year":"2013","journal-title":"J. Comput. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1126\/science.1134494","article-title":"Water catalysis of a radical-molecule gas-phase reaction","volume":"315","author":"Hansmann","year":"2007","journal-title":"Science"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.1021\/jp2077825","article-title":"The effects of a single water on the OH + H2O2 reaction","volume":"116","author":"Buszek","year":"2012","journal-title":"J. Phys. Chem. A"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1021\/nn402055k","article-title":"A molecular-scale perspective of water-catalyzed methanol dehydrogenation to formaldehyde","volume":"7","author":"Boucher","year":"2013","journal-title":"ACS Nano"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1703510","DOI":"10.1002\/smll.201703510","article-title":"Reactivating catalytic surface: Insights into the role of hot holes in plasmonic catalysis","volume":"14","author":"Peng","year":"2018","journal-title":"Small"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"17964","DOI":"10.1021\/jacs.7b08903","article-title":"Boosting hot electrons in hetero-superstructures for plasmon-enhanced catalysis","volume":"139","author":"Guo","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"ref_61","first-page":"171","article-title":"Plasmon-induced hole-depletion layer on hematite nanoflake photoanodes for highly efficient solar water splitting","volume":"35","author":"Wang","year":"2017","journal-title":"App. Energy"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1021\/nl303940z","article-title":"Hot electrons do the impossible: Plasmon-induced dissociation of H2 on Au","volume":"13","author":"Mukherjee","year":"2013","journal-title":"Nano Lett."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1002\/anie.201310097","article-title":"Activation of oxygen on gold and silver nanoparticles assisted by surface plasmon resonances","volume":"53","author":"Huang","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1039\/C7NR08474A","article-title":"Boosting electrocatalytic hydrogen evolution by Plasmon-driven hot-electron excitation","volume":"10","author":"Zhang","year":"2018","journal-title":"Nanoscale"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1021\/ac5039434","article-title":"Quantitative evaluation on activated property-tunable bulk liquid water with reduced hydrogen bonds using deconvoluted Raman spectroscopy","volume":"87","author":"Chen","year":"2015","journal-title":"Anal. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"22166","DOI":"10.1038\/srep22166","article-title":"Creation of electron-doping liquid water with reduced hydrogen bonds","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1038\/srep04425","article-title":"Innovative strategy with potential to increase hemodialysis efficiency and safety","volume":"4","author":"Chen","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jelechem.2015.05.007","article-title":"One-step fabrication of SERS-active substrates based on plasmon-induced activated water, with improved activity and excellent reproducibility","volume":"750","author":"Tsai","year":"2015","journal-title":"J. Electroanal. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"16263","DOI":"10.1038\/srep16263","article-title":"Innovative strategy on hydrogen evolution reaction utilizing activated liquid water","volume":"5","author":"Hwang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"18152","DOI":"10.1038\/srep18152","article-title":"Effective Energy transfer via plasmon-activated high-energy water promotes its fundamental activities of solubility, ionic conductivity, and extraction at room temperature","volume":"5","author":"Yang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1039\/C6GC00353B","article-title":"Environmentally friendly etching agent: Vapor from hot electron-activated liquid water","volume":"18","author":"Chen","year":"2016","journal-title":"Green Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"28456","DOI":"10.1038\/srep28456","article-title":"Triggering comprehensive enhancement in oxygen evolution reaction by using newly created solvent","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"19691","DOI":"10.1021\/acsami.6b05905","article-title":"Multifunctions of excited gold nanoparticles decorated artificial kidney with efficient hemodialysis and therapeutic potential","volume":"8","author":"Chen","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jtice.2017.09.031","article-title":"Polypyrrole electrode with a greater electroactive surface electrochemically polymerized in plasmon-activated water","volume":"82","author":"Chen","year":"2018","journal-title":"J. Taiwan Inst. Chem. E"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.desal.2018.02.013","article-title":"In situ and real-time reduction of water molecules\u2019 interaction for efficient water evaporation","volume":"436","author":"Chen","year":"2018","journal-title":"Desalination"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"9618","DOI":"10.1039\/C7RA13559A","article-title":"Plasmon-activated water effectively relieves hepatic oxidative damage resulted from chronic sleep deprivation","volume":"8","author":"Chen","year":"2018","journal-title":"RSC Adv."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"6316","DOI":"10.1038\/s41598-018-24752-x","article-title":"Innovatively therapeutic strategy on lung cancer by daily drinking antioxidative plasmon-induced activated water","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jelechem.2018.04.027","article-title":"Effectively reducing reagent concentrations for electrochemical reactions in aqueous solutions using plasmon-activated water","volume":"818","author":"Yang","year":"2018","journal-title":"J. Electroanal. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1021\/acsomega.8b00494","article-title":"Surface-enhanced Raman scattering-active substrate prepared with new plasmon-activated water","volume":"3","author":"Yang","year":"2018","journal-title":"ACS Omega"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nature11570","article-title":"Water structural transformation at molecular hydrophobic interfaces","volume":"491","author":"David","year":"2012","journal-title":"Nature"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/jrs.2262","article-title":"Effects of metal ion on the water structure studied by the Raman O[BOND]H stretching spectrum","volume":"40","author":"Li","year":"2009","journal-title":"J. Raman Spectrosc."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1063\/1.475659","article-title":"Measurement of the Raman spectrum of liquid water","volume":"108","author":"Carey","year":"1998","journal-title":"J. Chem. Phys."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jp111346s","article-title":"Structure and dynamics of water dangling OH bonds in hydrophobic hydration shells. Comparison of simulation and experiment","volume":"115","author":"Davis","year":"2011","journal-title":"J. Phys. Chem. A"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/378364a0","article-title":"Effect of high salt concentrations on water structure","volume":"378","author":"Leberman","year":"1995","journal-title":"Nature"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0167-7322(01)00148-9","article-title":"Cationic effect in aqueous solutions of 1:1 electrolytes by Raman spectral data","volume":"91","author":"Chumaevskii","year":"2001","journal-title":"J. Mol. Liq."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1021\/ar200117a","article-title":"The induced magnetic field","volume":"45","author":"Islas","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1021\/nl504473a","article-title":"Three-dimensional observation of magnetic vortex cores in stacked ferromagnetic discs","volume":"15","author":"Tanigaki","year":"2015","journal-title":"Nano Lett."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0070-2137(01)80009-1","article-title":"Antioxidant regulation of genes encoding enzymes that detoxify xenobiotics and carcinogens","volume":"36","author":"Dhakshinamoorthy","year":"2000","journal-title":"Curr. Top. Cell. Regul."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1146\/annurev.biochem.77.061606.161055","article-title":"Cellular defenses against superoxide and hydrogen peroxide","volume":"77","author":"Imlay","year":"2008","journal-title":"Annu. Rev. Biochem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/mmi.12061","article-title":"Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains","volume":"86","author":"Yamada","year":"2012","journal-title":"Mol. Microbiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"6907","DOI":"10.1038\/ncomms7907","article-title":"Amplification of oxidative stress by a dual stimuli-responsive hybrid drug enhances cancer cell death","volume":"6","author":"Noh","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1021\/jp044592+","article-title":"Water dependence of the HO2 self reaction: Kinetics of the HO2-H2O complex","volume":"109","author":"Kanno","year":"2005","journal-title":"J. Phys. Chem. A"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1021\/jp100204z","article-title":"A shock tube study of OH + H2O2 \u2192 H2O + HO2 and H2O2 + M \u2192 2OH + M using laser absorption of H2O and OH","volume":"114","author":"Hong","year":"2010","journal-title":"J. Phys. Chem. A"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nm0302-240","article-title":"Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice","volume":"8","author":"Lee","year":"2002","journal-title":"Nat. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.intimp.2008.03.011","article-title":"RV09, a novel resveratrol analogue, inhibits NO and TNF-\u03b1 production by LPS-activated microglia","volume":"8","author":"Meng","year":"2008","journal-title":"Int. Immunopharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1021\/bm400256h","article-title":"Inflammation-responsive antioxidant nanoparticles based on a polymeric prodrug of vanillin","volume":"14","author":"Kwon","year":"2013","journal-title":"Biomacromolecules"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1021\/acs.accounts.5b00170","article-title":"Hot-electron-mediated surface chemistry: Toward electronic control of catalytic activity","volume":"48","author":"Park","year":"2015","journal-title":"Acc. Chem. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"142","DOI":"10.7150\/thno.13130","article-title":"Anti-tumor efficiency of lipid -coated cisplatin nano-particles co-loaded with microRNA-375","volume":"6","author":"Yang","year":"2016","journal-title":"Theranostics"},{"key":"ref_99","first-page":"981","article-title":"Transport of cisplatin and bis-acetato-ammine-dichlorocyclohexylamine platinum(IV) (JM216) in human ovarian carcinoma cell lines: Identification of a plasma membrane protein associated with cisplatin resistance","volume":"1","author":"Sharp","year":"1995","journal-title":"Clin. Cancer Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"10348","DOI":"10.1039\/b918301a","article-title":"Hydrolysis of cisplatin\u2014A first-principles metadynamics study","volume":"12","author":"Lau","year":"2010","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_101","unstructured":"Greenwald, R.A. (1986). Catalase activity. CRC Handbook of Methods for Oxygen Radicals Research, CRC Press."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1021\/nn500685h","article-title":"Hyaluronate-gold nanoparticle\/tocilizumab complex for the treatment of rheumatoid rrthritis","volume":"8","author":"Lee","year":"2014","journal-title":"ACS Nano"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1039\/C3TB21388A","article-title":"Mussel-inspired self-coating at macro-interface with improved biocompatibility and bioactivity via dopamine grafted heparin-like polymers and heparin","volume":"2","author":"Ma","year":"2014","journal-title":"J. Mater. Chem. 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