{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:24:00Z","timestamp":1772994240626,"version":"3.50.1"},"reference-count":53,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2018,7,14]],"date-time":"2018-07-14T00:00:00Z","timestamp":1531526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Two known tin-based polymers of formula {[R3Sn(CH3COO)]n} where R = n-Bu\u2013 (1) and R = Ph\u2013 (2),were evaluated for their in vitro biological properties. The compounds were characterized via their physical properties and FT-IR, 119Sn M\u00f6ssbauer, and 1H NMR spectroscopic data. The molecular structures were confirmed by single-crystal X-Ray diffraction crystallography. The geometry around the tin(IV) ion is trigonal bi-pyramidal. Variations in O\u2013Sn\u2013O\u00b7\u00b7\u00b7Sn\u2032 torsion angles lead to zig-zag and helical supramolecular assemblies for 1 and 2, respectively. The in vitro cell viability against human breast adenocarcinoma cancer cell lines: MCF-7 positive to estrogens receptors (ERs) and MDA-MB-231 negative to ERs upon their incubation with 1 and 2 was investigated. Their toxicity has been studied against normal human fetal lung fibroblast cells (MRC-5). Compounds 1 and 2 exhibit 134 and 223-fold respectively stronger antiproliferative activity against MDA-MB-231 than cisplatin. The type of the cell death caused by 1 or 2 was also determined using flow cytometry assay. The binding affinity of 1 and 2 towards the CT-DNA was suspected from the differentiation of the viscosity which occurred in the solution containing increasing amounts of 1 and 2. Changes in fluorescent emission light of Ethidium bromide (EB) in the presence of DNA confirmed the intercalation mode of interactions into DNA of both complexes 1 and 2 which have been ascertained from viscosity measurements. The corresponding apparent binding constants (Kapp) of 1 and 2 towards CT-DNA calculated through fluorescence spectra are 4.9 \u00d7 104 (1) and 7.3 \u00d7 104 (2) M\u22121 respectively. Finally, the type of DNA binding interactions with 1 and 2 was confirmed by docking studies.<\/jats:p>","DOI":"10.3390\/ijms19072055","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T04:05:33Z","timestamp":1531713933000},"page":"2055","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Poly Organotin Acetates against DNA with Possible Implementation on Human Breast Cancer"],"prefix":"10.3390","volume":"19","author":[{"given":"George K.","family":"Latsis","sequence":"first","affiliation":[{"name":"Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6727-2711","authenticated-orcid":false,"given":"Christina N.","family":"Banti","sequence":"additional","affiliation":[{"name":"Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3264-2406","authenticated-orcid":false,"given":"Nikolaos","family":"Kourkoumelis","sequence":"additional","affiliation":[{"name":"Medical Physics Laboratory, Medical School, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantina","family":"Papatriantafyllopoulou","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cyprus, 1678 Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikos","family":"Panagiotou","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cyprus, 1678 Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasios","family":"Tasiopoulos","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cyprus, 1678 Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexios","family":"Douvalis","sequence":"additional","affiliation":[{"name":"M\u00f6ssbauer Spectroscopy and Physics of Material Laboratory, Department of Physics, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelos G.","family":"Kalampounias","sequence":"additional","affiliation":[{"name":"Physical Chemistry Laboratory, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bakas","sequence":"additional","affiliation":[{"name":"M\u00f6ssbauer Spectroscopy and Physics of Material Laboratory, Department of Physics, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sotiris K.","family":"Hadjikakou","sequence":"additional","affiliation":[{"name":"Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,7,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/BF00623551","article-title":"Platinum coordination complexes in cancer chemotherapy","volume":"60","author":"Rosenberg","year":"1973","journal-title":"Die Naturwissenschaften"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0010-8545(98)00192-1","article-title":"Impact of Cisplatin on the recent development of Pt coordination chemistry: A case study","volume":"182","author":"Lippert","year":"1999","journal-title":"Coord. Chem. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1016\/j.ccr.2009.01.028","article-title":"Mechanistic insight into the cellular uptake and processing of cisplatin 30 years after its approval by FDA","volume":"253","author":"Arnesano","year":"2009","journal-title":"Coord. Chem. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ccr.2014.07.016","article-title":"Effect of chirality in platinum drugs","volume":"284","author":"Arnesano","year":"2015","journal-title":"Coord. Chem. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.3892\/or.2013.2279","article-title":"Correlation of adverse effects of cisplatin administration in patients affected by solid tumours: A retrospective evaluation","volume":"29","author":"Astolfi","year":"2013","journal-title":"Oncol. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/onc.2011.384","article-title":"Molecular mechanisms of cisplatin resistance","volume":"31","author":"Galluzzi","year":"2012","journal-title":"Oncogene"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1021\/acs.jmedchem.7b01694","article-title":"Organometallic Gold(III) Complexes Similar to Tetrahydroisoquinoline Induce ER-Stress-Mediated Apoptosis and Pro-Death Autophagy in A549 Cancer Cells","volume":"61","author":"Huang","year":"2018","journal-title":"J. Med. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/bscb.19830920213","article-title":"Organotin compounds: New organometallic derivatives exhibiting anti-tuequr activity","volume":"92","author":"Haiduc","year":"1983","journal-title":"Bull. Soc. Chim. Belg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/0040-4020(89)80030-4","article-title":"Synthesis, characterization and antitumour activity of 7,7-di-n-butyi-5,9-dioxo-6,6-dioxa-7-stanna-spiro[3,5]nonane, a di-n-butyltin(lV) analog of \u201cparaplatin\u201d, and of a series of di-n-butyitin(lV) derivatives of mono- and disubstituted malonic acids","volume":"45","author":"Gielen","year":"1989","journal-title":"Tetrahedron"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0010-8545(89)80003-7","article-title":"Organotin compounds and cancer chemotherapy","volume":"95","author":"Saxena","year":"1989","journal-title":"Coord. Chem. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0010-8545(95)01216-8","article-title":"Tin-based antitumour drugs","volume":"151","author":"Gielen","year":"1996","journal-title":"Coord. Chem. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/aoc.331","article-title":"Organotin compounds and their therapeutic potential: A report from the Organometallic Chemistry Department of the Free University of Brussels","volume":"16","author":"Gielen","year":"2002","journal-title":"Appl. Organomet. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ccr.2007.12.026","article-title":"Antiproliferative and anti-tumor activity of organotin compounds","volume":"253","author":"Hadjikakou","year":"2009","journal-title":"Coord. Chem. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"14568","DOI":"10.1039\/c2dt31527k","article-title":"Synthesis, structural characterization and in vitro inhibitory studies against humanagainst human breast cancer of the bis-(2,6-di-tert-butylphenol)tin(IV) dichloride andits complexes","volume":"41","author":"Shpakovsky","year":"2012","journal-title":"Dalton Trans."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"6880","DOI":"10.1039\/C3DT53469C","article-title":"Synthesis, antiradical activity and in vitro cytotoxicity of novel organotin complexes based on 2,6-di-tert-butyl-4-mercaptophenol","volume":"43","author":"Shpakovsky","year":"2014","journal-title":"Dalton Trans."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1071\/CH12448","article-title":"Structural and in vitro biological studies of organotin(IV) precursors; selective inhibitory activity against human breast cancer cells, positive to estrogen receptors","volume":"65","author":"Balas","year":"2012","journal-title":"Austr. J. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1016\/j.ejmech.2011.04.005","article-title":"Synthesis, structural characterization and biological studies of the triphenyltin(IV)complex with 2-thiobarbituric acid","volume":"46","author":"Balas","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ejps.2010.11.015","article-title":"Anticancer and cytotoxic effects of a triorganotin compound with 2-mercapto-nicotinic acid in malignant cell lines and tumor bearing Wistar rats","volume":"42","author":"Verginadis","year":"2011","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1007\/s00044-018-2135-7","article-title":"Cytotoxic effect, antitumour activity and toxicity of organotin derivatives with ortho- or para-hydroxy-benzoic acids","volume":"27","author":"Agiorgiti","year":"2018","journal-title":"Med. Chem. Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Abdellah, M.A., Hadjikakou, S.K., Hadjiliadis, N., Kubicki, M., Bakas, T., Kourkoumelis, N., Simos, Y.V., Karkabounas, S., Barsan, M.M., and Butler, I.S. (2009). Synthesis, characterization, and biological studies of organotin(IV) derivatives with o- or p-hydroxybenzoic acids. Bioinorg. Chem. Appl., 12.","DOI":"10.1155\/2009\/542979"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ejmech.2007.03.028","article-title":"Biological studies of new organotin(IV) complexes ofthioamide ligands","volume":"43","author":"Xanthopoulou","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Balas, V.I., Hadjikakou, S.K., Hadjiliadis, N., Kourkoumelis, N., Light, M.E., Hursthouse, M., Metsios, A.K., and Karkabounas, S. (2008). Crystal structure and antitumor activity of the novel zwitterionic complex of tri-n-butyltin(IV) with 2-thiobarbituric acid. Bioinorg. Chem. Appl., 654137.","DOI":"10.1155\/2008\/654137"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s11172-007-0115-z","article-title":"Biological studies of organotin(IV) complexes with 2-mercaptopyrimidine","volume":"56","author":"Xanthopoulou","year":"2007","journal-title":"Russ. Chem. B"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/j.jorganchem.2005.11.073","article-title":"Synthesis and characterization of a new chloro-di-phenyltin(IV) complex with 2-mercapto-nicotinic acid: Study of its influence upon the catalytic oxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase","volume":"691","author":"Xanthopoulou","year":"2006","journal-title":"J. Organomet. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0162-0134(03)00178-8","article-title":"Synthesis, structural characterization and in vitro cytotoxicity of organotin(IV) derivatives of heterocyclic thioamides, 2-mercaptobenzothiazole, 5-chloro-2-mercaptobenzothiazole, 3-methyl-2-mercaptobenzothiazole and 2-mercaptonicotinic acid","volume":"96","author":"Xanthopoulou","year":"2003","journal-title":"J. Inorg. Biochem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ica.2014.02.006","article-title":"Assessment of organotins against the linoleic acid, glutathione and CT-DNA","volume":"423","author":"Banti","year":"2014","journal-title":"Inorg. Chim. Acta"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1016\/j.poly.2008.07.030","article-title":"Structural and biological studies of organotin(IV) derivatives with 2-mercapto-benzoic acid and -mercapto-4-methyl-pyrimidine","volume":"27","author":"Xanthopoulou","year":"2008","journal-title":"Polyhedron"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.jorganchem.2005.11.056","article-title":"Novel organotin(IV) compounds derived from bis(organostannyl)methanes: Synthesis and crystal structures of bis[diphenyl(pyridin-2-onato)stannyl]methane and bis[bromophenyl(pyrimidine-2-thionato)stannyl]methane C7H8","volume":"691","author":"Hadjikakou","year":"2006","journal-title":"J. Organomet. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1021\/ic061601f","article-title":"Synthesis, structural characterization, and biological studies of six and five-coordinate organotin(IV) Complexes with the Thioamides 2-Mercaptobenzothiazole, 5-Chloro-2-mercaptobenzothiazole, and 2-Mercaptobenzoxazole","volume":"46","author":"Xanthopoulou","year":"2007","journal-title":"Inorg. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jorganchem.2013.05.033","article-title":"Organotin polymers as anticancer and antiviral agents","volume":"751","author":"Carraher","year":"2014","journal-title":"J. Org. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1063\/1.1739921","article-title":"Infrared Spectra of CH3COONa and CD3COONa and Assignments of Vibrational Frequencies","volume":"22","author":"Jones","year":"1954","journal-title":"J. Chem. Phys."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Greenwood, N.N., and Gibb, T.C. (1971). Mossbauer Spectroscopy, Chapman and Hall.","DOI":"10.1007\/978-94-009-5697-1"},{"key":"ref_33","first-page":"m469","article-title":"catena-Poly[tributyltin(IV)-l-acetato]","volume":"E62","author":"Saeed","year":"2006","journal-title":"Acta Cryst."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0022-328X(84)80194-1","article-title":"Organotin biocides 1. The structure of triphenyltin acetate","volume":"267","author":"Molloy","year":"1984","journal-title":"J. Organomet. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"Djv073","DOI":"10.1093\/jnci\/djv073","article-title":"MCF-7 Cells\u2014Changing the Course of Breast Cancer Research and Care for 45 Years","volume":"107","author":"Lee","year":"2015","journal-title":"JNCI J. Nat. Cancer Inst."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1677\/erc.0.0100261","article-title":"How to target estrogen receptor-negative breast cancer?","volume":"10","author":"Rochefort","year":"2003","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1021\/acs.inorgchem.6b01241","article-title":"Nimesulide silver metallodrugs, containing the mitochondriotropic, triaryl derivatives of pnictogen; Anticancer activity against human breast cancer cells","volume":"55","author":"Banti","year":"2016","journal-title":"Inorg. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.etp.2014.11.008","article-title":"Cytotoxic and genotoxic effects of high concentrations of the immunosuppressive drugs cyclosporine and tacrolimus in MRC-5 cells","volume":"67","author":"Ribeiro","year":"2015","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"11187","DOI":"10.1039\/c2dt30990d","article-title":"Two new palladium(II) complexes: Synthesis, characterization and their interaction with HeLa cells","volume":"41","author":"Gao","year":"2012","journal-title":"Dalton Trans."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Boer, D.R., Canals, A., and Coll, M. (2009). DNA-binding drugs caught in action: The latest 3D pictures of drug-DNA complexes. Dalton Trans., 399\u2013414.","DOI":"10.1039\/B809873P"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1021\/ci400352t","article-title":"Docking studies on DNA intercalators","volume":"54","author":"Gilad","year":"2013","journal-title":"J. Chem. Inf. Model."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8791","DOI":"10.1021\/ja961631p","article-title":"Structure of actinomycin D bound with (GAAGCTTC)2 and (GATGCTTC)2 and its binding to the (CAG)n:(CTG)n triplet sequence as determined by NMR analysis","volume":"118","author":"Lian","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6880","DOI":"10.1039\/C5DT00728C","article-title":"New palladium (II) and platinum (II) 5, 5-diethylbarbiturate complexes with 2-phenylpyridine, 2, 2\u2032-bipyridine and 2, 2\u2032-dipyridylamine: Synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicity","volume":"44","author":"Icsel","year":"2015","journal-title":"Dalton Trans."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1021\/jm700964u","article-title":"Design and Synthesis of 4-Substituted Indolo [3, 2-e][1, 2, 3] triazolo [1, 5-a] pyrimidine Derivatives with Antitumor Activity","volume":"51","author":"Lauria","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1039\/C4DT02700K","article-title":"Metal complex interactions with DNA","volume":"44","author":"Pages","year":"2015","journal-title":"Dalton Trans."},{"key":"ref_46","unstructured":"Oxford Diffraction (2008). CrysAlis CCD and CrysAlis RED, Oxford Diffraction Ltd."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1107\/S002188980403225X","article-title":"SIR2004: An improved tool for crystal structure determination and refinement","volume":"38","author":"Burla","year":"2005","journal-title":"J. Appl. Cryst."},{"key":"ref_48","unstructured":"Sheldrick, G.M. (2014). SHELXL-2014\/7, Program for Refinement of Crystal Structures, University of Go\u0308ttingen."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1107\/S0021889899006020","article-title":"WinGX suite for small-molecule single-crystal crystallography","volume":"32","author":"Farrugia","year":"1999","journal-title":"J. Appl. Cryst."},{"key":"ref_50","unstructured":"Bevington, P.R., and Robinson, D.K. (1992). Data Reduction and Error Analysis for the Physical Sciences, McGraw Hill."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDockVina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading","volume":"31","author":"OTrott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"Autodock4 and AutoDockTools4: Automated docking with selective receptor flexibility","volume":"16","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"ref_53","unstructured":"Frisch, M.J., Trucks, G.W., Schlegel, H.B., Scuseria, G.E., Robb, M.A., Cheeseman, J.R., Montgomery, J.A., Vreven, T., Kudin, K.N., and Burant, J.C. (2004). GAUSSIAN 03 (Revision C.02), Gaussian, Inc."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/7\/2055\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:12:13Z","timestamp":1760195533000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/7\/2055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,14]]},"references-count":53,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7]]}},"alternative-id":["ijms19072055"],"URL":"https:\/\/doi.org\/10.3390\/ijms19072055","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,14]]}}}