{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:23:59Z","timestamp":1790421839231,"version":"4.1.0"},"reference-count":230,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:00:00Z","timestamp":1532649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Adipose-derived stromal\/stem cells (ASCs) seems to be a promising regenerative therapeutic agent due to the minimally invasive approach of their harvest and multi-lineage differentiation potential. The harvested adipose tissues are further digested to extract stromal vascular fraction (SVF), which is cultured, and the anchorage-dependent cells are isolated in order to characterize their stemness, surface markers, and multi-differentiation potential. The differentiation potential of ASCs is directed through manipulating culture medium composition with an introduction of growth factors to obtain the desired cell type. ASCs have been widely studied for its regenerative therapeutic solution to neurologic, skin, wound, muscle, bone, and other disorders. These therapeutic outcomes of ASCs are achieved possibly via autocrine and paracrine effects of their secretome comprising of cytokines, extracellular proteins and RNAs. Therefore, secretome-derivatives might offer huge advantages over cells through their synthesis and storage for long-term use. When considering the therapeutic significance and future prospects of ASCs, this review summarizes the recent developments made in harvesting, isolation, and characterization. Furthermore, this article also provides a deeper insight into secretome of ASCs mediating regenerative efficacy.<\/jats:p>","DOI":"10.3390\/ijms19082200","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T12:20:03Z","timestamp":1532694003000},"page":"2200","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":120,"title":["Revisiting the Advances in Isolation, Characterization and Secretome of Adipose-Derived Stromal\/Stem Cells"],"prefix":"10.3390","volume":"19","author":[{"given":"Navneet Kumar","family":"Dubey","sequence":"first","affiliation":[{"name":"Ceramics and Biomaterials Research Group, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam"},{"name":"Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viraj Krishna","family":"Mishra","sequence":"additional","affiliation":[{"name":"Applied Biotech Engineering Centre (ABEC), Department of Biotechnology, Ambala College of Engineering and Applied Research, Ambala 133101, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0506-7744","authenticated-orcid":false,"given":"Rajni","family":"Dubey","sequence":"additional","affiliation":[{"name":"Graduate Institute Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Hua","family":"Deng","sequence":"additional","affiliation":[{"name":"Stem Cell Research Center, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Department of Life Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Chou","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Win-Ping","family":"Deng","sequence":"additional","affiliation":[{"name":"Stem Cell Research Center, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Department of Basic medicine, Fu-Jen Catholic University, New Taipei City 24205, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1634\/stemcells.2005-0234","article-title":"Immunophenotype of human adipose-derived cells: Temporal changes in stromal-associated and stem cell-associated markers","volume":"24","author":"Mitchell","year":"2006","journal-title":"Stem Cells"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3206807","DOI":"10.1155\/2016\/3206807","article-title":"Advances in Adipose-Derived Stem Cells Isolation, Characterization, and Application in Regenerative Tissue Engineering","volume":"2016","author":"Wankhade","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.stem.2008.07.003","article-title":"A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs","volume":"3","author":"Crisan","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.bjps.2009.10.020","article-title":"Distribution of adipose-derived stem cells in adipose tissues from human cadavers","volume":"63","author":"Kishi","year":"2010","journal-title":"J. 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