{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:27:57Z","timestamp":1790807277851,"version":"4.1.0"},"reference-count":446,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T00:00:00Z","timestamp":1533254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["13353"],"award-info":[{"award-number":["13353"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondation Sant\u00e9","award":["ED2016"],"award-info":[{"award-number":["ED2016"]}]},{"DOI":"10.13039\/501100006408","name":"Ministry of National Education and Religious Affairs","doi-asserted-by":"publisher","award":["12RUS-11-65"],"award-info":[{"award-number":["12RUS-11-65"]}],"id":[{"id":"10.13039\/501100006408","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The timing, dosage and location of gene expression are fundamental determinants of brain architectural complexity. In neurons, this is, primarily, achieved by specific sets of trans-acting RNA-binding proteins (RBPs) and their associated factors that bind to specific cis elements throughout the RNA sequence to regulate splicing, polyadenylation, stability, transport and localized translation at both axons and dendrites. Not surprisingly, misregulation of RBP expression or disruption of its function due to mutations or sequestration into nuclear or cytoplasmic inclusions have been linked to the pathogenesis of several neuropsychiatric and neurodegenerative disorders such as fragile-X syndrome, autism spectrum disorders, spinal muscular atrophy, amyotrophic lateral sclerosis and frontotemporal dementia. This review discusses the roles of Pumilio, Staufen, IGF2BP, FMRP, Sam68, CPEB, NOVA, ELAVL, SMN, TDP43, FUS, TAF15, and TIA1\/TIAR in RNA metabolism by analyzing their specific molecular and cellular function, the neurological symptoms associated with their perturbation, and their axodendritic transport\/localization along with their target mRNAs as part of larger macromolecular complexes termed ribonucleoprotein (RNP) granules.<\/jats:p>","DOI":"10.3390\/ijms19082280","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T11:03:26Z","timestamp":1533294206000},"page":"2280","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Unraveling the Pathways to Neuronal Homeostasis and Disease: Mechanistic Insights into the Role of RNA-Binding Proteins and Associated Factors"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8347-218X","authenticated-orcid":false,"given":"Stylianos","family":"Ravanidis","sequence":"first","affiliation":[{"name":"Basic Sciences Division I, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-7420","authenticated-orcid":false,"given":"Fedon-Giasin","family":"Kattan","sequence":"additional","affiliation":[{"name":"Basic Sciences Division I, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1305-0739","authenticated-orcid":false,"given":"Epaminondas","family":"Doxakis","sequence":"additional","affiliation":[{"name":"Basic Sciences Division I, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/cne.21974","article-title":"Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain","volume":"513","author":"Azevedo","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ng.259","article-title":"Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing","volume":"40","author":"Pan","year":"2008","journal-title":"Nat. Genet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1093\/nar\/gkq008","article-title":"Splicing factor and exon profiling across human tissues","volume":"38","author":"Gratadou","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1038\/ng.264","article-title":"Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines","volume":"40","author":"Castle","year":"2008","journal-title":"Nat. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"R64","DOI":"10.1186\/gb-2007-8-4-r64","article-title":"Discovery of tissue-specific exons using comprehensive human exon microarrays","volume":"8","author":"Clark","year":"2007","journal-title":"Genome Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/s12264-014-1443-7","article-title":"RNA binding proteins: A common denominator of neuronal function and dysfunction","volume":"30","author":"Doxakis","year":"2014","journal-title":"Neurosci. Bull."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.sbi.2012.11.006","article-title":"Rrm-RNA recognition: Nmr or crystallography...and new findings","volume":"23","author":"Daubner","year":"2013","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.sbi.2015.01.002","article-title":"Kh-RNA interactions: Back in the groove","volume":"30","author":"Nicastro","year":"2015","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jmb.2010.12.041","article-title":"Characterization of a family of ranbp2-type zinc fingers that can recognize single-stranded RNA","volume":"407","author":"Nguyen","year":"2011","journal-title":"J. Mol. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.tibs.2014.05.003","article-title":"\u2018Black sheep\u2019 that don\u2019t leave the double-stranded RNA-binding domain fold","volume":"39","author":"Gleghorn","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12964-016-0132-3","article-title":"The new (dis)order in RNA regulation","volume":"14","author":"Jarvelin","year":"2016","journal-title":"Cell Commun. Signal"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.tcb.2016.05.004","article-title":"Principles and properties of stress granules","volume":"26","author":"Protter","year":"2016","journal-title":"Trends Cell Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.neuron.2012.02.036","article-title":"The local transcriptome in the synaptic neuropil revealed by deep sequencing and high-resolution imaging","volume":"74","author":"Cajigas","year":"2012","journal-title":"Neuron"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41467-017-00690-6","article-title":"Rna localization is a key determinant of neurite-enriched proteome","volume":"8","author":"Zappulo","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1038\/ncomms5510","article-title":"Functionally diverse dendritic mrnas rapidly associate with ribosomes following a novel experience","volume":"5","author":"Ainsley","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cell.2016.05.029","article-title":"Dynamic axonal translation in developing and mature visual circuits","volume":"166","author":"Shigeoka","year":"2016","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1073\/pnas.1111226109","article-title":"Neuronal mrnas travel singly into dendrites","volume":"109","author":"Batish","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1126\/science.1242939","article-title":"Single beta-actin mRNA detection in neurons reveals a mechanism for regulating its translatability","volume":"343","author":"Buxbaum","year":"2014","journal-title":"Science"},{"key":"ref_19","first-page":"1001","article-title":"Specific interaction of kif11 with zbp1 regulates the transport of beta-actin mRNA and cell motility","volume":"128","author":"Song","year":"2015","journal-title":"J. Cell Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"8381","DOI":"10.1038\/ncomms9381","article-title":"The structural basis of miranda-mediated staufen localization during drosophila neuroblast asymmetric division","volume":"6","author":"Jia","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1101\/gad.12.12.1847","article-title":"Miranda mediates asymmetric protein and RNA localization in the developing nervous system","volume":"12","author":"Schuldt","year":"1998","journal-title":"Genes Dev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.neuron.2004.07.022","article-title":"Kinesin transports RNA: Isolation and characterization of an RNA-transporting granule","volume":"43","author":"Kanai","year":"2004","journal-title":"Neuron"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"8844","DOI":"10.1073\/pnas.151231598","article-title":"A highly conserved protein family interacting with the fragile \u00d7 mental retardation protein (fmrp) and displaying selective interactions with fmrp-related proteins fxr1p and fxr2p","volume":"98","author":"Schenck","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1128\/MCB.02470-05","article-title":"Translational control by neuroguidin, a eukaryotic initiation factor 4e and cpeb binding protein","volume":"26","author":"Jung","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.neuron.2017.12.045","article-title":"A translational repression complex in developing mammalian neural stem cells that regulates neuronal specification","volume":"97","author":"Zahr","year":"2018","journal-title":"Neuron"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cell.2011.06.013","article-title":"Fmrp stalls ribosomal translocation on mrnas linked to synaptic function and autism","volume":"146","author":"Darnell","year":"2011","journal-title":"Cell"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.molcel.2006.08.016","article-title":"Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation","volume":"24","author":"Kim","year":"2006","journal-title":"Mol. Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1038\/s41598-017-01963-2","article-title":"Zbp1 phosphorylation at serine 181 regulates its dendritic transport and the development of dendritic trees of hippocampal neurons","volume":"7","author":"Urbanska","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"14349","DOI":"10.1523\/JNEUROSCI.2969-07.2007","article-title":"Fmrp phosphorylation reveals an immediate-early signaling pathway triggered by group i mglur and mediated by pp2a","volume":"27","author":"Narayanan","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1093\/hmg\/ddr527","article-title":"In vivo neuronal function of the fragile \u00d7 mental retardation protein is regulated by phosphorylation","volume":"21","author":"Coffee","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.yexcr.2008.12.008","article-title":"Prmt1 mediated methylation of taf15 is required for its positive gene regulatory function","volume":"315","author":"Jobert","year":"2009","journal-title":"Exp. Cell Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0378-1119(02)01060-0","article-title":"Cloning and comparative sequence analysis of pum1 and pum2 genes, human members of the pumilio family of RNA-binding proteins","volume":"299","author":"Spassov","year":"2002","journal-title":"Gene"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4487","DOI":"10.1073\/pnas.0509260103","article-title":"Genome-wide identification of mrnas associated with the translational regulator pumilio in drosophila melanogaster","volume":"103","author":"Gerber","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1021\/bi982264s","article-title":"The pumilio-rna interaction: A single rna-binding domain monomer recognizes a bipartite target sequence","volume":"38","author":"Zamore","year":"1999","journal-title":"Biochemistry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e17096","DOI":"10.7554\/eLife.17096","article-title":"Drosophila nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of pumilio","volume":"5","author":"Weidmann","year":"2016","journal-title":"Elife"},{"key":"ref_36","first-page":"1855","article-title":"Pum2, a novel murine puf protein, and its consensus RNA-binding site","volume":"7","author":"White","year":"2001","journal-title":"RNA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1261\/rna.1884610","article-title":"Pumilio 2 controls translation by competing with eif4e for 7-methyl guanosine cap recognition","volume":"16","author":"Cao","year":"2010","journal-title":"RNA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1523\/JNEUROSCI.0649-06.2006","article-title":"Dendritic localization of the translational repressor pumilio 2 and its contribution to dendritic stress granules","volume":"26","author":"Vessey","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.neuron.2004.10.028","article-title":"The translational repressor pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor eif-4e","volume":"44","author":"Menon","year":"2004","journal-title":"Neuron"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1080\/15476286.2017.1306168","article-title":"Combinatorial control of messenger rnas by pumilio, nanos and brain tumor proteins","volume":"14","author":"Arvola","year":"2017","journal-title":"RNA Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0960-9822(03)00064-2","article-title":"The staufen\/pumilio pathway is involved in drosophila long-term memory","volume":"13","author":"Dubnau","year":"2003","journal-title":"Curr. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.cub.2004.01.052","article-title":"Nanos and pumilio are essential for dendrite morphogenesis in drosophila peripheral neurons","volume":"14","author":"Ye","year":"2004","journal-title":"Curr. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1523\/JNEUROSCI.5092-07.2008","article-title":"Pumilio binds para mRNA and requires nanos and brat to regulate sodium current in drosophila motoneurons","volume":"28","author":"Muraro","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbrc.2015.04.019","article-title":"Loss of preimplantation embryo resulting from a pum1 gene trap mutation","volume":"462","author":"Zhang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.cell.2015.02.012","article-title":"Pumilio1 haploinsufficiency leads to sca1-like neurodegeneration by increasing wild-type ataxin1 levels","volume":"160","author":"Gennarino","year":"2015","journal-title":"Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.cell.2018.02.006","article-title":"A mild pum1 mutation is associated with adult-onset ataxia, whereas haploinsufficiency causes developmental delay and seizures","volume":"172","author":"Gennarino","year":"2018","journal-title":"Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1101\/gad.298752.117","article-title":"Post-transcriptional regulation of mouse neurogenesis by pumilio proteins","volume":"31","author":"Zhang","year":"2017","journal-title":"Genes Dev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1073\/pnas.0907128107","article-title":"Mammalian pumilio 2 regulates dendrite morphogenesis and synaptic function","volume":"107","author":"Vessey","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","first-page":"1333","article-title":"Pumilio2-deficient mice show a predisposition for epilepsy","volume":"10","author":"Follwaczny","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.yebeh.2015.05.017","article-title":"Reduced pumilio-2 expression in patients with temporal lobe epilepsy and in the lithium-pilocarpine induced epilepsy rat model","volume":"50","author":"Wu","year":"2015","journal-title":"Epilepsy Behav."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Siemen, H., Colas, D., Heller, H.C., Brustle, O., and Pera, R.A. (2011). Pumilio-2 function in the mouse nervous system. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0025932"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1128\/MCB.19.3.2212","article-title":"A human sequence homologue of staufen is an rna-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum","volume":"19","author":"Marion","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1128\/MCB.19.3.2220","article-title":"Mammalian staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum","volume":"19","author":"Wickham","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/geno.1999.6015","article-title":"Identification of a novel homolog of the drosophila staufen protein in the chromosome 8q13-q21.1 region","volume":"62","author":"Buchner","year":"1999","journal-title":"Genomics"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0092-8674(91)90138-O","article-title":"Staufen, a gene required to localize maternal rNAS in the drosophila egg","volume":"66","author":"Beuchle","year":"1991","journal-title":"Cell"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1242\/jcs.115.16.3285","article-title":"Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles","volume":"115","author":"Duchaine","year":"2002","journal-title":"J. Cell Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/0161-5890(80)90007-3","article-title":"Detection of thy-1.2 membrane complexes shed from thymocytes and lymphoma cells by an immunoradiometric assay","volume":"17","author":"Schwarz","year":"1980","journal-title":"Mol. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)80504-8","article-title":"Inscuteable and staufen mediate asymmetric localization and segregation of prospero RNA during drosophila neuroblast cell divisions","volume":"90","author":"Li","year":"1997","journal-title":"Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.stem.2012.06.010","article-title":"An asymmetrically localized staufen2-dependent RNA complex regulates maintenance of mammalian neural stem cells","volume":"11","author":"Vessey","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.stem.2012.06.006","article-title":"Asymmetric segregation of the double-stranded RNA binding protein staufen2 during mammalian neural stem cell divisions promotes lineage progression","volume":"11","author":"Kusek","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1128\/MCB.01844-07","article-title":"Staufen1 regulation of protein synthesis-dependent long-term potentiation and synaptic function in hippocampal pyramidal cells","volume":"28","author":"Lebeau","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"16374","DOI":"10.1073\/pnas.0804583105","article-title":"A loss of function allele for murine staufen1 leads to impairment of dendritic staufen1-rnp delivery and dendritic spine morphogenesis","volume":"105","author":"Vessey","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1083\/jcb.200509035","article-title":"The brain-specific double-stranded RNA-binding protein staufen2 is required for dendritic spine morphogenesis","volume":"172","author":"Goetze","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1261\/rna.720308","article-title":"A genome-wide approach identifies distinct but overlapping subsets of cellular mrnas associated with staufen1- and staufen2-containing ribonucleoprotein complexes","volume":"14","author":"Furic","year":"2008","journal-title":"RNA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"344","DOI":"10.5483\/BMBRep.2010.43.5.344","article-title":"Genome wide identification of staufen2-bound mrnas in embryonic rat brains","volume":"43","author":"DesGroseillers","year":"2010","journal-title":"BMB Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.celrep.2013.11.039","article-title":"Staufen2 regulates neuronal target rnas","volume":"5","author":"Sharangdhar","year":"2013","journal-title":"Cell Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cell.2004.11.050","article-title":"Mammalian staufen1 recruits upf1 to specific mRNA 3\u2019utrs so as to elicit mRNA decay","volume":"120","author":"Kim","year":"2005","journal-title":"Cell"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1093\/nar\/gki794","article-title":"Interaction of staufen1 with the 5\u2032 end of mRNA facilitates translation of these rnas","volume":"33","author":"Elvira","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1073\/pnas.1213508110","article-title":"Staufen2 functions in staufen1-mediated mRNA decay by binding to itself and its paralog and promoting upf1 helicase but not atpase activity","volume":"110","author":"Park","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1523\/JNEUROSCI.19-01-00288.1999","article-title":"The mammalian staufen protein localizes to the somatodendritic domain of cultured hippocampal neurons: Implications for its involvement in mRNA transport","volume":"19","author":"Kiebler","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1091\/mbc.10.9.2945","article-title":"Microtubule-dependent recruitment of staufen-green fluorescent protein into large rna-containing granules and subsequent dendritic transport in living hippocampal neurons","volume":"10","author":"Kohrmann","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1101\/lm.2100611","article-title":"Staufen 2 regulates mglur long-term depression and map1b mRNA distribution in hippocampal neurons","volume":"18","author":"Lebeau","year":"2011","journal-title":"Learn. Mem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1091\/mbc.e04-06-0516","article-title":"Staufen recruitment into stress granules does not affect early mRNA transport in oligodendrocytes","volume":"16","author":"Thomas","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1111\/j.1471-4159.2007.04697.x","article-title":"The transport of staufen2-containing ribonucleoprotein complexes involves kinesin motor protein and is modulated by mitogen-activated protein kinase pathway","volume":"102","author":"Jeong","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neulet.2005.11.047","article-title":"Role of staufen in dendritic mRNA transport and its modulation","volume":"397","author":"Kim","year":"2006","journal-title":"Neurosci. Lett."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0896-6273(01)00493-7","article-title":"A role for a rat homolog of staufen in the transport of RNA to neuronal dendrites","volume":"32","author":"Tang","year":"2001","journal-title":"Neuron"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1242\/jcs.038208","article-title":"Mammalian staufen 1 is recruited to stress granules and impairs their assembly","volume":"122","author":"Thomas","year":"2009","journal-title":"J. Cell Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1007\/s00018-012-1186-z","article-title":"Insulin-like growth factor 2 mRNA-binding proteins (igf2bps): Post-transcriptional drivers of cancer progression?","volume":"70","author":"Bell","year":"2013","journal-title":"Cell Mol. Life Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1242\/jcs.115.10.2087","article-title":"Cytoplasmic trafficking of igf-ii mrna-binding protein by conserved kh domains","volume":"115","author":"Nielsen","year":"2002","journal-title":"J. Cell Sci."},{"key":"ref_80","first-page":"2034","article-title":"Par-clip\u2014A method to identify transcriptome-wide the binding sites of RNA binding proteins","volume":"41","author":"Hafner","year":"2010","journal-title":"J. Vis. Exp."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.celrep.2016.03.052","article-title":"Enhanced clip uncovers imp protein-RNA targets in human pluripotent stem cells important for cell adhesion and survival","volume":"15","author":"Conway","year":"2016","journal-title":"Cell Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1128\/MCB.24.10.4448-4464.2004","article-title":"Dwarfism and impaired gut development in insulin-like growth factor ii mRNA-binding protein 1-deficient mice","volume":"24","author":"Hansen","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.cmet.2015.03.006","article-title":"Igf2bp2\/imp2-deficient mice resist obesity through enhanced translation of ucp1 mRNA and other mrnas encoding mitochondrial proteins","volume":"21","author":"Dai","year":"2015","journal-title":"Cell Metab."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Boylan, K.L., Mische, S., Li, M., Marques, G., Morin, X., Chia, W., and Hays, T.S. (2008). Motility screen identifies drosophila igf-ii mRNA-binding protein-zipcode-binding protein acting in oogenesis and synaptogenesis. PLoS Genet., 4.","DOI":"10.1371\/journal.pgen.0040036"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1242\/dev.00810","article-title":"The RNA-binding protein vg1 rbp is required for cell migration during early neural development","volume":"130","author":"Yaniv","year":"2003","journal-title":"Development"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e00924","DOI":"10.7554\/eLife.00924","article-title":"A network of heterochronic genes including imp1 regulates temporal changes in stem cell properties","volume":"2","author":"Nishino","year":"2013","journal-title":"Elife"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/gtc.12024","article-title":"Imp2 regulates differentiation potentials of mouse neocortical neural precursor cells","volume":"18","author":"Fujii","year":"2013","journal-title":"Genes Cells"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1523\/JNEUROSCI.23-08-03251.2003","article-title":"Activity-dependent trafficking and dynamic localization of zipcode binding protein 1 and beta-actin mRNA in dendrites and spines of hippocampal neurons","volume":"23","author":"Tiruchinapalli","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0896-6273(01)00357-9","article-title":"Neurotrophin-induced transport of a beta-actin mrnp complex increases beta-actin levels and stimulates growth cone motility","volume":"31","author":"Zhang","year":"2001","journal-title":"Neuron"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1074\/mcp.M600346-MCP200","article-title":"Molecular composition of imp1 ribonucleoprotein granules","volume":"6","author":"Jonson","year":"2007","journal-title":"Mol. Cell. Proteom."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1261\/rna.1175909","article-title":"Control of c-myc mRNA stability by igf2bp1-associated cytoplasmic rnps","volume":"15","author":"Weidensdorfer","year":"2009","journal-title":"RNA"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/dneu.22111","article-title":"Dynamics of survival of motor neuron (smn) protein interaction with the mrna-binding protein imp1 facilitates its trafficking into motor neuron axons","volume":"74","author":"Fallini","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature04115","article-title":"Spatial regulation of beta-actin translation by src-dependent phosphorylation of zbp1","volume":"438","author":"Zenklusen","year":"2005","journal-title":"Nature"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"E6877","DOI":"10.1073\/pnas.1614267113","article-title":"Glutamate-induced RNA localization and translation in neurons","volume":"113","author":"Yoon","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"10433","DOI":"10.1523\/JNEUROSCI.23-32-10433.2003","article-title":"Localization of a beta-actin messenger ribonucleoprotein complex with zipcode-binding protein modulates the density of dendritic filopodia and filopodial synapses","volume":"23","author":"Eom","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/nn1773","article-title":"An essential role for beta-actin mRNA localization and translation in Ca2+-dependent growth cone guidance","volume":"9","author":"Yao","year":"2006","journal-title":"Nat. Neurosci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/nn1775","article-title":"Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1","volume":"9","author":"Leung","year":"2006","journal-title":"Nat. Neurosci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"9800","DOI":"10.1523\/JNEUROSCI.0166-11.2011","article-title":"Netrin-1-induced local beta-actin synthesis and growth cone guidance requires zipcode binding protein 1","volume":"31","author":"Welshhans","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1523\/JNEUROSCI.2387-10.2011","article-title":"Zipcode binding protein 1 regulates the development of dendritic arbors in hippocampal neurons","volume":"31","author":"Perycz","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1038\/emboj.2011.347","article-title":"Limited availability of zbp1 restricts axonal mRNA localization and nerve regeneration capacity","volume":"30","author":"Donnelly","year":"2011","journal-title":"EMBO J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1126\/science.7692601","article-title":"Fmr1 protein: Conserved rnp family domains and selective RNA binding","volume":"262","author":"Ashley","year":"1993","journal-title":"Science"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/ng0193-36","article-title":"Tissue specific expression of fmr-1 provides evidence for a functional role in fragile \u00d7 syndrome","volume":"3","author":"Hinds","year":"1993","journal-title":"Nat. Genet."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0092-8674(93)90420-U","article-title":"The protein product of the fragile \u00d7 gene, fmr1, has characteristics of an RNA-binding protein","volume":"74","author":"Siomi","year":"1993","journal-title":"Cell"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1523\/JNEUROSCI.17-05-01539.1997","article-title":"Fragile \u00d7 mental retardation protein: Nucleocytoplasmic shuttling and association with somatodendritic ribosomes","volume":"17","author":"Feng","year":"1997","journal-title":"J. Neurosci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/hmg\/5.8.1083","article-title":"The fragile \u00d7 mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals","volume":"5","author":"Eberhart","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1261\/rna.5960503","article-title":"G-quartet-dependent recognition between the fmrp rgg box and RNA","volume":"9","author":"Ramos","year":"2003","journal-title":"RNA"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0092-8674(94)90232-1","article-title":"Essential role for kh domains in RNA binding: Impaired RNA binding by a mutation in the kh domain of fmr1 that causes fragile \u00d7 syndrome","volume":"77","author":"Siomi","year":"1994","journal-title":"Cell"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng0193-31","article-title":"A point mutation in the fmr-1 gene associated with fragile \u00d7 mental retardation","volume":"3","author":"Verkerk","year":"1993","journal-title":"Nat. Genet."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Zang, J.B., Nosyreva, E.D., Spencer, C.M., Volk, L.J., Musunuru, K., Zhong, R., Stone, E.F., Yuva-Paylor, L.A., Huber, K.M., and Paylor, R. (2009). A mouse model of the human fragile \u00d7 syndrome i304n mutation. PLoS Genet., 5.","DOI":"10.1371\/journal.pgen.1000758"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nature11737","article-title":"Fmrp targets distinct mRNA sequence elements to regulate protein expression","volume":"492","author":"Ascano","year":"2012","journal-title":"Nature"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"6649","DOI":"10.1093\/nar\/gkw593","article-title":"Identification of consensus binding sites clarifies fmrp binding determinants","volume":"44","author":"Anderson","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s004310050591","article-title":"[18f]-fluorodeoxyglucose-positron emission tomography findings in protein infants with severe periventricular leukomalacia and hypsarrhythmia","volume":"156","author":"Higuchi","year":"1997","journal-title":"Eur. J. Pediatr."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/0092-8674(91)90283-5","article-title":"Variation of the cgg repeat at the fragile \u00d7 site results in genetic instability: Resolution of the sherman paradox","volume":"67","author":"Fu","year":"1991","journal-title":"Cell"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(91)90125-I","article-title":"Absence of expression of the fmr-1 gene in fragile \u00d7 syndrome","volume":"66","author":"Pieretti","year":"1991","journal-title":"Cell"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(91)90397-H","article-title":"Identification of a gene (fmr-1) containing a cgg repeat coincident with a breakpoint cluster region exhibiting length variation in fragile \u00d7 syndrome","volume":"65","author":"Verkerk","year":"1991","journal-title":"Cell"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/hmg\/1.6.397","article-title":"DNA methylation represses fmr-1 transcription in fragile \u00d7 syndrome","volume":"1","author":"Sutcliffe","year":"1992","journal-title":"Hum. Mol. Genet."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1126\/science.1245831","article-title":"Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile \u00d7 syndrome","volume":"343","author":"Colak","year":"2014","journal-title":"Science"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fnmol.2018.00124","article-title":"Modeling fragile \u00d7 syndrome in drosophila","volume":"11","author":"Drozd","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fnmol.2018.00041","article-title":"Of men and mice: Modeling the fragile \u00d7 syndrome","volume":"11","author":"Dahlhaus","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3389\/fnmol.2017.00269","article-title":"Loss of fmrp impaired hippocampal long-term plasticity and spatial learning in rats","volume":"10","author":"Tian","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1037\/a0035988","article-title":"Fmr1 and nlgn3 knockout rats: Novel tools for investigating autism spectrum disorders","volume":"128","author":"Hamilton","year":"2014","journal-title":"Behav. Neurosci."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Fmr1 knockout mice: A model to study fragile \u00d7 mental retardation (1994). The dutch-belgian fragile \u00d7 consortium. Cell, 78, 23\u201333.","DOI":"10.1016\/0092-8674(94)90569-X"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.nbd.2005.08.019","article-title":"The generation of a conditional fmr1 knock out mouse model to study fmrp function in vivo","volume":"21","author":"Mientjes","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0092-8674(01)00589-X","article-title":"Drosophila fragile x-related gene regulates the map1b homolog futsch to control synaptic structure and function","volume":"107","author":"Zhang","year":"2001","journal-title":"Cell"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0896-6273(02)00724-9","article-title":"Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest","volume":"34","author":"Dockendorff","year":"2002","journal-title":"Neuron"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1046\/j.1365-2788.2000.00261.x","article-title":"Pathological and neuropathological findings in two males with fragile-x syndrome","volume":"44 Pt 1","author":"Sabaratnam","year":"2000","journal-title":"J. Intellect. Disabil. Res. JIDR"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000353248","article-title":"Programmed cell death is impaired in the developing brain of fmr1 mutants","volume":"35","author":"Cheng","year":"2013","journal-title":"Dev. Neurosci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ydbio.2011.05.001","article-title":"Fragile \u00d7 mental retardation protein is required for programmed cell death and clearance of developmentally-transient peptidergic neurons","volume":"356","author":"Gatto","year":"2011","journal-title":"Dev. Biol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/1096-8628(20010115)98:2<161::AID-AJMG1025>3.0.CO;2-B","article-title":"Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-x syndrome: A quantitative examination","volume":"98","author":"Irwin","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1523\/JNEUROSCI.1790-06.2006","article-title":"Local protein synthesis and spine morphogenesis: Fragile \u00d7 syndrome and beyond","volume":"26","author":"Grossman","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/j.cub.2004.09.085","article-title":"The drosophila fragile \u00d7 gene negatively regulates neuronal elaboration and synaptic differentiation","volume":"14","author":"Pan","year":"2004","journal-title":"Curr. Biol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"7793","DOI":"10.1523\/JNEUROSCI.0577-10.2010","article-title":"Delayed stabilization of dendritic spines in fragile \u00d7 mice","volume":"30","author":"Crespo","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1093\/cercor\/bhx128","article-title":"Relationship between synaptic ampar and spine dynamics: Impairments in the fxs mouse","volume":"27","author":"Suresh","year":"2017","journal-title":"Cereb Cortex"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1093\/hmg\/11.24.3007","article-title":"Trapping of messenger RNA by fragile \u00d7 mental retardation protein into cytoplasmic granules induces translation repression","volume":"11","author":"Mazroui","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.molcel.2014.03.023","article-title":"Fragile \u00d7 mental retardation protein regulates translation by binding directly to the ribosome","volume":"54","author":"Chen","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1101\/gad.1276805","article-title":"Kissing complex rNAS mediate interaction between the fragile-x mental retardation protein kh2 domain and brain polyribosomes","volume":"19","author":"Darnell","year":"2005","journal-title":"Genes Dev."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1097-2765(00)80012-X","article-title":"Fmrp associates with polyribosomes as an mrnp, and the i304n mutation of severe fragile \u00d7 syndrome abolishes this association","volume":"1","author":"Feng","year":"1997","journal-title":"Mol. Cell"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.cell.2008.07.031","article-title":"The fragile \u00d7 syndrome protein represses activity-dependent translation through cyfip1, a new 4e-bp","volume":"134","author":"Napoli","year":"2008","journal-title":"Cell"},{"key":"ref_139","first-page":"64347","article-title":"Dicer-derived micrornas are utilized by the fragile \u00d7 mental retardation protein for assembly on target rNAS","volume":"2006","author":"Plante","year":"2006","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.molcel.2011.05.006","article-title":"Reversible inhibition of psd-95 mRNA translation by mir-125a, fmrp phosphorylation, and mglur signaling","volume":"42","author":"Muddashetty","year":"2011","journal-title":"Mol. Cell"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1039\/c4mb00066h","article-title":"Fmrp regulates mir196a-mediated repression of hoxb8 via interaction with the ago2 mid domain","volume":"10","author":"Li","year":"2014","journal-title":"Mol. Biosyst."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neuron.2010.01.005","article-title":"Regulation of synaptic structure and function by fmrp-associated micrornas mir-125b and mir-132","volume":"65","author":"Edbauer","year":"2010","journal-title":"Neuron"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/s41467-018-03222-y","article-title":"Sumoylation regulates fmrp-mediated dendritic spine elimination and maturation","volume":"9","author":"Khayachi","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1242\/jcs.02882","article-title":"Methylation regulates the intracellular protein-protein and protein-RNA interactions of fmrp","volume":"119","author":"Dolzhanskaya","year":"2006","journal-title":"J. Cell Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"8438","DOI":"10.1128\/MCB.22.24.8438-8447.2002","article-title":"Casein kinase ii phosphorylates the fragile \u00d7 mental retardation protein and modulates its biological properties","volume":"22","author":"Siomi","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Bartley, C.M., O\u2019Keefe, R.A., and Bordey, A. (2014). Fmrp s499 is phosphorylated independent of mtorc1-s6k1 activity. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096956"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"ENEURO-0092","DOI":"10.1523\/ENEURO.0092-16.2016","article-title":"Mammalian fmrp s499 is phosphorylated by ck2 and promotes secondary phosphorylation of fmrp","volume":"3","author":"Bartley","year":"2016","journal-title":"eNeuro"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1093\/hmg\/ddg350","article-title":"Phosphorylation influences the translation state of fmrp-associated polyribosomes","volume":"12","author":"Ceman","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.cell.2017.07.033","article-title":"Excess translation of epigenetic regulators contributes to fragile \u00d7 syndrome and is alleviated by brd4 inhibition","volume":"170","author":"Korb","year":"2017","journal-title":"Cell"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neuroscience.2017.02.044","article-title":"A novel role of fragile \u00d7 mental retardation protein in pre-mRNA alternative splicing through RNA-binding protein 14","volume":"349","author":"Zhou","year":"2017","journal-title":"Neuroscience"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.cell.2014.03.040","article-title":"A chromatin-dependent role of the fragile \u00d7 mental retardation protein fmrp in the DNA damage response","volume":"157","author":"Alpatov","year":"2014","journal-title":"Cell"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s12035-011-8220-2","article-title":"Activity regulation of adenosine deaminases acting on RNA (adars)","volume":"45","author":"Orlandi","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/hmg\/ddr461","article-title":"Deregulation of the a-to-i RNA editing mechanism in psychiatric disorders","volume":"21","author":"Silberberg","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1080\/15476286.2017.1338232","article-title":"Absence of the fragile \u00d7 mental retardation protein results in defects of RNA editing of neuronal mrnas in mouse","volume":"14","author":"Filippini","year":"2017","journal-title":"RNA Biol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1038\/nn.2950","article-title":"Modulation of dadar-dependent RNA editing by the drosophila fragile \u00d7 mental retardation protein","volume":"14","author":"Bhogal","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Shamay-Ramot, A., Khermesh, K., Porath, H.T., Barak, M., Pinto, Y., Wachtel, C., Zilberberg, A., Lerer-Goldshtein, T., Efroni, S., and Levanon, E.Y. (2015). Fmrp interacts with adar and regulates RNA editing, synaptic density and locomotor activity in zebrafish. PLoS Genet., 11.","DOI":"10.1371\/journal.pgen.1005702"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"10263","DOI":"10.1523\/JNEUROSCI.1125-10.2010","article-title":"Fragile \u00d7 mental retardation protein is required for rapid experience-dependent regulation of the potassium channel kv3.1b","volume":"30","author":"Strumbos","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.neuron.2012.12.018","article-title":"Fmrp regulates neurotransmitter release and synaptic information transmission by modulating action potential duration via bk channels","volume":"77","author":"Deng","year":"2013","journal-title":"Neuron"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mcn.2006.02.001","article-title":"Local functions for fmrp in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses","volume":"32","author":"Antar","year":"2006","journal-title":"Mol. Cell Neurosci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0896-6273(03)00034-5","article-title":"Rna cargoes associating with fmrp reveal deficits in cellular functioning in fmr1 null mice","volume":"37","author":"Miyashiro","year":"2003","journal-title":"Neuron"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.neuron.2006.10.028","article-title":"Staufen- and fmrp-containing neuronal rnps are structurally and functionally related to somatic p bodies","volume":"52","author":"Barbee","year":"2006","journal-title":"Neuron"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/j.neuroscience.2006.05.047","article-title":"The RNA binding and transport proteins staufen and fragile \u00d7 mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons","volume":"141","author":"Price","year":"2006","journal-title":"Neuroscience"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.devcel.2008.04.003","article-title":"A direct role for fmrp in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile \u00d7 syndrome","volume":"14","author":"Dictenberg","year":"2008","journal-title":"Dev. Cell"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1091\/mbc.e07-06-0583","article-title":"Dynamic association of the fragile \u00d7 mental retardation protein as a messenger ribonucleoprotein between microtubules and polyribosomes","volume":"19","author":"Wang","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"ref_165","first-page":"192","article-title":"Axonal ribosomes and mrnas associate with fragile \u00d7 granules in adult rodent and human brains","volume":"26","author":"Akins","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"27274","DOI":"10.1074\/jbc.272.43.27274","article-title":"Specificity and determinants of sam68 RNA binding. Implications for the biological function of k homology domains","volume":"272","author":"Lin","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1093\/nar\/gkf673","article-title":"Identification of cellular mRNA targets for RNA-binding protein sam68","volume":"30","author":"Itoh","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"10120","DOI":"10.1074\/jbc.270.17.10120","article-title":"Functional interaction between c-src and its mitotic target, sam 68","volume":"270","author":"Taylor","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1083\/jcb.200811138","article-title":"Sam68 regulates translation of target mrnas in male germ cells, necessary for mouse spermatogenesis","volume":"185","author":"Paronetto","year":"2009","journal-title":"J. Cell Biol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1073\/pnas.1209811110","article-title":"Rna-binding protein sam68 controls synapse number and local beta-actin mRNA metabolism in dendrites","volume":"110","author":"Klein","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_171","first-page":"73","article-title":"Sam68, the kh domain-containing superstar","volume":"1653","author":"Lukong","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s10571-016-0384-x","article-title":"Expression of sam68 associates with neuronal apoptosis and reactive astrocytes after spinal cord injury","volume":"37","author":"Chen","year":"2017","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"e20750","DOI":"10.7554\/eLife.20750","article-title":"Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating aldh1a3 pre-mrna 3\u2032-end processing","volume":"5","author":"Bielli","year":"2016","journal-title":"Elife"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1242\/jcs.00927","article-title":"Depolarization-induced translocation of the rna-binding protein sam68 to the dendrites of hippocampal neurons","volume":"117","author":"Grange","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.cell.2011.11.028","article-title":"Sam68 regulates neuronal activity-dependent alternative splicing of neurexin-1","volume":"147","author":"Iijima","year":"2011","journal-title":"Cell"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1083\/jcb.200701005","article-title":"The RNA-binding protein sam68 modulates the alternative splicing of bcl-x","volume":"176","author":"Paronetto","year":"2007","journal-title":"J. Cell Biol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.molcel.2011.05.007","article-title":"Sam68 is required for both nf-kappab activation and apoptosis signaling by the tnf receptor","volume":"43","author":"Ramakrishnan","year":"2011","journal-title":"Mol. Cell"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/jnr.20003","article-title":"Somatodendritic localization and mRNA association of the splicing regulatory protein sam68 in the hippocampus and cortex","volume":"75","author":"Grange","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1016\/j.yexcr.2009.07.011","article-title":"Sam68 relocalization into stress granules in response to oxidative stress through complexing with tia-1","volume":"315","author":"He","year":"2009","journal-title":"Exp. Cell Res."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/emboj.2010.21","article-title":"Sam68 sequestration and partial loss of function are associated with splicing alterations in fxtas patients","volume":"29","author":"Sellier","year":"2010","journal-title":"EMBO J."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/emboj.2010.19","article-title":"The splicing regulator sam68 binds to a novel exonic splicing silencer and functions in smn2 alternative splicing in spinal muscular atrophy","volume":"29","author":"Pedrotti","year":"2010","journal-title":"EMBO J."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s004390100473","article-title":"Smn gene duplication and the emergence of the smn2 gene occurred in distinct hominids: Smn2 is unique to homo sapiens","volume":"108","author":"Rochette","year":"2001","journal-title":"Hum. Genet."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1083\/jcb.201502059","article-title":"Sam68 is a physiological regulator of smn2 splicing in spinal muscular atrophy","volume":"211","author":"Pagliarini","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"9646","DOI":"10.1038\/s41598-018-27821-3","article-title":"Accumulation of poly(a) RNA in nuclear granules enriched in sam68 in motor neurons from the smndelta7 mouse model of sma","volume":"8","author":"Narcis","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0378-1119(00)00588-6","article-title":"Identification and characterization of the gene encoding human cytoplasmic polyadenylation element binding protein","volume":"263","author":"Welk","year":"2001","journal-title":"Gene"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1095\/biolreprod.103.015677","article-title":"Cpeb2, a novel putative translational regulator in mouse haploid germ cells","volume":"69","author":"Kurihara","year":"2003","journal-title":"Biol. Reprod."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"9602","DOI":"10.1073\/pnas.1133424100","article-title":"Two previously undescribed members of the mouse cpeb family of genes and their inducible expression in the principal cell layers of the hippocampus","volume":"100","author":"Theis","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.1735809","article-title":"Making synaptic plasticity and memory last: Mechanisms of translational regulation","volume":"23","author":"Richter","year":"2009","journal-title":"Genes Dev."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1038\/sj.emboj.7601322","article-title":"Cpeb3 and cpeb4 in neurons: Analysis of RNA-binding specificity and translational control of ampa receptor glur2 mRNA","volume":"25","author":"Huang","year":"2006","journal-title":"EMBO J."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.tibs.2007.04.004","article-title":"Cpeb: A life in translation","volume":"32","author":"Richter","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.molcel.2012.05.016","article-title":"Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex","volume":"47","author":"Udagawa","year":"2012","journal-title":"Mol. Cell"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.cell.2004.10.029","article-title":"Symplekin and xgld-2 are required for cpeb-mediated cytoplasmic polyadenylation","volume":"119","author":"Barnard","year":"2004","journal-title":"Cell"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1093\/emboj\/cdf353","article-title":"Dissolution of the maskin-eif4e complex by cytoplasmic polyadenylation and poly(a)-binding protein controls cyclin b1 mrna translation and oocyte maturation","volume":"21","author":"Cao","year":"2002","journal-title":"EMBO J."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature03205","article-title":"Regulation of cap-dependent translation by eif4e inhibitory proteins","volume":"433","author":"Richter","year":"2005","journal-title":"Nature"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"5604","DOI":"10.1523\/JNEUROSCI.5051-04.2005","article-title":"Bidirectional regulation of cytoplasmic polyadenylation element-binding protein phosphorylation by Ca2+\/calmodulin-dependent protein kinase ii and protein phosphatase 1 during hippocampal long-term potentiation","volume":"25","author":"Atkins","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1523\/JNEUROSCI.0854-04.2004","article-title":"Cytoplasmic polyadenylation element binding protein-dependent protein synthesis is regulated by calcium\/calmodulin-dependent protein kinase ii","volume":"24","author":"Atkins","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1093\/emboj\/21.9.2139","article-title":"N-methyl-d-aspartate receptor signaling results in aurora kinase-catalyzed cpeb phosphorylation and alpha camkii mRNA polyadenylation at synapses","volume":"21","author":"Huang","year":"2002","journal-title":"EMBO J."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1101\/gad.1136004","article-title":"Progesterone and insulin stimulation of cpeb-dependent polyadenylation is regulated by aurora a and glycogen synthase kinase-3","volume":"18","author":"Sarkissian","year":"2004","journal-title":"Genes Dev."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nature11901","article-title":"Cpeb1 coordinates alternative 3\u2032-utr formation with translational regulation","volume":"495","author":"Bava","year":"2013","journal-title":"Nature"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0896-6273(00)80630-3","article-title":"Cpeb-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of alpha-camkii mRNA at synapses","volume":"21","author":"Wu","year":"1998","journal-title":"Neuron"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1101\/lm.72704","article-title":"Selective modulation of some forms of schaffer collateral-ca1 synaptic plasticity in mice with a disruption of the cpeb-1 gene","volume":"11","author":"Alarcon","year":"2004","journal-title":"Learn. Mem."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"8502","DOI":"10.1523\/JNEUROSCI.1756-08.2008","article-title":"A molecular circuit composed of cpeb-1 and c-jun controls growth hormone-mediated synaptic plasticity in the mouse hippocampus","volume":"28","author":"Zearfoss","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1101\/lm.73706","article-title":"Reduced extinction of hippocampal-dependent memories in cpeb knockout mice","volume":"13","author":"Zearfoss","year":"2006","journal-title":"Learn. Mem."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"6400","DOI":"10.1523\/JNEUROSCI.5211-06.2007","article-title":"Cytoplasmic polyadenylation element binding protein 1-mediated mRNA translation in purkinje neurons is required for cerebellar long-term depression and motor coordination","volume":"27","author":"McEvoy","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.cell.2011.09.056","article-title":"Neuralized1 activates cpeb3: A function for nonproteolytic ubiquitin in synaptic plasticity and memory storage","volume":"147","author":"Pavlopoulos","year":"2011","journal-title":"Cell"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1261\/rna.2870505","article-title":"Activity-dependent polyadenylation in neurons","volume":"11","author":"Du","year":"2005","journal-title":"RNA"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"8898","DOI":"10.1523\/JNEUROSCI.0289-13.2013","article-title":"Dendritic glun2a synthesis mediates activity-induced nmda receptor insertion","volume":"33","author":"Swanger","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"9425","DOI":"10.1523\/JNEUROSCI.2457-04.2004","article-title":"Rapid, activity-induced increase in tissue plasminogen activator is mediated by metabotropic glutamate receptor-dependent mRNA translation","volume":"24","author":"Shin","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0076-6879(07)31008-2","article-title":"Analysis of mRNA translation in cultured hippocampal neurons","volume":"431","author":"Huang","year":"2007","journal-title":"Methods Enzymol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1126\/science.1378648","article-title":"Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase ii mutant mice","volume":"257","author":"Silva","year":"1992","journal-title":"Science"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cmet.2012.11.002","article-title":"Translational control of mitochondrial energy production mediates neuron morphogenesis","volume":"16","author":"Ng","year":"2012","journal-title":"Cell Metab."},{"key":"ref_212","first-page":"225","article-title":"Axonal protein synthesis and the regulation of local mitochondrial function","volume":"48","author":"Kaplan","year":"2009","journal-title":"Results Probl. Cell Differ."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"20494","DOI":"10.1073\/pnas.0806296105","article-title":"The RNA binding protein cpeb regulates dendrite morphogenesis and neuronal circuit assembly in vivo","volume":"105","author":"Bestman","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1101\/gad.1053003","article-title":"Facilitation of dendritic mRNA transport by cpeb","volume":"17","author":"Huang","year":"2003","journal-title":"Genes Dev."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrm2080","article-title":"P bodies: At the crossroads of post-transcriptional pathways","volume":"8","author":"Eulalio","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1242\/jcs.01692","article-title":"The translational regulator cpeb1 provides a link between dcp1 bodies and stress granules","volume":"118","author":"Wilczynska","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/0896-6273(93)90077-5","article-title":"Nova, the paraneoplastic ri antigen, is homologous to an rna-binding protein and is specifically expressed in the developing motor system","volume":"11","author":"Buckanovich","year":"1993","journal-title":"Neuron"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"13254","DOI":"10.1073\/pnas.95.22.13254","article-title":"The neuronal rna-binding protein nova-2 is implicated as the autoantigen targeted in poma patients with dementia","volume":"95","author":"Yang","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/ana.410290303","article-title":"Anti-ri: An antibody associated with paraneoplastic opsoclonus and breast cancer","volume":"29","author":"Luque","year":"1991","journal-title":"Ann. Neurol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/ana.410360615","article-title":"Immunological and pathological study of anti-ri-associated encephalopathy","volume":"36","author":"Hormigo","year":"1994","journal-title":"Ann. Neurol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.neuron.2010.05.007","article-title":"Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling","volume":"66","author":"Yano","year":"2010","journal-title":"Neuron"},{"key":"ref_222","first-page":"5","article-title":"The neuronal splicing factor nova co-localizes with target rNAS in the dendrite","volume":"4","author":"Racca","year":"2010","journal-title":"Front. Neural Circuits"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.1073\/pnas.090553997","article-title":"The tetranucleotide ucay directs the specific recognition of RNA by the nova k-homology 3 domain","volume":"97","author":"Jensen","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0969-2126(99)80025-2","article-title":"Crystal structures of nova-1 and nova-2 k-homology RNA-binding domains","volume":"7","author":"Lewis","year":"1999","journal-title":"Structure"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0896-6273(00)80900-9","article-title":"Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability","volume":"25","author":"Jensen","year":"2000","journal-title":"Neuron"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.conb.2006.01.003","article-title":"RNA binding proteins and the regulation of neuronal synaptic plasticity","volume":"16","author":"Ule","year":"2006","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1073\/pnas.0813112106","article-title":"Rescuing z+ agrin splicing in nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing","volume":"106","author":"Ruggiu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cell.2005.07.033","article-title":"Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition","volume":"123","author":"Huang","year":"2005","journal-title":"Cell"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"R203","DOI":"10.1016\/j.cub.2005.03.010","article-title":"Synaptogenesis: A balancing act between excitation and inhibition","volume":"15","author":"Cline","year":"2005","journal-title":"Curr. Biol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nature05304","article-title":"An RNA map predicting nova-dependent splicing regulation","volume":"444","author":"Ule","year":"2006","journal-title":"Nature"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"e14371","DOI":"10.7554\/eLife.14371","article-title":"Nova2-mediated RNA regulation is required for axonal pathfinding during development","volume":"5","author":"Saito","year":"2016","journal-title":"Elife"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/wrna.31","article-title":"Hits-clip: Panoramic views of protein-RNA regulation in living cells","volume":"1","author":"Darnell","year":"2010","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nrg2673","article-title":"RNA processing and its regulation: Global insights into biological networks","volume":"11","author":"Licatalosi","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nature07488","article-title":"Hits-clip yields genome-wide insights into brain alternative RNA processing","volume":"456","author":"Licatalosi","year":"2008","journal-title":"Nature"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"e00178","DOI":"10.7554\/eLife.00178","article-title":"Nova-dependent regulation of cryptic nmd exons controls synaptic protein levels after seizure","volume":"2","author":"Eom","year":"2013","journal-title":"eLife"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/ng1610","article-title":"Nova regulates brain-specific splicing to shape the synapse","volume":"37","author":"Ule","year":"2005","journal-title":"Nat. Genet."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"e14264","DOI":"10.7554\/eLife.14264","article-title":"Nova regulates dcc alternative splicing during neuronal migration and axon guidance in the spinal cord","volume":"5","author":"Leggere","year":"2016","journal-title":"Elife"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"6350","DOI":"10.1073\/pnas.110128397","article-title":"A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of nova to regulate neuron-specific alternative splicing","volume":"97","author":"Polydorides","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/01677068509100150","article-title":"Mutant alleles at the locus elav in drosophila melanogaster lead to nervous system defects. A developmental-genetic analysis","volume":"2","author":"Campos","year":"1985","journal-title":"J. Neurogenet."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1523\/JNEUROSCI.17-09-03024.1997","article-title":"A hierarchy of hu RNA binding proteins in developing and adult neurons","volume":"17","author":"Okano","year":"1997","journal-title":"J. Neurosci."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.neuron.2012.07.009","article-title":"Neuronal elav-like (hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability","volume":"75","author":"Okano","year":"2012","journal-title":"Neuron"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.molcel.2011.06.008","article-title":"Transcriptome-wide analysis of regulatory interactions of the rna-binding protein hur","volume":"43","author":"Lebedeva","year":"2011","journal-title":"Mol. Cell"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1073\/pnas.92.10.4557","article-title":"A conserved family of elav-like genes in vertebrates","volume":"92","author":"Good","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1093\/emboj\/17.12.3461","article-title":"Rna stabilization by the au-rich element binding protein, hur, an elav protein","volume":"17","author":"Peng","year":"1998","journal-title":"EMBO J."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"15293","DOI":"10.1073\/pnas.95.26.15293","article-title":"Hns, a nuclear-cytoplasmic shuttling sequence in hur","volume":"95","author":"Fan","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1093\/nar\/gkt166","article-title":"All three RNA recognition motifs and the hinge region of huc play distinct roles in the regulation of alternative splicing","volume":"41","author":"Hinman","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1006\/exnr.2000.7599","article-title":"Overexpression of hud accelerates neurite outgrowth and increases gap-43 mRNA expression in cortical neurons and retinoic acid-induced embryonic stem cells in vitro","volume":"168","author":"Anderson","year":"2001","journal-title":"Exp. Neurol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/j.1471-4159.2005.03607.x","article-title":"In vivo post-transcriptional regulation of gap-43 mRNA by overexpression of the rna-binding protein hud","volume":"96","author":"Bolognani","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1046\/j.1365-2443.1999.00292.x","article-title":"Cytoplasmic localization is required for the mammalian elav-like protein hud to induce neuronal differentiation","volume":"4","author":"Kasashima","year":"1999","journal-title":"Genes Cells Devoted Mol. Cell. Mech."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4049\/jimmunol.1701501","article-title":"Neuron-specific hur-deficient mice spontaneously develop motor neuron disease","volume":"201","author":"Sun","year":"2018","journal-title":"J. Immunol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"11668","DOI":"10.1073\/pnas.191388398","article-title":"Posttranscriptional regulation of gene expression in learning by the neuronal elav-like mrna-stabilizing proteins","volume":"98","author":"Quattrone","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1038\/s41598-018-21130-5","article-title":"Elavl3 is essential for the maintenance of purkinje neuron axons","volume":"8","author":"Ogawa","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1523\/JNEUROSCI.3703-13.2014","article-title":"Prenatal deletion of the RNA-binding protein hud disrupts postnatal cortical circuit maturation and behavior","volume":"34","author":"DeBoer","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.nlm.2006.11.004","article-title":"Associative and spatial learning and memory deficits in transgenic mice overexpressing the RNA-binding protein hud","volume":"87","author":"Bolognani","year":"2007","journal-title":"Neurobiol. Learn. Mem."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1073\/pnas.0407523102","article-title":"The rna-binding protein hud regulates neuronal cell identity and maturation","volume":"102","author":"Akamatsu","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"11559","DOI":"10.1523\/JNEUROSCI.1528-17.2017","article-title":"Hud and the survival motor neuron protein interact in motoneurons and are essential for motoneuron development, function, and mRNA regulation","volume":"37","author":"Duy","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1128\/MCB.00316-10","article-title":"Mir-375 inhibits differentiation of neurites by lowering hud levels","volume":"30","author":"Abdelmohsen","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"e27384","DOI":"10.4161\/onci.27384","article-title":"Immunopathogenesis of paraneoplastic neurological syndromes associated with anti-hu antibodies: A beneficial antitumor immune response going awry","volume":"2","author":"Pignolet","year":"2013","journal-title":"Oncoimmunology"},{"key":"ref_259","doi-asserted-by":"crossref","unstructured":"Yamada, K., Iwayama, Y., Hattori, E., Iwamoto, K., Toyota, T., Ohnishi, T., Ohba, H., Maekawa, M., Kato, T., and Yoshikawa, T. (2011). Genome-wide association study of schizophrenia in japanese population. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0020468"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00439-005-1259-2","article-title":"Association between the neuron-specific rna-binding protein elavl4 and parkinson disease","volume":"117","author":"Noureddine","year":"2005","journal-title":"Hum. Genet."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00439-008-0526-4","article-title":"Replication of association between elavl4 and parkinson disease: The genepd study","volume":"124","author":"DeStefano","year":"2008","journal-title":"Hum. Genet."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3233\/JAD-2009-0967","article-title":"Nelav proteins alteration in alzheimer\u2019s disease brain: A novel putative target for amyloid-beta reverberating on abetapp processing","volume":"16","author":"Amadio","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.celrep.2014.04.050","article-title":"Hud regulates coding and noncoding RNA to induce app->abeta processing","volume":"7","author":"Kang","year":"2014","journal-title":"Cell Rep."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.molcel.2009.11.013","article-title":"The elav protein hud stimulates cap-dependent translation in a poly(a)- and eif4a-dependent manner","volume":"36","author":"Fukao","year":"2009","journal-title":"Mol. Cell"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.molcel.2011.06.007","article-title":"Integrative regulatory mapping indicates that the rna-binding protein hur couples pre-mrna processing and mRNA stability","volume":"43","author":"Mukherjee","year":"2011","journal-title":"Mol. Cell"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"E627","DOI":"10.1073\/pnas.1103344108","article-title":"Hu proteins regulate alternative splicing by inducing localized histone hyperacetylation in an RNA-dependent manner","volume":"108","author":"Zhou","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"44507","DOI":"10.1038\/srep44507","article-title":"Neuronal elavl proteins utilize auf-1 as a co-partner to induce neuron-specific alternative splicing of app","volume":"7","author":"Fragkouli","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.1074\/jbc.M706082200","article-title":"Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins elav","volume":"283","author":"Ratti","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1074\/jbc.M609349200","article-title":"Hu proteins regulate polyadenylation by blocking sites containing u-rich sequences","volume":"282","author":"Zhu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1101\/gad.13.4.449","article-title":"Elav tumor antigen, hel-n1, increases translation of neurofilament m mRNA and induces formation of neurites in human teratocarcinoma cells","volume":"13","author":"Antic","year":"1999","journal-title":"Genes Dev."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/jnr.21473","article-title":"Rna-protein interactions and control of mRNA stability in neurons","volume":"86","author":"Bolognani","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1128\/MCB.21.3.721-730.2001","article-title":"The 3\u2032 untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor hur","volume":"21","author":"Dean","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1093\/emboj\/17.12.3448","article-title":"Overexpression of hur, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of are-containing mrnas","volume":"17","author":"Fan","year":"1998","journal-title":"EMBO J."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1101\/gad.11.19.2557","article-title":"Au-rich elements target small nuclear rNAS as well as mrnas for rapid degradation","volume":"11","author":"Fan","year":"1997","journal-title":"Genes Dev."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"5088","DOI":"10.1093\/nar\/gks148","article-title":"Hur protein attenuates mirna-mediated repression by promoting mirisc dissociation from the target rna","volume":"40","author":"Kundu","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/978-1-4419-7823-3_10","article-title":"Properties of the regulatory rna-binding protein hur and its role in controlling mirna repression","volume":"700","author":"Meisner","year":"2011","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.molcel.2014.09.005","article-title":"Micrornas trigger dissociation of eif4ai and eif4aii from target mrnas in humans","volume":"56","author":"Fukao","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1471-4159.2004.02371.x","article-title":"The insulin-like growth factor mRNA binding-protein imp-1 and the ras-regulatory protein g3bp associate with tau mRNA and hud protein in differentiated p19 neuronal cells","volume":"89","author":"Atlas","year":"2004","journal-title":"J. Neurochem."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"10337","DOI":"10.1073\/pnas.1104928108","article-title":"Interaction of survival of motor neuron (smn) and hud proteins with mRNA cpg15 rescues motor neuron axonal deficits","volume":"108","author":"Akten","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1083\/jcb.201212089","article-title":"Degradation of high affinity hud targets releases kv1.1 mRNA from mir-129 repression by mtorc1","volume":"202","author":"Sosanya","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"16357","DOI":"10.1074\/jbc.M114.599399","article-title":"Mammalian target of rapamycin (mtor) tagging promotes dendritic branch variability through the capture of Ca2+\/calmodulin-dependent protein kinase ii alpha (camkiialpha) mrnas by the rna-binding protein hud","volume":"290","author":"Sosanya","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/jnc.12266","article-title":"A hud-zbp1 ribonucleoprotein complex localizes gap-43 mRNA into axons through its 3\u2032 untranslated region au-rich regulatory element","volume":"126","author":"Yoo","year":"2013","journal-title":"J. Neurochem."},{"key":"ref_283","doi-asserted-by":"crossref","unstructured":"Vanevski, F., and Xu, B. (2015). Hud interacts with bdnf mRNA and is essential for activity-induced bdnf synthesis in dendrites. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117264"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1093\/nar\/gkf567","article-title":"Complex formation of the neuron-specific elav-like hu rna-binding proteins","volume":"30","author":"Kasashima","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1242\/jcs.00058","article-title":"Visualization of translated tau protein in the axons of neuronal p19 cells and characterization of tau rnp granules","volume":"115","author":"Aronov","year":"2002","journal-title":"J. Cell Sci."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.biochi.2011.01.008","article-title":"Microtubule association of a neuronal rna-binding protein hud through its binding to the light chain of map1b","volume":"93","author":"Fujiwara","year":"2011","journal-title":"Biochimie"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1111\/j.1471-4159.2008.05718.x","article-title":"Activity-dependent expression of elav\/hu rbps and neuronal mrnas in seizure and cocaine brain","volume":"107","author":"Tiruchinapalli","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1523\/JNEUROSCI.3631-10.2011","article-title":"The survival of motor neuron (smn) protein interacts with the mrna-binding protein hud and regulates localization of poly(a) mRNA in primary motor neuron axons","volume":"31","author":"Fallini","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1111\/j.1460-9568.1998.00298.x","article-title":"Survival motor neuron (smn) protein in rat is expressed as different molecular forms and is developmentally regulated","volume":"10","author":"Cisterni","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.1073\/pnas.96.11.6307","article-title":"A single nucleotide in the smn gene regulates splicing and is responsible for spinal muscular atrophy","volume":"96","author":"Lorson","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1080\/15476286.2016.1236168","article-title":"Smn\u2014A chaperone for nuclear rnp social occasions?","volume":"14","author":"Raimer","year":"2017","journal-title":"RNA Biol."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"E2347","DOI":"10.1073\/pnas.1613181114","article-title":"Smn deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage","volume":"114","author":"Jangi","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/nar\/gkw731","article-title":"Rna-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of u12-dependent introns","volume":"45","author":"Doktor","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_294","doi-asserted-by":"crossref","unstructured":"Custer, S.K., Gilson, T.D., Li, H., Todd, A.G., Astroski, J.W., Lin, H., Liu, Y., and Androphy, E.J. (2016). Altered mRNA splicing in smn-depleted motor neuron-like cells. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0163954"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a spinal muscular atrophy-determining gene","volume":"80","author":"Lefebvre","year":"1995","journal-title":"Cell"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/ejhg.2011.134","article-title":"Pan-ethnic carrier screening and prenatal diagnosis for spinal muscular atrophy: Clinical laboratory analysis of >72,400 specimens","volume":"20","author":"Sugarman","year":"2012","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/3030","article-title":"Differential smn2 expression associated with sma severity","volume":"20","author":"Gavrilov","year":"1998","journal-title":"Nat. Genet."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/ng0797-265","article-title":"Correlation between severity and smn protein level in spinal muscular atrophy","volume":"16","author":"Lefebvre","year":"1997","journal-title":"Nat. Genet."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1128\/MCB.26.4.1333-1346.2006","article-title":"Splicing of a critical exon of human survival motor neuron is regulated by a unique silencer element located in the last intron","volume":"26","author":"Singh","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"ref_300","doi-asserted-by":"crossref","unstructured":"Hua, Y., Vickers, T.A., Baker, B.F., Bennett, C.F., and Krainer, A.R. (2007). Enhancement of smn2 exon 7 inclusion by antisense oligonucleotides targeting the exon. PLoS Biol., 5.","DOI":"10.1371\/journal.pbio.0050073"},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1101\/gad.1941310","article-title":"Antisense correction of smn2 splicing in the cns rescues necrosis in a type iii sma mouse model","volume":"24","author":"Hua","year":"2010","journal-title":"Genes Dev."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature10485","article-title":"Peripheral smn restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model","volume":"478","author":"Hua","year":"2011","journal-title":"Nature"},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nn.4508","article-title":"Nusinersen, an antisense oligonucleotide drug for spinal muscular atrophy","volume":"20","author":"Corey","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.nbd.2011.02.003","article-title":"A new model to study spinal muscular atrophy: Neurite degeneration and cell death is counteracted by bcl-x(l) overexpression in motoneurons","volume":"42","author":"Garcera","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"9920","DOI":"10.1073\/pnas.94.18.9920","article-title":"Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos","volume":"94","author":"Schrank","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1093\/brain\/awf155","article-title":"Neuronal death is enhanced and begins during foetal development in type i spinal muscular atrophy spinal cord","volume":"125","author":"Ferrer","year":"2002","journal-title":"Brain"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cell.2012.09.012","article-title":"An smn-dependent u12 splicing event essential for motor circuit function","volume":"151","author":"Lotti","year":"2012","journal-title":"Cell"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1093\/hmg\/ddn156","article-title":"Reduced smn protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy","volume":"17","author":"Kariya","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1093\/hmg\/11.12.1439","article-title":"Neurofilament accumulation at the motor endplate and lack of axonal sprouting in a spinal muscular atrophy mouse model","volume":"11","author":"Nicole","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s12031-007-0024-5","article-title":"Smn depletion alters profilin ii expression and leads to upregulation of the rhoa\/rock pathway and defects in neuronal integrity","volume":"32","author":"Bowerman","year":"2007","journal-title":"J. Mol. Neurosci."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1083\/jcb.200304128","article-title":"Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons","volume":"163","author":"Rossoll","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1093\/hmg\/ddr425","article-title":"The spinal muscular atrophy disease protein smn is linked to the rho-kinase pathway via profilin","volume":"20","author":"Nolle","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.1523\/JNEUROSCI.23-16-06627.2003","article-title":"Active transport of the survival motor neuron protein and the role of exon-7 in cytoplasmic localization","volume":"23","author":"Zhang","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1261\/rna.047373.114","article-title":"Subcellular transcriptome alterations in a cell culture model of spinal muscular atrophy point to widespread defects in axonal growth and presynaptic differentiation","volume":"20","author":"Saal","year":"2014","journal-title":"RNA"},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1523\/JNEUROSCI.2396-15.2016","article-title":"Deficiency of the survival of motor neuron protein impairs mRNA localization and local translation in the growth cone of motor neurons","volume":"36","author":"Fallini","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/hmg\/11.1.93","article-title":"Specific interaction of smn, the spinal muscular atrophy determining gene product, with hnrnp-r and gry-rbp\/hnrnp-q: A role for smn in RNA processing in motor axons?","volume":"11","author":"Rossoll","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.celrep.2017.01.059","article-title":"The survival of motor neuron protein acts as a molecular chaperone for mrnp assembly","volume":"18","author":"Fallini","year":"2017","journal-title":"Cell Rep."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1093\/hmg\/ddq073","article-title":"The heterogeneous nuclear ribonucleoprotein-r is necessary for axonal beta-actin mRNA translocation in spinal motor neurons","volume":"19","author":"Glinka","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10571-011-9647-8","article-title":"Smn deficiency reduces cellular ability to form stress granules, sensitizing cells to stress","volume":"31","author":"Zou","year":"2011","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1128\/jvi.69.6.3584-3596.1995","article-title":"Cloning and characterization of a novel cellular protein, tdp-43, that binds to human immunodeficiency virus type 1 tar DNA sequence motifs","volume":"69","author":"Ou","year":"1995","journal-title":"J. Virol."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/emmm.201202303","article-title":"Spliceosome integrity is defective in the motor neuron diseases als and sma","volume":"5","author":"Tsuiji","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jsb.2009.06.006","article-title":"Tdp-43 localizes in mRNA transcription and processing sites in mammalian neurons","volume":"167","author":"Casafont","year":"2009","journal-title":"J. Struct. Biol."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"15635","DOI":"10.1074\/jbc.M111.333450","article-title":"Tdp-43 and fus rna-binding proteins bind distinct sets of cytoplasmic messenger rnas and differently regulate their post-transcriptional fate in motoneuron-like cells","volume":"287","author":"Colombrita","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1074\/jbc.M110.190884","article-title":"Identification of neuronal RNA targets of tdp-43-containing ribonucleoprotein complexes","volume":"286","author":"Sephton","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nn.2779","article-title":"Long pre-mrna depletion and RNA missplicing contribute to neuronal vulnerability from loss of tdp-43","volume":"14","author":"Polymenidou","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nn.2778","article-title":"Characterizing the RNA targets and position-dependent splicing regulation by tdp-43","volume":"14","author":"Tollervey","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.mcn.2011.02.013","article-title":"Rna targets of tdp-43 identified by uv-clip are deregulated in als","volume":"47","author":"Xiao","year":"2011","journal-title":"Mol. Cell Neurosci."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1126\/science.aab0983","article-title":"Tdp-43 repression of nonconserved cryptic exons is compromised in als-ftd","volume":"349","author":"Ling","year":"2015","journal-title":"Science"},{"key":"ref_329","first-page":"5083","article-title":"Extensive cryptic splicing upon loss of rbm17 and tdp43 in neurodegeneration models","volume":"25","author":"Tan","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1093\/emboj\/20.7.1774","article-title":"Nuclear factor tdp-43 and sr proteins promote in vitro and in vivo cftr exon 9 skipping","volume":"20","author":"Buratti","year":"2001","journal-title":"EMBO J."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jmb.2011.11.003","article-title":"Ug repeats\/tdp-43 interactions near 5\u2019 splice sites exert unpredictable effects on splicing modulation","volume":"415","author":"Passoni","year":"2012","journal-title":"J. Mol. Biol."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1093\/nar\/gkr1082","article-title":"Tdp-43 regulates global translational yield by splicing of exon junction complex component skar","volume":"40","author":"Fiesel","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"6000","DOI":"10.1093\/nar\/gki897","article-title":"Depletion of tdp 43 overrides the need for exonic and intronic splicing enhancers in the human apoa-ii gene","volume":"33","author":"Mercado","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s00439-017-1830-7","article-title":"Genetic mutations in rna-binding proteins and their roles in als","volume":"136","author":"Kapeli","year":"2017","journal-title":"Hum. Genet."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00401-013-1192-8","article-title":"Antisense transcripts of the expanded c9orf72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-atg translation in c9ftd\/als","volume":"126","author":"Gendron","year":"2013","journal-title":"Acta Neuropathol."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature20413","article-title":"Decoding als: From genes to mechanism","volume":"539","author":"Taylor","year":"2016","journal-title":"Nature"},{"key":"ref_337","first-page":"181","article-title":"Risk factors for amyotrophic lateral sclerosis","volume":"7","author":"Ingre","year":"2015","journal-title":"Clin. Epidemiol."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1242\/jcs.038950","article-title":"Structural determinants of the cellular localization and shuttling of tdp-43","volume":"121","author":"Ayala","year":"2008","journal-title":"J. Cell Sci."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1128\/MCB.01279-10","article-title":"Tdp-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor","volume":"31","author":"Dewey","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.cell.2013.07.038","article-title":"Altered ribostasis: Rna-protein granules in degenerative disorders","volume":"154","author":"Ramaswami","year":"2013","journal-title":"Cell"},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrneurol.2010.18","article-title":"Tar DNA-binding protein 43 in neurodegenerative disease","volume":"6","author":"Lee","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1084\/jem.20092164","article-title":"Elevated expression of tdp-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking ftld-u","volume":"207","author":"Tsai","year":"2010","journal-title":"J. Exp. Med."},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1093\/brain\/awr159","article-title":"Pathological hallmarks of amyotrophic lateral sclerosis\/frontotemporal lobar degeneration in transgenic mice produced with tdp-43 genomic fragments","volume":"134","author":"Swarup","year":"2011","journal-title":"Brain"},{"key":"ref_344","first-page":"3630","article-title":"Synapse dysfunction of layer v pyramidal neurons precedes neurodegeneration in a mouse model of tdp-43 proteinopathies","volume":"27","author":"Handley","year":"2017","journal-title":"Cereb Cortex"},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"37968","DOI":"10.1038\/srep37968","article-title":"Cortical synaptic and dendritic spine abnormalities in a presymptomatic tdp-43 model of amyotrophic lateral sclerosis","volume":"6","author":"Fogarty","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/brain\/awt029","article-title":"Loss of tdp-43 causes age-dependent progressive motor neuron degeneration","volume":"136","author":"Iguchi","year":"2013","journal-title":"Brain"},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1756-6606-2-30","article-title":"Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein tdp-43 promotes dendritic branching","volume":"2","author":"Lu","year":"2009","journal-title":"Mol. Brain"},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1093\/hmg\/dds205","article-title":"The als disease protein tdp-43 is actively transported in motor neuron axons and regulates axon outgrowth","volume":"21","author":"Fallini","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1091\/mbc.E16-07-0519","article-title":"Role of bmp receptor traffic in synaptic growth defects in an als model","volume":"27","author":"Deshpande","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3109\/21678421.2012.734520","article-title":"Identification of RNA bound to the tdp-43 ribonucleoprotein complex in the adult mouse brain","volume":"14","author":"Narayanan","year":"2013","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.brainres.2013.11.019","article-title":"Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a drosophila, tdp-43 loss of function model of als","volume":"1584","author":"Chang","year":"2014","journal-title":"Brain Res."},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.nbd.2014.07.007","article-title":"Chronological requirements of tdp-43 function in synaptic organization and locomotive control","volume":"71","author":"Romano","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"ref_353","doi-asserted-by":"crossref","unstructured":"Godena, V.K., Romano, G., Romano, M., Appocher, C., Klima, R., Buratti, E., Baralle, F.E., and Feiguin, F. (2011). Tdp-43 regulates drosophila neuromuscular junctions growth by modulating futsch\/map1b levels and synaptic microtubules organization. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0017808"},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"15962","DOI":"10.1523\/JNEUROSCI.2526-14.2014","article-title":"Futsch\/map1b mRNA is a translational target of tdp-43 and is neuroprotective in a drosophila model of amyotrophic lateral sclerosis","volume":"34","author":"Coyne","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.brainres.2018.04.034","article-title":"Dynamic duo\u2014FMRP and tdp-43: Regulating common targets, causing different diseases","volume":"1693","author":"Ferro","year":"2018","journal-title":"Brain Res."},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1093\/nar\/gkx175","article-title":"Tdp-43 suppresses tau expression via promoting its mRNA instability","volume":"45","author":"Gu","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"10600","DOI":"10.1074\/jbc.M117.783498","article-title":"Transactive response DNA-binding protein 43 (tdp-43) regulates alternative splicing of tau exon 10: Implications for the pathogenesis of tauopathies","volume":"292","author":"Gu","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/s41593-018-0113-5","article-title":"Tdp-43 gains function due to perturbed autoregulation in a tardbp knock-in mouse model of als-ftd","volume":"21","author":"White","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nm.4130","article-title":"The inhibition of tdp-43 mitochondrial localization blocks its neuronal toxicity","volume":"22","author":"Wang","year":"2016","journal-title":"Nat. Med."},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41593-017-0047-3","article-title":"Tdp-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in als\/ftd","volume":"21","author":"Chou","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/j.1471-4159.2009.06383.x","article-title":"Tdp-43 is recruited to stress granules in conditions of oxidative insult","volume":"111","author":"Colombrita","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_362","doi-asserted-by":"crossref","unstructured":"Liu-Yesucevitz, L., Bilgutay, A., Zhang, Y.-J., Vanderweyde, T., Vanderwyde, T., Citro, A., Mehta, T., Zaarur, N., McKee, A., and Bowser, R. (2010). Tar DNA binding protein-43 (tdp-43) associates with stress granules: Analysis of cultured cells and pathological brain tissue. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013250"},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.neuint.2012.01.019","article-title":"Endogenous tdp-43 localized to stress granules can subsequently form protein aggregates","volume":"60","author":"Parker","year":"2012","journal-title":"Neurochem. Int."},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.neuron.2013.12.018","article-title":"Axonal transport of tdp-43 mRNA granules is impaired by als-causing mutations","volume":"81","author":"Alami","year":"2014","journal-title":"Neuron"},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/gtc.12352","article-title":"Tdp-43 binds and transports g-quadruplex-containing mrnas into neurites for local translation","volume":"21","author":"Ishiguro","year":"2016","journal-title":"Genes Cells Devoted Mol. Cell. Mech."},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1093\/hmg\/ddr021","article-title":"Tar DNA-binding protein 43 (tdp-43) regulates stress granule dynamics via differential regulation of g3bp and tia-1","volume":"20","author":"McDonald","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1523\/JNEUROSCI.2350-13.2014","article-title":"Als-linked mutations enlarge tdp-43-enriched neuronal RNA granules in the dendritic arbor","volume":"34","author":"Lin","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1471-4159.2007.05190.x","article-title":"Tdp-43, the signature protein of ftld-u, is a neuronal activity-responsive factor","volume":"105","author":"Wang","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"E2466","DOI":"10.1073\/pnas.1614462114","article-title":"Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like tdp-43 rnp granules in neurons","volume":"114","author":"Gopal","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_370","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/srep00603","article-title":"Widespread binding of fus along nascent RNA regulates alternative splicing in the brain","volume":"2","author":"Rogelj","year":"2012","journal-title":"Sci. Rep."},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/nn.3230","article-title":"Divergent roles of als-linked proteins fus\/tls and tdp-43 intersect in processing long pre-mrnas","volume":"15","author":"Polymenidou","year":"2012","journal-title":"Nat. Neurosci."},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"6807","DOI":"10.1074\/jbc.M008304200","article-title":"Identification of an RNA binding specificity for the potential splicing factor tls","volume":"276","author":"Lerga","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1101\/gad.255737.114","article-title":"Position-specific binding of fus to nascent RNA regulates mRNA length","volume":"29","author":"Masuda","year":"2015","journal-title":"Genes Dev."},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"6030","DOI":"10.1073\/pnas.1203028109","article-title":"Tls\/fus (translocated in liposarcoma\/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements","volume":"109","author":"Tan","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/srep00529","article-title":"Position-dependent fus-rna interactions regulate alternative splicing events and transcriptions","volume":"2","author":"Ishigaki","year":"2012","journal-title":"Sci. Rep."},{"key":"ref_376","doi-asserted-by":"crossref","first-page":"8608","DOI":"10.1073\/pnas.1506282112","article-title":"Fus functions in coupling transcription to splicing by mediating an interaction between rnap ii and u1 snrnp","volume":"112","author":"Yu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1242\/jcs.110.15.1741","article-title":"Tls (fus) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling","volume":"110 Pt 15","author":"Zinszner","year":"1997","journal-title":"J. Cell Sci."},{"key":"ref_378","doi-asserted-by":"crossref","first-page":"12143","DOI":"10.1038\/ncomms12143","article-title":"Distinct and shared functions of als-associated proteins tdp-43, fus and taf15 revealed by multisystem analyses","volume":"7","author":"Kapeli","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1038\/emboj.2012.319","article-title":"Fus stimulates microrna biogenesis by facilitating co-transcriptional drosha recruitment","volume":"31","author":"Morlando","year":"2012","journal-title":"EMBO J."},{"key":"ref_380","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nature06992","article-title":"Induced ncrnas allosterically modify rna-binding proteins in cis to inhibit transcription","volume":"454","author":"Wang","year":"2008","journal-title":"Nature"},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/nn.3514","article-title":"Interaction of fus and hdac1 regulates DNA damage response and repair in neurons","volume":"16","author":"Wang","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref_382","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1165942","article-title":"Mutations in fus, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6","volume":"323","author":"Vance","year":"2009","journal-title":"Science"},{"key":"ref_383","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1126\/science.1166066","article-title":"Mutations in the fus\/tls gene on chromosome 16 cause familial amyotrophic lateral sclerosis","volume":"323","author":"Kwiatkowski","year":"2009","journal-title":"Science"},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1093\/hmg\/ddt117","article-title":"Als mutant fus disrupts nuclear localization and sequesters wild-type fus within cytoplasmic stress granules","volume":"22","author":"Vance","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"ref_385","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/jnc.13625","article-title":"Physiological functions and pathobiology of tdp-43 and fus\/tls proteins","volume":"138","author":"Ratti","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_386","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1093\/brain\/awp214","article-title":"A new subtype of frontotemporal lobar degeneration with fus pathology","volume":"132","author":"Neumann","year":"2009","journal-title":"Brain"},{"key":"ref_387","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1212\/WNL.0b013e3181ccc732","article-title":"Genetic contribution of fus to frontotemporal lobar degeneration","volume":"74","author":"Sleegers","year":"2010","journal-title":"Neurology"},{"key":"ref_388","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.neuroscience.2014.12.007","article-title":"Overexpression of nuclear fus induces neuronal cell death","volume":"287","author":"Suzuki","year":"2015","journal-title":"Neuroscience"},{"key":"ref_389","doi-asserted-by":"crossref","unstructured":"Huang, C., Zhou, H., Tong, J., Chen, H., Liu, Y.J., Wang, D., Wei, X., and Xia, X.G. (2011). Fus transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. PLoS Genet., 7.","DOI":"10.1371\/journal.pgen.1002011"},{"key":"ref_390","doi-asserted-by":"crossref","first-page":"10465","DOI":"10.1038\/ncomms10465","article-title":"Als-associated mutant fus induces selective motor neuron degeneration through toxic gain of function","volume":"7","author":"Sharma","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_391","doi-asserted-by":"crossref","unstructured":"Kabashi, E., Bercier, V., Lissouba, A., Liao, M., Brustein, E., Rouleau, G.A., and Drapeau, P. (2011). Fus and tardbp but not sod1 interact in genetic models of amyotrophic lateral sclerosis. PLoS Genet., 7.","DOI":"10.1371\/journal.pgen.1002214"},{"key":"ref_392","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1172\/JCI57883","article-title":"The als-associated proteins fus and tdp-43 function together to affect drosophila locomotion and life span","volume":"121","author":"Wang","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"15030","DOI":"10.1038\/cddiscovery.2015.30","article-title":"Als-associated mutant fus inhibits macroautophagy which is restored by overexpression of rab1","volume":"1","author":"Soo","year":"2015","journal-title":"Cell Death Discov."},{"key":"ref_394","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1038\/ncomms7171","article-title":"Als-causative mutations in fus\/tls confer gain and loss of function by altered association with smn and u1-snrnp","volume":"6","author":"Sun","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_395","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1093\/hmg\/ddt222","article-title":"Als-associated mutations in fus disrupt the axonal distribution and function of smn","volume":"22","author":"Groen","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"ref_396","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1093\/hmg\/ddq335","article-title":"Mutant fus proteins that cause amyotrophic lateral sclerosis incorporate into stress granules","volume":"19","author":"Bosco","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_397","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1016\/j.cub.2006.10.024","article-title":"Myosin-va facilitates the accumulation of mrna\/protein complex in dendritic spines","volume":"16","author":"Yoshimura","year":"2006","journal-title":"Curr. Biol."},{"key":"ref_398","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1523\/JNEUROSCI.2463-11.2012","article-title":"RNA binding proteins accumulate at the postsynaptic density with synaptic activity","volume":"32","author":"Zhang","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_399","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00401-012-0984-6","article-title":"Localization of fused in sarcoma (fus) protein to the post-synaptic density in the brain","volume":"124","author":"Aoki","year":"2012","journal-title":"Acta Neuropathol."},{"key":"ref_400","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neulet.2004.12.071","article-title":"Delocalization of the multifunctional RNA splicing factor tls\/fus in hippocampal neurones: Exclusion from the nucleus and accumulation in dendritic granules and spine heads","volume":"379","author":"Belly","year":"2005","journal-title":"Neurosci. Lett."},{"key":"ref_401","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cub.2005.01.058","article-title":"The RNA binding protein tls is translocated to dendritic spines by mglur5 activation and regulates spine morphology","volume":"15","author":"Fujii","year":"2005","journal-title":"Curr. Biol."},{"key":"ref_402","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.1242\/jcs.02692","article-title":"Tls facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines","volume":"118","author":"Fujii","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_403","first-page":"496","article-title":"Super-resolution microscopy reveals presynaptic localization of the als\/ftd related protein fus in hippocampal neurons","volume":"9","author":"Schoen","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_404","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1083\/jcb.201306058","article-title":"The rna-binding protein fus directs translation of localized mrnas in apc-rnp granules","volume":"203","author":"Yasuda","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_405","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.celrep.2013.01.021","article-title":"Identification of in vivo, conserved, taf15 RNA binding sites reveals the impact of taf15 on the neuronal transcriptome","volume":"3","author":"Ibrahim","year":"2013","journal-title":"Cell Rep."},{"key":"ref_406","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/nsmb.2143","article-title":"Total RNA sequencing reveals nascent transcription and widespread co-transcriptional splicing in the human brain","volume":"18","author":"Ameur","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_407","first-page":"5064","article-title":"Fusion of the ews-related gene taf2n to tec in extraskeletal myxoid chondrosarcoma","volume":"59","author":"Sjogren","year":"1999","journal-title":"Cancer Res."},{"key":"ref_408","first-page":"5408","article-title":"Recurrent rearrangement of the ewing\u2019s sarcoma gene, ewsr1, or its homologue, taf15, with the transcription factor ciz\/nmp4 in acute leukemia","volume":"62","author":"Martini","year":"2002","journal-title":"Cancer Res."},{"key":"ref_409","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/ajmg.b.31158","article-title":"Mutational analysis reveals the fus homolog taf15 as a candidate gene for familial amyotrophic lateral sclerosis","volume":"156","author":"Ticozzi","year":"2011","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_410","doi-asserted-by":"crossref","first-page":"20881","DOI":"10.1073\/pnas.1109434108","article-title":"A yeast functional screen predicts new candidate als disease genes","volume":"108","author":"Couthouis","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_411","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1093\/brain\/awr201","article-title":"Fet proteins taf15 and ews are selective markers that distinguish ftld with fus pathology from amyotrophic lateral sclerosis with fus mutations","volume":"134","author":"Neumann","year":"2011","journal-title":"Brain"},{"key":"ref_412","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.gene.2012.06.088","article-title":"Domains involved in taf15 subcellular localisation: Dependence on cell type and ongoing transcription","volume":"506","author":"Marko","year":"2012","journal-title":"Gene"},{"key":"ref_413","doi-asserted-by":"crossref","unstructured":"Blechingberg, J., Luo, Y., Bolund, L., Damgaard, C.K., and Nielsen, A.L. (2012). Gene expression responses to fus, ews, and taf15 reduction and stress granule sequestration analyses identifies fet-protein non-redundant functions. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0046251"},{"key":"ref_414","doi-asserted-by":"crossref","unstructured":"Andersson, M.K., Stahlberg, A., Arvidsson, Y., Olofsson, A., Semb, H., Stenman, G., Nilsson, O., and Aman, P. (2008). The multifunctional fus, ews and taf15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response. BMC Cell Biol., 9.","DOI":"10.1186\/1471-2121-9-37"},{"key":"ref_415","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1073\/pnas.89.18.8681","article-title":"Identification and functional characterization of a tia-1-related nucleolysin","volume":"89","author":"Kawakami","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_416","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1093\/nar\/24.19.3829","article-title":"Structure, tissue distribution and genomic organization of the murine rrm-type RNA binding proteins tia-1 and tiar","volume":"24","author":"Beck","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"ref_417","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.molcel.2007.05.036","article-title":"Sr proteins function in coupling rnap ii transcription to pre-mrna splicing","volume":"26","author":"Das","year":"2007","journal-title":"Mol. Cell"},{"key":"ref_418","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1093\/nar\/gki763","article-title":"Novel DNA-binding properties of the rna-binding protein tiar","volume":"33","author":"Suswam","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"ref_419","doi-asserted-by":"crossref","first-page":"579","DOI":"10.4161\/rna.24341","article-title":"Distinct binding properties of tiar rrms and linker region","volume":"10","author":"Kim","year":"2013","journal-title":"RNA Biol."},{"key":"ref_420","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.1128\/MCB.23.17.5959-5971.2003","article-title":"U1 snrnp-dependent function of tiar in the regulation of alternative RNA processing of the human calcitonin\/cgrp pre-mrna","volume":"23","author":"Zhu","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_421","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1128\/MCB.01509-07","article-title":"Regulation of neuron-specific alternative splicing of neurofibromatosis type 1 pre-mrna","volume":"28","author":"Zhu","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"ref_422","doi-asserted-by":"crossref","unstructured":"Wang, Z., Kayikci, M., Briese, M., Zarnack, K., Luscombe, N.M., Rot, G., Zupan, B., Curk, T., and Ule, J. (2010). Iclip predicts the dual splicing effects of tia-rna interactions. PLoS Biol., 8.","DOI":"10.1371\/journal.pbio.1000530"},{"key":"ref_423","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1101\/gr.073155.107","article-title":"A systematic analysis of intronic sequences downstream of 5\u2032 splice sites reveals a widespread role for u-rich motifs and tia1\/tial1 proteins in alternative splicing regulation","volume":"18","author":"Aznarez","year":"2008","journal-title":"Genome Res."},{"key":"ref_424","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.molcel.2018.01.011","article-title":"The tia1 rna-binding protein family regulates eif2ak2-mediated stress response and cell cycle progression","volume":"69","author":"Meyer","year":"2018","journal-title":"Mol. Cell"},{"key":"ref_425","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1091\/mbc.e04-08-0715","article-title":"Stress granule assembly is mediated by prion-like aggregation of tia-1","volume":"15","author":"Gilks","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"ref_426","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.1093\/nar\/gku193","article-title":"Structure, dynamics and RNA binding of the multi-domain splicing factor tia-1","volume":"42","author":"Wang","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_427","doi-asserted-by":"crossref","first-page":"9520","DOI":"10.1128\/MCB.25.21.9520-9531.2005","article-title":"Identification and functional outcome of mrnas associated with RNA-binding protein tia-1","volume":"25","author":"Galban","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref_428","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1093\/nar\/gku1275","article-title":"Stress granules are dispensable for mRNA stabilization during cellular stress","volume":"43","author":"Bley","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_429","doi-asserted-by":"crossref","first-page":"10252","DOI":"10.1038\/ncomms10252","article-title":"Tia1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis","volume":"7","author":"Saito","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_430","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.neuron.2017.07.025","article-title":"Tia1 mutations in amyotrophic lateral sclerosis and frontotemporal dementia promote phase separation and alter stress granule dynamics","volume":"95","author":"Mackenzie","year":"2017","journal-title":"Neuron"},{"key":"ref_431","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1093\/emboj\/19.15.4154","article-title":"Tia-1 is a translational silencer that selectively regulates the expression of tnf-alpha","volume":"19","author":"Piecyk","year":"2000","journal-title":"EMBO J."},{"key":"ref_432","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1073\/pnas.95.5.2331","article-title":"Rna-binding protein tiar is essential for primordial germ cell development","volume":"95","author":"Beck","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_433","doi-asserted-by":"crossref","first-page":"E2610","DOI":"10.1210\/jc.2013-3488","article-title":"Mrna-binding protein tia-1 reduces cytokine expression in human endometrial stromal cells and is down-regulated in ectopic endometrium","volume":"99","author":"Karalok","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_434","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1084\/jem.20030616","article-title":"Regulation of cyclooxygenase-2 expression by the translational silencer tia-1","volume":"198","author":"Dixon","year":"2003","journal-title":"J. Exp. Med."},{"key":"ref_435","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1074\/jbc.274.4.2322","article-title":"Identification of tiar as a protein binding to the translational regulatory au-rich element of tumor necrosis factor alpha mrna","volume":"274","author":"Gueydan","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_436","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1074\/jbc.M203526200","article-title":"Translational repression of human matrix metalloproteinases-13 by an alternatively spliced form of t-cell-restricted intracellular antigen-related protein (tiar)","volume":"278","author":"Yu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_437","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10048-014-0397-x","article-title":"Dysregulated expression of lipid storage and membrane dynamics factors in tia1 knockout mouse nervous tissue","volume":"15","author":"Heck","year":"2014","journal-title":"Neurogenetics"},{"key":"ref_438","doi-asserted-by":"crossref","unstructured":"Kharraz, Y., Salmand, P.A., Camus, A., Auriol, J., Gueydan, C., Kruys, V., and Morello, D. (2010). Impaired embryonic development in mice overexpressing the rna-binding protein tiar. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0011352"},{"key":"ref_439","doi-asserted-by":"crossref","unstructured":"Sanchez-Jimenez, C., and Izquierdo, J.M. (2013). T-cell intracellular antigen (tia)-proteins deficiency in murine embryonic fibroblasts alters cell cycle progression and induces autophagy. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075127"},{"key":"ref_440","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/cdd.2016.90","article-title":"T-cell-restricted intracellular antigen 1 facilitates mitochondrial fragmentation by enhancing the expression of mitochondrial fission factor","volume":"24","author":"Tak","year":"2017","journal-title":"Cell Death Differ."},{"key":"ref_441","doi-asserted-by":"crossref","first-page":"e00174-17","DOI":"10.1128\/MCB.00174-17","article-title":"T-cell intracellular antigens and hu antigen r antagonistically modulate mitochondrial activity and dynamics by regulating optic atrophy 1 gene expression","volume":"37","author":"Carrascoso","year":"2017","journal-title":"Mol. Cell. Biol."},{"key":"ref_442","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/(SICI)1097-4547(20000315)59:6<767::AID-JNR9>3.0.CO;2-K","article-title":"Expression of the rna-binding protein tiar is increased in neurons after ischemic cerebral injury","volume":"59","author":"Jin","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"ref_443","first-page":"731526","article-title":"Structure and pathology of tau protein in alzheimer disease","volume":"2012","author":"Kolarova","year":"2012","journal-title":"Int. J. Alzheimers Dis."},{"key":"ref_444","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.celrep.2016.04.045","article-title":"Interaction of tau with the rna-binding protein tia1 regulates tau pathophysiology and toxicity","volume":"15","author":"Vanderweyde","year":"2016","journal-title":"Cell Rep."},{"key":"ref_445","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41593-017-0022-z","article-title":"Reducing the RNA binding protein tia1 protects against tau-mediated neurodegeneration in vivo","volume":"21","author":"Apicco","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_446","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrm.2017.130","article-title":"A brave new world of rna-binding proteins","volume":"19","author":"Hentze","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/8\/2280\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:16:26Z","timestamp":1760195786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/8\/2280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,3]]},"references-count":446,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8]]}},"alternative-id":["ijms19082280"],"URL":"https:\/\/doi.org\/10.3390\/ijms19082280","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,3]]}}}