{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:46:46Z","timestamp":1787028406230,"version":"build-2736575974"},"reference-count":37,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T00:00:00Z","timestamp":1533686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project of the Ministry of Science and Technology of China","doi-asserted-by":"publisher","award":["2014ZX09J14106-03A"],"award-info":[{"award-number":["2014ZX09J14106-03A"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Logistics Research Project of China","award":["AWS16J022"],"award-info":[{"award-number":["AWS16J022"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502770"],"award-info":[{"award-number":["81502770"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Trans-ferulic acid-4-\u03b2-glucoside (C16H20O9, TFA-4\u03b2-G) is a monomer extracted from the Chinese medicine called radix aconiti carmichaeli (Fuzi). To date, research on this substance is lacking. Here, we found that trans-ferulic acid-4-\u03b2-glucoside effectively promoted cold acclimatization in mice via increased heat production and alleviation of oxidative stress in a cold environment. Thus, our work indicates that ferulic acid-4-\u03b2-glucoside is a potential therapeutic candidate for prevention and treatment of cold stress injury.<\/jats:p>","DOI":"10.3390\/ijms19082321","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T03:33:48Z","timestamp":1533785628000},"page":"2321","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Trans-Ferulic Acid-4-\u03b2-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance"],"prefix":"10.3390","volume":"19","author":[{"given":"Chong","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanyu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiye","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tem.2014.01.001","article-title":"Cold exposure\u2014An approach to increasing energy expenditure in humans","volume":"25","author":"Lichtenbelt","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s004210000329","article-title":"Measurement and prediction of peak shivering intensity in humans","volume":"84","author":"Eyolfson","year":"2001","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: Function and physiological significance","volume":"84","author":"Cannon","year":"2004","journal-title":"Physiol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/35007527","article-title":"Towards a molecular understanding of adaptive thermogenesis","volume":"404","author":"Lowell","year":"2000","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2013.12.012","article-title":"What We Talk About When We Talk About Fat","volume":"156","author":"Rosen","year":"2014","journal-title":"Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2337\/diabetes.48.2.292","article-title":"Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting","volume":"48","author":"Ekberg","year":"1999","journal-title":"Diabetes"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nrendo.2017.80","article-title":"Regulation of hepatic glucose metabolism in health and disease","volume":"13","author":"Petersen","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1172\/JCI68993","article-title":"Cold acclimation recruits human brown fat and increases nonshivering thermogenesis","volume":"123","author":"Hoeks","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1152\/jappl.1961.16.6.1011","article-title":"Chamber cold acclimatization in man","volume":"16","author":"Davis","year":"1961","journal-title":"J. Appl. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/cphy.c130043","article-title":"Maintaining thermogenesis in cold exposed humans: Relying on multiple metabolic pathways","volume":"4","author":"Blondin","year":"2014","journal-title":"Compr. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1113\/expphysiol.1997.sp004024","article-title":"Oxidative stress: Oxidants and antioxidants","volume":"82","author":"Sies","year":"1997","journal-title":"Exp. Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20061131","article-title":"Oxidative stress and cancer: Have we moved forward?","volume":"401","author":"Halliwell","year":"2007","journal-title":"Biochem. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"416","DOI":"10.2741\/s161","article-title":"Cold defence responses: The role of oxidative stress","volume":"3","author":"Blagojevic","year":"2011","journal-title":"Front. Biosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1242\/jeb.043307","article-title":"Oxidative stress in cold-induced hyperthyroid state","volume":"213","author":"Venditti","year":"2010","journal-title":"J. Exp. Biol."},{"key":"ref_15","first-page":"305","article-title":"Effects of low temperature on lipid peroxidation and intensity of proteolysis in rat brain and liver","volume":"52","author":"Lomakina","year":"1980","journal-title":"Ukrainskii Biokhimicheskii Zhurnal"},{"key":"ref_16","first-page":"69","article-title":"Chronic cold exposure affects the antioxidant defense system in various rat tissues. Clinica chimica acta","volume":"333","author":"Kaushik","year":"2003","journal-title":"Int. J. Clin. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.biocel.2003.11.005","article-title":"Cold-induced hyperthyroidism produces oxidative damage in rat tissues and increases susceptibility to oxidants","volume":"36","author":"Venditti","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.redox.2017.04.019","article-title":"Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway","volume":"12","author":"Contreras","year":"2017","journal-title":"Redox Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.autneu.2016.02.009","article-title":"Human physiological responses to cold exposure: Acute responses and acclimatization to prolonged exposure","volume":"196","author":"Castellani","year":"2016","journal-title":"Auton. Neurosci. Basic Clin."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1172\/JCI67803","article-title":"Recruited brown adipose tissue as an antiobesity agent in humans","volume":"123","author":"Yoneshiro","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sepa-Kishi, D.M., Katsnelson, G., Bikopoulos, G., Iqbal, A., and Ceddia, R.B. (2018). Cold acclimation reduces hepatic protein Kinase B and AMP-activated protein kinase phosphorylation and increases gluconeogenesis in Rats. Physiol. Rep., 6.","DOI":"10.14814\/phy2.13592"},{"key":"ref_22","first-page":"4674","article-title":"Recognition and use of Aconitum carmichaeli from the pre-Qin period to Tang Dynasty-Also on rules in evolution of traditional Chinese medicine","volume":"42","author":"Yang","year":"2017","journal-title":"China J. Chin. Mater. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jep.2009.07.031","article-title":"Aconitum in traditional Chinese medicine: A valuable drug or an unpredictable risk?","volume":"126","author":"Singhuber","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"ref_24","first-page":"187","article-title":"A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine","volume":"44","author":"Wu","year":"2018","journal-title":"Phytomed. Int. J. Phytother. Phytopharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/FJC.0000000000000056","article-title":"Sodium ferulate protects against daunorubicin-induced cardiotoxicity by inhibition of mitochondrial apoptosis in juvenile rats","volume":"63","author":"Wu","year":"2014","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1113\/jphysiol.2010.198598","article-title":"Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice","volume":"588 Pt 21","author":"Bruton","year":"2010","journal-title":"J. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1527-3466.2005.tb00163.x","article-title":"Pharmacological actions of sodium ferulate in cardiovascular system","volume":"23","author":"Wang","year":"2005","journal-title":"Cardiovasc. Drug Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0891-5849(02)00874-2","article-title":"The consequences of acute cold exposure on protein oxidation and proteasome activity in short-tailed field voles, microtus agrestis","volume":"33","author":"Selman","year":"2002","journal-title":"Free Radical Biol. Med."},{"key":"ref_29","first-page":"171","article-title":"Thermogenic mechanisms in cold-acclimated animals","volume":"21","author":"Griggio","year":"1988","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.molcel.2010.09.023","article-title":"Autophagy and the integrated stress response","volume":"40","author":"Kroemer","year":"2010","journal-title":"Mol. cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.bbalip.2012.12.009","article-title":"Autophagy: Emerging roles in lipid homeostasis and metabolic control","volume":"1831","author":"Christian","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.phrs.2012.09.004","article-title":"Autophagy in adipose tissue biology","volume":"66","author":"Zhang","year":"2012","journal-title":"Pharmacol. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.celrep.2017.04.035","article-title":"miRNA-32 Drives Brown Fat Thermogenesis and Trans-activates Subcutaneous White Fat Browning in Mice","volume":"19","author":"Ng","year":"2017","journal-title":"Cell Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.celrep.2017.06.069","article-title":"Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat","volume":"20","author":"Yao","year":"2017","journal-title":"Cell Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/bmb.20836","article-title":"Comprehensive experiment-clinical biochemistry: Determination of blood glucose and triglycerides in normal and diabetic rats","volume":"43","author":"Jiao","year":"2015","journal-title":"Biochem. Mol. Biol. Educ. A Bimon. Publ. Int. Union Biochem. Mol. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-4939-7163-3_14","article-title":"Periodic Acid-Schiff Staining with Diastase","volume":"1639","author":"Fu","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.molmet.2017.05.004","article-title":"Loss of ADAMTS5 enhances brown adipose tissue mass and promotes browning of white adipose tissue via CREB signaling","volume":"6","author":"Bauters","year":"2017","journal-title":"Mol. Metab."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/8\/2321\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:17:17Z","timestamp":1760195837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/8\/2321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,8]]},"references-count":37,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8]]}},"alternative-id":["ijms19082321"],"URL":"https:\/\/doi.org\/10.3390\/ijms19082321","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,8]]}}}