{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:08:43Z","timestamp":1766066923126,"version":"build-2065373602"},"reference-count":70,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["PO1HL036573"],"award-info":[{"award-number":["PO1HL036573"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MIIR","award":["Funds"],"award-info":[{"award-number":["Funds"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The first reports of cardiac Na\/K-ATPase signaling, published 20 years ago, have opened several major fields of investigations into the cardioprotective action of low\/subinotropic concentrations of cardiotonic steroids (CTS). This review focuses on the protective cardiac Na\/K-ATPase-mediated signaling triggered by low concentrations of ouabain and other CTS, in the context of the enduring debate over the use of CTS in the ischemic heart. Indeed, as basic and clinical research continues to support effectiveness and feasibility of conditioning interventions against ischemia\/reperfusion injury in acute myocardial infarction (AMI), the mechanistic information available to date suggests that unique features of CTS-based conditioning could be highly suitable, alone \/or as a combinatory approach.<\/jats:p>","DOI":"10.3390\/ijms19082336","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T10:36:31Z","timestamp":1533810991000},"page":"2336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Na\/K-ATPase Signaling and Cardiac Pre\/Postconditioning with Cardiotonic Steroids"],"prefix":"10.3390","volume":"19","author":[{"given":"Pauline V.","family":"Marck","sequence":"first","affiliation":[{"name":"Marshall Institute for Interdisciplinary Research, Marshall University, Huntington, West Virginia, WV 25701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine V.","family":"Pierre","sequence":"additional","affiliation":[{"name":"Marshall Institute for Interdisciplinary Research, Marshall University, Huntington, West Virginia, WV 25701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1001\/jama.2009.1178","article-title":"Reduction in acute myocardial infarction mortality in the United States: Risk-standardized mortality rates from 1995\u22122006","volume":"302","author":"Krumholz","year":"2009","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: A neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J. 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