{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:21:51Z","timestamp":1790709711110,"version":"4.1.0"},"reference-count":25,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T00:00:00Z","timestamp":1535414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chronic venous disorders are common vascular pathology of great medical and socioeconomic impact, characterized by a wide spectrum of clinical manifestations occurring with symptoms and\/or signs that vary in type and severity. The predominant pathophysiological mechanisms of chronic venous disease start from the development of venous hypertension from shear stress and reflux, leading to endothelial dysfunction and venous wall dilatation. The altered hemodynamic transduces physical signals into harmful bio-molecular pathways, creating a vicious cycle among shear stress, proteolytic remodeling, and inflammatory processes. This intricate network is further exacerbated by the degradation of protective endothelial glycocalyx. In this special issue, at least three main aspects of these interactions are highlighted: the dangerous, the good, and the diverse, which may help to focus attention on the biomolecular mechanisms and the possible targeted therapy of chronic venous disorders (CVeD).<\/jats:p>","DOI":"10.3390\/ijms19092544","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T12:19:06Z","timestamp":1535458746000},"page":"2544","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Chronic Venous Disorders: The Dangerous, the Good, and the Diverse"],"prefix":"10.3390","volume":"19","author":[{"given":"Daniela","family":"Ligi","sequence":"first","affiliation":[{"name":"Department of Biomolecular Sciences, Section of Clinical Biochemistry and Molecular Genetics, University \u201cCarlo Bo\u201d, 61029 Urbino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Croce","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, Section of Clinical Biochemistry and Molecular Genetics, University \u201cCarlo Bo\u201d, 61029 Urbino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8112-6139","authenticated-orcid":false,"given":"Ferdinando","family":"Mannello","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, Section of Clinical Biochemistry and Molecular Genetics, University \u201cCarlo Bo\u201d, 61029 Urbino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12938-018-0494-4","article-title":"Peripheral vascular disease assessment in the lower limb: A review of current and emerging non-invasive diagnostic methods","volume":"17","author":"Gargiulo","year":"2018","journal-title":"Biomed. 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