{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:51:40Z","timestamp":1776487900139,"version":"3.51.2"},"reference-count":47,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Crizotinib is highly effective against anaplastic lymphoma kinase-positive and c-ros oncogen1-positive non-small cell lung cancer. Renal dysfunction is associated with crizotinib therapy but the mechanism is unknown. Here, we report a case of anaplastic lymphoma kinase positive non-small cell lung cancer showing multiple cysts and dysfunction of the kidneys during crizotinib administration. We also present results demonstrating that long-term crizotinib treatment induces fibrosis and dysfunction of the kidneys by activating the tumor necrosis factor-\u03b1\/nuclear factor-\u03baB signaling pathway. In conclusion, this study shows the renal detrimental effects of crizotinib, suggesting the need of careful monitoring of renal function during crizotinib therapy.<\/jats:p>","DOI":"10.3390\/ijms19102902","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T11:12:26Z","timestamp":1537873946000},"page":"2902","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Renal Injury during Long-Term Crizotinib Therapy"],"prefix":"10.3390","volume":"19","author":[{"given":"Taro","family":"Yasuma","sequence":"first","affiliation":[{"name":"Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"},{"name":"Department of Diabetes and Endocrinology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina N.","family":"D\u2019Alessandro-Gabazza","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Ito","sequence":"additional","affiliation":[{"name":"Respiratory Center, Matsusaka Municipal Hospital, Tonomachi 1550, Matsusaka, Mie 515-8544, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Nishii","sequence":"additional","affiliation":[{"name":"Respiratory Center, Matsusaka Municipal Hospital, Tonomachi 1550, Matsusaka, Mie 515-8544, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Nishihama","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prince","family":"Baffour Tonto","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuro","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"},{"name":"Department of Diabetes and Endocrinology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Toda","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban C.","family":"Gabazza","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Respiratory Center, Matsusaka Municipal Hospital, Tonomachi 1550, Matsusaka, Mie 515-8544, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigenori","family":"Yonemura","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Matsusaka Municipal Hospital, Tonomachi 1550, Matsusaka, Mie 515-8544, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Hataji","sequence":"additional","affiliation":[{"name":"Respiratory Center, Matsusaka Municipal Hospital, Tonomachi 1550, Matsusaka, Mie 515-8544, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1158\/1535-7163.MCT-07-0365","article-title":"Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma","volume":"6","author":"Christensen","year":"2007","journal-title":"Mol. 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