{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:22:26Z","timestamp":1791804146813,"version":"4.3.4"},"reference-count":370,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular senescence is a homeostatic biological process that has a key role in driving ageing. There is evidence that senescent cells accumulate in the nervous system with ageing and neurodegenerative disease and may predispose a person to the appearance of a neurodegenerative condition or may aggravate its course. Research into senescence has long been hindered by its variable and cell-type specific features and the lack of a universal marker to unequivocally detect senescent cells. Recent advances in senescence markers and genetically modified animal models have boosted our knowledge on the role of cellular senescence in ageing and age-related disease. The aim now is to fully elucidate its role in neurodegeneration in order to efficiently and safely exploit cellular senescence as a therapeutic target. Here, we review evidence of cellular senescence in neurons and glial cells and we discuss its putative role in Alzheimer\u2019s disease, Parkinson\u2019s disease and multiple sclerosis and we provide, for the first time, evidence of senescence in neurons and glia in multiple sclerosis, using the novel GL13 lipofuscin stain as a marker of cellular senescence.<\/jats:p>","DOI":"10.3390\/ijms19102937","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T02:54:54Z","timestamp":1538103294000},"page":"2937","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":419,"title":["Ageing, Cellular Senescence and Neurodegenerative Disease"],"prefix":"10.3390","volume":"19","author":[{"given":"Marios","family":"Kritsilis","sequence":"first","affiliation":[{"name":"Laboratory of Histology &amp; Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Goudi, 115-27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"V. Rizou","sequence":"additional","affiliation":[{"name":"Laboratory of Histology &amp; Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Goudi, 115-27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi N.","family":"Koutsoudaki","sequence":"additional","affiliation":[{"name":"Laboratory of Histology &amp; Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Goudi, 115-27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Evangelou","sequence":"additional","affiliation":[{"name":"Laboratory of Histology &amp; Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Goudi, 115-27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis G.","family":"Gorgoulis","sequence":"additional","affiliation":[{"name":"Laboratory of Histology &amp; Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Goudi, 115-27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1806-7740","authenticated-orcid":false,"given":"Dimitrios","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Laboratory of Histology &amp; Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Goudi, 115-27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3389\/fnagi.2015.00168","article-title":"Age-related neurodegenerative disease research needs aging models","volume":"7","author":"Johnson","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1212\/WNL.0b013e3182553be6","article-title":"Is dementia incidence declining? Trends in dementia incidence since 1990 in the Rotterdam Study","volume":"78","author":"Schrijvers","year":"2012","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jalz.2010.11.002","article-title":"Trends in the incidence and prevalence of Alzheimer\u2019s disease, dementia, and cognitive impairment in the United States","volume":"7","author":"Rocca","year":"2011","journal-title":"Alzheimers Dement."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1056\/NEJM2003ra020003","article-title":"Alzheimer\u2019s Disease and Parkinson\u2019s Disease","volume":"348","author":"Nussbaum","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1155\/2012\/463909","article-title":"Age-related neurodegeneration and memory loss in down syndrome","volume":"2012","author":"Lockrow","year":"2012","journal-title":"Curr. Gerontol. Geriatr. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0047-6374(81)90084-1","article-title":"A new murine model of accelerated senescence","volume":"17","author":"Takeda","year":"1981","journal-title":"Mech. Ageing Dev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0196-9781(00)00342-9","article-title":"Beta-amyloid precursor polypeptide in SAMP8 mice affects learning and memory","volume":"21","author":"Morley","year":"2000","journal-title":"Peptides"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/ene.12592","article-title":"Parkinson\u2019s disease incidence and prevalence assessment in France using the national healthcare insurance database","volume":"22","author":"Blin","year":"2015","journal-title":"Eur. J. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/ageing\/aft091","article-title":"The incidence of Parkinson\u2019s disease in the North-East of England","volume":"43","author":"Duncan","year":"2014","journal-title":"Age Ageing"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.neuro.30.051606.094313","article-title":"Multiple Sclerosis: An Immune or Neurodegenerative Disorder?","volume":"31","author":"Trapp","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1212\/WNL.0b013e318230a17d","article-title":"Age and disability accumulation in multiple sclerosis","volume":"77","author":"Scalfari","year":"2011","journal-title":"Neurology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"R701","DOI":"10.1016\/j.cub.2011.07.020","article-title":"On the Programmed\/Non-Programmed Nature of Ageing within the Life History","volume":"21","author":"Kirkwood","year":"2011","journal-title":"Curr. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.mad.2004.09.008","article-title":"What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?","volume":"126","author":"Kirkwood","year":"2005","journal-title":"Mech. Ageing Dev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The Hallmarks of Aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nrm3823","article-title":"Cellular senescence: From physiology to pathology","volume":"15","author":"Serrano","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Barbouti, A., Evangelou, K., Pateras, I.S., Papoudou-Bai, A., Patereli, A., Stefanaki, K., Rontogianni, D., Mu\u00f1oz-Esp\u00edn, D., Kanavaros, P., and Gorgoulis, V.G. (2018). In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution. Mech. Ageing Dev.","DOI":"10.1016\/j.mad.2018.02.005"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1101\/gad.227512.113","article-title":"Cell fusion induced by ERVWE1 or measles virus causes cellular senescence","volume":"27","author":"Chuprin","year":"2013","journal-title":"Genes Dev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.devcel.2014.11.012","article-title":"An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA","volume":"31","author":"Demaria","year":"2014","journal-title":"Dev. Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"20596","DOI":"10.1073\/pnas.1208248109","article-title":"Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling","volume":"109","author":"Rajagopalan","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.18632\/aging.100531","article-title":"The role of inflammation in age-related disease","volume":"5","author":"Howcroft","year":"2013","journal-title":"Aging (Albany NY)"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0014-4827(61)90192-6","article-title":"The serial cultivation of human diploid strains","volume":"25","author":"Hayflick","year":"1961","journal-title":"Exp. Cell Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.ceb.2010.07.013","article-title":"Oncogene-induced senescence: The bright and dark side of the response","volume":"22","author":"Gorgoulis","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.tcb.2018.02.001","article-title":"Hallmarks of Cellular Senescence","volume":"28","author":"Nehme","year":"2018","journal-title":"Trends Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/2041-9414-2-7","article-title":"Cellular Senescence\u2014Its role in cancer and the response to ionizing radiation","volume":"2","author":"Sabin","year":"2011","journal-title":"Genome Integr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature12437","article-title":"Synthetic lethal metabolic targeting of cellular senescence in cancer therapy","volume":"501","author":"Yu","year":"2013","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0531-5565(00)00180-7","article-title":"Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes","volume":"35","author":"Toussaint","year":"2000","journal-title":"Exp. Gerontol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Kang, H.T., Lee, K.B., Kim, S.Y., Choi, H.R., and Park, S.C. (2011). Autophagy impairment induces premature senescence in primary human fibroblasts. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023367"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/acel.12632","article-title":"Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence","volume":"16","author":"Wiley","year":"2017","journal-title":"Aging Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1756-8935-1-6","article-title":"Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence","volume":"1","author":"Nakamura","year":"2008","journal-title":"Epigenet. Chromatin"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.201009094","article-title":"Four faces of cellular senescence","volume":"192","author":"Rodier","year":"2011","journal-title":"J. Cell Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1101\/gad.859201","article-title":"Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions","volume":"15","author":"Ramirez","year":"2001","journal-title":"Genes Dev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/ncb1909","article-title":"Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion","volume":"11","author":"Rodier","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1038\/sj.onc.1204665","article-title":"Activation of p53 transcriptional activity requires ATM\u2019s kinase domain and multiple N-terminal serine residues of p53","volume":"20","author":"Turenne","year":"2001","journal-title":"Oncogene"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nature05529","article-title":"Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas","volume":"445","author":"Xue","year":"2007","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/carcin\/bgs124","article-title":"Immune surveillance of senescent cells\u2014Biological significance in cancer- and non-cancer pathologies","volume":"33","author":"Hoenicke","year":"2012","journal-title":"Carcinogenesis"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S1097-2765(04)00256-4","article-title":"Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a","volume":"14","author":"Herbig","year":"2004","journal-title":"Mol. Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.exger.2010.01.018","article-title":"Quantitative assessment of markers for cell senescence","volume":"45","author":"Lawless","year":"2010","journal-title":"Exp. Gerontol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16Ink4a -positive senescent cells delays ageing- associated disorders","volume":"479","author":"Baker","year":"2012","journal-title":"Nature"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.molcel.2014.05.007","article-title":"Transient activation of p53 in G2 phase is sufficient to induce senescence","volume":"55","author":"Krenning","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1128\/MCB.19.3.2109","article-title":"Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts","volume":"19","author":"Stein","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1254\/jphs.11026FP","article-title":"Possible underlying influence of p38MAPK and NF-\u03baB in the diminished anti-anxiety effect of diazepam in stressed mice","volume":"116","author":"Sharma","year":"2011","journal-title":"J. Pharmacol. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"E4612","DOI":"10.1073\/pnas.1705499114","article-title":"cGAS is essential for cellular senescence","volume":"114","author":"Yang","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression","volume":"5","author":"Desprez","year":"2010","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ncb2784","article-title":"A complex secretory program orchestrated by the inflammasome controls paracrine senescence","volume":"15","author":"Acosta","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.molcel.2015.07.011","article-title":"MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype","volume":"59","author":"Chen","year":"2015","journal-title":"Mol. Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ncb3397","article-title":"NOTCH1 mediates a switch between two distinct secretomes during senescence","volume":"18","author":"Hoare","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/msb.2010.5","article-title":"Feedback between p21 and reactive oxygen production is necessary for cell senescence","volume":"6","author":"Passos","year":"2010","journal-title":"Mol. Syst. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0116480","article-title":"SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation","volume":"10","author":"Hayakawa","year":"2015","journal-title":"PLoS ONE"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"7864","DOI":"10.1158\/0008-5472.CAN-07-6538","article-title":"Senescence-Associated Exosome Release from Human Prostate Cancer Cells","volume":"68","author":"Lehmann","year":"2008","journal-title":"Cancer Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"15729","DOI":"10.1038\/ncomms15728","article-title":"Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2","volume":"8","author":"Takasugi","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1128\/MCB.20.8.2803-2808.2000","article-title":"Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage","volume":"20","author":"Webley","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.4161\/cc.9.16.12688","article-title":"Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence","volume":"9","author":"Tavana","year":"2010","journal-title":"Cell Cycle"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.molcel.2006.11.021","article-title":"Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis","volume":"24","author":"Tang","year":"2006","journal-title":"Mol. Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1474-9726.2006.00199.x","article-title":"Senescence-associated \u03b2-galactosidase is lysosomal \u03b2-galactosidase","volume":"5","author":"Lee","year":"2006","journal-title":"Aging Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000484629","article-title":"mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review","volume":"64","author":"Weichhart","year":"2018","journal-title":"Gerontology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.redox.2013.01.006","article-title":"Lipofuscin: Formation, effects and role of macroautophagy","volume":"1","author":"Grune","year":"2013","journal-title":"Redox Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"37","DOI":"10.18632\/aging.100527","article-title":"Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues","volume":"5","author":"Georgakopoulou","year":"2013","journal-title":"Aging (Albany NY)"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/acel.12545","article-title":"Robust, universal biomarker assay to detect senescent cells in biological specimens","volume":"16","author":"Evangelou","year":"2017","journal-title":"Aging Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1021\/acs.jproteome.7b00111","article-title":"Metabolomics\u2013Proteomics Combined Approach Identifies Differential Metabolism-Associated Molecular Events between Senescence and Apoptosis","volume":"16","author":"Wu","year":"2017","journal-title":"J. Proteome Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"724","DOI":"10.15252\/embj.201592862","article-title":"Mitochondria are required for pro-ageing features of the senescent phenotype","volume":"35","author":"Marques","year":"2016","journal-title":"EMBO J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"22977","DOI":"10.1074\/jbc.M700679200","article-title":"Mitochondrial Fission and Fusion Mediators, hFis1 and OPA1, Modulate Cellular Senescence","volume":"282","author":"Lee","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1242\/jcs.059246","article-title":"Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1","volume":"123","author":"Mai","year":"2010","journal-title":"J. Cell Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nature16187","article-title":"Autophagy maintains stemness by preventing senescence","volume":"529","author":"Perdiguero","year":"2016","journal-title":"Nature"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"9369","DOI":"10.1128\/MCB.25.21.9369-9382.2005","article-title":"Loss of Bif-1 suppresses Bax\/Bak conformational change and mitochondrial apoptosis","volume":"25","author":"Takahashi","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.bbabio.2015.05.017","article-title":"Mitochondria: Are they causal players in cellular senescence?","volume":"1847","author":"Passos","year":"2015","journal-title":"Biochim. Biophys. Acta-Bioenerg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.1093\/nar\/gkm893","article-title":"DNA damage in telomeres and mitochondria during cellular senescence: Is there a connection?","volume":"35","author":"Passos","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nsmb.3202","article-title":"SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence","volume":"23","author":"Tasselli","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.tig.2014.04.007","article-title":"Sirtuins: Guardians of mammalian healthspan","volume":"30","author":"Giblin","year":"2014","journal-title":"Trends Genet."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Komseli, E.-S., Pateras, I.S., Krejsgaard, T., Stawiski, K., Rizou, S.V., Polyzos, A., Roumelioti, F.-M., Chiourea, M., Mourkioti, I., and Paparouna, E. (2018). A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence. BMC Genomics, 19.","DOI":"10.1186\/s12864-017-4375-1"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/35065138","article-title":"Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain","volume":"410","author":"Bannister","year":"2001","journal-title":"Nature"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature24050","article-title":"Cytoplasmic chromatin triggers inflammation in senescence and cancer","volume":"550","author":"Dou","year":"2017","journal-title":"Nature"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/ncb2170","article-title":"Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer","volume":"13","author":"Sulli","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1101\/gad.235184.113","article-title":"Cellular senescence and its effector programs","volume":"28","author":"Salama","year":"2014","journal-title":"Genes Dev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1091\/mbc.e11-10-0884","article-title":"Lamin B1 loss is a senescence-associated biomarker","volume":"23","author":"Freund","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"67699","DOI":"10.18632\/oncotarget.11505","article-title":"ATF6\u03b1 regulates morphological changes associated with senescence in human fibroblasts","volume":"7","author":"Druelle","year":"2016","journal-title":"Oncotarget"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.mad.2017.08.003","article-title":"The ATF6\u03b1 arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2\/prostaglandin E 2 intracrine pathway","volume":"170","author":"Cormenier","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"ref_77","first-page":"S41","article-title":"Plasma membrane microdomains in aging and disease","volume":"10","author":"Shimada","year":"2010","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/366704a0","article-title":"A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D\/CDK4","volume":"366","author":"Serrano","year":"1993","journal-title":"Nature"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrc3960","article-title":"Forging a signature of in vivo senescence","volume":"15","author":"Sharpless","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/sj.onc.1201178","article-title":"Expression of the p16(INK4a) tumor suppressor versus other INK4 family members during mouse development and aging","volume":"15","author":"Zindy","year":"1997","journal-title":"Oncogene"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.cell.2012.12.010","article-title":"Monitoring tumorigenesis and senescence in vivo with a p16 INK4a-luciferase model","volume":"152","author":"Burd","year":"2013","journal-title":"Cell"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1172\/JCI22475","article-title":"Ink4a\/Arf expression is a biomarker of aging","volume":"114","author":"Krishnamurthy","year":"2004","journal-title":"J. Clin. Invest."},{"key":"ref_83","first-page":"505","article-title":"Reciprocal Rb Inactivation and p16 INK4 Expression in Primary Lung Cancers and Cell Lines","volume":"55","author":"Shapiro","year":"1995","journal-title":"Cancer Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.4161\/cc.10.15.16776","article-title":"The meaning of p16 ink4a expression in tumors: Functional significance, clinical associations and future developments","volume":"10","author":"Witkiewicz","year":"2011","journal-title":"Cell Cycle"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1101\/gad.13.12.1501","article-title":"CDK inhibitors: Positive and negative regulators of G1-phase progression","volume":"13","author":"Sherr","year":"1999","journal-title":"Genes Dev."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.cellsig.2010.01.013","article-title":"Examination of the expanding pathways for the regulation of p21 expression and activity","volume":"22","author":"Jung","year":"2010","journal-title":"Cell. Signal."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"Dimri","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1242\/jcs.113.20.3613","article-title":"Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells","volume":"113","author":"Kurz","year":"2000","journal-title":"J. Cell Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/excr.2000.4875","article-title":"Is \u03b2-galactosidase staining a marker of senescence in vitro and in vivo?","volume":"257","author":"Severino","year":"2000","journal-title":"Exp. Cell Res."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Gorgoulis, V.G., Pefani, D., Pateras, I.S., and Trougakos, I.P. (2018). Integrating the DNA damage and protein stress responses during cancer development and treatment. J. Pathol.","DOI":"10.1002\/path.5097"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.biocel.2003.08.009","article-title":"Lipofuscin","volume":"36","author":"Terman","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1196\/annals.1404.008","article-title":"Lipofuscin: Formation, distribution, and metabolic consequences","volume":"1119","author":"Jung","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Rizou, S.V., Evangelou, K., Myrianthopoulos, V., Mourouzis, I., Havaki, S., Vasileiou, P., Kotsinas, A., Kastrinakis, N., Sfikakis, P., Townsend, P., Mikros, E., Pantos, C., and Gorgoulis, V.G. (2018). A novel quantitative method for the detection of lipofuscin, the main byproduct of cellular senescence, in fluids. Meth. Mol. Biol., in press.","DOI":"10.1007\/978-1-4939-8931-7_12"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1474-9726.2012.00795.x","article-title":"A senescent cell bystander effect: Senescence-induced senescence","volume":"11","author":"Nelson","year":"2012","journal-title":"Aging Cell"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.semcancer.2015.12.005","article-title":"Systemic DNA damage responses in aging and diseases","volume":"37\u201338","author":"Ribezzo","year":"2016","journal-title":"Semin. Cancer Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0014-5793(91)80737-N","article-title":"Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer\u2019s disease cortices","volume":"285","author":"Bauer","year":"1991","journal-title":"FEBS Lett."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/BF00571510","article-title":"Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer\u2019s disease patients","volume":"89","author":"Huell","year":"1995","journal-title":"Acta Neuropathol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"9090","DOI":"10.1073\/pnas.1531903100","article-title":"Chronic stress and age-related increases in the proinflammatory cytokine IL-6","volume":"100","author":"Preacher","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"10061","DOI":"10.1073\/pnas.90.21.10061","article-title":"Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6","volume":"90","author":"Campbell","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/glia.10319","article-title":"Dystrophic Microglia in the Aging Human Brain","volume":"45","author":"Streit","year":"2004","journal-title":"Glia"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/brain\/awv395","article-title":"Immunosenescence of microglia and macrophages: Impact on the ageing central nervous system","volume":"139","author":"Rawji","year":"2016","journal-title":"Brain"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/9076485","article-title":"Cellular Senescence and Inflammaging in Age-Related Diseases","volume":"2018","author":"Olivieri","year":"2018","journal-title":"Med. Inflamm."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrc2560","article-title":"Senescence-messaging secretome: SMS-ing cellular stress","volume":"9","author":"Kuilman","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: When bad things happen to good cells","volume":"8","author":"Campisi","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1742-2094-5-51","article-title":"Inflammaging as a prodrome to Alzheimer\u2019s disease","volume":"5","author":"Giunta","year":"2008","journal-title":"J. Neuroinflamm."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.freeradbiomed.2017.10.379","article-title":"Aging and Parkinson\u2019s Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis","volume":"115","author":"Calabrese","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.neuro.051508.135600","article-title":"The Glial Nature of Embryonic and Adult Neural Stem Cells","volume":"32","author":"Kriegstein","year":"2009","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1093\/cercor\/bhy096","article-title":"Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer\u2019s Disease Adults","volume":"28","author":"Cipriani","year":"2018","journal-title":"Cereb Cortex"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/acel.12594","article-title":"Age-related decline in BubR1 impairs adult hippocampal neurogenesis","volume":"16","author":"Yang","year":"2017","journal-title":"Aging Cell"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13024-017-0207-7","article-title":"Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer\u2019s disease by compromising hippocampal inhibition","volume":"12","author":"Hollands","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13024-015-0035-6","article-title":"Human neural stem cells alleviate Alzheimer-like pathology in a mouse model","volume":"10","author":"Lee","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1023\/A:1025747832215","article-title":"The response of NG2-expressing oligodendrocyte progenitors to demyelination in MOG-EAE and MS","volume":"31","author":"Reynolds","year":"2002","journal-title":"J. Neurocytol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1056\/NEJMoa010994","article-title":"Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis","volume":"346","author":"Chang","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/ana.410330203","article-title":"Multiple sclerosis: Remyelination of nascent lesions","volume":"33","author":"Prineas","year":"1993","journal-title":"Ann. Neurol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1523\/JNEUROSCI.22-07-02451.2002","article-title":"The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation","volume":"22","author":"Sim","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0002-9440(10)64537-3","article-title":"Multiple Sclerosis and Chronic Autoimmune Encephalomyelitis","volume":"157","author":"Kornek","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1093\/brain\/awl217","article-title":"Remyelination is extensive in a subset of multiple sclerosis patients","volume":"129","author":"Patrikios","year":"2006","journal-title":"Brain"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.4161\/15384101.2014.973327","article-title":"Gene expression profiling of replicative and induced senescence","volume":"13","author":"Purcell","year":"2014","journal-title":"Cell Cycle"},{"key":"ref_120","first-page":"93","article-title":"Establishing pathological cut-offs of brain atrophy rates in multiple sclerosis","volume":"87","author":"Stromillo","year":"2016","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/pr.57.2.4","article-title":"The blood-brain barrier\/neurovascular unit in health and disease","volume":"57","author":"Hawkins","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1365-2990.2010.01139.x","article-title":"Review: Cerebral microvascular pathology in ageing and neurodegeneration","volume":"37","author":"Brown","year":"2011","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00401-009-0522-3","article-title":"Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer\u2019s disease","volume":"118","author":"Bell","year":"2009","journal-title":"Acta Neuropathol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neurobiolaging.2007.07.015","article-title":"Blood-brain barrier: Ageing and microvascular disease\u2013systematic review and meta-analysis","volume":"30","author":"Farrall","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1148\/radiol.2016152244","article-title":"Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease","volume":"281","author":"Burgmans","year":"2016","journal-title":"Radiology"},{"key":"ref_126","first-page":"463","article-title":"Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model","volume":"10","author":"Ujiie","year":"2003","journal-title":"Microcirculation"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.neurobiolaging.2006.05.016","article-title":"Microvascular injury and blood-brain barrier leakage in Alzheimer\u2019s disease","volume":"28","author":"Zipser","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1152\/japplphysiol.91353.2008","article-title":"Vascular endothelial senescence: From mechanisms to pathophysiology","volume":"106","author":"Erusalimsky","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1161\/STROKEAHA.115.010835","article-title":"Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown","volume":"47","author":"Yamazaki","year":"2016","journal-title":"Stroke"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Stamatanovic, S., Martinez, G., Hu, A., Choi, J., Keep, R., and Andjelkovic, A. (2018). Decline in Sirtuin-1 expression and activity plays a critical role in blood-brain barrier permeability in aging. Neurobiol Dis.","DOI":"10.1016\/j.nbd.2018.09.006"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(97)09234-9","article-title":"Relationship of senescence of cerebrospinal fluid circulatory system to dementias of the aged","volume":"351","author":"Rubenstein","year":"1998","journal-title":"Lancet"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3389\/fnagi.2018.00245","article-title":"Blood-Cerebrospinal Fluid Barrier Gradients in Mild Cognitive Impairment and Alzheimer\u2019s Disease: Relationship to Inflammatory Cytokines and Chemokines","volume":"10","author":"Ott","year":"2018","journal-title":"Front Aging Neurosci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"8389","DOI":"10.1073\/pnas.1433000100","article-title":"Human cerebrospinal fluid central memory CD4+ T cells: Evidence for trafficking through choroid plexus and meninges via P-selectin","volume":"100","author":"Mahad","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"C673","DOI":"10.1152\/ajpcell.00041.2017","article-title":"Transport across the choroid plexus epithelium","volume":"312","author":"Praetorius","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.1252945","article-title":"Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function","volume":"346","author":"Baruch","year":"2014","journal-title":"Science"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: Biology and pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/j.1471-4159.2006.04369.x","article-title":"Astrocytes aged in vitro show a decreased neuroprotective capacity","volume":"101","author":"Pertusa","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1474-9726.2008.00402.x","article-title":"Aging-related changes in astrocytes in the rat retina: Imbalance between cell proliferation and cell death reduces astrocyte availability","volume":"7","author":"Mansour","year":"2008","journal-title":"Aging Cell"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1460-9568.2011.07738.x","article-title":"Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype","volume":"34","author":"Salminen","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cell.2010.05.008","article-title":"Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations","volume":"141","author":"Lee","year":"2010","journal-title":"Cell"},{"key":"ref_141","first-page":"4854","article-title":"A P53-dependent, telomere-independent proliferative life span barrier in human astrocytes consistent with the molecular genetics of glioma development","volume":"63","author":"Evans","year":"2003","journal-title":"Cancer Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1016\/j.yexcr.2010.06.021","article-title":"Stress-induced senescence in human and rodent astrocytes","volume":"316","author":"Bitto","year":"2010","journal-title":"Exp. Cell Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/jat.3084","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin induces premature senescence of astrocytes via WNT\/\u03b2-catenin signaling and ROS production","volume":"35","author":"Nie","year":"2015","journal-title":"J. Appl. Toxicol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/glia.22731","article-title":"Ammonia-induced senescence in cultured rat astrocytes and in human cerebral cortex in hepatic encephalopathy","volume":"63","author":"Karababa","year":"2015","journal-title":"Glia"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.celrep.2017.12.092","article-title":"Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson\u2019s Disease","volume":"22","author":"Chinta","year":"2018","journal-title":"Cell Rep."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-pharmtox-011613-135937","article-title":"Environmental Toxins and Parkinson\u2019s Disease","volume":"54","author":"Goldman","year":"2014","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fnagi.2016.00208","article-title":"Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence","volume":"8","author":"Crowe","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0045069","article-title":"Astrocyte Senescence as a Component of Alzheimer\u2019s Disease","volume":"7","author":"Bhat","year":"2012","journal-title":"PLoS ONE"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cbi.2018.02.002","article-title":"Ginsenoside F1 suppresses astrocytic senescence-associated secretory phenotype","volume":"283","author":"Hou","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0125217","article-title":"A model for p38MAPK-induced astrocyte senescence","volume":"10","author":"Mombach","year":"2015","journal-title":"PLoS ONE"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.neurobiolaging.2006.05.012","article-title":"Mutant mice with small amounts of BubR1 display accelerated age-related gliosis","volume":"28","author":"Hartman","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1172\/JCI58644","article-title":"Innate immunity in the central nervous system","volume":"122","author":"Ransohoff","year":"2012","journal-title":"J. Clin. Invest."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/glia.10301","article-title":"Progressive Telomere Shortening Occurs in Cultured Rat Microglia, but Not Astrocytes","volume":"45","author":"Flanary","year":"2004","journal-title":"Glia"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1089\/rej.2006.9096","article-title":"Evidence That Aging and Amyloid Promote Microglial Cell Senescence","volume":"10","author":"Flanary","year":"2007","journal-title":"Rejuvenation Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000330254","article-title":"Repeated Lipopolysaccharide Stimulation Induces Cellular Senescence in BV2 Cells","volume":"19","author":"Yu","year":"2012","journal-title":"Neuroimmunomodulation"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/01.jnen.0000202887.22082.63","article-title":"Microglia in the Aging Brain","volume":"65","author":"Conde","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00401-009-0556-6","article-title":"Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer\u2019s disease","volume":"118","author":"Streit","year":"2009","journal-title":"Acta Neuropathol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"E1896","DOI":"10.1073\/pnas.1800165115","article-title":"Normal aging induces A1-like astrocyte reactivity","volume":"115","author":"Clarke","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"6491","DOI":"10.1523\/JNEUROSCI.1898-17.2018","article-title":"Oligodendroglia Are Particularly Vulnerable to Oxidative Damage after Neurotrauma In Vivo","volume":"38","author":"Giacci","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/bpa.12216","article-title":"Oxidative glial cell damage associated with white matter lesions in the aging human brain","volume":"25","author":"Simpson","year":"2015","journal-title":"Brain Pathol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11910-013-0415-7","article-title":"Contemplating Alzheimer\u2019s Disease and the Contribution of White Matter Hyperintensities","volume":"13","author":"Brickman","year":"2013","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1161\/STROKEAHA.107.498535","article-title":"Progression of White Matter Hyperintensities and Incidence of New Lacunes Over a 3-Year Period: The Leukoaraiosis and Disability Study","volume":"39","author":"Gouw","year":"2008","journal-title":"Stroke"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1212\/WNL.0b013e3182a43e45","article-title":"Neuropathologic basis of white matter hyperintensity accumulation with advanced age","volume":"81","author":"Woltjer","year":"2013","journal-title":"Neurology"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40478-018-0515-3","article-title":"White matter changes in Alzheimer\u2019s disease: A focus on myelin and oligodendrocytes","volume":"6","author":"Nasrabady","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S1044-7431(03)00210-0","article-title":"NG2-expressing glial progenitor cells: An abundant and widespread population of cycling cells in the adult rat CNS","volume":"24","author":"Dawson","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1126\/science.1056780","article-title":"Lack of replicative senescence in cultured rat oligodendrocyte precursor cells","volume":"291","author":"Tang","year":"2001","journal-title":"Science (80-.)"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"8259","DOI":"10.1073\/pnas.0911446107","article-title":"Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells","volume":"107","author":"Kujuro","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1093\/brain\/122.12.2279","article-title":"A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases","volume":"122","author":"Lucchinetti","year":"1999","journal-title":"Brain"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1365-2990.2007.00805.x","article-title":"Remyelination can be extensive in multiple sclerosis despite a long disease course","volume":"33","author":"Patani","year":"2007","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.18632\/aging.101032","article-title":"The progeroid gene BubR1 regulates axon myelination and motor function","volume":"8","author":"Choi","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3109\/00207454.2015.1025778","article-title":"Oligodendrocytes and Alzheimer\u2019s disease","volume":"126","author":"Cai","year":"2016","journal-title":"Int. J. Neurosci."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ncb1095","article-title":"Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks","volume":"6","author":"Sedelnikova","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/j.1474-9726.2012.00870.x","article-title":"Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response","volume":"11","author":"Jurk","year":"2012","journal-title":"Aging Cell"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3389\/fnins.2018.00464","article-title":"An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration","volume":"12","author":"Kun","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1523\/JNEUROSCI.5166-10.2011","article-title":"SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons","volume":"31","author":"Panossian","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.stemcr.2018.04.001","article-title":"Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence","volume":"10","author":"Ohashi","year":"2018","journal-title":"Stem Cell Rep."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13287-017-0567-5","article-title":"Alzheimer\u2019s disease, dementia, and stem cell therapy","volume":"8","author":"Duncan","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1242\/dev.01215","article-title":"Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells","volume":"131","author":"Ferron","year":"2004","journal-title":"Development"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"e924","DOI":"10.1038\/cddis.2013.437","article-title":"Amyloid-\u03b21\u201342 oligomer accelerates senescence in adult hippocampal neural stem\/progenitor cells via formylpeptide receptor 2","volume":"4","author":"He","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/2470351","article-title":"N-Stearoyl-L-Tyrosine Inhibits the Senescence of Neural Stem\/Progenitor Cells Induced by A\u03b2 1-42 via the CB2 Receptor","volume":"2016","author":"Li","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1038\/cddis.2010.60","article-title":"Glucocorticoids induce long-lasting effects in neural stem cells resulting in senescence-related alterations","volume":"1","author":"Bose","year":"2010","journal-title":"Cell Death Dis."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"14394","DOI":"10.1523\/JNEUROSCI.3836-09.2009","article-title":"Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis","volume":"29","author":"Ferron","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.biocel.2014.11.001","article-title":"Abnormal cortical lysosomal \u03b2-hexosaminidase and \u03b2-galactosidase activity at post-synaptic sites during Alzheimer\u2019s disease progression","volume":"58","author":"Magini","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"785","DOI":"10.3233\/JAD-2011-100525","article-title":"Lysosomal \u03b2-galactosidase and \u03b2-hexosaminidase activities correlate with clinical stages of dementia associated with Alzheimer\u2019s disease and type 2 diabetes mellitus","volume":"24","author":"Tiribuzi","year":"2011","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neurobiolaging.2013.08.003","article-title":"MiR128 up-regulation correlates with impaired amyloid \u03b2(1\u201342) degradation in monocytes from patients with sporadic Alzheimer\u2019s disease","volume":"35","author":"Tiribuzi","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1083\/jcb.132.3.413","article-title":"Mitotic mechanisms in Alzheimer\u2019s disease?","volume":"132","author":"Vincent","year":"1996","journal-title":"J. Cell Biol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nrn2124","article-title":"Cell cycle regulation in the postmitotic neuron: Oxymoron or new biology?","volume":"8","author":"Herrup","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1582-4934.2005.tb00485.x","article-title":"The last neuronal division: A unifying hypothesis for the pathogenesis of Alzheimer\u2019s disease","volume":"9","author":"Nagy","year":"2005","journal-title":"J. Cell. Mol. Med."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"363","DOI":"10.18632\/aging.100045","article-title":"The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer\u2019s","volume":"1","author":"Currais","year":"2009","journal-title":"Aging (Albany NY)"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1073\/pnas.97.8.4291","article-title":"Effects of p21Waf1\/Cip1\/Sdi1 on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases","volume":"97","author":"Chang","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0304-3940(01)01618-4","article-title":"Expression of apoptosis related proteins in brains of patients with Alzheimer\u2019s disease","volume":"303","author":"Engidawork","year":"2001","journal-title":"Neurosci. Lett."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Yates, S.C., Zafar, A., Rabai, E.M., Foxall, J.B., Nagy, S., Morrison, K.E., Clarke, C., Esiri, M.M., Christie, S., and Smith, A.D. (2015). The Effects of Two Polymorphisms on p21cip1 Function and Their Association with Alzheimer\u2019s Disease in a Population of European Descent. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0114050"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s007020050104","article-title":"Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer\u2019s disease","volume":"105","author":"Arendt","year":"1998","journal-title":"J. Neural Transm."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1111\/j.1460-9568.2012.08178.x","article-title":"Altered cell cycle-related gene expression in brain and lymphocytes from a transgenic mouse model of Alzheimer\u2019s disease [amyloid precursor protein\/presenilin 1 (PS1)]","volume":"36","author":"Esteras","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"878","DOI":"10.2353\/ajpath.2006.050540","article-title":"Cell-Cycle Markers in a Transgenic Mouse Model of Human Tauopathy","volume":"168","author":"Delobel","year":"2006","journal-title":"Am. J. Pathol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.neulet.2012.03.093","article-title":"Combination of p53(ser15) and p21\/p21(thr145) in peripheral blood lymphocytes as potential Alzheimer\u2019s disease biomarkers","volume":"516","author":"Tan","year":"2012","journal-title":"Neurosci. Lett."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.neurobiolaging.2012.10.014","article-title":"Downregulation of extracellular signal-regulated kinase 1\/2 activity by calmodulin KII modulates p21 Cip1 levels and survival of immortalized lymphocytes from Alzheimer\u2019s disease patients","volume":"34","author":"Esteras","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"2319-e13","DOI":"10.1016\/j.neurobiolaging.2010.04.017","article-title":"Cell cycle regulation distinguishes lymphocytes from sporadic and familial Alzheimer\u2019s disease patients","volume":"32","author":"Bialopiotrowicz","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000330468","article-title":"Two Blood Monocytic Biomarkers (CCL15 and p21) Combined with the Mini-Mental State Examination Discriminate Alzheimer\u2019s Disease Patients from Healthy Subjects","volume":"1","author":"Hochstrasser","year":"2011","journal-title":"Dement. Geriatr. Cogn. Disord. Extra"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1097\/00001756-199611250-00050","article-title":"Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer\u2019s disease","volume":"7","author":"Arendt","year":"1996","journal-title":"Neuroreport"},{"key":"ref_202","first-page":"1933","article-title":"Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer\u2019s disease","volume":"150","author":"McShea","year":"1997","journal-title":"Am. J. Pathol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0006-8993(99)02178-2","article-title":"Aberrant expression of nNOS in pyramidal neurons in Alzheimer\u2019s disease is highly co-localized with p21 ras and p16","volume":"852","author":"Luth","year":"2000","journal-title":"Brain Res."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0022-510X(97)00131-7","article-title":"Correlates of p53- and Fas (CD95) -mediated apoptosis in Alzheimer\u2019s disease","volume":"152","author":"Monte","year":"1997","journal-title":"J. Neurol. Sci."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1111\/j.1582-4934.2008.00163.x","article-title":"Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE, in brain from subjects with amnestic mild cognitive impairment and Alzheimer\u2019s disease","volume":"12","author":"Cenini","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1006\/bbrc.1997.6301","article-title":"Changes of p53 in the brains of patients with Alzheimer\u2019s disease","volume":"232","author":"Kitamura","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1096\/fj.04-2637fje","article-title":"Intracellular A\u03b242 activates p53 promoter: A pathway to neurodegeneration in Alzheimer\u2019s disease","volume":"19","author":"Ohyagi","year":"2005","journal-title":"FASEB J."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3233\/JAD-2001-3107","article-title":"Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer\u2019s disease brains at different stages of neurofibrillary degeneration","volume":"3","author":"Pei","year":"2001","journal-title":"J. Alzheimers Dis."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S0014-4886(03)00180-8","article-title":"P38 MAP kinase is activated at early stages in Alzheimer\u2019s disease brain","volume":"183","author":"Sun","year":"2003","journal-title":"Exp. Neurol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jocn.2013.08.017","article-title":"Peripheral expression of MAPK pathways in Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"21","author":"Wang","year":"2014","journal-title":"J. Clin. Neurosci."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1523\/JNEUROSCI.22-09-03376.2002","article-title":"Activation of c-Jun N-Terminal Kinase and p38 in an Alzheimer\u2019s Disease Model Is Associated with Amyloid Deposition","volume":"22","author":"Savage","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/emboj.2011.69","article-title":"p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype","volume":"30","author":"Freund","year":"2011","journal-title":"EMBO J."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1136\/jnnp-2017-316201","article-title":"Peripheral inflammatory markers in Alzheimer\u2019s disease: A systematic review and meta-analysis of 175 studies","volume":"88","author":"Lai","year":"2017","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3389\/fimmu.2018.00586","article-title":"Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines","volume":"9","author":"Rea","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0006-8993(93)91327-O","article-title":"Cytokine indices in Alzheimer\u2019s temporal cortex: No changes in mature IL-1 beta or IL-1RA but increases in the associated acute phase proteins IL-6, alpha 2-macroglobulin and C-reactive protein","volume":"629","author":"Wood","year":"1993","journal-title":"Brain Res."},{"key":"ref_216","first-page":"141","article-title":"Brain interleukin-1 beta in Alzheimer\u2019s disease and vascular dementia","volume":"16","author":"Cacabelos","year":"1994","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1001\/archneur.57.8.1153","article-title":"Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia","volume":"57","author":"Luterman","year":"2000","journal-title":"Arch. Neurol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0304-3940(95)12192-7","article-title":"Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer\u2019s and de novo Parkinson\u2019s disease patients","volume":"202","author":"Kuhn","year":"1995","journal-title":"Neurosci. Lett."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.biopsych.2010.06.012","article-title":"A Meta-Analysis of Cytokines in Alzheimer\u2019s Disease","volume":"68","author":"Swardfager","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0361-9230(03)00088-1","article-title":"Cerebral pattern of pro-and anti-inflammatory cytokines in dementias","volume":"61","author":"Tarkowski","year":"2003","journal-title":"Brain Res. Bull."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3233\/JAD-130497","article-title":"BDNF, TNF\u03b1, HSP90, CFH, and IL-10 Serum Levels in Patients with Early or Late Onset Alzheimer\u2019s Disease or Mild Cognitive Impairment","volume":"37","author":"Dursun","year":"2013","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jneuroim.2015.04.014","article-title":"The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer\u2019s disease, mild cognitive impairment or Parkinson\u2019s disease","volume":"283","author":"Dursun","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0304-3940(00)01418-X","article-title":"Brain matrix metalloproteinase 1 levels are elevated in Alzheimer\u2019s disease","volume":"291","author":"Leake","year":"2000","journal-title":"Neurosci. Lett."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3233\/JAD-2011-110566","article-title":"Cerebrospinal fluid matrix metalloproteinases and tissue inhibitor of metalloproteinases in combination with subcortical and cortical biomarkers in vascular dementia and Alzheimer\u2019s disease","volume":"27","author":"Bjerke","year":"2011","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_225","first-page":"966","article-title":"Matrix metalloproteinases in peripheral blood and cerebrospinal fluid in patients with Alzheimer\u2019s disease","volume":"226","author":"Horstmann","year":"2018","journal-title":"Int. Psychogeriatr. C Int. Psychogeriatr. Assoc."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/PL00007428","article-title":"Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer\u2019s disease brain","volume":"99","author":"Yoshiyama","year":"2000","journal-title":"Acta Neuropathol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1007\/s12035-016-0357-6","article-title":"Epigenetics in Alzheimer\u2019s Disease: Perspective of DNA Methylation","volume":"55","author":"Qazi","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13073-015-0258-8","article-title":"Genome-wide12 DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer\u2019s disease","volume":"8","author":"Watson","year":"2016","journal-title":"Genome Med."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/nn.3792","article-title":"The epigenetic landscape of Alzheimer\u2019s disease","volume":"17","author":"Lord","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Silva, A.R.T., Santos, A.C.F., Farfel, J.M., Grinberg, L.T., Ferretti, R.E.L., Campos, A.H.J.F.M., Cunha, I.W., Begnami, M.D., Rocha, R.M., and Carraro, D.M. (2014). Repair of Oxidative DNA Damage, Cell-Cycle Regulation and Neuronal Death May Influence the Clinical Manifestation of Alzheimer\u2019s Disease. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0099897"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.mrgentox.2018.03.001","article-title":"\u03b3H2AX is increased in peripheral blood lymphocytes of Alzheimer\u2019s disease patients in the South Australian Neurodegeneration, Nutrition and DNA Damage (SAND) study of aging","volume":"829\u2013830","author":"Siddiqui","year":"2018","journal-title":"Mutat. Res.-Genet. Toxicol. Environ. Mutagen."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.3232","article-title":"The role of autophagy in neurodegenerative disease","volume":"19","author":"Nixon","year":"2013","journal-title":"Nat. Med."},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Chung, K.M., Hern\u00e1ndez, N., Sproul, A., and Yu, W.H. (2018). Alzheimer\u2019s disease and the autophagic-lysosomal system. Neurosci. Lett.","DOI":"10.1016\/j.neulet.2018.05.017"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"a006361","DOI":"10.1101\/cshperspect.a006361","article-title":"The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease","volume":"2","author":"Ihara","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_235","first-page":"385","article-title":"Autophagy in Alzheimer\u2019s disease","volume":"26","author":"Masliah","year":"2015","journal-title":"Rev. Neurosci."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainres.2016.03.018","article-title":"Alzheimer\u2019s disease genes and autophagy","volume":"1649","author":"Yoon","year":"2016","journal-title":"Brain Res."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/15548627.2016.1247143","article-title":"Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence","volume":"13","author":"Tai","year":"2017","journal-title":"Autophagy"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"6078","DOI":"10.1007\/s12035-015-9515-5","article-title":"Mechanisms of Mitochondrial Dysfunction in Alzheimer\u2019s Disease","volume":"53","author":"Cadonic","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Gao, J., Wang, L., Liu, J., Xie, F., Su, B., and Wang, X. (2017). Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases. Antioxid. (Basel, Switz.), 6.","DOI":"10.3390\/antiox6020025"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.neures.2017.11.012","article-title":"Reactive astrocytes in Alzheimer\u2019s disease: A double-edged sword","volume":"126","author":"Chun","year":"2018","journal-title":"Neurosci. Res."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11357-008-9050-7","article-title":"Evidence of DNA damage in Alzheimer disease: Phosphorylation of histone H2AX in astrocytes","volume":"30","author":"Myung","year":"2008","journal-title":"Age (Omaha)"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jnr.20093","article-title":"Microglia and Alzheimer\u2019s disease pathogenesis","volume":"77","author":"Streit","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.bcp.2014.01.008","article-title":"Microglial dysfunction in brain aging and Alzheimer\u2019s disease","volume":"88","author":"Mosher","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fncel.2014.00152","article-title":"Microglia change from a reactive to an age-like phenotype with the time in culture","volume":"8","author":"Caldeira","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2017.00277","article-title":"Key aging-associated alterations in primary microglia response to beta-amyloid stimulation","volume":"9","author":"Caldeira","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.tins.2014.02.010","article-title":"Telomere shortening in neurological disorders: An abundance of unanswered questions","volume":"37","author":"Eitan","year":"2014","journal-title":"Trends Neurosci."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2015.04.003","article-title":"From cellular senescence to Alzheimer\u2019s disease: The role of telomere shortening","volume":"22","author":"Boccardi","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/gerona\/glw053","article-title":"Meta-analysis of Telomere Length in Alzheimer\u2019s Disease","volume":"71","author":"Forero","year":"2016","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00702-017-1721-z","article-title":"Leukocyte telomere length is linked to vascular risk factors not to Alzheimer\u2019s disease in the VITA study","volume":"124","author":"Hinterberger","year":"2017","journal-title":"J. Neural Transm."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/jnen\/62.1.68","article-title":"Expression patterns of retinoblastoma protein in Parkinson disease","volume":"62","author":"Dorsey","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1073\/pnas.0611671104","article-title":"The pRb\/E2F cell-cycle pathway mediates cell death in Parkinson\u2019s disease","volume":"104","author":"Hoglinger","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/mds.25495","article-title":"Changes in endolysosomal enzyme activities in cerebrospinal fluid of patients with Parkinson\u2019s disease","volume":"28","author":"Persichetti","year":"2013","journal-title":"Mov. Disord."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0304-3940(94)90508-8","article-title":"Interleukin-1\u03b2, interleukin-6, epidermal growth factor and transforming growth factor-\u03b1 are elevated in the brain from parkinsonian patients","volume":"180","author":"Mogi","year":"1994","journal-title":"Neurosci. Lett."},{"key":"ref_254","doi-asserted-by":"crossref","unstructured":"Lindqvist, D., Kaufman, E., Brundin, L., Hall, S., Surova, Y., and Hansson, O. (2012). Non-Motor Symptoms in Patients with Parkinson\u2019s Disease\u2014Correlations with Inflammatory Cytokines in Serum. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047387"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neulet.2008.06.040","article-title":"Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNF\u03b1, and INF\u03b3 concentrations are elevated in patients with atypical and idiopathic parkinsonism","volume":"441","author":"Brodacki","year":"2008","journal-title":"Neurosci. Lett."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neulet.2009.10.062","article-title":"Serum levels of interleukin-6 are elevated in patients with Parkinson\u2019s disease and correlate with physical performance","volume":"468","author":"Scalzo","year":"2010","journal-title":"Neurosci. Lett."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s11064-009-9921-z","article-title":"Interleukin-6 serum levels in patients with parkinson\u2019s disease","volume":"34","author":"Hofmann","year":"2009","journal-title":"Neurochem. Res."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0304-3940(94)90746-3","article-title":"Tumor necrosis factor-\u03b1 (TNF-\u03b1) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients","volume":"165","author":"Mogi","year":"1994","journal-title":"Neurosci. Lett."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"14168","DOI":"10.1074\/jbc.M111.222430","article-title":"Role of Matrix Metalloproteinase 3-mediated \u03b1-Synuclein Cleavage in Dopaminergic Cell Death","volume":"286","author":"Choi","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jns.2017.08.3251","article-title":"Neuroinflammation\u2014A major cause for striatal dopaminergic degeneration in Parkinson\u2019s disease","volume":"381","author":"Kaur","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11910-018-0829-3","article-title":"Mitochondrial Dysfunction in Parkinson\u2019s Disease: New Mechanistic Insights and Therapeutic Perspectives","volume":"18","author":"Park","year":"2018","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_262","doi-asserted-by":"crossref","unstructured":"Pitcairn, C., Wani, W.Y., and Mazzulli, J.R. (2018). Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson\u2019s disease. Neurobiol. Dis.","DOI":"10.1016\/j.nbd.2018.03.008"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2174\/1570159X13666151030103027","article-title":"Targeting the Autophagy\/Lysosomal Degradation Pathway in Parkinson\u2019s Disease","volume":"14","author":"Hilfiker","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3389\/fcell.2017.00110","article-title":"Crosstalk between Lysosomes and Mitochondria in Parkinson\u2019s Disease","volume":"5","author":"Plotegher","year":"2017","journal-title":"Front. Cell Dev. Biol. Cell Dev. Biol"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12603-010-0275-7","article-title":"Study of telomere length and different markers of oxidative stress in patients with Parkinson\u2019s disease","volume":"15","author":"Watfa","year":"2011","journal-title":"J. Nutr. Health Aging"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/01677063.2011.651665","article-title":"Aging-Associated Alteration of Telomere Length and Subtelomeric Status in Female Patients with Parkinson\u2019s Disease","volume":"26","author":"Maeda","year":"2012","journal-title":"J. Neurogenet."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/gerona\/63.5.467","article-title":"A percentage analysis of the telomere length in Parkinson\u2019s disease patients","volume":"63","author":"Guan","year":"2008","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1093\/gerona\/glq125","article-title":"No Evidence for Shorter Leukocyte Telomere Length in Parkinson\u2019s Disease Patients","volume":"65A","author":"Eerola","year":"2010","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_269","doi-asserted-by":"crossref","unstructured":"Degerman, S., Domell\u00f6f, M., Landfors, M., Linder, J., Lundin, M., Haraldsson, S., Elgh, E., Roos, G., and Forsgren, L. (2014). Long leukocyte telomere length at diagnosis is a risk factor for dementia progression in idiopathic parkinsonism. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113387"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.exger.2016.01.002","article-title":"Telomere length in Parkinson\u2019s disease: A meta-analysis HHS Public Access","volume":"75","author":"Forero","year":"2016","journal-title":"Exp. Gerontol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"Compston","year":"2008","journal-title":"Lancet"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S1474-4422(08)70042-5","article-title":"Environmental factors and multiple sclerosis","volume":"7","author":"Ebers","year":"2008","journal-title":"Lancet Neurol."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1007\/s00415-017-8594-9","article-title":"The sequence of disease-modifying therapies in relapsing multiple sclerosis: Safety and immunologic considerations","volume":"264","author":"Pardo","year":"2017","journal-title":"J. Neurol."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.expneurol.2005.10.033","article-title":"Axon loss is responsible for chronic neurological deficit following inflammatory demyelination in the rat","volume":"197","author":"Papadopoulos","year":"2006","journal-title":"Exp. Neurol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1750-3639.2008.00177.x","article-title":"Substantial Archaeocortical Atrophy and Neuronal Loss in Multiple Sclerosis","volume":"19","author":"Papadopoulos","year":"2009","journal-title":"Brain Pathol."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1750-3639.2007.00064.x","article-title":"The Immunopathology of Multiple Sclerosis: An Overview","volume":"17","author":"Lassmann","year":"2007","journal-title":"Brain Pathol."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00415-004-0348-9","article-title":"The role of oxidative stress in the pathogenesis of multiple sclerosis: The need for effective antioxidant therapy","volume":"251","author":"Melamed","year":"2004","journal-title":"J. Neurol."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1365-2990.2008.00987.x","article-title":"Mitochondria and disease progression in multiple sclerosis","volume":"34","author":"Mahad","year":"2008","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1093\/brain\/awn105","article-title":"Mitochondrial defects in acute multiple sclerosis lesions","volume":"131","author":"Mahad","year":"2008","journal-title":"Brain"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/brain\/awp046","article-title":"Mitochondrial changes within axons in multiple sclerosis","volume":"132","author":"Mahad","year":"2009","journal-title":"Brain"},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1177\/1352458512445941","article-title":"Immunomodulatory therapies delay disease progression in multiple sclerosis","volume":"22","author":"Bergamaschi","year":"2016","journal-title":"Mult. Scler. J."},{"key":"ref_282","doi-asserted-by":"crossref","unstructured":"Karamita, M., Nicholas, R., Kokoti, L., Rizou, S., Mitsikostas, D.D., Gorgoulis, V., Probert, L., and Papadopoulos, D. (2018). Cellular Senescence Correlates with Demyelination, Brain Atrophy and Motor Impairment in a Model of Multiple Sclerosis (P2.405). Neurology, 90.","DOI":"10.1212\/WNL.90.15_supplement.P2.405"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/jnen\/62.7.723","article-title":"Subpial demyelination in the cerebral cortex of multiple sclerosis patients","volume":"62","author":"Vedeler","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nrneurol.2010.93","article-title":"Cortical lesions in multiple sclerosis","volume":"6","author":"Calabrese","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/ana.22230","article-title":"A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis","volume":"68","author":"Magliozzi","year":"2010","journal-title":"Ann. Neurol."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/ana.1123","article-title":"Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions","volume":"50","author":"Peterson","year":"2001","journal-title":"Ann. Neurol."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1056\/NEJM199801293380502","article-title":"Axonal transection in the lesions of multiple sclerosis","volume":"338","author":"Trapp","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/S0140-6736(17)32399-1","article-title":"Why do so many clinical trials of therapies for Alzheimer\u2019s disease fail?","volume":"390","author":"Anderson","year":"2017","journal-title":"Lancet"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/cts.12491","article-title":"Lessons Learned from Alzheimer Disease: Clinical Trials with Negative Outcomes","volume":"11","author":"Cummings","year":"2018","journal-title":"Clin. Transl. Sci."},{"key":"ref_290","doi-asserted-by":"crossref","unstructured":"Marchant, N.L., Reed, B.R., DeCarli, C.S., Madison, C.M., Weiner, M.W., Chui, H.C., and Jagust, W.J. (2012). Cerebrovascular disease, \u03b2-amyloid, and cognition in aging. Neurobiol. Aging, 33.","DOI":"10.1016\/j.neurobiolaging.2011.10.001"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.neurobiolaging.2009.08.007","article-title":"Alzheimer\u2019s disease as homeostatic responses to age-related myelin breakdown","volume":"32","author":"Bartzokis","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1001\/jama.2015.4669","article-title":"Prevalence of Amyloid PET Positivity in Dementia Syndromes","volume":"313","author":"Ossenkoppele","year":"2015","journal-title":"JAMA"},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1001\/jama.2015.4668","article-title":"Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia","volume":"313","author":"Jansen","year":"2015","journal-title":"JAMA"},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0140-6736(18)30475-6","article-title":"Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): A double-blind, randomised, phase 3 study","volume":"391","author":"Kappos","year":"2018","journal-title":"Lancet"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"6173","DOI":"10.1158\/1078-0432.CCR-13-1675","article-title":"Dual CDK4\/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma","volume":"19","author":"Rader","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1200\/JCO.2012.46.5476","article-title":"Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma","volume":"31","author":"Dickson","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"627","DOI":"10.18632\/aging.100201","article-title":"Cellular senescence controls fibrosis in wound healing","volume":"2","author":"Jun","year":"2010","journal-title":"Aging (Albany NY)"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1681\/ASN.2012050512","article-title":"Wnt4\/ -Catenin Signaling in Medullary Kidney Myofibroblasts","volume":"24","author":"DiRocco","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/acel.12087","article-title":"Implications of time-series gene expression profiles of replicative senescence","volume":"12","author":"Kim","year":"2013","journal-title":"Aging Cell"},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/hep.25744","article-title":"Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice","volume":"56","author":"Kong","year":"2012","journal-title":"Hepatology"},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.bbamcr.2014.01.023","article-title":"The anti-fibrotic effects of CCN1\/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-\u03b2 signaling","volume":"1843","author":"Schaffrath","year":"2014","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/ana.22284","article-title":"Age-specific progression of nigrostriatal dysfunction in Parkinson\u2019s disease","volume":"69","author":"Schulzer","year":"2011","journal-title":"Ann. Neurol."},{"key":"ref_303","doi-asserted-by":"crossref","unstructured":"Myrianthopoulos, V., Evangelou, K., Vasileiou, P.V.S., Cooks, T., Vassilakopoulos, T.P., Pangalis, G.A., Kouloukoussa, M., Kittas, C., Georgakilas, A.G., and Gorgoulis, V.G. (2018). Senescence and senotherapeutics: A new field in cancer therapy. Pharmacol. Ther.","DOI":"10.1016\/j.pharmthera.2018.08.006"},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3233\/JAD-131901","article-title":"Long-Term Metformin Usage and Cognitive Function among Older Adults with Diabetes","volume":"41","author":"Ng","year":"2014","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pnpbp.2017.06.002","article-title":"Effects of metformin exposure on neurodegenerative diseases in elderly patients with type 2 diabetes mellitus","volume":"79","author":"Kuan","year":"2017","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"e1528","DOI":"10.1038\/cddis.2014.489","article-title":"Characterization of novel markers of senescence and their prognostic potential in cancer","volume":"5","author":"Althubiti","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"6819","DOI":"10.1021\/jm060727j","article-title":"2-Aminothiazole as a Novel Kinase Inhibitor Template. Structure\u2212Activity Relationship Studies toward the Discovery of N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, BMS-354825) as a potent pan-Src Kinase Inhibitor","volume":"49","author":"As","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s00277-010-0948-7","article-title":"Dasatinib impairs long-term expansion of leukemic progenitors in a subset of acute myeloid leukemia cases","volume":"89","author":"Han","year":"2010","journal-title":"Ann. Hematol."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s40265-016-0677-x","article-title":"Dasatinib: A Review in Chronic Myeloid Leukaemia and Ph+ Acute Lymphoblastic Leukaemia","volume":"77","author":"Keating","year":"2017","journal-title":"Drugs"},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nchembio.332","article-title":"A chemical and phosphoproteomic characterization of dasatinib action in lung cancer","volume":"6","author":"Li","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"ref_311","unstructured":"Gupta, R.C. (2016). Quercetin. Nutraceuticals, Academic Press."},{"key":"ref_312","unstructured":"Watson, R.R., Preedy, V.R., and Sherma, Z. (2014). Polyphenolics Evoke Healing Responses: Clinical Evidence and Role of Predictive Biomarkers. Polyphenols in Human Health and Disease, Academic Press."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0031-6997(24)01472-8","article-title":"The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer","volume":"52","author":"Middleton","year":"2000","journal-title":"Pharmacol. Rev."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.tifs.2016.07.004","article-title":"The biological activities, chemical stability, metabolism and delivery systems of quercetin: A review","volume":"56","author":"Wang","year":"2016","journal-title":"Trends Food Sci. Technol."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/bs.enz.2015.05.001","article-title":"Quercetin and Tryptanthrin: Two Broad Spectrum Anticancer Agents for Future Chemotherapeutic Interventions","volume":"Volume 37","author":"Bathaie","year":"2015","journal-title":"The Enzymes"},{"key":"ref_316","unstructured":"Gray, S.G. (2015). Nutritional Epigenetic Regulators in the Field of Cancer: New Avenues for Chemopreventive Approaches. Epigenetic Cancer Therapy, Academic Press."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1046\/j.1538-7836.2003.00212.x","article-title":"Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway","volume":"1","author":"Hubbard","year":"2003","journal-title":"J. Thromb. Haemost."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1111\/j.1538-7836.2004.01067.x","article-title":"Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans","volume":"2","author":"Hubbard","year":"2004","journal-title":"J. Thromb. Haemost."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.semcancer.2015.02.006","article-title":"Sustained proliferation in cancer: Mechanisms and novel therapeutic targets","volume":"35","author":"Feitelson","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.freeradbiomed.2004.01.001","article-title":"Flavonoids: Antioxidants or signalling molecules?","volume":"36","author":"Williams","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"ref_321","doi-asserted-by":"crossref","unstructured":"Zappia, V., Panico, S., Russo, G.L., Budillon, A., and Della Ragione, F. (2014). Quercetin: A Pleiotropic Kinase Inhibitor Against Cancer BT\u2014Advances in Nutrition and Cancer, Springer.","DOI":"10.1007\/978-3-642-38007-5"},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"27008","DOI":"10.1074\/jbc.M403588200","article-title":"The G Protein-coupled Receptor GPR30 Mediates c-fos up-regulation by 17\u03b2-Estradiol and Phytoestrogens in Breast Cancer Cells","volume":"279","author":"Maggiolini","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/acel.12344","article-title":"The Achilles\u2019 heel of senescent cells: From transcriptome to senolytic drugs","volume":"14","author":"Zhu","year":"2015","journal-title":"Aging Cell"},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/acel.12445","article-title":"Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors","volume":"15","author":"Zhu","year":"2016","journal-title":"Aging Cell"},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nm.4010","article-title":"Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice","volume":"22","author":"Chang","year":"2016","journal-title":"Nat. Med."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1158\/0008-5472.CAN-07-5836","article-title":"ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor","volume":"68","author":"Tse","year":"2008","journal-title":"Cancer Res."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/B978-0-12-417150-3.00015-6","article-title":"Targeting Protein\u2013Protein Interactions to Treat Cancer\u2014Recent Progress and Future Directions","volume":"Volume 48","author":"Desai","year":"2013","journal-title":"Annual Reports in Medicinal Chemistry"},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/acel.12597","article-title":"DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age","volume":"16","author":"Kim","year":"2017","journal-title":"Aging Cell"},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ijrobp.2017.02.216","article-title":"Inhibition of Bcl-2\/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice","volume":"99","author":"Pan","year":"2017","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1158\/2159-8290.CD-16-0241","article-title":"Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse","volume":"7","author":"Demaria","year":"2017","journal-title":"Cancer Discov."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"11190","DOI":"10.1038\/ncomms11190","article-title":"Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL","volume":"7","author":"Yosef","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1172\/JCI28281","article-title":"Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737","volume":"117","author":"Brown","year":"2007","journal-title":"J. Clin. Invest."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ccr.2006.08.027","article-title":"The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak\/Bax if Mcl-1 is neutralized","volume":"10","author":"Wei","year":"2006","journal-title":"Cancer Cell"},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ccr.2006.10.006","article-title":"Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia","volume":"10","author":"Konopleva","year":"2006","journal-title":"Cancer Cell"},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"955","DOI":"10.18632\/aging.101202","article-title":"New agents that target senescent cells: The flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463","volume":"9","author":"Zhu","year":"2017","journal-title":"Aging (Albany NY)"},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2741\/s425","article-title":"Fisetin Acts on Multiple Pathways to Reduce the Impact of Age and Disease on CNS Function","volume":"7","author":"Maher","year":"2015","journal-title":"Front. Biosci. (Schol. Ed.)"},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tifs.2017.10.003","article-title":"Antioxidant properties of the flavonoid fisetin: An updated review of in vivo and in vitro studies","volume":"70","author":"Naeimi","year":"2017","journal-title":"Trends Food Sci. Technol."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-12-380864-6.00001-8","article-title":"Induction of Epigenetic Alterations by Dietary and Other Environmental Factors","volume":"Volume 71","author":"Herceg","year":"2010","journal-title":"Advances in Genetics"},{"key":"ref_339","doi-asserted-by":"crossref","unstructured":"Kim, J., Lee, K.W., and Lee, H.J. (2014). Polyphenols Suppress and Modulate Inflammation: Possible Roles in Health and Disease. Polyphenols in Human Health and Disease, Academic Press.","DOI":"10.1016\/B978-0-12-398456-2.00029-3"},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/B978-0-444-63406-1.00004-0","article-title":"Food-Borne Topoisomerase Inhibitors: Risk or Benefit","volume":"Volume 8","author":"Fishbein","year":"2014","journal-title":"Advances in Molecular Toxicology"},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.bcp.2012.07.012","article-title":"Dietary flavonoid fisetin: A novel dual inhibitor of PI3K\/Akt and mTOR for prostate cancer management","volume":"84","author":"Adhami","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1021\/jm049353p","article-title":"Crystal Structure of a Human Cyclin-Dependent Kinase 6 Complex with a Flavonol Inhibitor, Fisetin","volume":"48","author":"Lu","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1042\/BJ20040474","article-title":"Comparative analysis of topoisomerase IB inhibition and DNA intercalation by flavonoids and similar compounds: Structural determinates of activity","volume":"384","author":"WEBB","year":"2004","journal-title":"Biochem. J."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"995","DOI":"10.2174\/18715206113139990129","article-title":"Inhibition of Akt\/mTOR signaling by the dietary flavonoid fisetin","volume":"13","author":"Syed","year":"2013","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.abb.2014.06.006","article-title":"Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols","volume":"559","author":"Gupta","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1089\/ars.2012.4901","article-title":"Fisetin: A Dietary Antioxidant for Health Promotion","volume":"19","author":"Khan","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.18632\/aging.101100","article-title":"Discovery of piperlongumine as a potential novel lead for the development of senolytic agents","volume":"8","author":"Wang","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"26357","DOI":"10.1038\/srep26357","article-title":"Piperlongumine inhibits lung tumor growth via inhibition of nuclear factor kappa B signaling pathway","volume":"6","author":"Zheng","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/s41467-017-00314-z","article-title":"Identification of HSP90 inhibitors as a novel class of senolytics","volume":"8","author":"Ling","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1021\/jm980403y","article-title":"Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin","volume":"42","author":"Roe","year":"1999","journal-title":"J. Med. Chem."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1038\/s41598-017-01964-1","article-title":"A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC","volume":"7","author":"Samaraweera","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.bcp.2015.06.013","article-title":"Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts","volume":"96","author":"Lim","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12154-008-0003-5","article-title":"Rapamycin and mTOR kinase inhibitors","volume":"1","author":"Ballou","year":"2008","journal-title":"J. Chem. Biol."},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.4161\/cc.20882","article-title":"Suppression of replicative senescence by rapamycin in rodent embryonic cells","volume":"11","author":"Pospelova","year":"2012","journal-title":"Cell Cycle"},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cmet.2014.01.001","article-title":"Rapamycin: One Drug, Many Effects","volume":"19","author":"Li","year":"2014","journal-title":"Cell Metab."},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/gerona\/glw090","article-title":"Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island","volume":"71","author":"Lamming","year":"2016","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"E6301","DOI":"10.1073\/pnas.1515386112","article-title":"JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age","volume":"112","author":"Xu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/acel.12075","article-title":"Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK\/NF-\u03baB activation","volume":"12","author":"Moiseeva","year":"2013","journal-title":"Aging Cell"},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"e2441","DOI":"10.1038\/cddis.2016.334","article-title":"Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo","volume":"7","author":"Chen","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_360","doi-asserted-by":"crossref","unstructured":"Barzilai, N.R. (2017). Targeting aging with metformin (tame). Innov. Aging, 743.","DOI":"10.1093\/geroni\/igx004.2682"},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s00125-017-4342-z","article-title":"The mechanisms of action of metformin","volume":"60","author":"Rena","year":"2017","journal-title":"Diabetologia"},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1474-9726.2012.00818.x","article-title":"Glucocorticoids suppress selected components of the senescence-associated secretory phenotype","volume":"11","author":"Laberge","year":"2012","journal-title":"Aging Cell"},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev-pharmtox-010611-134657","article-title":"Small-Molecule Allosteric Activators of Sirtuins","volume":"54","author":"Sinclair","year":"2014","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tips.2013.12.004","article-title":"Small molecule SIRT1 activators for the treatment of aging and age-related diseases","volume":"35","author":"Hubbard","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"17187","DOI":"10.1074\/jbc.M501250200","article-title":"Mechanism of Human SIRT1 Activation by Resveratrol","volume":"280","author":"Borra","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/gerona\/gls183","article-title":"Chronic Resveratrol Treatment Ameliorates Cell Adhesion and Mitigates the Inflammatory Phenotype in Senescent Human Fibroblasts","volume":"68","author":"Pitozzi","year":"2013","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1126\/science.1092472","article-title":"In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2","volume":"303","author":"Vassilev","year":"2004","journal-title":"Science (80-.)"},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/CIRCULATIONAHA.113.002434","article-title":"Activation of Lung p53 by Nutlin-3a Prevents andeverses Experimental Pulmonary Hypertension","volume":"127","author":"Mouraret","year":"2013","journal-title":"Circulation"},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1136\/annrheumdis-2012-203146","article-title":"Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53\/p21 pathway: In vivo and in vitro evidence","volume":"73","author":"Poulsen","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"ref_370","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1091\/mbc.e05-09-0858","article-title":"DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation","volume":"17","author":"Moiseeva","year":"2006","journal-title":"Mol. Biol. Cell."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/10\/2937\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:22:42Z","timestamp":1760196162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/10\/2937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,27]]},"references-count":370,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10]]}},"alternative-id":["ijms19102937"],"URL":"https:\/\/doi.org\/10.3390\/ijms19102937","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,27]]}}}