{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T21:08:06Z","timestamp":1775164086769,"version":"3.50.1"},"reference-count":74,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:00:00Z","timestamp":1540512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Ricerca finalizzata  2017"],"award-info":[{"award-number":["Ricerca finalizzata  2017"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Multiple myeloma (MM) is the second most common hematologic malignancy and, although the development of novel agents has improved survival of patients, to date, it remains incurable. Thus, newer and more effective therapeutic strategies against this malignancy are necessary. Plant extracts play an important role in anti-tumor drug discovery. For this reason, in the investigation of novel natural anti-MM agents, we evaluated the phytochemical profiles, in vitro antioxidant activity, and effects on MM cells of Azorella glabra (AG) Wedd. Total polyphenols (TPC), flavonoids (TFC), and terpenoids (TTeC) contents were different among samples and the richest fractions in polyphenols demonstrated a higher antioxidant activity in in vitro assays. Some fractions showed a dose and time dependent anti-proliferative activity on MM cells. The chloroform fraction (CHCl3) showed major effects in terms of reduction of cell viability, induction of apoptosis, and cell cycle arrest on MM cells. The apoptosis induction was also confirmed by the activation of caspase-3. Importantly, the CHCl3 fraction exhibited a negligible effect on the viability of healthy cells. These results encourage further investigations on AG extracts to identify specific bioactive compounds and to define their potential applications in MM.<\/jats:p>","DOI":"10.3390\/ijms19113348","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T10:51:01Z","timestamp":1540551061000},"page":"3348","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Future in the Past: Azorella glabra Wedd. as a Source of New Natural Compounds with Antiproliferative and Cytotoxic Activity on Multiple Myeloma Cells"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1114-1963","authenticated-orcid":false,"given":"Daniela","family":"Lamorte","sequence":"first","affiliation":[{"name":"Laboratory of Preclinical and Translational Research, IRCCS \u201cReferral Cancer Center of Basilicata\u201d (CROB), 85028 Rionero in Vulture, PZ, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5274-8633","authenticated-orcid":false,"given":"Immacolata","family":"Faraone","sequence":"additional","affiliation":[{"name":"Department of Science, University of Basilicata, 85100 Potenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-8325","authenticated-orcid":false,"given":"Ilaria","family":"Laurenzana","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical and Translational Research, IRCCS \u201cReferral Cancer Center of Basilicata\u201d (CROB), 85028 Rionero in Vulture, PZ, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-1237","authenticated-orcid":false,"given":"Luigi","family":"Milella","sequence":"additional","affiliation":[{"name":"Department of Science, University of Basilicata, 85100 Potenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Trino","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical and Translational Research, IRCCS \u201cReferral Cancer Center of Basilicata\u201d (CROB), 85028 Rionero in Vulture, PZ, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2332-3086","authenticated-orcid":false,"given":"Luciana","family":"De Luca","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical and Translational Research, IRCCS \u201cReferral Cancer Center of Basilicata\u201d (CROB), 85028 Rionero in Vulture, PZ, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Del Vecchio","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnology, Federico II University, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5607-5288","authenticated-orcid":false,"given":"Maria Francesca","family":"Armentano","sequence":"additional","affiliation":[{"name":"Department of Science, University of Basilicata, 85100 Potenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Sinisgalli","sequence":"additional","affiliation":[{"name":"Department of Science, University of Basilicata, 85100 Potenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8181-9138","authenticated-orcid":false,"given":"Lucia","family":"Chiummiento","sequence":"additional","affiliation":[{"name":"Department of Science, University of Basilicata, 85100 Potenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Science, University of Basilicata, 85100 Potenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faustino","family":"Bisaccia","sequence":"additional","affiliation":[{"name":"Department of Science, University of Basilicata, 85100 Potenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pellegrino","family":"Musto","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplantation Unit, IRCCS \u201cReferral Cancer Center of Basilicata\u201d (CROB), 85028 Rionero in Vulture, PZ, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Caivano","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical and Translational Research, IRCCS \u201cReferral Cancer Center of Basilicata\u201d (CROB), 85028 Rionero in Vulture, PZ, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Soekojo, C., de Mel, S., Ooi, M., Yan, B., and Chng, W. 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