{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:05:09Z","timestamp":1760241909972,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T00:00:00Z","timestamp":1540684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["NRF-2015R1A5A2009656"],"award-info":[{"award-number":["NRF-2015R1A5A2009656"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>IL-7 is an essential, nonredundant growth factor for T and B cell generation and maintenance. While IL-7 deficiency results in lymphopenia, overexpression of IL-7 can cause neoplasia in experimental models. IL-7\u2019s involvement in neoplasia has been appreciated through studies of IL-7 transgenic (Tg) mice models and human lymphoma patients. Since we recently found that a soluble form of the common \u03b3-chain (\u03b3c) cytokine receptor (s\u03b3c) antagonistically regulates IL-7 signaling, IL-7 and s\u03b3c double-Tg mice were generated to investigate the effects of s\u03b3c overexpression in IL-7-mediated lymphoproliferative disorders (LPDs). The overexpression of s\u03b3c prevents IL-7Tg-induced abnormal increase of LN cell numbers and the development of splenomegaly, resulting in striking amelioration of mortality and disease development. These results suggest that modification of \u03b3c cytokine responsiveness by s\u03b3c molecules might control various \u03b3c cytokine-associated hematologic malignancy, and also provide an alternative view to approach antitumor therapy.<\/jats:p>","DOI":"10.3390\/ijms19113375","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T11:10:41Z","timestamp":1540811441000},"page":"3375","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Potential Role of a Soluble \u03b3-Chain Cytokine Receptor as a Regulator of IL-7-Induced Lymphoproliferative Disorders"],"prefix":"10.3390","volume":"19","author":[{"given":"Geona","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Anatomy, Pusan National University School of Medicine, Yangsan 50612, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuna","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Pusan National University School of Medicine, Yangsan 50612, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byunghyuk","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Pusan National University School of Medicine, Yangsan 50612, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laraib Amir","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Pusan National University School of Medicine, Yangsan 50612, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2805-3943","authenticated-orcid":false,"given":"Boae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Pusan National University School of Medicine, Yangsan 50612, Korea"},{"name":"Department of Rehabilitation Medicine, Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2567-2973","authenticated-orcid":false,"given":"Changwan","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Pusan National University School of Medicine, Yangsan 50612, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.smim.2012.02.002","article-title":"Intrathymic IL-7: The where, when, and why of IL-7 signaling during T cell development","volume":"24","author":"Hong","year":"2012","journal-title":"Semin. 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