{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:26:49Z","timestamp":1790231209039,"version":"4.1.0"},"reference-count":132,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["No. NRF-2015M3C9A2054326"],"award-info":[{"award-number":["No. NRF-2015M3C9A2054326"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["No. 2017R1A5A2015385"],"award-info":[{"award-number":["No. 2017R1A5A2015385"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>5\u2032-AMP-activated protein kinase (AMPK) plays diverse roles in various physiological and pathological conditions. AMPK is involved in energy metabolism, which is perturbed by infectious stimuli. Indeed, various pathogens modulate AMPK activity, which affects host defenses against infection. In some viral infections, including hepatitis B and C viral infections, AMPK activation is beneficial, but in others such as dengue virus, Ebola virus, and human cytomegaloviral infections, AMPK plays a detrimental role. AMPK-targeting agents or small molecules enhance the antiviral response and contribute to the control of microbial and parasitic infections. In addition, this review focuses on the double-edged role of AMPK in innate and adaptive immune responses to infection. Understanding how AMPK regulates host defenses will enable development of more effective host-directed therapeutic strategies against infectious diseases.<\/jats:p>","DOI":"10.3390\/ijms19113495","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T03:45:22Z","timestamp":1541562322000},"page":"3495","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["AMP-Activated Protein Kinase and Host Defense against Infection"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8332-024X","authenticated-orcid":false,"given":"Prashanta","family":"Silwal","sequence":"first","affiliation":[{"name":"Department of Microbiology, Chungnam National University School of Medicine, Daejeon 35015, Korea"},{"name":"Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon 35015, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Chungnam National University School of Medicine, Daejeon 35015, Korea"},{"name":"Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon 35015, Korea"},{"name":"Department of Medical Science, Chungnam National University School of Medicine, Daejeon 35015, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Min","family":"Yuk","sequence":"additional","affiliation":[{"name":"Department of Infection Biology, Chungnam National University School of Medicine, Daejeon 35015, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Kyeong","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Chungnam National University School of Medicine, Daejeon 35015, Korea"},{"name":"Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon 35015, Korea"},{"name":"Department of Medical Science, Chungnam National University School of Medicine, Daejeon 35015, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: A nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. 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