{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:54:39Z","timestamp":1791564879322,"version":"4.3.4"},"reference-count":57,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T00:00:00Z","timestamp":1541548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Research Foundation of Korea (NRF) grant funded by the Korea government","award":["(NRF-2015R1C1A2A01051880)"],"award-info":[{"award-number":["(NRF-2015R1C1A2A01051880)"]}]},{"name":"the Agricultural Microbiomes R&amp;D program in Agriculture and Food funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA), Republic of Korea (as part of the (multi-ministerial) Genome Technology to Business Translation Program)","award":["(916008-02-2-SB010)"],"award-info":[{"award-number":["(916008-02-2-SB010)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cordyceps militaris is a medicinal mushroom used to treat immune-related diseases in East Asia. We investigated the anti-inflammatory effect of the extract of C. militaris grown on germinated Rhynchosia nulubilis (GRC) fermented with Pediococcus pentosaceus ON89A isolated from onion (GRC-ON89A) in vivo as well as in vitro. The anti-inflammatory effect of GRC-ON89A was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The total polyphenol content (TPC) and total flavonoid content (TFC) in the GRC-ON89A ethanol extract were significantly increased compared to that in GRC. GRC-ON89A hexane fraction (GRC-ON89A-Hex) inhibited the release of nitric oxide (NO) compared to that of the LPS-treated control without cytotoxicity in LPS-stimulated RAW 264.7 macrophages. GRC-ON89A-Hex decreased the inducible NO synthase (iNOS), cyclooxygenase 2 (COX2), and tumor necrosis factor (TNF)-\u03b1 mRNA expression in LPS-stimulated RAW 264.7 macrophages. In addition, pre-treatment with GRC-ON89A-Hex significantly inhibited LPS-stimulated phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-\u03baB. To induce allergic contact dermatitis (ACD), 1-fluoro-2, 4-dinitrofluorobenzene (DNFB) was applied to the surface of the right ears of C57BL\/6N mice. GRC-ON89A reduced the ear swelling and thickness in DNFB-induced ACD mice. This study demonstrates the potential usefulness of GRC-ON89A as an anti-inflammatory dietary supplement or drug.<\/jats:p>","DOI":"10.3390\/ijms19113504","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T10:32:07Z","timestamp":1541586727000},"page":"3504","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Pediococcus pentosaceus-Fermented Cordyceps militaris Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis"],"prefix":"10.3390","volume":"19","author":[{"given":"Ha-Kyoung","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Food Science and Biotechnology, College of BioNano Technology, Gachon University, Gyeonggi-do 13120, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Jung","family":"Song","sequence":"additional","affiliation":[{"name":"Department of, College of Food Biotechnology, Division of Bioindustry, Silla University, Busan 46958, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Ji","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, College of BioNano Technology, Gachon University, Gyeonggi-do 13120, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4629-947X","authenticated-orcid":false,"given":"Tae-Sik","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Life Science, College of BioNano Technology, Gachon University, Gyeonggi-do 13120, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1844-0939","authenticated-orcid":false,"given":"Moon Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of BioNano Technology, College of BioNano Technology, Gachon University, Gyeonggi-do 13120, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, College of BioNano Technology, Gachon University, Gyeonggi-do 13120, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jep.2012.04.053","article-title":"Effect of Sophora flavescens Aiton extract on degranulation of mast cells and contact dermatitis induced by dinitrofluorobenzene in mice","volume":"142","author":"Kim","year":"2012","journal-title":"J. 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