{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:33:11Z","timestamp":1792855991995,"version":"4.5.0"},"reference-count":126,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Orsz\u00e1gos Tudom\u00e1nyos Kutat\u00e1si Alapprogramok","doi-asserted-by":"publisher","award":["K115990"],"award-info":[{"award-number":["K115990"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"name":"GINOP","award":["GINOP-2.3.2-15-2016-00006"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Nuclear, mitochondrial and cytoplasmic signal transducer and activator of transcription 3 (STAT3) regulates many cellular processes, e.g., the transcription or opening of mitochondrial permeability transition pore, and its activity depends on the phosphorylation of Tyr705 and\/or Ser727 sites. In the heterogeneous network of cardiac cells, STAT3 promotes cardiac muscle differentiation, vascular element formation and extracellular matrix homeostasis. Overwhelming evidence suggests that STAT3 is beneficial for the heart, plays a role in the prevention of age-related and postpartum heart failure, protects the heart against cardiotoxic doxorubicin or ischaemia\/reperfusion injury, and is involved in many cardioprotective strategies (e.g., ischaemic preconditioning, perconditioning, postconditioning, remote or pharmacological conditioning). Ischaemic heart disease is still the leading cause of death worldwide, and many cardiovascular risk factors contribute to the development of the disease. This review focuses on the effects of various cardiovascular risk factors (diabetes, aging, obesity, smoking, alcohol, depression, gender, comedications) on cardiac STAT3 under non-ischaemic baseline conditions, and in settings of ischaemia\/reperfusion injury with or without cardioprotective strategies.<\/jats:p>","DOI":"10.3390\/ijms19113572","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T02:42:41Z","timestamp":1542163361000},"page":"3572","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Effects of Cardiovascular Risk Factors on Cardiac STAT3"],"prefix":"10.3390","volume":"19","author":[{"given":"M\u00e1rton","family":"Pipicz","sequence":"first","affiliation":[{"name":"Metabolic Diseases and Cell Signaling (MEDICS) Research Group, Department of Biochemistry, Interdisciplinary Excellence Centre, University of Szeged, D\u00f3m t\u00e9r. 9., H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vir\u00e1g","family":"Demj\u00e1n","sequence":"additional","affiliation":[{"name":"Metabolic Diseases and Cell Signaling (MEDICS) Research Group, Department of Biochemistry, Interdisciplinary Excellence Centre, University of Szeged, D\u00f3m t\u00e9r. 9., H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5929-2146","authenticated-orcid":false,"given":"M\u00e1rta","family":"S\u00e1rk\u00f6zy","sequence":"additional","affiliation":[{"name":"Metabolic Diseases and Cell Signaling (MEDICS) Research Group, Department of Biochemistry, Interdisciplinary Excellence Centre, University of Szeged, D\u00f3m t\u00e9r. 9., H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Csont","sequence":"additional","affiliation":[{"name":"Metabolic Diseases and Cell Signaling (MEDICS) Research Group, Department of Biochemistry, Interdisciplinary Excellence Centre, University of Szeged, D\u00f3m t\u00e9r. 9., H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.3390\/cancers6042012","article-title":"Monoclonal antibodies specific for STAT3\u03b2 reveal its contribution to constitutive STAT3 phosphorylation in breast cancer","volume":"6","author":"Bharadwaj","year":"2014","journal-title":"Cancers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S414","DOI":"10.1038\/bjp.2008.1","article-title":"Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects","volume":"153","author":"Fischer","year":"2008","journal-title":"Br. 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