{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:05:12Z","timestamp":1790726712486,"version":"4.1.0"},"reference-count":99,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2018M3A9C4076473"],"award-info":[{"award-number":["NRF-2018M3A9C4076473"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Functional dyspepsia (FD) is the most common functional gastrointestinal disorder (FGID). FD is characterized by bothersome symptoms such as postprandial fullness, early satiety, and epigastric pain or burning sensations in the upper abdomen. The complexity and heterogeneity of FD pathophysiology, which involves multiple mechanisms, make both treatment and new drug development for FD difficult. Current medicines for FD targeting a single pathway have failed to show satisfactory efficacy and safety. On the other hand, multicomponent herbal medicines that act on multiple targets may be a promising alternative treatment for FD. DA-9701 (Motilitone), a botanical drug consisting of Corydalis Tuber and Pharbitidis Semen, has been prescribed for FD since it was launched in Korea in 2011. It has multiple mechanisms of action such as prokinetic effects, fundus relaxation, and visceral analgesia, which are mediated by dopamine D2 and several serotonin receptors involved in gastrointestinal (GI) functions. In clinical studies, DA-9701 has been found to be beneficial for improvement of FD symptoms and GI functions in FD patients, while showing better safety compared to that associated with conventional medicines. In this review, we provide updated information on the pharmacological effects, safety, and clinical results of DA-9701 for the treatment of FGIDs.<\/jats:p>","DOI":"10.3390\/ijms19124035","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T03:58:17Z","timestamp":1544759897000},"page":"4035","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["DA-9701 (Motilitone): A Multi-Targeting Botanical Drug for the Treatment of Functional Dyspepsia"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7268-3400","authenticated-orcid":false,"given":"Mirim","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Microbiology, College of Medicine, Gachon University, Incheon 21999, Korea"},{"name":"Department of Health Science and Technology, GAIHST, Gachon University, Incheon 21936, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miwon","family":"Son","sequence":"additional","affiliation":[{"name":"Research Center &amp; Phytotherapeutics Group, Viromed, Co. Ltd., Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/1756283X10362639","article-title":"Functional dyspepsia","volume":"3","author":"Brun","year":"2010","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1053\/j.gastro.2011.02.025","article-title":"Neurogastroenterology: A great career choice for aspiring gastroenterologists thinking about the future","volume":"140","author":"Pasricha","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1053\/j.gastro.2016.02.032","article-title":"Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features, and Rome IV","volume":"150","author":"Drossman","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1056\/NEJMra1501505","article-title":"Functional Dyspepsia","volume":"373","author":"Talley","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/apt.12355","article-title":"Functional dyspepsia: The economic impact to patients","volume":"38","author":"Lacy","year":"2013","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_6","first-page":"896","article-title":"Functional Dyspepsia","volume":"374","author":"Talley","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cgh.2017.09.002","article-title":"Definition, Pathogenesis, and Management of That Cursed Dyspepsia","volume":"16","author":"Koduru","year":"2018","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_8","first-page":"II1","article-title":"The functional gastrointestinal disorders and the Rome II process","volume":"45","author":"Drossman","year":"1999","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","article-title":"Functional gastroduodenal disorders","volume":"130","author":"Tack","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nrgastro.2013.14","article-title":"Functional dyspepsia--symptoms, definitions and validity of the Rome III criteria","volume":"10","author":"Tack","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1053\/j.gastro.2016.02.011","article-title":"Gastroduodenal Disorders","volume":"150","author":"Stanghellini","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nrgastro.2010.5","article-title":"Gastrointestinal eosinophils in health, disease and functional disorders","volume":"7","author":"Powell","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.5056\/jnm.2010.16.3.251","article-title":"Duodenal implications in the pathophysiology of functional dyspepsia","volume":"16","author":"Lee","year":"2010","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1111\/j.1365-2036.2010.04282.x","article-title":"Implications of eosinophilia in the normal duodenal biopsy\u2014An association with allergy and functional dyspepsia","volume":"31","author":"Walker","year":"2010","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1136\/gutjnl-2015-309252","article-title":"Kyoto global consensus report on Helicobacter pylori gastritis","volume":"64","author":"Sugano","year":"2015","journal-title":"Gut"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1572-0241.2003.07389.x","article-title":"Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia","volume":"98","author":"Sarnelli","year":"2003","journal-title":"Am. J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"303","DOI":"10.5056\/jnm15093","article-title":"Clinical Relevance of Serotonin Receptor Splice Variant Distribution in Human Colon","volume":"21","author":"Lee","year":"2015","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1365-2982.2007.01059.x","article-title":"5-HT4 receptor agonists: Similar but not the same","volume":"20","author":"Lefebvre","year":"2008","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2147\/TCRM.S140","article-title":"Serotonin receptor modulators in the treatment of irritable bowel syndrome","volume":"4","author":"Fayyaz","year":"2008","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1365-2982.2008.01223.x","article-title":"Distribution of serotonin receptors and interacting proteins in the human sigmoid colon","volume":"21","author":"Chetty","year":"2009","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.gtc.2014.11.008","article-title":"Prokinetics in gastroparesis","volume":"44","author":"Acosta","year":"2015","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1517\/14728214.2015.1009827","article-title":"Emerging drugs for functional dyspepsia","volume":"20","author":"Zala","year":"2015","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/jgh.12662","article-title":"Mosapride treatment for functional dyspepsia: A meta-analysis","volume":"30","author":"Bang","year":"2015","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1053\/j.gastro.2007.04.057","article-title":"Desperately seeking serotonin. A commentary on the withdrawal of tegaserod and the state of drug development for functional and motility disorders","volume":"132","author":"Pasricha","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7371","DOI":"10.3748\/wjg.v18.i48.7371","article-title":"Itopride therapy for functional dyspepsia: A meta-analysis","volume":"18","author":"Huang","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/gut.2007.132449","article-title":"Itopride in functional dyspepsia: Results of two phase III multicentre, randomised, double-blind, placebo-controlled trials","volume":"57","author":"Talley","year":"2008","journal-title":"Gut"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/MCG.0000000000000543","article-title":"Domperidone is Commonly Prescribed With QT-Interacting Drugs: Review of a Community-based Practice and a Postmarketing Adverse Drug Event Reporting Database","volume":"51","author":"Ehrenpreis","year":"2017","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1001\/archinte.1993.00410120051007","article-title":"The prevalence of metoclopramide-induced tardive dyskinesia and acute extrapyramidal movement disorders","volume":"153","author":"Ganzini","year":"1993","journal-title":"Arch. Intern. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.cgh.2012.06.036","article-title":"Efficacy of buspirone, a fundus-relaxing drug, in patients with functional dyspepsia","volume":"10","author":"Tack","year":"2012","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1365-2982.2012.01984.x","article-title":"Influence of sumatriptan on gastric accommodation and on antral contraction in healthy subjects assessed by ultrasonography","volume":"24","author":"Sekino","year":"2012","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1517\/13543784.2011.562890","article-title":"Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia","volume":"20","author":"Tack","year":"2011","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1365-2982.2012.01897.x","article-title":"Therapeutic efficacy of acotiamide in patients with functional dyspepsia based on enhanced postprandial gastric accommodation and emptying: Randomized controlled study evaluation by real-time ultrasonography","volume":"24","author":"Kusunoki","year":"2012","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1136\/gutjnl-2011-301454","article-title":"A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia","volume":"61","author":"Matsueda","year":"2012","journal-title":"Gut"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/0016-5085(94)90536-3","article-title":"Selective gastric hypersensitivity and reflex hyporeactivity in functional dyspepsia","volume":"107","author":"Coffin","year":"1994","journal-title":"Gastroenterology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/BF01300087","article-title":"Visceral perception in health and functional dyspepsia. Crossover study of gastric distension with placebo and domperidone","volume":"36","author":"Bradette","year":"1991","journal-title":"Dig. Dis. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/0016-5085(91)90726-2","article-title":"The origin of symptoms on the brain-gut axis in functional dyspepsia","volume":"101","author":"Mearin","year":"1991","journal-title":"Gastroenterology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1053\/gast.2001.27180","article-title":"Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia","volume":"121","author":"Tack","year":"2001","journal-title":"Gastroenterology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1053\/j.gastro.2013.05.018","article-title":"In functional dyspepsia, hypersensitivity to postprandial distention correlates with meal-related symptom severity","volume":"145","author":"Farre","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1517\/14728222.11.4.527","article-title":"The 5-HT3 receptor as a therapeutic target","volume":"11","author":"Thompson","year":"2007","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1046\/j.1365-2036.1998.00375.x","article-title":"Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome","volume":"12","author":"Delvaux","year":"1998","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_41","first-page":"15","article-title":"Alosetron: An effective treatment for diarrhea-predominant irritable bowel syndrome","volume":"3","author":"Harris","year":"2007","journal-title":"Womens Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.2042-7158.1990.tb07056.x","article-title":"Effects of fedotozine on gastrointestinal motility in dogs: Mechanism of action and related pharmacokinetics","volume":"42","author":"Pascaud","year":"1990","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0014-2999(94)90265-8","article-title":"Peripheral kappa-opioid receptors mediate the antinociceptive effect of fedotozine (correction of fetodozine) on the duodenal pain reflex inrat","volume":"271","author":"Diop","year":"1994","journal-title":"Eur J. Pharmacol."},{"key":"ref_44","first-page":"7","article-title":"Drug development for the irritable bowel syndrome: Current challenges and future perspectives","volume":"4","year":"2013","journal-title":"Front. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1053\/j.gastro.2005.09.019","article-title":"American Gastroenterological Association medical position statement: Evaluation of dyspepsia","volume":"129","author":"Talley","year":"2005","journal-title":"Gastroenterology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1053\/j.gastro.2015.04.020","article-title":"Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized Controlled Study","volume":"149","author":"Talley","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000358111","article-title":"Therapeutic options for functional dyspepsia","volume":"32","author":"Vanheel","year":"2014","journal-title":"Dig. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.cgh.2015.09.043","article-title":"Efficacy of Mirtazapine in Patients With Functional Dyspepsia and Weight Loss","volume":"14","author":"Tack","year":"2016","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1365-2982.2007.01029.x","article-title":"The effect of short-term, low-dose tricyclic and tetracyclic antidepressant treatment on satiation, postnutrient load gastrointestinal symptoms and gastric emptying: A double-blind, randomized, placebo-controlled trial","volume":"20","author":"Choung","year":"2008","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1046\/j.1365-2036.2000.00742.x","article-title":"Comparative effects of levosulpiride and cisapride on gastric emptying and symptoms in patients with functional dyspepsia and gastroparesis","volume":"14","author":"Mansi","year":"2000","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S1542-3565(04)00059-X","article-title":"Levosulpiride and cisapride in the treatment of dysmotility-like functional dyspepsia: A randomized, double-masked trial","volume":"2","author":"Mearin","year":"2004","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1053\/j.gastro.2005.08.062","article-title":"Pharmacological and pharmacokinetic aspects of functional gastrointestinal disorders","volume":"130","author":"Camilleri","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4062\/biomolther.2012.096","article-title":"DA-9701: A New Multi-Acting Drug for the Treatment of Functional Dyspepsia","volume":"21","author":"Kwon","year":"2013","journal-title":"Biomol. Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jpba.2007.06.009","article-title":"Qualitative and quantitative determination of ten alkaloids in traditional Chinese medicine Corydalis yanhusuo W.T. Wang by LC-MS\/MS and LC-DAD","volume":"45","author":"Ding","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"p-100","DOI":"10.1055\/s-2009-1216538","article-title":"Anti-inflammatory, Analgesic and Antioxidant Activities of Ipomoea hederaceae Linn","volume":"75","author":"Kumar","year":"2009","journal-title":"Planta Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1254\/fpj.65.196","article-title":"Effects of Corydalis alkaloid upon inhibition of gastric juice secretion and prevention of gastric ulcer in experimental animals","volume":"65","author":"Soji","year":"1969","journal-title":"Nihon Yakurigaku Zasshi"},{"key":"ref_57","first-page":"93","article-title":"Corydalis spp.: In Vitro Culture and the Biotransformation of Protoberberines","volume":"26","author":"Kamigauchi","year":"1994","journal-title":"Biotechnol. Agric. For."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.intimp.2009.08.001","article-title":"Quaternary alkaloid, pseudocoptisine isolated from tubers of Corydalis turtschaninovi inhibits LPS-induced nitric oxide, PGE2, and pro-inflammatory cytokines production via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage cells","volume":"9","author":"Yun","year":"2009","journal-title":"Int. Immunopharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3109\/00498254.2013.874610","article-title":"Pharmacokinetics of chlorogenic acid and corydaline in DA-9701, a new botanical gastroprokinetic agent, in rats","volume":"44","author":"Jung","year":"2014","journal-title":"Xenobiotica"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.phymed.2008.02.019","article-title":"Gastroprokinetic effects of DA-9701, a new prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber","volume":"15","author":"Lee","year":"2008","journal-title":"Phytomedicine"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10059-009-0039-6","article-title":"Induction of pacemaker currents by DA-9701, a prokinetic agent, in interstitial cells of Cajal from murine small intestine","volume":"27","author":"Choi","year":"2009","journal-title":"Mol. Cells"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.3748\/wjg.v19.i27.4380","article-title":"Effect of DA-9701 on gastric emptying in a mouse model: Assessment by 13C-octanoic acid breath test","volume":"19","author":"Lim","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"304","DOI":"10.5056\/jnm15131","article-title":"Effect of DA-9701 on the Normal Motility and Clonidine-induced Hypomotility of the Gastric Antrum in Rats","volume":"22","author":"Kang","year":"2016","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"529","DOI":"10.5056\/jnm15194","article-title":"The Effect of DA-9701 in Opioid-induced Bowel Dysfunction of Guinea Pig","volume":"22","author":"Hussain","year":"2016","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"109","DOI":"10.5056\/jnm16003","article-title":"Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats","volume":"23","author":"Lee","year":"2017","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e13385","DOI":"10.1111\/nmo.13385","article-title":"Corticotrophin-releasing factor-mediated effects of DA-9701 in Postoperative Ileus Guinea Pig Model","volume":"30","author":"Jo","year":"2018","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/nmo.12053","article-title":"Effect of DA-9701, a novel prokinetic agent, on stress-induced delayed gastric emptying and hormonal changes in rats","volume":"25","author":"Jung","year":"2013","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1248\/bpb.33.958","article-title":"Effects of corydaline from Corydalis tuber on gastric motor function in an animal model","volume":"33","author":"Lee","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/j.1440-1746.2011.06924.x","article-title":"Effects of DA-9701, a novel prokinetic agent, on gastric accommodation in conscious dogs","volume":"27","author":"Kim","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"50","DOI":"10.7704\/kjhugr.2018.18.1.50","article-title":"Effect of DA-9701 on Feeding Inhibition Induced by Acute Restraint Stress in Rats","volume":"18","author":"Kim","year":"2018","journal-title":"Korean J. Helicobacter Up. Gastrointest. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1124\/jpet.111.182048","article-title":"Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function","volume":"338","author":"Lee","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.3390\/molecules19045135","article-title":"The effect of DA-9701 on 5-hydroxytryptamine-induced contraction of feline esophageal smooth muscle cells","volume":"19","author":"Oh","year":"2014","journal-title":"Molecules"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"318","DOI":"10.5056\/jnm13098","article-title":"Nitrergic Pathway Is the Major Mechanism for the Effect of DA-9701 on the Rat Gastric Fundus Relaxation","volume":"20","author":"Min","year":"2014","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"388","DOI":"10.5009\/gnl.2014.8.4.388","article-title":"Effect of DA-9701 on colorectal distension-induced visceral hypersensitivity in a rat model","volume":"8","author":"Kim","year":"2014","journal-title":"Gut Liver"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.pbb.2011.08.016","article-title":"Antinociceptive effects of intragastric DL-tetrahydropalmatine on visceral and somatic persistent nociception and pain hypersensitivity in rats","volume":"100","author":"Cao","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"140","DOI":"10.5009\/gnl.2014.8.2.140","article-title":"Effects of DA-9701, a novel prokinetic agent, on phosphorylated extracellular signal-regulated kinase expression in the dorsal root ganglion and spinal cord induced by colorectal distension in rats","volume":"8","author":"Lee","year":"2014","journal-title":"Gut Liver"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1136\/gut.11.12.989","article-title":"Studies of the effect of metoclopramide and apomorphine on gastric emptying and secretion in man","volume":"11","author":"Ramsbottom","year":"1970","journal-title":"Gut"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0016-5085(93)91018-D","article-title":"Inhibition of intestinal motility and reversal of postlaparotomy ileus by selective alpha 2-adrenergic drugs in the rat","volume":"104","author":"Tanila","year":"1993","journal-title":"Gastroenterology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/S0960-894X(98)00341-2","article-title":"A novel series of 6-methoxy-1H-benzotriazole-5-carboxamide derivatives with dual antiemetic and gastroprokinetic activities","volume":"8","author":"Hirokawa","year":"1998","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0022-3999(94)90033-7","article-title":"Psychological factors and somatic symptoms in functional dyspepsia. A comparison with duodenal ulcer and healthy controls","volume":"38","author":"Haug","year":"1994","journal-title":"J. Psychosom. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"R427","DOI":"10.1152\/ajpregu.00499.2004","article-title":"Restraint stress delays solid gastric emptying via a central CRF and peripheral sympathetic neuron in rats","volume":"288","author":"Nakade","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"G173","DOI":"10.1152\/ajpgi.2001.280.2.G173","article-title":"Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: Role of brain corticotropin-releasing factor receptors","volume":"280","author":"Tache","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"S-893","DOI":"10.1016\/S0016-5085(12)63472-6","article-title":"Tu1985 effects of DA-9701, a novel prokinetic agent on gastric motor function in guinea pig","volume":"142","author":"Lim","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.33549\/physiolres.930255","article-title":"Neurohumoral control of gastrointestinal motility","volume":"52","author":"Hansen","year":"2003","journal-title":"Physiol. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1053\/j.gastro.2005.06.062","article-title":"Abdominal bloating","volume":"129","author":"Azpiroz","year":"2005","journal-title":"Gastroenterology"},{"key":"ref_86","first-page":"G229","article-title":"Physiological variations in canine gastric tone measured by an electronic barostat","volume":"248","author":"Azpiroz","year":"1985","journal-title":"Am. J. Physiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"G96","DOI":"10.1152\/ajpgi.00280.2002","article-title":"Role of 5-HT1B\/D receptors in canine gastric accommodation: Effect of sumatriptan and 5-HT1B\/D receptor antagonists","volume":"285","author":"Crema","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_88","first-page":"G727","article-title":"Vagally mediated gastric relaxation induced by intestinal nutrients in the dog","volume":"251","author":"Azpiroz","year":"1986","journal-title":"Am. J. Physiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1365-2036.2005.02392.x","article-title":"Review article: Drugs interfering with visceral sensitivity for the treatment of functional gastrointestinal disorders--the clinical evidence","volume":"21","author":"Kuiken","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_90","first-page":"G373","article-title":"Role of nitric oxide in fasting gastric fundus tone and in 5-HT1 receptor-mediated relaxation of gastric fundus","volume":"276","author":"Coulie","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/00000542-199003000-00004","article-title":"Clonidine-induced analgesia in postoperative patients: Epidural versus intramuscular administration","volume":"72","author":"Bonnet","year":"1990","journal-title":"Anesthesiology"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0016-5085(94)90086-8","article-title":"Basic and clinical aspects of visceral hyperalgesia","volume":"107","author":"Mayer","year":"1994","journal-title":"Gastroenterology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/gut.48.1.125","article-title":"Visceral hypersensitivity: Facts, speculations, and challenges","volume":"48","author":"Camilleri","year":"2001","journal-title":"Gut"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"414","DOI":"10.5056\/jnm14117","article-title":"Randomized, Controlled, Multi-center Trial: Comparing the Safety and Efficacy of DA-9701 and Itopride Hydrochloride in Patients With Functional Dyspepsia","volume":"21","author":"Choi","year":"2015","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"254","DOI":"10.5056\/jnm15178","article-title":"Efficacy of DA-9701 (Motilitone) in Functional Dyspepsia Compared to Pantoprazole: A Multicenter, Randomized, Double-blind, Non-inferiority Study","volume":"22","author":"Jung","year":"2016","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"338","DOI":"10.5056\/jnm14019","article-title":"Effects of the New Prokinetic Agent DA-9701 Formulated With Corydalis Tuber and Pharbitis Seed in Patients With Minimal Change Esophagitis: A Bicenter, Randomized, Double Blind, Placebo-controlled Study","volume":"20","author":"Park","year":"2014","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.parkreldis.2018.04.018","article-title":"DA-9701 on gastric motility in patients with Parkinson\u2019s disease: A randomized controlled trial","volume":"54","author":"Shin","year":"2018","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Min, Y.W., Min, B.H., Kim, S., Choi, D., and Rhee, P.L. (2015). Effect of DA-9701 on Gastric Motor Function Assessed by Magnetic Resonance Imaging in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Trial. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0138927"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1111\/jgh.13807","article-title":"DA-9701 improves colonic transit time and symptoms in patients with functional constipation: A prospective study","volume":"32","author":"Kim","year":"2017","journal-title":"J. Gastroenterol. Hepatol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/12\/4035\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:33:48Z","timestamp":1760196828000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/12\/4035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,13]]},"references-count":99,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["ijms19124035"],"URL":"https:\/\/doi.org\/10.3390\/ijms19124035","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,13]]}}}