{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:35:03Z","timestamp":1792193703762,"version":"4.4.0"},"reference-count":55,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271692"],"award-info":[{"award-number":["81271692"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Ocean Antithrombotic Fibrinolytic Enzyme Gene Bank of Taiwan Strait","award":["2014FJPT08"],"award-info":[{"award-number":["2014FJPT08"]}]},{"name":"the Science and Technology Innovation Public Technology Service Platform of Function of Drugs and Food","award":["3502Z20141015"],"award-info":[{"award-number":["3502Z20141015"]}]},{"DOI":"10.13039\/501100003815","name":"Huaqiao University","doi-asserted-by":"publisher","award":["14BS-111"],"award-info":[{"award-number":["14BS-111"]}],"id":[{"id":"10.13039\/501100003815","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Education Department of Fujian Province","award":["JA14020"],"award-info":[{"award-number":["JA14020"]}]},{"name":"the Science and Technology Bureau of Quanzhou City","award":["2018Z012"],"award-info":[{"award-number":["2018Z012"]}]},{"name":"Subsidized Project for Cultivating Postgraduates\u2019 Innovative Ability in Scientific Research of Huaqiao University","award":["1601116004"],"award-info":[{"award-number":["1601116004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Prostate cancer (PCa) is a major health problem in males. Metastasis-associated with lung adenocarcinoma transcript-1 (MALAT1), which is overexpressed in PCa tissue, is associated with physiological and pathological conditions of PCa. M2 macrophages are major immune cells abundant in the tumor microenvironment. However, it remains unknown whether M2 macrophages are involved in the effects or not, and molecular mechanisms of MALAT1 on PCa progression have not yet been comprehensively explored. Here we reported that, M2 macrophages (PMA\/IL-4 treated THP1) induced MALAT1 expression in PCa cell lines. Knockdown MALAT1 expression level in PCa cell lines inhibited cellular proliferation, invasion, and tumor formation. Further mechanistic dissection revealed that M2 macrophages secreted IL-8 was sufficient to drive up MALAT1 expression level via activating STAT3 signaling pathway. Additional chromatin immunoprecipitation (ChIP) and luciferase reporter assays displayed that STAT3 could bind to the MALAT1 promoter region and transcriptionally stimulate the MALAT1 expression. In summary, our present study identified the IL-8\/STAT3\/MALAT1 axis as key regulators during prostate tumorigenesis and therefore demonstrated a new mechanism for the MALAT1 transcriptional regulation.<\/jats:p>","DOI":"10.3390\/ijms20010098","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T11:29:43Z","timestamp":1545910183000},"page":"98","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["IL-8 Secreted from M2 Macrophages Promoted Prostate Tumorigenesis via STAT3\/MALAT1 Pathway"],"prefix":"10.3390","volume":"20","author":[{"given":"Tingjin","family":"Zheng","sequence":"first","affiliation":[{"name":"Engineering Research Center of Molecular Medicine, Ministry of Education, Fujian Provincial Key Laboratory of Molecular Medicine, School of Medicine, Huaqiao University, Xiamen 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxing","family":"Ma","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Molecular Medicine, Ministry of Education, Fujian Provincial Key Laboratory of Molecular Medicine, School of Medicine, Huaqiao University, Xiamen 361021, China"},{"name":"Organization Department, Tangshan Normal University, Tangshan 063500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqing","family":"Tang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Molecular Medicine, Ministry of Education, Fujian Provincial Key Laboratory of Molecular Medicine, School of Medicine, Huaqiao University, Xiamen 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwan","family":"Li","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Molecular Medicine, Ministry of Education, Fujian Provincial Key Laboratory of Molecular Medicine, School of Medicine, Huaqiao University, Xiamen 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruian","family":"Xu","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Molecular Medicine, Ministry of Education, Fujian Provincial Key Laboratory of Molecular Medicine, School of Medicine, Huaqiao University, Xiamen 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0140-6736(14)61947-4","article-title":"Prostate cancer","volume":"387","author":"Attard","year":"2016","journal-title":"The Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11912-018-0692-z","article-title":"Emerging Therapies in Metastatic Prostate Cancer","volume":"20","author":"Sonnenburg","year":"2018","journal-title":"Curr. 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