{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:26:07Z","timestamp":1790479567273,"version":"4.1.0"},"reference-count":29,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T00:00:00Z","timestamp":1547424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-16-IFEC-0003-05, in the \"Infect-ERA\" program."],"award-info":[{"award-number":["ANR-16-IFEC-0003-05, in the \"Infect-ERA\" program."]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Resistance of the opportunistic pathogen Candida albicans to antifungal drugs has increased significantly in recent years. After screening 55 potential antifungal compounds from a chemical library, 2,3-dihydroxy-4-methoxybenzaldehyde (DHMB) was identified as having potential antifungal activity. The properties of DHMB were then assessed in vitro and in vivo against C. albicans overgrowth and intestinal inflammation. Substitution on the aromatic ring of DHMB led to a strong decrease in its biological activity against C. albicans. The MIC of DHMB was highly effective at eliminating C. albicans when compared to that of caspofungin or fluconazole. Additionally, DHMB was also effective against clinically isolated fluconazole- or caspofungin-resistant C. albicans strains. DHMB was administered to animals at high doses. This compound was not cytotoxic and was well-tolerated. In experimental dextran sodium sulphate (DSS)-induced colitis in mice, DHMB reduced the clinical and histological score of inflammation and promoted the elimination of C. albicans from the gut. This finding was supported by a decrease in aerobic bacteria while anaerobic bacteria populations were re-established in mice treated with DHMB. DHMB is a small organic molecule with antifungal properties and anti-inflammatory activity by exerting protective effects on intestinal epithelial cells.<\/jats:p>","DOI":"10.3390\/ijms20020321","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T12:20:07Z","timestamp":1547468407000},"page":"321","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A Small Aromatic Compound Has Antifungal Properties and Potential Anti-Inflammatory Effects against Intestinal Inflammation"],"prefix":"10.3390","volume":"20","author":[{"given":"Clovis","family":"Bortolus","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U995\/Team2, F-59000 Lille, France"},{"name":"Lille Inflammation Research International Center, University Lille, U995-LIRIC, F-59000 Lille, France"},{"name":"Service de Parasitologie Mycologie, P\u00f4le de Biologie Pathologie G\u00e9n\u00e9tique, CHU Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1486-7206","authenticated-orcid":false,"given":"Muriel","family":"Billamboz","sequence":"additional","affiliation":[{"name":"Lille Inflammation Research International Center, University Lille, U995-LIRIC, F-59000 Lille, France"},{"name":"Laboratoire de Chimie Durable et Sant\u00e9, Ecole des Hautes Etudes d\u2019Ing\u00e9nieur (HEI), Yncr\u00e9a Hauts-de-France, 13 Rue de Toul, F-59046 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogatien","family":"Charlet","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U995\/Team2, F-59000 Lille, France"},{"name":"Lille Inflammation Research International Center, University Lille, U995-LIRIC, F-59000 Lille, France"},{"name":"Service de Parasitologie Mycologie, P\u00f4le de Biologie Pathologie G\u00e9n\u00e9tique, CHU Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9916-5088","authenticated-orcid":false,"given":"Karine","family":"Lecointe","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U995\/Team2, F-59000 Lille, France"},{"name":"Lille Inflammation Research International Center, University Lille, U995-LIRIC, F-59000 Lille, France"},{"name":"Service de Parasitologie Mycologie, P\u00f4le de Biologie Pathologie G\u00e9n\u00e9tique, CHU Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boualem","family":"Sendid","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U995\/Team2, F-59000 Lille, France"},{"name":"Lille Inflammation Research International Center, University Lille, U995-LIRIC, F-59000 Lille, France"},{"name":"Service de Parasitologie Mycologie, P\u00f4le de Biologie Pathologie G\u00e9n\u00e9tique, CHU Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6468-4331","authenticated-orcid":false,"given":"Alina","family":"Ghinet","sequence":"additional","affiliation":[{"name":"Lille Inflammation Research International Center, University Lille, U995-LIRIC, F-59000 Lille, France"},{"name":"Laboratoire de Chimie Durable et Sant\u00e9, Ecole des Hautes Etudes d\u2019Ing\u00e9nieur (HEI), Yncr\u00e9a Hauts-de-France, 13 Rue de Toul, F-59046 Lille, France"},{"name":"Faculty of Chemistry, Al. 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Cuza\u2019 University of Iasi, B-dul Carol 1 nr. 11, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2759-975X","authenticated-orcid":false,"given":"Samir","family":"Jawhara","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U995\/Team2, F-59000 Lille, France"},{"name":"Lille Inflammation Research International Center, University Lille, U995-LIRIC, F-59000 Lille, France"},{"name":"Service de Parasitologie Mycologie, P\u00f4le de Biologie Pathologie G\u00e9n\u00e9tique, CHU Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/S0140-6736(07)60751-X","article-title":"Inflammatory bowel disease: Clinical aspects and established and evolving therapies","volume":"369","author":"Baumgart","year":"2007","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cimid.2015.10.005","article-title":"Dysbiotic gut microbiome: A key element of Crohn\u2019s disease","volume":"43","author":"Oyri","year":"2015","journal-title":"Comp. 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