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Mechanical and chemical stresses exerted on the membrane can be transduced by specialized proteins into meaningful intracellular biochemical signaling, resulting in physiological changes. Of particular interest are compounds that can change the local physical properties of the membrane, thereby affecting nearby proteins, such as TRP channels, which are highly sensitive to the membrane environment. In this review, we provide an overview of the current knowledge of TRP channel activation as a result of changes in the membrane properties induced by amphipathic structural lipidic components such as cholesterol and diacylglycerol, and by exogenous amphipathic bacterial endotoxins.<\/jats:p>","DOI":"10.3390\/ijms20020371","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T03:02:03Z","timestamp":1547694123000},"page":"371","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["TRP Channels as Sensors of Chemically-Induced Changes in Cell Membrane Mechanical Properties"],"prefix":"10.3390","volume":"20","author":[{"given":"Justyna","family":"Startek","sequence":"first","affiliation":[{"name":"Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven;<br>VIB Center for Brain & Disease Research, Herestraat 49, Campus Gasthuisberg O&N1 bus 802, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5026-3963","authenticated-orcid":false,"given":"Brett","family":"Boonen","sequence":"additional","affiliation":[{"name":"Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven;<br>VIB Center for Brain & Disease Research, Herestraat 49, Campus Gasthuisberg O&N1 bus 802, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3124-138X","authenticated-orcid":false,"given":"Karel","family":"Talavera","sequence":"additional","affiliation":[{"name":"Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven;<br>VIB Center for Brain & Disease Research, Herestraat 49, Campus Gasthuisberg O&N1 bus 802, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Meseguer","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias de Alicante, Universidad Miguel Hern\u00e1ndez y CSIC, E-03550 Alicante , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0076-6879(07)28010-3","article-title":"Chapter ten\u2014Transient receptor potential channels in mechanosensing and cell volume regulation","volume":"Volume 428","author":"Sies","year":"2007","journal-title":"Methods in Enzymology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1098\/rstb.2007.2128","article-title":"The shear stress of it all: The cell membrane and mechanochemical transduction","volume":"362","author":"White","year":"2007","journal-title":"Philos. 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