{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:09:11Z","timestamp":1783789751862,"version":"3.55.0"},"reference-count":55,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Bio &amp; Medical Technology Development Program of the NRF funded by the Korean government, MSIP","award":["NRF-2015M3A9B6066835"],"award-info":[{"award-number":["NRF-2015M3A9B6066835"]}]},{"name":"Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ01321101) Rural Development Administration, Republic of Korea","award":["Project No. PJ01321101"],"award-info":[{"award-number":["Project No. PJ01321101"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Fucoidan, a natural sulfated polysaccharide, displays various biological activities including antioxidant properties. We examined the neuroprotective effect of fucoidan against transient global cerebral ischemia (tGCI) in high-fat diet (HFD)-induced obese gerbils and its related mechanisms. Gerbils received HFD for 12 weeks and fucoidan (50 mg\/kg) daily for the last 5 days during HFD exposure, and they were subjected to 5-min tGCI. Pyramidal cell death was observed only in the CA 1 area (CA1) of the hippocampus in non-obese gerbils 5 days after tGCI. However, in obese gerbils, pyramidal cell death in the CA1 and CA2\/3 occurred at 2 days and 5 days, respectively, after tGCI. In the obese gerbils, oxidative stress indicators (dihydroethidium, 8-hydroxyguanine and 4-hydroxy-2-nonenal) were significantly enhanced and antioxidant enzymes (SOD1 and SOD2) were significantly reduced in pre- and post-ischemic phases compared to the non-obese gerbils. Fucoidan treatment attenuated acceleration and exacerbation of tGCI-induced neuronal death in the CA1\u20133, showing that oxidative stress was significantly reduced, and antioxidant enzymes were significantly increased in pre- and post-ischemic phases. These findings indicate that pretreated fucoidan can relieve the acceleration and exacerbation of ischemic brain injury in an obese state via the attenuation of obesity-induced severe oxidative damage.<\/jats:p>","DOI":"10.3390\/ijms20030554","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T03:40:55Z","timestamp":1548733255000},"page":"554","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Antioxidant Properties of Fucoidan Alleviate Acceleration and Exacerbation of Hippocampal Neuronal Death Following Transient Global Cerebral Ischemia in High-Fat Diet-Induced Obese Gerbils"],"prefix":"10.3390","volume":"20","author":[{"given":"Ji Hyeon","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung Cheol","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, and Research Institute of Oral Sciences, College of Dentistry, Gangnung-Wonju National University, Gangneung, Gangwon 25457, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minah","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Kyeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Chul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Korea"},{"name":"Department of Anesthesiology and Pain Medicine, Chungju Hospital, Konkuk University School of Medicine, Chungju, Chungcheongbuk 27376, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Hwi","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8326-7768","authenticated-orcid":false,"given":"Young-Myeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Dai","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon, Gangwon 24341, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7178-6501","authenticated-orcid":false,"given":"Moo-Ho","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-1968","authenticated-orcid":false,"given":"Joon Ha","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/jcbfm.1992.34","article-title":"Global cerebral ischemia associated with cardiac arrest in the rat: I. 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