{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:09:53Z","timestamp":1788296993494,"version":"build-2803163510"},"reference-count":133,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Aging is an inevitable process in the human body that is associated with a multitude of systemic and localized changes. All these conditions have a common pathogenic mechanism characterized by the presence of a low-grade proinflammatory status. Inflammaging refers to all the processes that contribute to the occurrence of various diseases associated with aging such as frailty, atherosclerosis, Alzheimer\u2019s disease, sarcopenia, type 2 diabetes, or osteoarthritis. Inflammaging is systemic, chronic, and asymptomatic. Osteoarthritis and many age-related degenerative joint diseases are correlated with aging mechanisms such as the presence of an inflammatory microenvironment and the impaired link between inflammasomes and autophagy. There is a close relationship between chondrocyte activity and local articular environment changes due to cell senescence, followed by secretion of inflammatory mediators. In addition, systemic inflammaging can lead to cartilage destruction, pain, disability, and an impaired quality of life. The purpose of this review is to summarize the main mechanisms implicated in inflammaging and the connection it has with degenerative joint diseases.<\/jats:p>","DOI":"10.3390\/ijms20030614","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T03:08:05Z","timestamp":1548990485000},"page":"614","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["The Link Between Inflammaging and Degenerative Joint Diseases"],"prefix":"10.3390","volume":"20","author":[{"given":"Elena","family":"Rezu\u0219","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Physiotherapy, \u201cGrigore T. Popa\u2019\u2019 University of Medicine and Pharmacy Ia\u0219i, University Street no. 16, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Cardoneanu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Physiotherapy, \u201cGrigore T. Popa\u2019\u2019 University of Medicine and Pharmacy Ia\u0219i, University Street no. 16, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7361-4685","authenticated-orcid":false,"given":"Alexandra","family":"Burlui","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Physiotherapy, \u201cGrigore T. Popa\u2019\u2019 University of Medicine and Pharmacy Ia\u0219i, University Street no. 16, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Luca","sequence":"additional","affiliation":[{"name":"Advanced Center for Research and Development in Experimental Medicine (CEMEX), \u201cGrigore T. 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Popa\u2019\u2019 University of Medicine and Pharmacy Ia\u0219i, University Street no. 16, zip code 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Fulop, T., Franceschi, C., Hirokawa, K., and Pawelec, G. (2009). Inflamm-Aging: Handbook on Immunosenesce\u2014basic Understanding and Clinical Applications 1, Springer Science Business Media, B.V.","DOI":"10.1007\/978-1-4020-9063-9"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2174\/1570161113666150105112820","article-title":"Cardiovascular Risk Factors in Chronic Inflammatory Rheumatic Diseases: Modern Assessment and Diagnosis","volume":"13","author":"Rezus","year":"2015","journal-title":"Curr. Vasc. 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