{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:29:32Z","timestamp":1792801772940,"version":"4.5.0"},"reference-count":221,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T00:00:00Z","timestamp":1549584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006280","name":"Ministerio de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["SAF2014-52940-R and SAF2017-85199"],"award-info":[{"award-number":["SAF2014-52940-R and SAF2017-85199"]}],"id":[{"id":"10.13039\/501100006280","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Neurodegenerative disorders affect around one billion people worldwide. They can arise from a combination of genomic, epigenomic, metabolic, and environmental factors. Aging is the leading risk factor for most chronic illnesses of old age, including Alzheimer\u2019s and Parkinson\u2019s diseases. A progressive neurodegenerative process and neuroinflammation occur, and no current therapies can prevent, slow, or halt disease progression. To date, no novel disease-modifying therapies have been shown to provide significant benefit for patients who suffer from these devastating disorders. Therefore, early diagnosis and the discovery of new targets and novel therapies are of upmost importance. Neurodegenerative diseases, like in other age-related disorders, the progression of pathology begins many years before the onset of symptoms. Many efforts in this field have led to the conclusion that exits some similar events among these diseases that can explain why the aging brain is so vulnerable to suffer neurodegenerative diseases. This article reviews the current knowledge about these diseases by summarizing the most common features of major neurodegenerative disorders, their causes and consequences, and the proposed novel therapeutic approaches.<\/jats:p>","DOI":"10.3390\/ijms20030719","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T03:26:01Z","timestamp":1549855561000},"page":"719","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":158,"title":["Novel Approaches for the Treatment of Alzheimer\u2019s and Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0253-4914","authenticated-orcid":false,"given":"Michiel","family":"Van Bulck","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas (CSIC-UAM), Arturo Duperier, 4. 28029 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Valderrebollo, 5, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Sierra-Magro","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas (CSIC-UAM), Arturo Duperier, 4. 28029 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Valderrebollo, 5, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Alarcon-Gil","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas (CSIC-UAM), Arturo Duperier, 4. 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Perez-Castillo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas (CSIC-UAM), Arturo Duperier, 4. 28029 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Valderrebollo, 5, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9008-0056","authenticated-orcid":false,"given":"Jose A.","family":"Morales-Garcia","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas (CSIC-UAM), Arturo Duperier, 4. 28029 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Valderrebollo, 5, 28031 Madrid, Spain"},{"name":"Departamento de Biolog\u00eda Celular, Facultad de Medicina, Universidad Complutense de Madrid (UCM), Plaza Ram\u00f3n y Cajal s\/n, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,8]]},"reference":[{"key":"ref_1","unstructured":"GBD 2016 Parkinson\u2019s Disease Collaborators (2018). 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