{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:49:08Z","timestamp":1790862548285,"version":"4.1.0"},"reference-count":37,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T00:00:00Z","timestamp":1549584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000783","name":"Research Executive Agency","doi-asserted-by":"publisher","award":["286548"],"award-info":[{"award-number":["286548"]}],"id":[{"id":"10.13039\/501100000783","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Achieving the stable osteointegration of prosthetic implants is one of the great challenges of modern orthopedic surgery. The fixation of ceramic acetabular cups of hip joint prostheses is usually achieved using a metal shell provided with screws or pegs that penetrate into the host pelvic bone. The deposition of bioactive coatings on the implant surface to be put in contact with bone could be a valuable strategy to promote a more \u201cphysiological\u201d osteointegration. In this work, bioactive glass porous coatings were manufactured on the top of alumina\/zirconia composite implants by two different methods, i.e., sponge replication and laser cladding. The coated samples underwent immersion studies in Kokubo\u2019s simulated body fluid (SBF) to assess in vitro bioactivity and were found to exhibit an excellent hydroxyapatite-forming ability, which is key to allow bonding to bone. Biological tests using mesenchymal stem and osteoblast-like cells revealed the good biocompatibility of both types of materials. Furthermore, a higher level of mineralization was induced by the sponge-replicated coatings at 10 days. Overall, these results are highly promising and encourage further research on these materials.<\/jats:p>","DOI":"10.3390\/ijms20030722","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T03:26:01Z","timestamp":1549855561000},"page":"722","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["In Vitro Assessment of Bioactive Glass Coatings on Alumina\/Zirconia Composite Implants for Potential Use in Prosthetic Applications"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8860-0497","authenticated-orcid":false,"given":"Francesco","family":"Baino","sequence":"first","affiliation":[{"name":"Politecnico di Torino, Department of Applied Science and Technology, Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0552-1687","authenticated-orcid":false,"given":"Joaquim","family":"Minguella-Canela","sequence":"additional","affiliation":[{"name":"Centre CIM\/Departament d\u2019Enginyeria Mec\u00e0nica, Universitat Polit\u00e8cnica de Catalunya, Av. Diagonal, 647, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9486-3541","authenticated-orcid":false,"given":"Feza","family":"Korkusuz","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Medical Faculty, Hacettepe University, Sihhiye, Ankara 06100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petek","family":"Korkusuz","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical Faculty, Hacettepe University, Sihhiye, Ankara 06100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berna","family":"Kank\u0131l\u0131\u00e7","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Graduate School of Natural and Applied Sciences, Middle East Technical University, Cankaya, Ankara 06800, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Montealegre","sequence":"additional","affiliation":[{"name":"AIMEN Technology Centre, Relva 27A\u2014Torneiros, 36410 Porri\u00f1o, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"De los Santos-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Centre CIM\/Departament d\u2019Enginyeria Mec\u00e0nica, Universitat Polit\u00e8cnica de Catalunya, Av. Diagonal, 647, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Vitale-Brovarone","sequence":"additional","affiliation":[{"name":"Politecnico di Torino, Department of Applied Science and Technology, Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jmbbm.2013.06.001","article-title":"Artificial hip joints: The biomaterials challenge","volume":"31","author":"Pezzotti","year":"2014","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_2","first-page":"192","article-title":"Mechanical properties and composition of cortical bones","volume":"135","author":"Carter","year":"1978","journal-title":"Clin. Orthop. Relat. 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