{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:41:56Z","timestamp":1777506116146,"version":"3.51.4"},"reference-count":81,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T00:00:00Z","timestamp":1550448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Lantana camara (L.) is employed by several ethnical groups to treat numerous diseases. Although there are no ethnomedical reports on its use against leishmaniasis, organic extracts prepared from L. camara were shown to display leishmanicidal activity. In the present study, we carried out a bioassay-guided fractionation of the dichloromethane extract from Mexican L. camara in order to identify the compounds responsible for the leishmanicidal activity. Eighteen chromatographic fractions (FI\u2013FXVIII) were evaluated in vitro against Leishmania mexicana and L. amazonensis. FII, FX, FXI, FXV, and FXVI showed significant activity against both Leishmania strains, the most potent of which was FXV. Eicosane (1), squalene (2), \u03b2-ionone (3), caryophyllene oxide (4), \u03b2-caryophyllene (5), hexanoic acid (6), tiglic acid (7), a mixture of lantanilic (8) and camaric (9) acids, and lantadene B (10) were identified and obtained from the active fractions and evaluated for their leishmanicidal activity. The mixture of lantanilic (8) and camaric (9) acids (79%\/21%) was the most potent one (half maximal inhibitory concentration (IC50) = 12.02 \u00b1 0.36 \u03bcM). This study indicates that this cultivar of L. camara has high potential for the development of phytomedicines or as a source of natural products, which might represent lead compounds for the design of new drugs against leishmaniasis.<\/jats:p>","DOI":"10.3390\/ijms20040872","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T04:08:20Z","timestamp":1550549300000},"page":"872","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Chemical Constituents with Leishmanicidal Activity from a Pink-Yellow Cultivar of Lantana camara var. aculeata (L.) Collected in Central Mexico"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3265-4554","authenticated-orcid":false,"given":"Ronna","family":"Delgado-Altamirano","sequence":"first","affiliation":[{"name":"Posgrado en Ciencias Qu\u00edmico Biol\u00f3gicas, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro, Cerro de las Campanas s\/n, Quer\u00e9taro 76010, M\u00e9xico"},{"name":"Laboratorio de Investigaci\u00f3n Qu\u00edmica y Farmacol\u00f3gica de Productos Naturales, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro, Cerro de las Campanas s\/n, Quer\u00e9taro 76010, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Isela","family":"L\u00f3pez-Palma","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunoparasitolog\u00eda, Unidad de Investigaci\u00f3n en Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Hospital General de M\u00e9xico \u201cDr. Eduardo Liceaga\u201d, Dr. Balmis 148, Doctores, Ciudad de M\u00e9xico 06720, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianet","family":"Monzote","sequence":"additional","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Instituto de Medicina Tropical \u201cPedro Kour\u00ed\u201d, Apdo Postal 601, Havana 10400, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Delgado-Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunoparasitolog\u00eda, Unidad de Investigaci\u00f3n en Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Hospital General de M\u00e9xico \u201cDr. Eduardo Liceaga\u201d, Dr. Balmis 148, Doctores, Ciudad de M\u00e9xico 06720, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingeborg","family":"Becker","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunoparasitolog\u00eda, Unidad de Investigaci\u00f3n en Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Hospital General de M\u00e9xico \u201cDr. Eduardo Liceaga\u201d, Dr. Balmis 148, Doctores, Ciudad de M\u00e9xico 06720, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5932-1333","authenticated-orcid":false,"given":"Jos\u00e9 Fausto","family":"Rivero-Cruz","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-5346","authenticated-orcid":false,"given":"Nuria","family":"Esturau-Escofet","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro A.","family":"V\u00e1zquez-Landaverde","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencia Aplicada y Tecnolog\u00eda Avanzada del Instituto Polit\u00e9cnico Nacional, Unidad Quer\u00e9taro, Cerro Blanco 141 Colonia del Cimatario, Quer\u00e9taro 76090, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6131-9013","authenticated-orcid":false,"given":"Alejandra","family":"Rojas-Molina","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n Qu\u00edmica y Farmacol\u00f3gica de Productos Naturales, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro, Cerro de las Campanas s\/n, Quer\u00e9taro 76010, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Alvar, J., V\u00e9lez, I.D., Bern, C., Herrero, M., Desjeux, P., Cano, J., Jannin, J., and de Boer, M. 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