{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:59:46Z","timestamp":1781593186704,"version":"3.54.5"},"reference-count":43,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T00:00:00Z","timestamp":1550448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PI13\/02730"],"award-info":[{"award-number":["FIS PI13\/02730"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003086","name":"Eusko Jaurlaritza","doi-asserted-by":"publisher","award":["BIO12\/ALZ\/007"],"award-info":[{"award-number":["BIO12\/ALZ\/007"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006671","name":"Fundaci\u00f3n Caja Navarra","doi-asserted-by":"publisher","award":["EPIBIOD"],"award-info":[{"award-number":["EPIBIOD"]}],"id":[{"id":"10.13039\/501100006671","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Trans-Pyrenean Biomedical Research Network (REFBIO)","award":["EPIBIOD"],"award-info":[{"award-number":["EPIBIOD"]}]},{"name":"Departamento de Industria-Gobierno de Navarra","award":["AUC"],"award-info":[{"award-number":["AUC"]}]},{"DOI":"10.13039\/100010434","name":"\u201cla Caixa\u201d Foundation","doi-asserted-by":"publisher","award":["Intensificaci\u00f3n Navarrabiomed"],"award-info":[{"award-number":["Intensificaci\u00f3n Navarrabiomed"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Lamins are fibrillary proteins that are crucial in maintaining nuclear shape and function. Recently, B-type lamin dysfunction has been linked to tauopathies. However, the role of A-type lamin in neurodegeneration is still obscure. Here, we examined A-type and B-type lamin expression levels by RT-qPCR in Alzheimer\u2019s disease (AD) patients and controls in the hippocampus, the core of tau pathology in the brain. LMNA, LMNB1, and LMNB2 genes showed moderate mRNA levels in the human hippocampus with highest expression for the LMNA gene. Moreover, LMNA mRNA levels were increased at the late stage of AD (1.8-fold increase; p-value &lt; 0.05). In addition, a moderate positive correlation was found between age and LMNA mRNA levels (Pearson\u2019s r = 0.581, p-value = 0.018) within the control hippocampal samples that was not present in the hippocampal samples affected by AD. A-type and B-type lamin genes are expressed in the human hippocampus at the transcript level. LMNA mRNA levels are up-regulated in the hippocampal tissue in late stages of AD. The effect of age on increasing LMNA expression levels in control samples seems to be disrupted by the development of AD pathology.<\/jats:p>","DOI":"10.3390\/ijms20040878","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T04:08:20Z","timestamp":1550549300000},"page":"878","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Hippocampal LMNA Gene Expression is Increased in Late-Stage Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"20","author":[{"given":"Iv\u00e1n","family":"M\u00e9ndez-L\u00f3pez","sequence":"first","affiliation":[{"name":"Neuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad P\u00fablica de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain"},{"name":"Department of Internal Medicine, Hospital Garc\u00eda Orcoyen, Estella 31200, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idoia","family":"Blanco-Luquin","sequence":"additional","affiliation":[{"name":"Neuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad P\u00fablica de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"S\u00e1nchez-Ruiz de Gordoa","sequence":"additional","affiliation":[{"name":"Neuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad P\u00fablica de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain"},{"name":"Department of Neurology, Complejo Hospitalario de Navarra- IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaya","family":"Urd\u00e1noz-Casado","sequence":"additional","affiliation":[{"name":"Neuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad P\u00fablica de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miren","family":"Rold\u00e1n","sequence":"additional","affiliation":[{"name":"Neuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad P\u00fablica de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Acha","sequence":"additional","affiliation":[{"name":"Neuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad P\u00fablica de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Echavarri","sequence":"additional","affiliation":[{"name":"Neuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad P\u00fablica de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain"},{"name":"Hospital Psicogeri\u00e1trico Josefina Arregui, Alsasua, Navarra 31800, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Zelaya","sequence":"additional","affiliation":[{"name":"Department of Pathology, Complejo Hospitalario de Navarra- IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivonne","family":"Jeric\u00f3","sequence":"additional","affiliation":[{"name":"Department of Neurology, Complejo Hospitalario de Navarra- IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4179-5781","authenticated-orcid":false,"given":"Maite","family":"Mendioroz","sequence":"additional","affiliation":[{"name":"Neuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad P\u00fablica de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain"},{"name":"Department of Neurology, Complejo Hospitalario de Navarra- IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00412-012-0360-2","article-title":"Inner nuclear membrane proteins: Impact on human 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