{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:19:59Z","timestamp":1768472399600,"version":"3.49.0"},"reference-count":113,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T00:00:00Z","timestamp":1550707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AgroForWealth: Biorefining of agricultural and forest by-products and wastes: integrated strategic for valorization of resources towards society wealth and sustainability, funded by Centro2020, through FEDER and PT2020.","award":["(CENTRO-01-0145-FEDER-000001)"],"award-info":[{"award-number":["(CENTRO-01-0145-FEDER-000001)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Worldwide, foodborne diseases are a growing public health problem. Among the infectious bacteria, non-typhoidal Salmonella enterica serovars (NTS) are the major cause of hospitalization and death, and the emergence and spread of their antibiotic-resistance is becoming a worldwide health issue. This, coupled with the restrictions of antibiotics use in agriculture and animal production, calls for alternative approaches to solve this problem. Plant-derived aqueous extracts compounds could provide novel straightforward approaches to control pathogenic bacteria. This review discusses the antimicrobial activity of aqueous plant extracts against Salmonella serovars, the possible mechanisms of action involved, which components\/structures might be responsible for such activity, and the current challenges for the use of these extracts\/components in Salmonella infection management and their application perspectives.<\/jats:p>","DOI":"10.3390\/ijms20040940","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T03:49:44Z","timestamp":1550807384000},"page":"940","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Current Challenges and Perspectives for the Use of Aqueous Plant Extracts in the Management of Bacterial Infections: The Case-Study of Salmonella enterica Serovars"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6749-7619","authenticated-orcid":false,"given":"S\u00f3nia A. O.","family":"Santos","sequence":"first","affiliation":[{"name":"CICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8350-5455","authenticated-orcid":false,"given":"C\u00e1tia","family":"Martins","sequence":"additional","affiliation":[{"name":"QOPNA-Qu\u00edmica Org\u00e2nica, Produtos Naturais e Agroalimentares, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Pereira","sequence":"additional","affiliation":[{"name":"QOPNA-Qu\u00edmica Org\u00e2nica, Produtos Naturais e Agroalimentares, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5403-8416","authenticated-orcid":false,"given":"Armando J. D.","family":"Silvestre","sequence":"additional","affiliation":[{"name":"CICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00edlvia M.","family":"Rocha","sequence":"additional","affiliation":[{"name":"QOPNA-Qu\u00edmica Org\u00e2nica, Produtos Naturais e Agroalimentares, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,21]]},"reference":[{"key":"ref_1","first-page":"932","article-title":"Antimicrobial plant metabolites: Structural diversity and mechanism of action","volume":"20","year":"2013","journal-title":"Curr. Med. 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