{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:17:38Z","timestamp":1768454258639,"version":"3.49.0"},"reference-count":71,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In pregnancy, maternal physiology is subject to considerable adaptations, including alterations in cardiovascular and metabolic function as well as development of immunological tolerance towards the fetus. In an oocyte donation pregnancy, the fetus is fully allogeneic towards the mother, since it carries both oocyte donor antigens and paternal antigens. Therefore, oocyte donation pregnancies result in an immunologically challenging pregnancy, which is reflected by a higher-than-normal risk to develop pre-eclampsia. Based on the allogeneic conditions in oocyte donation pregnancies, we hypothesized that this situation may translate into alterations in concentration of stable readouts of constituents of the reactive species interactome (RSI) compared to normal pregnancies, especially serum free thiols, nitric oxide (NO) and hydrogen sulfide (H2S) related metabolites. Indeed, total free thiol levels and nitrite (NO2\u2212) concentrations were significantly lower whereas protein-bound NO and sulfate (SO42\u2212) concentrations were significantly higher in both oocyte donation and naturally conceived pregnancies complicated by pre-eclampsia. The increased concentrations of nitrite observed in uncomplicated oocyte donation pregnancies suggest that endothelial NO production is compensatorily enhanced to lower vascular tone. More research is warranted on the role of the RSI and bioenergetic status in uncomplicated oocyte donation pregnancies and oocyte donation pregnancies complicated by pre-eclampsia.<\/jats:p>","DOI":"10.3390\/ijms20051150","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T10:52:22Z","timestamp":1551955942000},"page":"1150","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8636-888X","authenticated-orcid":false,"given":"Manon","family":"Bos","sequence":"first","affiliation":[{"name":"Department of Pathology, Leiden University Medical Center, 2333ZA Leiden, The Netherlands"},{"name":"Department of Obstetrics and Gynaecology, Leiden University Medical Center, 2333ZA Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirthe H.","family":"Schoots","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6337-0381","authenticated-orcid":false,"given":"Bernadette O.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Clinical &amp; Experimental Sciences, Faculty of Medicine, University of Southampton and Southampton General Hospital, Southampton SO17 1BJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Mikus-Lelinska","sequence":"additional","affiliation":[{"name":"Clinical &amp; Experimental Sciences, Faculty of Medicine, University of Southampton and Southampton General Hospital, Southampton SO17 1BJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie C.","family":"Lau","sequence":"additional","affiliation":[{"name":"Clinical &amp; Experimental Sciences, Faculty of Medicine, University of Southampton and Southampton General Hospital, Southampton SO17 1BJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Eikmans","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333ZA Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6670-1577","authenticated-orcid":false,"given":"Harry","family":"van Goor","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanne J.","family":"Gordijn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Pasch","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research, University of Bern, 3012 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2320-1158","authenticated-orcid":false,"given":"Martin","family":"Feelisch","sequence":"additional","affiliation":[{"name":"Clinical &amp; Experimental Sciences, Faculty of Medicine, University of Southampton and Southampton General Hospital, Southampton SO17 1BJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Louise P.","family":"van der Hoorn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Leiden University Medical Center, 2333ZA Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0378(03)00083-4","article-title":"The immunological problem of pregnancy: 50 years with the hope of progress. A tribute to Peter Medawar","volume":"60","author":"Billington","year":"2003","journal-title":"J. Reproduct. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1002\/eji.201470065","article-title":"Medawar and the immunological paradox of pregnancy: 60 years on","volume":"44","author":"Colucci","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/S0002-9149(97)00738-8","article-title":"Cardiovascular function before, during, and after the first and subsequent pregnancies","volume":"80","author":"Clapp","year":"1997","journal-title":"Am. J. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/01.mnh.0000436545.94132.52","article-title":"Renal function in normal and disordered pregnancy","volume":"23","author":"Hussein","year":"2014","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.trim.2011.06.004","article-title":"Egg donation pregnancy as an immunological model for solid organ transplantation","volume":"25","author":"Scherjon","year":"2011","journal-title":"Transplant Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.molmed.2014.12.009","article-title":"Maternal uterine natural killer cells nurture fetal growth: In medio stat virtus","volume":"21","author":"Colucci","year":"2015","journal-title":"Trends Mol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1423-0410.2011.01533.x","article-title":"Placental immunology and maternal alloimmune responses","volume":"102","author":"Kumpel","year":"2012","journal-title":"Vox Sang."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0198-8859(02)00396-8","article-title":"Kinetics of the pregnancy-induced humoral and cellular immune response against the paternal HLA class I antigens of the child","volume":"63","author":"Roelen","year":"2002","journal-title":"Hum. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0198-8859(01)00209-9","article-title":"Pregnancy can induce long-persisting primed CTLs specific for inherited paternal HLA antigens","volume":"62","author":"Roelen","year":"2001","journal-title":"Hum. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/molehr\/gav047","article-title":"Tissue microchimerism is increased during pregnancy: A human autopsy study","volume":"21","author":"Rijnink","year":"2015","journal-title":"Mol. Hum. Reproduct."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/humupd\/8.6.493","article-title":"Cell-free fetal DNA and intact fetal cells in maternal blood circulation: Implications for first and second trimester non-invasive prenatal diagnosis","volume":"8","author":"Bischoff","year":"2002","journal-title":"Hum. Reproduct. Update"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/307174a0","article-title":"The establishment and maintenance of pregnancy using in vitro fertilization and embryo donation in a patient with primary ovarian failure","volume":"307","author":"Lutjen","year":"1984","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/humupd\/dmq017","article-title":"Clinical and immunologic aspects of egg donation pregnancies: A systematic review","volume":"16","author":"Lashley","year":"2010","journal-title":"Hum. Reproduct. Update"},{"key":"ref_14","first-page":"96","article-title":"Differential immunoregulation in successful oocyte donation pregnancies compared with naturally conceived pregnancies","volume":"101\u2013102","author":"Swings","year":"2014","journal-title":"J. Reproduct. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Saito, S., Nakabayashi, Y., Nakashima, A., Shima, T., and Yoshino, O. (2016). A new era in reproductive medicine: Consequences of third-party oocyte donation for maternal and fetal health. Semin. Immunopathol.","DOI":"10.1007\/s00281-016-0577-x"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Blazquez, A., Garcia, D., Rodriguez, A., Vassena, R., Figueras, F., and Vernaeve, V. (2016). Is oocyte donation a risk factor for preeclampsia? A systematic review and meta-analysis. J. Assist. Reproduct. Genet.","DOI":"10.1007\/s10815-016-0701-9"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Mol, B.W., Roberts, C.T., Thangaratinam, S., Magee, L.A., de Groot, C.J., and Hofmeyr, G.J. (2016). Pre-eclampsia. Lancet (Lond. Engl.).","DOI":"10.1016\/S0140-6736(15)00070-7"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/00003081-199909000-00002","article-title":"Risk factors for preeclampsia","volume":"42","author":"Dekker","year":"1999","journal-title":"Clin. Obstet. Gynecol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1136\/bmj.38380.674340.E0","article-title":"Risk factors for pre-eclampsia at antenatal booking: Systematic review of controlled studies","volume":"330","author":"Duckitt","year":"2005","journal-title":"BMJ"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/OGX.0b013e31826a5d4a","article-title":"Reproductive outcomes after assisted conception","volume":"67","author":"Talaulikar","year":"2012","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/01.AOG.0000140682.63746.be","article-title":"Advanced maternal age and adverse perinatal outcome","volume":"104","author":"Jacobsson","year":"2004","journal-title":"Obstet. Gynecol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejogrb.2014.07.033","article-title":"Obstetric and perinatal outcomes of twin pregnancies conceived following IVF\/ICSI treatment compared with spontaneously conceived twin pregnancies","volume":"181","author":"Geisler","year":"2014","journal-title":"Eur. J. Obstet. Gynecol. Reproduct. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.fertnstert.2007.06.014","article-title":"Obstetric outcomes in donor oocyte pregnancies compared with advanced maternal age in in vitro fertilization pregnancies","volume":"90","author":"Krieg","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ajog.2015.11.020","article-title":"Oocyte donation pregnancies and the risk of preeclampsia or gestational hypertension: A systematic review and metaanalysis","volume":"214","author":"Masoudian","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Schwarze, J.E., Borda, P., Vasquez, P., Ortega, C., Villa, S., Crosby, J.A., and Pommer, R. (2017). Is the risk of preeclampsia higher in donor oocyte pregnancies? A systematic review and meta-analysis. JBRA Assist. Reproduct.","DOI":"10.5935\/1518-0557.20180001"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/1471-0528.14257","article-title":"Obstetric and neonatal complications in pregnancies conceived after oocyte donation: A systematic review and meta-analysis","volume":"124","author":"Storgaard","year":"2017","journal-title":"BJOG"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet (Lond. Engl.)"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.preghy.2014.02.001","article-title":"The classification, diagnosis and management of the hypertensive disorders of pregnancy: A revised statement from the ISSHP","volume":"4","author":"Tranquilli","year":"2014","journal-title":"Pregnancy Hypertens."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1111\/bph.13544","article-title":"The oxidative stress theory of disease: Levels of evidence and epistemological aspects","volume":"174","author":"Ghezzi","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1016\/j.placenta.2009.12.021","article-title":"Review: Reactive oxygen and nitrogen species and functional adaptation of the placenta","volume":"31","author":"Myatt","year":"2010","journal-title":"Placenta"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0002-9378(99)70259-0","article-title":"Increased contents of phospholipids, cholesterol, and lipid peroxides in decidua basalis in women with preeclampsia","volume":"180","author":"Staff","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Schoots, M.H., Gordijn, S.J., Scherjon, S.A., van Goor, H., and Hillebrands, J.L. (2018). Oxidative stress in placental pathology. Placenta.","DOI":"10.1016\/j.placenta.2018.03.003"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0140-6736(99)80002-6","article-title":"Is oxidative stress the link in the two-stage model of pre-eclampsia?","volume":"354","author":"Roberts","year":"1999","journal-title":"Lancet (Lond. Engl.)"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.3390\/ijms16034600","article-title":"Nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia","volume":"16","author":"Matsubara","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1447-0756.2009.01128.x","article-title":"Role of nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia","volume":"36","author":"Matsubara","year":"2010","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1161\/01.HYP.33.1.83","article-title":"Evidence for peroxynitrite formation in the vasculature of women with preeclampsia","volume":"33","author":"Roggensack","year":"1999","journal-title":"Hypertension"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/HYPERTENSIONAHA.113.01625","article-title":"Gasotransmitters: A solution for the therapeutic dilemma in preeclampsia?","volume":"62","author":"Holwerda","year":"2013","journal-title":"Hypertension"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.placenta.2012.02.014","article-title":"Hydrogen sulfide producing enzymes in pregnancy and preeclampsia","volume":"33","author":"Holwerda","year":"2012","journal-title":"Placenta"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/1753944708092277","article-title":"The role of the L-arginine-nitric oxide pathway in preeclampsia","volume":"2","author":"Arenas","year":"2008","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1080\/00016340701763015","article-title":"Decidual expression and maternal serum levels of heme oxygenase 1 are increased in pre-eclampsia","volume":"87","author":"Eide","year":"2008","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1089\/ars.2017.7083","article-title":"The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine","volume":"27","author":"Koning","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.freeradbiomed.2016.08.024","article-title":"Serum free sulfhydryl status is associated with patient and graft survival in renal transplant recipients","volume":"99","author":"Frenay","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1111\/ajt.12483","article-title":"Emerging role of gasotransmitters in renal transplantation","volume":"13","author":"Snijder","year":"2013","journal-title":"Am. J. Transplant."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.transproceed.2006.10.023","article-title":"DNA fragmentation in acute and chronic rejection after renal transplantation","volume":"39","author":"Ott","year":"2007","journal-title":"Transplant. Proc."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1159\/000329320","article-title":"Reduction of oxidative damage reflects a better kidney transplantation outcome","volume":"34","author":"Lanci","year":"2011","journal-title":"Am. J. Nephrol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/S0891-5849(02)01183-8","article-title":"Concomitant presence of N-nitroso and S-nitroso proteins in human plasma","volume":"33","author":"Rassaf","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.freeradbiomed.2003.11.011","article-title":"Circulating NO pool: Assessment of nitrite and nitroso species in blood and tissues","volume":"36","author":"Rassaf","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"ref_48","first-page":"272","article-title":"Oxidized and free whole blood thiols in preeclampsia","volume":"97","author":"Raijmakers","year":"2001","journal-title":"Obstet. Gynecol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/S0002-9378(94)70064-8","article-title":"The role of nitric oxide in the pathogenesis of preeclampsia","volume":"171","author":"Seligman","year":"1994","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_50","first-page":"130","article-title":"Observations on the inorganic sulphate content of the blood in eclampsia","volume":"13","author":"Anderson","year":"1932","journal-title":"Brit. J. Exp. Pathol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3109\/10641955.2016.1139718","article-title":"Serum nitrate and NOx levels in preeclampsia are higher than in normal pregnancy","volume":"35","author":"Ogando","year":"2016","journal-title":"Hypertens. Pregnancy"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1479-828X.1999.tb03139.x","article-title":"Estimation of oxidative products of nitric oxide (nitrates, nitrites) in preeclampsia","volume":"39","author":"Pathak","year":"1999","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"101126","DOI":"10.1016\/j.redox.2019.101126","article-title":"High glutathionylation of placental endothelial nitric oxide synthase in preeclampsia","volume":"22","author":"Guerby","year":"2019","journal-title":"Redox Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.semcdb.2011.03.004","article-title":"Sulfate in fetal development","volume":"22","author":"Dawson","year":"2011","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.freeradbiomed.2005.08.025","article-title":"Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans","volume":"40","author":"Kleinbongard","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"12814","DOI":"10.1073\/pnas.221381098","article-title":"Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action","volume":"98","author":"Lauer","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_57","first-page":"109","article-title":"Nitric oxide: Physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/ki.1996.420","article-title":"Impact of nitric oxide deficiency on blood pressure and glomerular hemodynamic adaptations to pregnancy in the rat","volume":"50","author":"Deng","year":"1996","journal-title":"Kidney Int."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.phrs.2016.06.027","article-title":"Serum free thiols in chronic heart failure","volume":"111","author":"Koning","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.placenta.2017.01.001","article-title":"Review: Nutrient sulfate supply from mother to fetus: Placental adaptive responses during human and animal gestation","volume":"54","author":"Dawson","year":"2017","journal-title":"Placenta"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Bender Atik, R., Christiansen, O.B., Elson, J., Kolte, A.M., Lewis, S., Middeldorp, S., Nelen, W., Peramo, B., Quenby, S., and Vermeulen, N. (2018). ESHRE guideline: Recurrent pregnancy loss. Hum. Reproduct. Open, 2018.","DOI":"10.1093\/hropen\/hoy004"},{"key":"ref_62","unstructured":"Guideline, G.-T. (2019, March 04). The Investigation and Treatment of Couples with Recurrent First-Trimester and Second-Trimester Miscarriage. Available online: https:\/\/www.rcog.org.uk\/globalassets\/documents\/guidelines\/gtg_17.pdf."},{"key":"ref_63","unstructured":"Kleiverda, G., and Derksen, J. (2019, March 04). Zwangerschapsafbreking tot 24 Weken [Termination of Pregnancy Until 24 Weeks of Gestational Age]. Guidelines of the Netherlands Association for Obstetrics and Gynaecology (NVOG): 2015. Available online: https:\/\/www.nvog.nl\/wp-content\/uploads\/2018\/02\/Zwangerschapsafbreking-tot-24-weken-2.0-28-05-2015.pdf."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1097\/AOG.0b013e3182392977","article-title":"Nomenclature for pregnancy outcomes: Time for a change","volume":"118","author":"Silver","year":"2011","journal-title":"Obstet. Gynecol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Brown, M.A., Lindheimer, M.D., de Swiet, M., Van Assche, A., and Moutquin, J.M. (2001). The classification and diagnosis of the hypertensive disorders of pregnancy: Statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens. Pregnancy, 20.","DOI":"10.3109\/10641950109152635"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s00431-016-2740-8","article-title":"Defining small-for-gestational-age: Prescriptive versus descriptive birthweight standards","volume":"175","author":"Hoftiezer","year":"2016","journal-title":"Eur. J. Pediatr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_68","first-page":"257","article-title":"Antioxidant protection against hypochlorous acid in human plasma","volume":"121","author":"Hu","year":"1993","journal-title":"J. Lab. Clin. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0003-2697(81)90498-X","article-title":"Analysis of biological thiols: Derivatization with monobromobimane and separation by reverse-phase high-performance liquid chromatography","volume":"114","author":"Newton","year":"1981","journal-title":"Anal. Biochem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.2215\/CJN.10241110","article-title":"Sodium thiosulfate pharmacokinetics in hemodialysis patients and healthy volunteers","volume":"6","author":"Farese","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1681\/ASN.2013050497","article-title":"Urinary sulfur metabolites associate with a favorable cardiovascular risk profile and survival benefit in renal transplant recipients","volume":"25","author":"Pasch","year":"2014","journal-title":"J. Am. Soc. 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