{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:35:15Z","timestamp":1791909315911,"version":"4.3.4"},"reference-count":40,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation","award":["TCRD-TPE-MOST-105-03, TCRD-TPE-MOST-106-01, TCRD-TPE-106-C1-1, TCRD-TPE-106-RT-3"],"award-info":[{"award-number":["TCRD-TPE-MOST-105-03, TCRD-TPE-MOST-106-01, TCRD-TPE-106-C1-1, TCRD-TPE-106-RT-3"]}]},{"name":"Buddhist Tzu Chi Medical Foundation Academic Advancement","award":["TCMF-A 106-01-16"],"award-info":[{"award-number":["TCMF-A 106-01-16"]}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["MOST 104-2314-B-303-013-MY3"],"award-info":[{"award-number":["MOST 104-2314-B-303-013-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["MOST 103-2314-B-002-189 and MOST 107-2314-B-002 -009 and MOST 107-2314-B-002 -261-MY3"],"award-info":[{"award-number":["MOST 103-2314-B-002-189 and MOST 107-2314-B-002 -009 and MOST 107-2314-B-002 -261-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natinal taiwan univeristy hospital","award":["NTUH-104-S2649, NTUH-104-S2671, NTUH104-2640, NTUH104-UN001, NTUH104L005, MOST-104-2314-B-002-193-MY3, MOST 103-2314-B-002-189"],"award-info":[{"award-number":["NTUH-104-S2649, NTUH-104-S2671, NTUH104-2640, NTUH104-UN001, NTUH104L005, MOST-104-2314-B-002-193-MY3, MOST 103-2314-B-002-189"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chemerin, a novel adipokine, has been associated with metabolic, inflammatory, and atherosclerotic diseases. We aimed to determine the genetic basis of chemerin levels by conducting a genome-wide association study (GWAS) and to investigate the role of RARRES2 polymorphisms and circulating chemerin levels in the long-term outcome of coronary artery disease (CAD). A total of 2197 participants from the Taiwan Biobank (TWB) were recruited for the GWAS analysis, and 481 patients with angiographically confirmed CAD were enrolled for long-term outcome analysis. One locus of genome-wide significance with a single independent association signal was identified in the GWAS for chemerin levels with the peak association at the RARRES2 gene promoter region polymorphism rs3735167 (p = 2.35 \u00d7 10\u221221). In the CAD population, borderline significance was noted between RARRES2 polymorphisms and chemerin levels, whereas high chemerin levels were associated with obesity, female sex, diabetes mellitus, hypertension, current smoking, high platelet and leukocyte counts, anemia, impaired renal function, high C-reactive protein (CRP) levels, and multi-vessel disease. Kaplan\u2013Meier survival curves indicated that the patients with high chemerin and CRP levels, but not those with RARRES2 polymorphisms, had a lower survival rate and higher combined cerebral and cardiovascular event rates. Combined chemerin and CRP levels further revealed a stepwise increase in poor clinical outcomes from low- to high-risk subgroups. In conclusion, rs3735167 is the lead RARRES2 polymorphism for chemerin levels in Taiwanese. Chemerin levels, but not the rs3735167 genotypes, predicted the long-term outcome of CAD, especially when combined with CRP levels.<\/jats:p>","DOI":"10.3390\/ijms20051174","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T04:58:35Z","timestamp":1552021115000},"page":"1174","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Circulating Chemerin Levels, but not the RARRES2 Polymorphisms, Predict the Long-Term Outcome of Angiographically Confirmed Coronary Artery Disease"],"prefix":"10.3390","volume":"20","author":[{"given":"Leay Kiaw","family":"Er","sequence":"first","affiliation":[{"name":"The Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan"},{"name":"School of Medicine, Tzu Chi University, Hualien 97004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0012-2804","authenticated-orcid":false,"given":"Lung-An","family":"Hsu","sequence":"additional","affiliation":[{"name":"The First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan 33305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyh-Ming Jimmy","family":"Juang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital city, Taipei 10002, Taiwan"},{"name":"Taipei, Taiwan and National Taiwan University College of Medicine, Taipei 10002, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Tien","family":"Chiang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital city, Taipei 10002, Taiwan"},{"name":"Taipei, Taiwan and National Taiwan University College of Medicine, Taipei 10002, Taiwan"},{"name":"Cardiovascular Center and Division of Cardiology, Fu-Jen Catholic University Hospital, New Taipei city 24352, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Sheng","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei city 23142, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9047-8141","authenticated-orcid":false,"given":"I-Shiang","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei city 23142, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semon","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Life Science, Chinese Culture University, Taipei 11114, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeng-Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Medicine, Tzu Chi University, Hualien 97004, Taiwan"},{"name":"Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei city 23142, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Lin","family":"Ko","sequence":"additional","affiliation":[{"name":"School of Medicine, Tzu Chi University, Hualien 97004, Taiwan"},{"name":"Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei city 23142, Taiwan"},{"name":"Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei city 23142, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12020-012-9698-8","article-title":"Chemerin: A potential endocrine link between obesity and type 2 diabetes","volume":"42","author":"Roman","year":"2012","journal-title":"Endocrine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1160\/TH14-06-0513","article-title":"Adipokines at the crossroad between obesity and cardiovascular disease","volume":"113","author":"Molica","year":"2015","journal-title":"Thromb. 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