{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T08:28:05Z","timestamp":1772526485981,"version":"3.50.1"},"reference-count":62,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012164","name":"Mrs Gladys Row Fogo Charitable Trust","doi-asserted-by":"publisher","award":["BROD.FID3668413"],"award-info":[{"award-number":["BROD.FID3668413"]}],"id":[{"id":"10.13039\/100012164","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["088134\/Z\/0"],"award-info":[{"award-number":["088134\/Z\/0"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020","doi-asserted-by":"publisher","award":["PHC-03-15, project No 666881, \u2018SVDs@Target\u2019"],"award-info":[{"award-number":["PHC-03-15, project No 666881, \u2018SVDs@Target\u2019"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","award":["16 CVD 05"],"award-info":[{"award-number":["16 CVD 05"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Brain iron deposits (IDs) are inversely associated with cognitive function in community-dwelling older people, but their association with cognition after ischemic stroke, and whether that differs from microbleeds, is unknown. We quantified basal ganglia IDs (BGID) and microbleeds (BMBs) semi-automatically on brain magnetic resonance images from patients with minor stroke (NIHSS &lt; 7), at presentation and 12 months after stroke. We administered the National Adult Reading Test (NART, estimates premorbid or peak adult cognition) and the Revised Addenbrooke\u2019s Cognitive Examination (ACE-R; current cognition) at 1 and 12 months after stroke. We adjusted analyses for baseline cognition, age, gender, white matter hyperintensity (WMH) volume and vascular risk factors. In 200 patients, mean age 65 years, striatal IDs and BMBs volumes did not change over the 12 months. Baseline BGID volumes correlated positively with NART scores at both times (\u03c1 = 0.19, p &lt; 0.01). Baseline and follow-up BGID volumes correlated positively with age (\u03c1 = 0.248, p &lt; 0.001 and \u03c1 = 0.271, p &lt; 0.001 respectively), but only baseline (and not follow-up) BMB volume correlated with age (\u03c1 = 0.129, p &lt; 0.05). Both smoking and baseline WMH burden predicted verbal fluency and visuospatial abilities scores (B = \u22121.13, p &lt; 0.02 and B = \u22120.22, p = 0.001 respectively) at 12 months after stroke. BGIDs and BMBs are associated differently with cognition post-stroke; studies of imaging and post-stroke cognition should adjust for premorbid cognition. The positive correlation of BGID with NART may reflect the lower premorbid cognition in patients with stroke at younger vs older ages.<\/jats:p>","DOI":"10.3390\/ijms20061293","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T04:12:09Z","timestamp":1552623129000},"page":"1293","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association between Striatal Brain Iron Deposition, Microbleeds and Cognition 1 Year After a Minor Ischaemic Stroke"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2771-6546","authenticated-orcid":false,"given":"Maria del C.","family":"Vald\u00e9s Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH16 4SB, UK"},{"name":"Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK"},{"name":"Dementia Research Institute, University of Edinburgh, Edinburgh EH16 4SB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tessa","family":"Case","sequence":"additional","affiliation":[{"name":"Row Fogo Centre for Ageing and the Brain, University of Edinburgh, Edinburgh EH16 4SB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca M.","family":"Chappell","sequence":"additional","affiliation":[{"name":"College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH16 4SB, UK"},{"name":"Dementia Research Institute, University of Edinburgh, Edinburgh EH16 4SB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Glatz","sequence":"additional","affiliation":[{"name":"College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH16 4SB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Makin","sequence":"additional","affiliation":[{"name":"College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH16 4SB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fergus","family":"Doubal","sequence":"additional","affiliation":[{"name":"College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH16 4SB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna M.","family":"Wardlaw","sequence":"additional","affiliation":[{"name":"College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH16 4SB, UK"},{"name":"Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK"},{"name":"Dementia Research Institute, University of Edinburgh, Edinburgh EH16 4SB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s11357-015-9837-2","article-title":"Brain iron deposits and lifespan cognitive ability","volume":"37","author":"Ritchie","year":"2015","journal-title":"Age"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1111\/ene.13006","article-title":"Do white matter hyperintensities mediate the association between brain iron deposition and cognitive abilities in older people?","volume":"23","author":"Allerhand","year":"2016","journal-title":"Eur. J. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.neurobiolaging.2010.04.032","article-title":"Brain iron deposits are associated with general cognitive ability and cognitive aging","volume":"33","author":"Penke","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.neuroimage.2013.06.013","article-title":"Characterization of multifocal T2*-weighted MRI hypointensities in the basal ganglia of elderly, community-dwelling subjects","volume":"82","author":"Glatz","year":"2013","journal-title":"NeuroImage"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jtemb.2013.08.001","article-title":"Iron levels in the human brain: A post-mortem study of anatomical region differences and age-related changes","volume":"28","author":"Ramos","year":"2014","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1471-4159.2006.04079.x","article-title":"Deposition of iron and \u03b2-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets","volume":"99","author":"Ghribi","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/01.STR.25.8.1543","article-title":"Iron-related damage in acute ischemic stroke","volume":"25","author":"Davalos","year":"1994","journal-title":"Stroke"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1212\/WNL.54.8.1568","article-title":"Body iron stores and early neurologic deterioration in acute cerebral infarction","volume":"54","author":"Davalos","year":"2000","journal-title":"Neurology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1093\/brain\/awl387","article-title":"Spontaneous brain microbleeds: Systematic review, subgroup analyses and standards for study design and reporting","volume":"130","author":"Cordonnier","year":"2007","journal-title":"Brain"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1093\/brain\/awh253","article-title":"Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI","volume":"127","author":"Werring","year":"2004","journal-title":"Brain"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1161\/STROKEAHA.118.021981","article-title":"Neuroimaging Determinants of Poststroke Cognitive Performance","volume":"49","author":"Puy","year":"2018","journal-title":"Stroke"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1097\/HJH.0000000000001294","article-title":"MRI progression of cerebral small vessel disease and cognitive decline in patients with hypertension","volume":"35","author":"Uiterwijk","year":"2017","journal-title":"J. Hypertens."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/ana.10380","article-title":"Late secondary ischemic injury in patients receiving intraarterial thrombolysis","volume":"52","author":"Kidwell","year":"2002","journal-title":"Ann. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1161\/01.STR.31.4.946","article-title":"Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats: Correlation with histopathology","volume":"31","author":"Li","year":"2000","journal-title":"Stroke"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1148\/radiology.168.1.3380958","article-title":"Iron accumulation in the basal ganglia following severe ischemic-anoxic insults in children","volume":"168","author":"Dietrich","year":"1988","journal-title":"Radiology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1177\/1747493016641966","article-title":"Decreased kidney function relates to progression of cerebral microbleeds in lacunar stroke patients","volume":"11","author":"Staals","year":"2016","journal-title":"Int. J. Stroke"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1161\/STROKEAHA.118.021160","article-title":"Effect of Antihypertensive Medication on Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis","volume":"49","author":"Argillander","year":"2018","journal-title":"Stroke"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1212\/WNL.0000000000003123","article-title":"Accelerated development of cerebral small vessel disease in young stroke patients","volume":"87","author":"Arntz","year":"2016","journal-title":"Neurology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1177\/0300060518755623","article-title":"Considerations on accuracy, pattern and possible underlying factors of brain microbleed progression in older adults with absence or mild presence of vascular pathology","volume":"46","author":"Harper","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1177\/0271678X16647396","article-title":"Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease","volume":"36","author":"Jouvent","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.jalz.2016.09.006","article-title":"Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: Evidence from a cohort study","volume":"13","author":"Wardlaw","year":"2017","journal-title":"Alz. Dement."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Lee, S.H., Lee, S.T., Kim, B.J., Park, H.K., Kim, C.K., Jung, K.H., and Roh, J.K. (2011). Dynamic temporal change of cerebral microbleeds: Long-term follow-up MRI study. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0025930"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1148\/radiology.189.1.8372185","article-title":"MR appearance of hemorrhage in the brain","volume":"189","author":"Bradley","year":"1993","journal-title":"Radiology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/jmri.24348","article-title":"Differentiation of calcified regions and iron deposits in the ageing brain on conventional structural MR images","volume":"40","author":"Glatz","year":"2014","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1161\/01.STR.0000018012.65108.86","article-title":"Silent cerebral microbleeds on T2*-weighted MRI: Correlation with stroke subtype, stroke recurrence, and leukoaraiosis","volume":"33","author":"Kato","year":"2002","journal-title":"Stroke"},{"key":"ref_26","first-page":"88","article-title":"Brain microhemorrhages detected on T2*-weighted gradient-echo MR images","volume":"24","author":"Tsushima","year":"2003","journal-title":"Am. J. Neuroradiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jstrokecerebrovasdis.2009.12.001","article-title":"Clinical characteristics by topographical distribution of brain microbleeds, with a particular emphasis on diffuse microbleeds","volume":"20","author":"Yakushiji","year":"2011","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0304-3940(03)00121-6","article-title":"Cerebral microbleeds in Binswanger\u2019s disease: A gradient-echo T2*-weighted magnetic resonance imaging study","volume":"340","author":"Hanyu","year":"2003","journal-title":"Neurosci. Lett."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1161\/01.STR.0000090841.90286.81","article-title":"Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic stroke","volume":"34","author":"Fan","year":"2003","journal-title":"Stroke"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jstrokecerebrovasdis.2005.05.003","article-title":"The prevalence of microhemorrhage on gradient-echo magnetic resonance imaging in acute lacunar infarction","volume":"14","author":"Schonewille","year":"2005","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.neuroimage.2014.10.001","article-title":"Automated segmentation of multifocal basal ganglia T2*-weighted MRI hypointensities","volume":"105","author":"Glatz","year":"2015","journal-title":"NeuroImage"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S1474-4422(10)70164-2","article-title":"Predictors and assessment of cognitive dysfunction resulting from ischaemic stroke","volume":"9","author":"Gottesman","year":"2010","journal-title":"Lancet Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1600-0404.2006.00768.x","article-title":"Recovery after stroke: Cognition, ADL function and return to work","volume":"115","author":"Hofgren","year":"2007","journal-title":"Acta Neurol. Scand."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"McHutchison, C.A., Cvoro, V., Makin, S., Chappell, F.M., Shuler, K., and Wardlaw, J.M. (2018). Functional, cognitive and physical outcomes 3 years after minor lacunar or cortical ischaemic stroke. J. Neurol. Neurosurg. Psychiatr.","DOI":"10.1136\/jnnp-2018-319134"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11682-008-9059-7","article-title":"Relevance of iron deposition in deep gray matter brain structures to cognitive and motor performance in healthy elderly men and women: Exploratory findings","volume":"3","author":"Sullivan","year":"2009","journal-title":"Brain Imaging Behav."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/RMR.0b013e31802c14e6","article-title":"Why is the study of iron important for magnetic resonance imaging?","volume":"17","author":"Killiany","year":"2006","journal-title":"Top. Magn. Reson. Imaging"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1747-4949.2011.00682.x","article-title":"Absence of cerebral microbleeds predicts reversion of vascular \u2018cognitive impairment no dementia\u2019 in stroke","volume":"6","author":"Tang","year":"2011","journal-title":"Int. J. Stroke"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1159\/000336237","article-title":"Cerebral microbleeds and long-term cognitive outcome: Longitudinal cohort study of stroke clinic patients","volume":"33","author":"Gregoire","year":"2012","journal-title":"Cerebrovasc. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1161\/STROKEAHA.108.516112","article-title":"Brain microbleeds and global cognitive function in adults without neurological disorder","volume":"39","author":"Yakushiji","year":"2008","journal-title":"Stroke"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jstrokecerebrovasdis.2009.11.007","article-title":"Clinical correlating factors and cognitive function in community-dwelling healthy subjects with cerebral microbleeds","volume":"20","author":"Takashima","year":"2011","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1161\/STROKEAHA.110.607184","article-title":"Incidence of cerebral microbleeds in the general population: The Rotterdam Scan Study","volume":"42","author":"Poels","year":"2011","journal-title":"Stroke"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Mijajlovi\u0107, M.D., Pavlovi\u0107, A., Brainin, M., Heiss, W.D., Quinn, T.J., Ihle-Hansen, H.B., Hermann, D.M., Assayag, E.B., Richard, E., and Thiel, A. (2017). Post-stroke dementia\u2014A comprehensive review. BMC Med., 15.","DOI":"10.1186\/s12916-017-0779-7"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1136\/jnnp-2013-306776","article-title":"Progression of cognitive impairment in stroke\/TIA patients over 3 years","volume":"85","author":"Sachdev","year":"2014","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"229-e16","DOI":"10.1111\/ene.12626","article-title":"Post-stroke cognitive decline: An update and perspectives for clinical research","volume":"22","author":"Brainin","year":"2015","journal-title":"Eur. J. Neurol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3233\/JAD-160939","article-title":"Only White Matter Hyperintensities Predicts Post-Stroke Cognitive Performances Among Cerebral Small Vessel Disease Markers: Results from the TABASCO Study","volume":"56","author":"Molad","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: An American Heart Association\/National Heart, Lung, and Blood Institute scientific statement","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1161\/STROKEAHA.114.004130","article-title":"Risk factors, stroke prevention treatments, and prevalence of cerebral microbleeds in the Framingham Heart Study","volume":"45","author":"Romero","year":"2014","journal-title":"Stroke"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3174\/ajnr.A4176","article-title":"Cerebral microbleeds: Different prevalence, topography, and risk factors depending on dementia diagnosis\u2014The Karolinska Imaging Dementia Study","volume":"36","author":"Shams","year":"2015","journal-title":"Am. J. Neuroradiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1196\/annals.1379.018","article-title":"Brain aging and its modifiers","volume":"1097","author":"Raz","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.neuroimage.2010.09.068","article-title":"Differential effects of age and history of hypertension on regional brain volumes and iron","volume":"54","author":"Rodrigue","year":"2011","journal-title":"Neuroimage"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00041552-200103000-00014","article-title":"Oxidative stress and vascular damage in hypertension","volume":"10","author":"Berry","year":"2001","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1523\/JNEUROSCI.4717-14.2015","article-title":"Striatal iron content predicts its shrinkage and changes in verbal working memory after two years in healthy adults","volume":"35","author":"Daugherty","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fnagi.2013.00034","article-title":"A delicate balance: Iron metabolism and diseases of the brain","volume":"5","author":"Hare","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1046\/j.1471-4159.2003.02221.x","article-title":"Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain","volume":"88","author":"Deane","year":"2004","journal-title":"J. Neurochem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1161\/HYPERTENSIONAHA.107.100610","article-title":"Brain microbleeds are associated with ambulatory blood pressure levels in a hypertensive population","volume":"51","author":"Henskens","year":"2008","journal-title":"Hypertension"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"200","DOI":"10.7326\/0003-4819-121-3-199408010-00008","article-title":"The use of predicted confidence intervals when planning experiments and the misuse of power when interpreting results","volume":"121","author":"Goodman","year":"1994","journal-title":"Ann. Int. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.3174\/ajnr.A4351","article-title":"Cerebral microbleeds, CSF p-tau, and cognitive decline: Significance of anatomic distribution","volume":"36","author":"Chiang","year":"2015","journal-title":"Am. J. Neuroradiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/jcbfm.2015.64","article-title":"Blood pressure and sodium: Association with MRI markers in cerebral small vessel disease","volume":"36","author":"Heye","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e00415","DOI":"10.1002\/brb3.415","article-title":"Rationale, design and methodology of the image analysis protocol for studies of patients with cerebral small vessel disease and mild stroke","volume":"5","author":"Armitage","year":"2015","journal-title":"Brain Behav."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/gps.1610","article-title":"The Addenbrooke\u2019s Cognitive Examination Revised (ACE-R): A brief cognitive test battery for dementia screening","volume":"21","author":"Mioshi","year":"2006","journal-title":"Int. J. Geriatr. Psychiatr."},{"key":"ref_61","unstructured":"Nelson, H.E., and Willison, J. (1991). National Adult Reading Test (NART), Nfer-Nelson."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e606","DOI":"10.3389\/fpsyg.2012.00606","article-title":"Robust correlation analyses: False positive and power validation using a new open source Matlab toolbox","volume":"3","author":"Pernet","year":"2013","journal-title":"Front. Psychol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/6\/1293\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:38:53Z","timestamp":1760186333000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/6\/1293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,14]]},"references-count":62,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,3]]}},"alternative-id":["ijms20061293"],"URL":"https:\/\/doi.org\/10.3390\/ijms20061293","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,14]]}}}