{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T01:32:15Z","timestamp":1775871135820,"version":"3.50.1"},"reference-count":93,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006345","name":"Uniwersytet Mikolaja Kopernika w Toruniu","doi-asserted-by":"publisher","award":["MN-8\/WF\/2016"],"award-info":[{"award-number":["MN-8\/WF\/2016"]}],"id":[{"id":"10.13039\/501100006345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The growing interest in anticancer hybrids in the last few years has resulted in a great number of reports on hybrid design, synthesis and bioevaluation. Many novel multi-target-directed drug candidates were synthesized, and their biological activities were evaluated. For the design of anticancer hybrid compounds, the molecules of stilbenes, aromatic quinones, and heterocycles (benzimidazole, imidazole, pyrimidine, pyridine, pyrazole, quinoline, quinazoline) were applied. A distinct group of hybrids comprises the molecules built with natural compounds: Resveratrol, curcumin, coumarin, and oleanolic acid. In this review, we present the studies on bioactive hybrid molecules of a well-known tubulin polymerization inhibitor, combretastatin A-4 and its analogs with other pharmacologically active entities. The mechanism of anticancer activity of selected hybrids is discussed considering the structure-activity relationship.<\/jats:p>","DOI":"10.3390\/ijms20061300","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T04:12:09Z","timestamp":1552623129000},"page":"1300","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Hybrid cis-stilbene Molecules: Novel Anticancer Agents"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3011-7536","authenticated-orcid":false,"given":"Natalia","family":"Pieku\u015b-S\u0142omka","sequence":"first","affiliation":[{"name":"Department of Inorganic and Analytical Chemistry, Nicolaus Copernicus University in Toru\u0144, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-089 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1908-7858","authenticated-orcid":false,"given":"Renata","family":"Mikstacka","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Analytical Chemistry, Nicolaus Copernicus University in Toru\u0144, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-089 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Ronowicz","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Analytical Chemistry, Nicolaus Copernicus University in Toru\u0144, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-089 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanis\u0142aw","family":"Sobiak","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Analytical Chemistry, Nicolaus Copernicus University in Toru\u0144, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-089 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.4155\/fmc-2017-0014","article-title":"Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration","volume":"9","author":"Ramos","year":"2017","journal-title":"Future Med. 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