{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:50:43Z","timestamp":1788371443729,"version":"build-2803163510"},"reference-count":21,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health, Labour and Welfare of Japan","award":["H23-Jisedai-Ippan-001, H25-Jisedai-Shitei-003, and H30-Kansei-Shitei-002"],"award-info":[{"award-number":["H23-Jisedai-Ippan-001, H25-Jisedai-Shitei-003, and H30-Kansei-Shitei-002"]}]},{"name":"Japan Agency for Medical Research and Development, AMED","award":["15gk0110003h0103 and 16gk0110021h0001"],"award-info":[{"award-number":["15gk0110003h0103 and 16gk0110021h0001"]}]},{"name":"Kawano Masanori Memorial Foundation for Promotion of Pediatrics","award":["2018"],"award-info":[{"award-number":["2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Although earlier studies have shown that antiviral treatment regimens using valganciclovir (VGCV) improved hearing function in some infants with congenital cytomegalovirus (CMV) infection; its efficacy on the severity of hearing dysfunction is unclear. We conducted a prospective study among 26 infants with congenital CMV infections from 2009 to 2018. Oral VGCV (32 mg\/kg\/day) was administered for 6 weeks (November 2009 to June 2015; n = 20) or 6 months (July 2015 to March 2018, n = 6). Hearing function was evaluated by measuring the auditory brainstem response before VGCV treatment and at 6 months. Hearing dysfunction, defined as a V-wave threshold &gt;40 dB, was categorized into: most severe, \u226591 dB; severe, 61\u201390 dB; and moderate, 41\u201360 dB. Hearing improvement was defined as a decrease of \u226520 dB from the pretreatment V-wave threshold. Of 52 ears in 26 infants with congenital CMV infection, 29 (56%) had hearing dysfunction, and of 29 ears, 16 (55%) improved after VGCV treatment. Although, 16 (84%) of 19 ears with moderate or severe hearing dysfunction improved after treatment (p &lt; 0.001), 10 ears with the most severe form did not. In conclusion, VGCV treatment is effective in improving moderate and severe hearing dysfunction in infants with congenital CMV infection.<\/jats:p>","DOI":"10.3390\/ijms20061388","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T12:12:25Z","timestamp":1552997545000},"page":"1388","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Efficacy of Valganciclovir Treatment Depends on the Severity of Hearing Dysfunction in Symptomatic Infants with Congenital Cytomegalovirus Infection"],"prefix":"10.3390","volume":"20","author":[{"given":"Shohei","family":"Ohyama","sequence":"first","affiliation":[{"name":"Departments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5685-2670","authenticated-orcid":false,"given":"Ichiro","family":"Morioka","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"},{"name":"Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiyo","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Yamana","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Nishida","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2871-4000","authenticated-orcid":false,"given":"Sota","family":"Iwatani","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9913-6447","authenticated-orcid":false,"given":"Kazumichi","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisayuki","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Departments of Clinical Laboratory, Kobe University Hospital, Kobe 650-0017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamitsu","family":"Imanishi","sequence":"additional","affiliation":[{"name":"Departments of Clinical Laboratory, Kobe University Hospital, Kobe 650-0017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Nakamachi","sequence":"additional","affiliation":[{"name":"Departments of Clinical Laboratory, Kobe University Hospital, Kobe 650-0017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Deguchi","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Tanimura","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumoto","family":"Iijima","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9839-2214","authenticated-orcid":false,"given":"Hideto","family":"Yamada","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1056\/NEJMra050700","article-title":"Newborn hearing screening\u2014A silent revolution","volume":"354","author":"Morton","year":"2006","journal-title":"N. 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