{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:52:31Z","timestamp":1787928751594,"version":"build-2784847793"},"reference-count":88,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Centers in Minority Institutions","award":["U54MD007586-01"],"award-info":[{"award-number":["U54MD007586-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Pericytes are multipotent cells of the vascular system with cytoplasmic extensions proximal to endothelial cells that occur along the abluminal surface of the endothelium. The interactions between endothelial cells and pericytes are essential for proper microvascular formation, development, stabilization, and maintenance. Pericytes are essential for the regulation of paracellular flow between cells, transendothelial fluid transport, angiogenesis, and vascular immunosurveillance. They also influence the chemical composition of the surrounding microenvironment to protect endothelial cells from potential harm. Dysregulation or loss of pericyte function can result in microvascular instability and pathological consequences. Human pericytes have been shown to be targets for human cytomegalovirus (HCMV) infection and lytic replication that likely contribute to vascular inflammation. This review focuses on human vascular pericytes and their permissiveness for HCMV infection. It also discusses their implication in pathogenesis in the blood\u2013brain barrier (BBB), the inner blood\u2013retinal barrier (IBRB), the placenta\u2013blood barrier, and the renal glomerulus as well as their potential role in subclinical vascular disease.<\/jats:p>","DOI":"10.3390\/ijms20061456","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T06:56:52Z","timestamp":1553497012000},"page":"1456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Human Vascular Pericytes and Cytomegalovirus Pathobiology"],"prefix":"10.3390","volume":"20","author":[{"given":"Donald J.","family":"Alcendor","sequence":"first","affiliation":[{"name":"Center for AIDS Health Disparities Research, Department of Microbiology, Immunology, and Physiology, School of Medicine, Meharry Medical College, 1005 Dr. D.B. Todd Jr. Blvd., Hubbard Hospital, 5th Floor, Rm. 5025, Nashville, TN 37208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"ref_1","unstructured":"Eberth, C.J. (1871). Handbuch der Lehre von der Gewegen des Menschen und der Tiere, Engelmann."},{"key":"ref_2","first-page":"603","article-title":"Me\u2019moire sur le de\u00b4veloppement, la structure et les propriete\u00b4s physiologiques des capillaires sanguins et lymphatiques","volume":"5","author":"Rouget","year":"1873","journal-title":"Arch. Physiol. Norm Path."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF02593544","article-title":"Der feinere Bau der Blutkapillaren","volume":"68","author":"Zimmermann","year":"1923","journal-title":"Z. Anat. 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