{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:26:03Z","timestamp":1777555563338,"version":"3.51.4"},"reference-count":71,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016034","name":"Fondation du Rein","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100016034","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Lipid disorders have been associated with glomerulopathies, a distinct type of renal pathologies, such as nephrotic syndrome. Global analyses targeting kidney lipids in this pathophysiologic context have been extensively performed, but most often regardless of the architectural and functional complexity of the kidney. The new developments in mass spectrometry imaging technologies have opened a promising field in localized lipidomic studies focused on this organ. In this article, we revisit the main works having employed the Matrix Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF) technology, and the few reports on the use of TOF-Secondary Ion Mass Spectrometry (TOF-SIMS). We also present a first analysis of mouse kidney cortex sections by cluster TOF-SIMS. The latter represents a good option for high resolution lipid imaging when frozen unfixed histological samples are available. The advantages and drawbacks of this developing field are discussed.<\/jats:p>","DOI":"10.3390\/ijms20071623","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T03:21:26Z","timestamp":1554175286000},"page":"1623","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Kidney Lipidomics by Mass Spectrometry Imaging: A Focus on the Glomerulus"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8804-0757","authenticated-orcid":false,"given":"Imane","family":"Abbas","sequence":"first","affiliation":[{"name":"Lebanese Atomic Energy Commission, NCSR, Beirut 11-8281, Lebanon"},{"name":"Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, Universit\u00e9 Paris-Saclay, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manale","family":"Noun","sequence":"additional","affiliation":[{"name":"Lebanese Atomic Energy Commission, NCSR, Beirut 11-8281, Lebanon"},{"name":"Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, Universit\u00e9 Paris-Saclay, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Touboul","sequence":"additional","affiliation":[{"name":"Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, Universit\u00e9 Paris-Saclay, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dil","family":"Sahali","sequence":"additional","affiliation":[{"name":"Institut Mondor de Recherche Biom\u00e9dicale, INSERM, U955 EQ21, 8, rue du G\u00e9n\u00e9ral Sarrail, 94010 Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris Est Cr\u00e9teil, 61, avenue du G\u00e9n\u00e9ral de Gaulle, 94010 Cr\u00e9teil, France"},{"name":"H\u00f4pital Henri Mondor, 51 avenue du Mar\u00e9chal de Lattre de Tassigny, 94010 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6526-6481","authenticated-orcid":false,"given":"Alain","family":"Brunelle","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Arch\u00e9ologie Mol\u00e9culaire et Structurale, LAMS UMR8220, CNRS, Sorbonne Universit\u00e9, 4 place Jussieu, 75005 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3590-706X","authenticated-orcid":false,"given":"Mario","family":"Ollero","sequence":"additional","affiliation":[{"name":"Institut Mondor de Recherche Biom\u00e9dicale, INSERM, U955 EQ21, 8, rue du G\u00e9n\u00e9ral Sarrail, 94010 Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris Est Cr\u00e9teil, 61, avenue du G\u00e9n\u00e9ral de Gaulle, 94010 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.kint.2016.02.026","article-title":"Disorders of lipid metabolism in nephrotic syndrome: Mechanisms and consequences","volume":"90","author":"Vaziri","year":"2016","journal-title":"Kidney Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1172\/JCI114750","article-title":"Proteinuria, not altered albumin metabolism, affects hyperlipidemia in the nephrotic rat","volume":"86","author":"Davies","year":"1990","journal-title":"J. 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