{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:45:10Z","timestamp":1790693110548,"version":"4.1.0"},"reference-count":49,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010081","name":"Conseil R\u00e9gional de La R\u00e9union","doi-asserted-by":"publisher","award":["ZIKAlert program, N\u00b0 SYNERGIE: RE00001902"],"award-info":[{"award-number":["ZIKAlert program, N\u00b0 SYNERGIE: RE00001902"]}],"id":[{"id":"10.13039\/501100010081","id-type":"DOI","asserted-by":"publisher"}]},{"name":"INSERM-Transfert","award":["project: n\u00b0R16029FS"],"award-info":[{"award-number":["project: n\u00b0R16029FS"]}]},{"name":"CAPES-COFECUB","award":["Me889\/17 ZIKANET"],"award-info":[{"award-number":["Me889\/17 ZIKANET"]}]},{"name":"Research Federation BioST, Universit\u00e9 de La R\u00e9union","award":["ZIKAPAMIRE"],"award-info":[{"award-number":["ZIKAPAMIRE"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The recent emergence and re-emergence of viral infections transmitted by vectors, such as the Zika virus (ZIKV) and Dengue virus (DENV), is a cause for international concern. These highly pathogenic arboviruses represent a serious health burden in tropical and subtropical areas of the world. Despite the high morbidity and mortality associated with these viral infections, antiviral therapies are missing. Medicinal plants have been widely used to treat various infectious diseases since millenaries. Several compounds extracted from plants exhibit potent effects against viruses in vitro, calling for further investigations regarding their efficacy as antiviral drugs. Here, we demonstrate that an extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the infection of ZIKV in vitro without exhibiting cytotoxic effects. The extract was active against different ZIKV African and Asian strains, including an epidemic one. Time-of-drug-addition assays revealed that the P. mauritianum extract interfered with the attachment of the viral particles to the host cells. Importantly, the P. mauritianum extract was also able to prevent the infection of human cells by four dengue virus serotypes. Due to its potency and ability to target ZIKV and DENV particles, P. mauritianum may be of value for identifying and characterizing antiviral compounds to fight medically-important flaviviruses.<\/jats:p>","DOI":"10.3390\/ijms20081860","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T11:15:58Z","timestamp":1555326958000},"page":"1860","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["The Polyphenol-Rich Extract from Psiloxylon mauritianum, an Endemic Medicinal Plant from Reunion Island, Inhibits the Early Stages of Dengue and Zika Virus Infection"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3857-0378","authenticated-orcid":false,"given":"Elodie","family":"Clain","sequence":"first","affiliation":[{"name":"Universit\u00e9 de la R\u00e9union, INSERM U1187, CNRS UMR 9192, IRD UMR 249, Unit\u00e9 Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Sainte Clotilde, 97490 La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano G.","family":"Haddad","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de la R\u00e9union, INSERM U1187, CNRS UMR 9192, IRD UMR 249, Unit\u00e9 Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Sainte Clotilde, 97490 La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea C.","family":"Koishi","sequence":"additional","affiliation":[{"name":"Laboratorio de Virologia Molecular, Instituto Carlos Chagas, ICC\/FIOCRUZ\/PR, Curitiba, Parana 81350-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sinigaglia","sequence":"additional","affiliation":[{"name":"Viral Genomics and Vaccination Unit, UMR CNRS 3569, Institut Pasteur, 75724 Paris, France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Rachidi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, SYMMES\/CIBEST UMR 5819 UGA-CNRS-CEA, INAC\/CEA, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8926-4050","authenticated-orcid":false,"given":"Philippe","family":"Despr\u00e8s","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de la R\u00e9union, INSERM U1187, CNRS UMR 9192, IRD UMR 249, Unit\u00e9 Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Sainte Clotilde, 97490 La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"N. Duarte dos Santos","sequence":"additional","affiliation":[{"name":"Laboratorio de Virologia Molecular, Instituto Carlos Chagas, ICC\/FIOCRUZ\/PR, Curitiba, Parana 81350-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Guiraud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de la R\u00e9union, INSERM U1187, CNRS UMR 9192, IRD UMR 249, Unit\u00e9 Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Sainte Clotilde, 97490 La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6103-6048","authenticated-orcid":false,"given":"Nolwenn","family":"Jouvenet","sequence":"additional","affiliation":[{"name":"Viral Genomics and Vaccination Unit, UMR CNRS 3569, Institut Pasteur, 75724 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4673-6614","authenticated-orcid":false,"given":"Chaker","family":"El Kalamouni","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de la R\u00e9union, INSERM U1187, CNRS UMR 9192, IRD UMR 249, Unit\u00e9 Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Sainte Clotilde, 97490 La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3389\/fcimb.2017.00486","article-title":"Zika Virus: An Emerging Global Health Threat","volume":"7","author":"Mittal","year":"2017","journal-title":"Front. 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