{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:25:14Z","timestamp":1789075514476,"version":"build-2803163510"},"reference-count":108,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This work supported by Russian Academic Excellence project &quot;5-100\u201d for the Sechenov University, Moscow, Russia. This research was partially also supported in part within the framework of the State Proposal 0090-2017-0018, (topics 48.8. and 48.9), and by t","award":["Academic Excellence project \"5-100\u201d for the Sechenov University, The framework of the State Proposal 0090-2017-0018, (topics 48.8. and 48.9), and by the project of RAS Program \"Fundamental Research for Biomedical Technologies\u2019 (IPAC, RAS Chernogolovka, Mo"],"award-info":[{"award-number":["Academic Excellence project \"5-100\u201d for the Sechenov University, The framework of the State Proposal 0090-2017-0018, (topics 48.8. and 48.9), and by the project of RAS Program \"Fundamental Research for Biomedical Technologies\u2019 (IPAC, RAS Chernogolovka, Mo"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Zinc is one of the most important essential trace elements. It is involved in more than 300 enzyme systems and is an indispensable participant in many biochemical processes. Zinc deficiency causes a number of disorders in the human body, the main ones being the delay of growth and puberty, immune disorders, and cognitive dysfunctions. There are over two billion people in the world suffering from zinc deficiency conditions. Acyzol, a zinc-containing medicine, developed as an antidote against carbon monoxide poisoning, demonstrates a wide range of pharmacological activities: Anti-inflammatory, reparative, detoxifying, immunomodulatory, bacteriostatic, hepatoprotective, adaptogenic, antioxidant, antihypoxic, and cardioprotective. The presence of zinc in the composition of Acyzol suggests the potential of the drug in the treatment and prevention of zinc deficiency conditions, such as Prasad\u2019s disease, immune system pathology, alopecia, allergodermatoses, prostate dysfunction, psoriasis, stomatitis, periodontitis, and delayed mental and physical development in children. Currently, the efficiency of Acyzol in the cases of zinc deficiency is shown in a large number of experimental studies. So, Acyzol can be used as a highly effective drug for pharmacologic therapy of a wide range of diseases and conditions and it opens up new perspectives in the treatment and prevention of zinc deficiency conditions.<\/jats:p>","DOI":"10.3390\/ijms20092104","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T02:57:32Z","timestamp":1556506652000},"page":"2104","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Application of Acyzol in the Context of Zinc Deficiency and Perspectives"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7373-3182","authenticated-orcid":false,"given":"Gjumrakch","family":"Aliev","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russia"},{"name":"Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka 142432, Russia"},{"name":"GALLY International Research Institute, 7733 Louis Pasteur Drive #330, San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biological and Health Sciences, Texas A&amp;M University-Kingsville, TX 78363, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir N.","family":"Chubarev","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana A.","family":"Lebedeva","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidiya N.","family":"Parshina","sequence":"additional","affiliation":[{"name":"A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris A.","family":"Trofimov","sequence":"additional","affiliation":[{"name":"A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna S.","family":"Sologova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfiya","family":"Makhmutova","sequence":"additional","affiliation":[{"name":"Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka 142432, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4612-3236","authenticated-orcid":false,"given":"Marco F.","family":"Avila-Rodriguez","sequence":"additional","affiliation":[{"name":"Universidad del Tolima, Facultad de Ciencias de la Salud, Barrio Santa Helena, Ibagu\u00e9 730006, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0299-9183","authenticated-orcid":false,"given":"Sergey G.","family":"Klochkov","sequence":"additional","affiliation":[{"name":"Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka 142432, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel A.","family":"Galenko-Yaroshevsky","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Kuban State Medical University, 4 Sedin St., Krasnodar 350063, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadim V.","family":"Tarasov","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10534-008-9186-z","article-title":"Molecular aspects of human cellular zinc homeostasis: Redox control of zinc potentials and zinc signals","volume":"22","author":"Maret","year":"2009","journal-title":"Biometals"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jtemb.2012.04.004","article-title":"Discovery of human zinc deficiency: 50 years later","volume":"26","author":"Prasad","year":"2012","journal-title":"J. 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