{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:04:32Z","timestamp":1790251472565,"version":"4.1.0"},"reference-count":48,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y universidades","doi-asserted-by":"publisher","award":["MAT201573656-JIN"],"award-info":[{"award-number":["MAT201573656-JIN"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["CONACYT (711120)"],"award-info":[{"award-number":["CONACYT (711120)"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Craniofacial bone defect anomalies affect both soft and hard tissues and can be caused by trauma, bone recessions from tumors and cysts, or even from congenital disorders. On this note, cleft\/lip palate is the most prevalent congenital craniofacial defect caused by disturbed embryonic development of soft and hard tissues around the oral cavity and face area, resulting in most cases, of severe limitations with chewing, swallowing, and talking as well as problems of insufficient space for teeth, proper breathing, and self-esteem problems as a consequence of facial appearance. Spectacular advances in regenerative medicine have arrived, giving new hope to patients that can benefit from new tissue engineering therapies based on the supportive action of 3D biomaterials together with the synergic action of osteo-inductive molecules and recruited stem cells that can be driven to the process of bone regeneration. However, few studies have focused on the application of tissue engineering to the regeneration of the cleft\/lip and only a few have reported significant advances to offer real clinical solutions. This review provides an updated and deep analysis of the studies that have reported on the use of advanced biomaterials and cell therapies for the regeneration of cleft lip and palate regeneration.<\/jats:p>","DOI":"10.3390\/ijms20092176","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T03:15:22Z","timestamp":1556766922000},"page":"2176","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Biomaterials for Cleft Lip and Palate Regeneration"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3028-6228","authenticated-orcid":false,"given":"Marcela","family":"Mart\u00edn-del-Campo","sequence":"first","affiliation":[{"name":"Facultad de Estomatolog\u00eda, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Av. Dr. Salvador Nava No. 2, Zona Universitaria, San Luis Potos\u00ed (S.L.P.) 78290, Mexico"},{"name":"Consejo Superior de Investigaciones Cient\u00edficas, Instituto de Ciencia y Tecnolog\u00eda de Pol\u00edmeros, Calle Juan de la Cierva, 3, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Rosales-Iba\u00f1ez","sequence":"additional","affiliation":[{"name":"Laboratorio de Ingenier\u00eda Tisular y Medicina Traslacional, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de Mexico, Avenida de los Barrios N 1, Iztacala Tlalnepantla, Estado de Mexico 54090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6334-6736","authenticated-orcid":false,"given":"Luis","family":"Rojo","sequence":"additional","affiliation":[{"name":"Consejo Superior de Investigaciones Cient\u00edficas, Instituto de Ciencia y Tecnolog\u00eda de Pol\u00edmeros, Calle Juan de la Cierva, 3, 28006 Madrid, Spain"},{"name":"Consorcio Centro de Investigaci\u00f3n Biom\u00e9dica en Red CIBER-BBN, Calle Monforte de Lemos S\/N, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/j.joms.2007.06.648","article-title":"Tissue Engineering Solutions for Cleft Palates","volume":"65","author":"Moreau","year":"2007","journal-title":"J. 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