{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:44:19Z","timestamp":1782773059332,"version":"3.54.5"},"reference-count":78,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T00:00:00Z","timestamp":1557532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008463","name":"Universitas Airlangga","doi-asserted-by":"publisher","award":["Collaborative Research Grant"],"award-info":[{"award-number":["Collaborative Research Grant"]}],"id":[{"id":"10.13039\/501100008463","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008463","name":"Universitas Airlangga","doi-asserted-by":"publisher","award":["Mandate Research Grant"],"award-info":[{"award-number":["Mandate Research Grant"]}],"id":[{"id":"10.13039\/501100008463","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The regulation of cell death through apoptosis is essential to a number of physiological processes. Defective apoptosis regulation is associated with many abnormalities including anomalies in organ development, altered immune response and the development of cancer. Several signalling pathways are known to regulate apoptosis including the Tumour Necrosis Factor-\u03b1 (TNF-\u03b1) and Hippo signalling pathways. In this paper we review the cross-talk between the TNF-\u03b1 pathway and the Hippo signalling pathway. Several molecules that tightly regulate the Hippo pathway, such as members of the Ras-association domain family member (RASSF) family proteins, interact and modulate some key proteins within the TNF-\u03b1 pathway. Meanwhile, TNF-\u03b1 stimulation also affects the expression and activation of core components of the Hippo pathway. This implies the crucial role of signal integration between these two major pathways in regulating apoptosis.<\/jats:p>","DOI":"10.3390\/ijms20092346","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T05:35:39Z","timestamp":1557725739000},"page":"2346","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The Cross-Talk Between the TNF-\u03b1 and RASSF-Hippo Signalling Pathways"],"prefix":"10.3390","volume":"20","author":[{"given":"Delvac","family":"Oceandy","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK"},{"name":"Department of Biomedical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bella","family":"Amanda","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Ashari","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakiyatul","family":"Faizah","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Stafford","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0092-8674(00)81873-5","article-title":"Programmed cell death in animal development","volume":"88","author":"Jacobson","year":"1997","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/sj.cdd.4402182","article-title":"Apoptosis in the development of the immune system","volume":"15","author":"Opferman","year":"2008","journal-title":"Cell Death Differ."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.devcel.2015.01.019","article-title":"Programmed cell death in neurodevelopment","volume":"32","author":"Yamaguchi","year":"2015","journal-title":"Dev. Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/35040009","article-title":"Apoptosis in neurodegenerative disorders","volume":"1","author":"Mattson","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cardiores.2005.04.012","article-title":"Myocyte apoptosis in heart failure","volume":"67","author":"Bertrand","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1749-6632.2010.05749.x","article-title":"Apoptosis and autoimmune diseases","volume":"1209","author":"Nagata","year":"2010","journal-title":"Ann. N Y Acad. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1756-9966-30-87","article-title":"Apoptosis in cancer: From pathogenesis to treatment","volume":"30","author":"Wong","year":"2011","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev-immunol-042617-053010","article-title":"Apoptosis and Clearance of Apoptotic Cells","volume":"36","author":"Nagata","year":"2018","journal-title":"Annu Rev. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev-genet-120417-031621","article-title":"The Hippo Signaling Network and Its Biological Functions","volume":"52","author":"Misra","year":"2018","journal-title":"Annu Rev. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.cytogfr.2014.07.016","article-title":"TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants - past, present and future","volume":"25","author":"Sedger","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrrheum.2015.169","article-title":"TNF biology, pathogenic mechanisms and emerging therapeutic strategies","volume":"12","author":"Kalliolias","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nri3834","article-title":"Regulation of tumour necrosis factor signalling: Live or let die","volume":"15","author":"Brenner","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1128\/MCB.23.11.4026-4033.2003","article-title":"Role of SODD in regulation of tumor necrosis factor responses","volume":"23","author":"Takada","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2016.03.009","article-title":"TRAF2 multitasking in TNF receptor-induced signaling to NF-kappaB, MAP kinases and cell death","volume":"116","author":"Borghi","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.3389\/fimmu.2018.01849","article-title":"Tumor Necrosis Factor Receptor-Associated Factor Regulation of Nuclear Factor kappaB and Mitogen-Activated Protein Kinase Pathways","volume":"9","author":"Shi","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/cvr\/cvu111","article-title":"The tumour suppressor Ras-association domain family protein 1A (RASSF1A) regulates TNF-alpha signalling in cardiomyocytes","volume":"103","author":"Mohamed","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"ref_17","first-page":"83","article-title":"Mechanisms of action of the tumor necrosis factor and lymphotoxin ligand-receptor system","volume":"6","author":"Warzocha","year":"1995","journal-title":"Eur Cytokine Netw"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1101\/gad.210773.112","article-title":"The Hippo pathway: Regulators and regulations","volume":"27","author":"Yu","year":"2013","journal-title":"Genes Dev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0092-8674(03)00549-X","article-title":"hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts","volume":"114","author":"Wu","year":"2003","journal-title":"Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cell.2005.06.007","article-title":"The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP","volume":"122","author":"Huang","year":"2005","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41569-018-0063-3","article-title":"The Hippo pathway in the heart: Pivotal roles in development, disease, and regeneration","volume":"15","author":"Wang","year":"2018","journal-title":"Nat. Rev. Cardiol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ydbio.2012.12.017","article-title":"Hippo activation through homodimerization and membrane association for growth inhibition and organ size control","volume":"375","author":"Deng","year":"2013","journal-title":"Dev. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.devcel.2011.08.028","article-title":"Tao-1 phosphorylates Hippo\/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway","volume":"21","author":"Boggiano","year":"2011","journal-title":"Dev. Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nrd4161","article-title":"The two faces of Hippo: Targeting the Hippo pathway for regenerative medicine and cancer treatment","volume":"13","author":"Johnson","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"11930","DOI":"10.1073\/pnas.1103345108","article-title":"E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components","volume":"108","author":"Kim","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cub.2010.02.035","article-title":"Ajuba LIM proteins are negative regulators of the Hippo signaling pathway","volume":"20","author":"Feng","year":"2010","journal-title":"Curr. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1038\/onc.2012.431","article-title":"LKB1 tumor suppressor regulates AMP kinase\/mTOR-independent cell growth and proliferation via the phosphorylation of Yap","volume":"32","author":"Nguyen","year":"2013","journal-title":"Oncogene"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1083\/jcb.201009069","article-title":"NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway","volume":"193","author":"Habbig","year":"2011","journal-title":"J. Cell Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1042\/BJ20100870","article-title":"Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling","volume":"432","author":"Oka","year":"2010","journal-title":"Biochem. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1016\/j.febslet.2010.09.020","article-title":"TAZ interacts with zonula occludens-1 and -2 proteins in a PDZ-1 dependent manner","volume":"584","author":"Remue","year":"2010","journal-title":"FEBS Lett."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/onc.2011.216","article-title":"Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP","volume":"31","author":"Oka","year":"2012","journal-title":"Oncogene"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1101\/gad.2000111","article-title":"Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein","volume":"25","author":"Zhao","year":"2011","journal-title":"Genes Dev."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Chakraborty, S., and Hong, W. (2018). Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond. Cancers, 10.","DOI":"10.3390\/cancers10020045"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.trecan.2017.03.005","article-title":"Agrin to YAP in Cancer and Neuromuscular Junctions","volume":"3","author":"Xiong","year":"2017","journal-title":"Trends Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature22978","article-title":"The extracellular matrix protein agrin promotes heart regeneration in mice","volume":"547","author":"Bassat","year":"2017","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2012.06.037","article-title":"Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling","volume":"150","author":"Yu","year":"2012","journal-title":"Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/cdd.2017.99","article-title":"The LATS1 and LATS2 tumor suppressors: Beyond the Hippo pathway","volume":"24","author":"Furth","year":"2017","journal-title":"Cell Death Differ."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1083\/jcb.201507005","article-title":"MST kinases in development and disease","volume":"210","author":"Thompson","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1053\/j.gastro.2016.10.047","article-title":"Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis","volume":"152","author":"Patel","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"F241","DOI":"10.1152\/ajprenal.00500.2015","article-title":"Hippo signaling in the kidney: The good and the bad","volume":"311","author":"Wong","year":"2016","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.jacbts.2018.07.005","article-title":"Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury","volume":"3","author":"Hara","year":"2018","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/CIRCRESAHA.115.303632","article-title":"Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model","volume":"115","author":"Lin","year":"2014","journal-title":"Circ. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature24045","article-title":"Hippo pathway deficiency reverses systolic heart failure after infarction","volume":"550","author":"Leach","year":"2017","journal-title":"Nature"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"E1312","DOI":"10.1073\/pnas.1110428108","article-title":"Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance","volume":"108","author":"Zhou","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1073\/pnas.0911427107","article-title":"Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver","volume":"107","author":"Lu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1158\/0008-5472.CAN-11-3956","article-title":"Mammalian sterile 20-like kinase 1 suppresses lymphoma development by promoting faithful chromosome segregation","volume":"72","author":"Kim","year":"2012","journal-title":"Cancer Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Pan, W.W., Moroishi, T., Koo, J.H., and Guan, K.L. (2018). Cell type-dependent function of LATS1\/2 in cancer cell growth. Oncogene.","DOI":"10.1038\/s41388-018-0610-8"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.cell.2016.11.005","article-title":"The Hippo Pathway Kinases LATS1\/2 Suppress Cancer Immunity","volume":"167","author":"Moroishi","year":"2016","journal-title":"Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.humpath.2015.02.012","article-title":"Expression of LATS family proteins in ovarian tumors and its significance","volume":"46","author":"Xu","year":"2015","journal-title":"Hum. Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Van Haele, M., Moya, I.M., Karaman, R., Rens, G., Snoeck, J., Govaere, O., Nevens, F., Verslype, C., Topal, B., and Monbaliu, D. (2019). YAP and TAZ Heterogeneity in Primary Liver Cancer: An Analysis of Its Prognostic and Diagnostic Role. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030638"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41392-017-0005-2","article-title":"Yes-associated protein (YAP) in pancreatic cancer: At the epicenter of a targetable signaling network associated with patient survival","volume":"3","author":"Rozengurt","year":"2018","journal-title":"Signal. Transduct Target. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e45809","DOI":"10.15252\/embr.201845809","article-title":"YAP and TAZ are essential for basal and squamous cell carcinoma initiation","volume":"19","author":"Debaugnies","year":"2018","journal-title":"EMBO Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nrc3458","article-title":"The Hippo pathway and human cancer","volume":"13","author":"Harvey","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.semcdb.2016.06.007","article-title":"Ras signaling through RASSF proteins","volume":"58","author":"Donninger","year":"2016","journal-title":"Semin Cell Dev. Biol."},{"key":"ref_55","first-page":"114","article-title":"The RASSF proteins in cancer; from epigenetic silencing to functional characterization","volume":"1796","author":"Richter","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1016\/j.febslet.2014.02.041","article-title":"RASSF tumor suppressor gene family: Biological functions and regulation","volume":"588","author":"Volodko","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1038\/onc.2010.192","article-title":"The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-kappaB signaling pathways","volume":"29","author":"Lock","year":"2010","journal-title":"Oncogene"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/CIRCULATIONAHA.109.868554","article-title":"Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy","volume":"120","author":"Oceandy","year":"2009","journal-title":"Circulation"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1042\/BJ20040025","article-title":"Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras","volume":"381","author":"Praskova","year":"2004","journal-title":"Biochem. J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"ra59","DOI":"10.1126\/scisignal.2000300","article-title":"Hippo pathway-dependent and -independent roles of RASSF6","volume":"2","author":"Ikeda","year":"2009","journal-title":"Sci. Signal."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.1128\/MCB.02011-07","article-title":"Dynamics of RASSF1A\/MOAP-1 association with death receptors","volume":"28","author":"Foley","year":"2008","journal-title":"Mol. Cell Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.molcel.2005.05.010","article-title":"The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death","volume":"18","author":"Baksh","year":"2005","journal-title":"Mol. Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1158\/0008-5472.CAN-12-0572","article-title":"The RASSF3 candidate tumor suppressor induces apoptosis and G1-S cell-cycle arrest via p53","volume":"72","author":"Kudo","year":"2012","journal-title":"Cancer Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6203","DOI":"10.1038\/sj.onc.1210440","article-title":"RASSF6 is a novel member of the RASSF family of tumor suppressors","volume":"26","author":"Allen","year":"2007","journal-title":"Oncogene"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Gordon, M., El-Kalla, M., Zhao, Y., Fiteih, Y., Law, J., Volodko, N., Anwar-Mohamed, A., El-Kadi, A.O., Liu, L., and Odenbach, J. (2013). The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury. PLoS One, 8.","DOI":"10.1371\/journal.pone.0075483"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1172\/JCI43569","article-title":"Proapoptotic Rassf1A\/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice","volume":"120","author":"Matsuda","year":"2010","journal-title":"J. Clin. Invest."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4398","DOI":"10.1038\/sj.onc.1206603","article-title":"Lats2, a putative tumor suppressor, inhibits G1\/S transition","volume":"22","author":"Li","year":"2003","journal-title":"Oncogene"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.yexcr.2004.04.031","article-title":"Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L)","volume":"298","author":"Ke","year":"2004","journal-title":"Exp. Cell Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1101\/gad.1447006","article-title":"A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization","volume":"20","author":"Aylon","year":"2006","journal-title":"Genes Dev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/jop.12317","article-title":"LATS2 induced by TNF-alpha and inhibited cell proliferation and invasion by phosphorylating YAP in oral squamous cell carcinoma","volume":"44","author":"Dong","year":"2015","journal-title":"J. Oral Pathol. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e383","DOI":"10.1038\/oncsis.2017.83","article-title":"TNFalpha-YAP\/p65-HK2 axis mediates breast cancer cell migration","volume":"6","author":"Gao","year":"2017","journal-title":"Oncogenesis"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"7213","DOI":"10.2147\/OTT.S184337","article-title":"TNFalpha promotes glioblastoma A172 cell mitochondrial apoptosis via augmenting mitochondrial fission and repression of MAPK-ERK-YAP signaling pathways","volume":"11","author":"Lu","year":"2018","journal-title":"Onco. Targets Ther."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1038\/s41467-018-07022-2","article-title":"Reciprocal inhibition of YAP\/TAZ and NF-kappaB regulates osteoarthritic cartilage degradation","volume":"9","author":"Deng","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1172\/JCI93825","article-title":"YAP\/TAZ regulates sprouting angiogenesis and vascular barrier maturation","volume":"127","author":"Kim","year":"2017","journal-title":"J. Clin. Invest."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1161\/CIRCRESAHA.117.311950","article-title":"Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial Cells","volume":"122","author":"He","year":"2018","journal-title":"Circ. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.devcel.2017.08.002","article-title":"YAP\/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis","volume":"42","author":"Wang","year":"2017","journal-title":"Dev. Cell"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Choi, H.J., Kim, N.E., Kim, B.M., Seo, M., and Heo, J.H. (2018). TNF-alpha-Induced YAP\/TAZ Activity Mediates Leukocyte-Endothelial Adhesion by Regulating VCAM1 Expression in Endothelial Cells. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113428"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ydbio.2014.06.023","article-title":"Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst","volume":"394","author":"Kono","year":"2014","journal-title":"Dev. Biol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/9\/2346\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:51:09Z","timestamp":1760187069000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/9\/2346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,11]]},"references-count":78,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,5]]}},"alternative-id":["ijms20092346"],"URL":"https:\/\/doi.org\/10.3390\/ijms20092346","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,11]]}}}