{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:11:47Z","timestamp":1776701507016,"version":"3.51.2"},"reference-count":145,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The aim of this narrative review is to report on the current knowledge regarding the clinical use of umbilical cord blood (CB) based on articles from PubMed and clinical trials registered on ClinicalTrials.gov. An increasing amount of evidence suggests that CB may be used for both early diagnostics and treatment of cerebral palsy. The acidity of CB and its biochemical parameters, including dozens of cytokines, growth factors, and other metabolites (such as amino acids, acylcarnitines, phosphatidylcholines, succinate, glycerol, 3-hydroxybutyrate, and O-phosphocholine) are predictors of future neurodevelopment. In addition, several clinical studies confirmed the safety and efficacy of CB administration in both autologous and allogeneic models, including a meta-analysis of five clinical trials involving a total of 328 participants. Currently, nine clinical trials assessing the use of autologous umbilical CB in children diagnosed with hypoxic-ischemic encephalopathy or cerebral palsy are in progress. The total population assessed in these trials exceeds 2500 patients.<\/jats:p>","DOI":"10.3390\/ijms20102433","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T11:21:22Z","timestamp":1558005682000},"page":"2433","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Autologous Cord Blood in Children with Cerebral Palsy: A Review"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0055-3441","authenticated-orcid":false,"given":"Dariusz","family":"Boruczkowski","sequence":"first","affiliation":[{"name":"Polski Bank Kom\u00f3rek Macierzystych S.A. (FamiCord Group), Jana Paw\u0142a II 29, 00-867 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep-Maria","family":"Pujal","sequence":"additional","affiliation":[{"name":"Sevibe Cells, Parc Cient\u00edfic i Tecnol\u00f2gic de la UdG, C\/Pic de Peguera No. 11, 17003 Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"Zdoli\u0144ska-Malinowska","sequence":"additional","affiliation":[{"name":"Polski Bank Kom\u00f3rek Macierzystych S.A. (FamiCord Group), Jana Paw\u0142a II 29, 00-867 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,16]]},"reference":[{"key":"ref_1","first-page":"417","article-title":"Risk factors for cerebral palsy in very low-birthweight infants in the 1980s and 1990s","volume":"6","author":"Bauer","year":"2000","journal-title":"J. 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