{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:57:16Z","timestamp":1789469836691,"version":"build-2803163510"},"reference-count":53,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["MRC, 2017R1A5A2015541"],"award-info":[{"award-number":["MRC, 2017R1A5A2015541"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Neuroinflammation is implicated in dopaminergic neurodegeneration. We have previously demonstrated that (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (MMPP), a selective signal transducer and activator of transcription 3 (STAT3) inhibitor, has anti-inflammatory properties in several inflammatory disease models. We investigated whether MMPP could protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic cell loss and behavioral impairment. Imprinting control region (ICR) mice (8 weeks old, n = 10 per group) were administered MMPP (5 mg\/kg) in drinking water for 1 month, and injected with MPTP (15 mg\/kg, four times with 2 h intervals) during the last 7 days of treatment. MMPP decreased MPTP-induced behavioral impairments in rotarod, pole, and gait tests. We also showed that MMPP ameliorated dopamine depletion in the striatum and inflammatory marker elevation in primary cultured neurons by high-performance liquid chromatography and immunohistochemical analysis. Increased activation of STAT3, p38, and monoamine oxidase B (MAO-B) were observed in the substantia nigra and striatum after MPTP injection, effects that were attenuated by MMPP treatment. Furthermore, MMPP inhibited STAT3 activity and expression of neuroinflammatory proteins, including ionized calcium binding adaptor molecule 1 (Iba1), inducible nitric oxide synthase (iNOS), and glial fibrillary acidic protein (GFAP) in 1-methyl-4-phenylpyridinium (MPP+; 0.5 mM)-treated primary cultured cells. However, mitogen-activated protein kinase (MAPK) inhibitors augmented the activity of MMPP. Collectively, our results suggest that MMPP may be an anti-inflammatory agent that attenuates dopaminergic neurodegeneration and neuroinflammation through MAO-B and MAPK pathway-dependent inhibition of STAT3 activation.<\/jats:p>","DOI":"10.3390\/ijms20112632","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T11:31:28Z","timestamp":1559129488000},"page":"2632","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["(E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) Phenol Ameliorates MPTP-Induced Dopaminergic Neurodegeneration by Inhibiting the STAT3 Pathway"],"prefix":"10.3390","volume":"20","author":[{"given":"Ji Yeon","family":"Choi","sequence":"first","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaemgmyeong 1-ro, Cheongju 28160, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaesuk","family":"Yun","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaemgmyeong 1-ro, Cheongju 28160, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Ju","family":"Hwang","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaemgmyeong 1-ro, Cheongju 28160, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Pom","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaemgmyeong 1-ro, Cheongju 28160, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Deun","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaemgmyeong 1-ro, Cheongju 28160, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungok","family":"Chun","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaemgmyeong 1-ro, Cheongju 28160, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pil-Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yeungnam University, 280, Daehak-ro, Gyeongsan, Gyeongbuk 38541, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Young","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yeungnam University, 280, Daehak-ro, Gyeongsan, Gyeongbuk 38541, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Bae","family":"Han","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaemgmyeong 1-ro, Cheongju 28160, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-9575","authenticated-orcid":false,"given":"Jin Tae","family":"Hong","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaemgmyeong 1-ro, Cheongju 28160, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/mds.25945","article-title":"The prevalence of Parkinson\u2019s disease: A systematic review and meta-analysis","volume":"29","author":"Pringsheim","year":"2014","journal-title":"Mov. Disord."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"698","DOI":"10.4103\/1673-5374.182681","article-title":"TFP5\/TP5 peptide provides neuroprotection in the MPTP model of Parkinson\u2019s disease","volume":"11","author":"Binukumar","year":"2016","journal-title":"Neural Regen. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.2174\/1871527315666160920160512","article-title":"An overview on the role of alpha-synuclein in experimental models of Parkinson\u2019s disease from pathogenesis to therapeutics","volume":"15","author":"Javed","year":"2016","journal-title":"Cns Neurol. Disord. Drug Targets"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s12035-015-9103-8","article-title":"Validity of the MPTP-Treated Mouse as a Model for Parkinson\u2019s Disease","volume":"53","author":"Klemann","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3233\/JPD-2011-11023","article-title":"MPTP mouse models of Parkinson\u2019s disease: An update","volume":"1","author":"Meredith","year":"2011","journal-title":"J. Parkinson\u2019s Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1460-9568.2005.03889.x","article-title":"A novel thiol antioxidant that crosses the blood brain barrier protects dopaminergic neurons in experimental models of Parkinson\u2019s disease","volume":"21","author":"Offen","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0197-0186(01)00015-8","article-title":"Methyl-4-phenylpyridinium (MPP(+))-evoked dopamine release from rat striatal slices: Possible roles of voltage-dependent calcium channels and reverse dopamine transport","volume":"39","author":"Inazu","year":"2001","journal-title":"Neurochem. Int."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molbrainres.2004.09.017","article-title":"The MPTP model of Parkinson\u2019s disease","volume":"134","author":"Smeyne","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainres.2008.09.011","article-title":"Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor, GFR alpha1, gene","volume":"1241","author":"Boger","year":"2008","journal-title":"Brain Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0166-4328(01)00309-6","article-title":"Behavioral phenotyping of the MPTP mouse model of Parkinson\u2019s disease","volume":"125","author":"Sedelis","year":"2001","journal-title":"Behav. Brain Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"O\u2019Callaghan, J.P., Kelly, K.A., VanGilder, R.L., Sofroniew, M.V., and Miller, D.B. (2014). Early activation of STAT3 regulates reactive astrogliosis induced by diverse forms of neurotoxicity. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0102003"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"19936","DOI":"10.1074\/jbc.M309304200","article-title":"Induction of gp130-related cytokines and activation of JAK2\/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: Key signaling pathway for astrogliosis in vivo?","volume":"279","author":"Sriram","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2010.09.074","article-title":"Involvement of Stat3 in mouse brain development and sexual dimorphism: A proteomics approach","volume":"1362","author":"Casalena","year":"2010","journal-title":"Brain Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"6878","DOI":"10.1021\/bi500798n","article-title":"Transcriptional regulation of the novel monoamine oxidase renalase: Crucial roles of transcription factors Sp1, STAT3, and ZBP89","volume":"53","author":"Sonawane","year":"2014","journal-title":"Biochemistry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2012.10.553","article-title":"IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes\/macrophages","volume":"54","author":"Bhattacharjee","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bbi.2015.04.008","article-title":"Neuroprotective effects of nitidine against traumatic CNS injury via inhibiting microglia activation","volume":"48","author":"Yuan","year":"2015","journal-title":"BrainBehav. Immun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/1521654031000121666","article-title":"The role of c-Jun N-terminal kinase (JNK) in Parkinson\u2019s disease","volume":"55","author":"Peng","year":"2003","journal-title":"Iubmb Life"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"649079","DOI":"10.1155\/2012\/649079","article-title":"The Role of p38 MAPK and Its Substrates in Neuronal Plasticity and Neurodegenerative Disease","volume":"2012","author":"Correa","year":"2012","journal-title":"J. Signal Transduct."},{"key":"ref_19","first-page":"67","article-title":"p38 MAPK and PI3K\/AKT Signalling Cascades inParkinson\u2019s Disease","volume":"4","author":"Jha","year":"2015","journal-title":"Int. J. Mol. Cell. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1046\/j.1365-2443.2002.00591.x","article-title":"Neuronal p38 MAPK signalling: An emerging regulator of cell fate and function in the nervous system","volume":"7","author":"Takeda","year":"2002","journal-title":"Genes Cells"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.4103\/1673-5374.169606","article-title":"A role for mitogen-activated protein kinase phosphatase 1 (MKP1) in neural cell development and survival","volume":"10","author":"Toulouse","year":"2015","journal-title":"Neural Regen. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1073\/pnas.0307453101","article-title":"JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson\u2019s disease","volume":"101","author":"Hunot","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"22222","DOI":"10.1074\/jbc.M202844200","article-title":"Activation of human monoamine oxidase B gene expression by a protein kinase C MAPK signal transduction pathway involves c-Jun and Egr-1","volume":"277","author":"Wong","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.3892\/or.2015.4427","article-title":"Ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells through inhibition of STAT3 and activation of caspase-3\/9","volume":"35","author":"Xiong","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Si, Y., Zhang, Y., Han, L., Chen, L., Xu, Y., Sun, F., Ji, M., Yang, J., and Bao, H. (2016). Dexmedetomidine Acts via the JAK2\/STAT3 Pathway to Attenuate Isoflurane-Induced Neurocognitive Deficits in Senile Mice. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164763"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1111\/bph.12619","article-title":"Anti-arthritis effects of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal are mediated by inhibition of the STAT3 pathway","volume":"171","author":"Ban","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1007\/s12272-013-0326-9","article-title":"(E)-2,4-Bis(p-hydroxyphenyl)-2-butenal enhanced TRAIL-induced apoptosis in ovarian cancer cells through downregulation of NF-kappaB\/STAT3 pathway","volume":"37","author":"Cho","year":"2014","journal-title":"Arch. Pharmacal Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1742-2094-10-2","article-title":"Anti-inflammatory and anti-amyloidogenic effects of a small molecule, 2,4-bis(p-hydroxyphenyl)-2-butenal in Tg2576 Alzheimer\u2019s disease mice model","volume":"10","author":"Jin","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.7150\/thno.18630","article-title":"MMPP Attenuates Non-Small Cell Lung Cancer Growth by Inhibiting the STAT3 DNA-Binding Activity via Direct Binding to the STAT3 DNA-Binding Domain","volume":"7","author":"Son","year":"2017","journal-title":"Theranostics"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1742-2094-11-34","article-title":"Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation","volume":"11","author":"Herrera","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0165-6147(03)00176-7","article-title":"Novel anti-inflammatory therapy for Parkinson\u2019s disease","volume":"24","author":"Gao","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_32","first-page":"607","article-title":"Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation","volume":"293","author":"Liu","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1096\/fj.02-0799fje","article-title":"Neuroprotective effect of vasoactive intestinal peptide (VIP) in a mouse model of Parkinson\u2019s disease by blocking microglial activation","volume":"17","author":"Delgado","year":"2003","journal-title":"Faseb J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"46943","DOI":"10.18632\/oncotarget.10504","article-title":"Inhibitory effect of thiacremonone on MPTP-induced dopaminergic neurodegeneration through inhibition of p38 activation","volume":"7","author":"Hwang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/ejn.13232","article-title":"6-hydroxydopamine-induced Parkinson\u2019s disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis","volume":"43","author":"Fricke","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/jnc.12697","article-title":"Dopamine denervation of the prefrontal cortex increases expression of the astrocytic glutamate transporter GLT-1","volume":"130","author":"Vollbrecht","year":"2014","journal-title":"J. Neurochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nprot.2006.342","article-title":"Protocol for the MPTP mouse model of Parkinson\u2019s disease","volume":"2","author":"Przedborski","year":"2007","journal-title":"Nat. Protoc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/BF02336564","article-title":"MPTP induced parkinsonian syndrome: Long term follow-up and neurophysiological study","volume":"11","author":"Onofrj","year":"1990","journal-title":"Ital. J. Neurol. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2047-9158-2-19","article-title":"Monoamine oxidase-B (MAO-B) inhibitors: Implications for disease-modification in Parkinson\u2019s disease","volume":"2","author":"Teo","year":"2013","journal-title":"Transl. Neurodegener"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/npp.2014.214","article-title":"Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain","volume":"40","author":"Fowler","year":"2015","journal-title":"Neuropsychopharmacol"},{"key":"ref_41","first-page":"467","article-title":"Rasagiline\u2014A novel MAO B inhibitor in Parkinson\u2019s disease therapy","volume":"3","author":"Lecht","year":"2007","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/1742-2094-9-175","article-title":"JNK signaling is the shared pathway linking neuroinflammation, blood-brain barrier disruption, and oligodendroglial apoptosis in the white matter injury of the immature brain","volume":"9","author":"Wang","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6168","DOI":"10.1073\/pnas.111027698","article-title":"Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway","volume":"98","author":"Davis","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_44","first-page":"278","article-title":"Elusive roles for reactive astrocytes in neurodegenerative diseases","volume":"9","author":"Ceyzeriat","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s00702-014-1334-8","article-title":"Inhibition of i-NOS but not n-NOS protects rat primary cell cultures against MPP(+)-induced neuronal toxicity","volume":"122","author":"Brzozowski","year":"2015","journal-title":"J. Neural Transm."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"7519","DOI":"10.1128\/MCB.19.11.7519","article-title":"Requirement for Ras\/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein","volume":"19","author":"Turkson","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"185167","DOI":"10.1155\/2012\/185167","article-title":"The Inhibition of Spinal Astrocytic JAK2-STAT3 Pathway Activation Correlates with the Analgesic Effects of Triptolide in the Rat Neuropathic Pain Model","volume":"2012","author":"Tang","year":"2012","journal-title":"Evid. -Based Complementary Altern. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.3892\/etm.2014.2023","article-title":"Role of p38 MAPK and STAT3 in lipopolysaccharide-stimulated mouse alveolar macrophages","volume":"8","author":"Meng","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s12017-017-8469-3","article-title":"(E)-2-Methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) Phenol Ameliorates LPS-Mediated Memory Impairment by Inhibition of STAT3 Pathway","volume":"19","author":"Choi","year":"2017","journal-title":"Neuromolecular Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"36852","DOI":"10.1038\/srep36852","article-title":"Novel synthetic (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol inhibits arthritis by targeting signal transducer and activator of transcription 3","volume":"6","author":"Son","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.redox.2016.12.008","article-title":"Parkin deficiency exacerbate ethanol-induced dopaminergic neurodegeneration by P38 pathway dependent inhibition of autophagy and mitochondrial function","volume":"11","author":"Hwang","year":"2017","journal-title":"Redox Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.freeradbiomed.2010.10.698","article-title":"4-O-Methylhonokiol attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway","volume":"50","author":"Lee","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/glia.22803","article-title":"Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism","volume":"63","author":"Menzfeld","year":"2015","journal-title":"Glia"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/11\/2632\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:54:19Z","timestamp":1760187259000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/11\/2632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,29]]},"references-count":53,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,6]]}},"alternative-id":["ijms20112632"],"URL":"https:\/\/doi.org\/10.3390\/ijms20112632","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,29]]}}}