{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:58:23Z","timestamp":1790146703692,"version":"4.0.1"},"reference-count":59,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2011-02352638"],"award-info":[{"award-number":["RF-2011-02352638"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Evaluating cell migration after cell-based treatment is important for several disorders, including osteoarthritis (OA), as it might influence the clinical outcome. This research explores migrating expanded-adipose stromal cells (ASCs) and adipose niches after enzymatic and mechanical processes. Bilateral anterior cruciate ligament transection induced a mild grade of OA at eight weeks in adult male New Zealand rabbits. ASCs, enzymatic stromal vascular fraction (SVF), and micro fragmented adipose tissue (MFAT) were intra-articularly injected in the knee joint. Assessments of cell viability and expression of specific markers, including CD-163 wound-healing macrophages, were done. Cell migration was explored through labelling with PKH26 dye at 7 and 30 days alongside co-localization analyses for CD-146. All cells showed good viability and high percentages of CD-90 and CD-146. CD-163 was significantly higher in MFAT compared to SVF. Distinct migratory potential and time-dependent effects were observed among cell-based treatments. At day 7, both ASCs and SVF migrated towards synovium, whereas for MFAT versus cartilage, a different migration pattern was noticed at day 30. The long-term distinct cell migration of ASCs, SVF, and MFAT open interesting clinical insights on their potential use for OA treatment. Moreover, the highest expression of CD-163 in MFAT, rather than SVF, might have an important role in directly mediating cartilage tissue repair responses.<\/jats:p>","DOI":"10.3390\/ijms20112636","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T11:31:28Z","timestamp":1559129488000},"page":"2636","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Regenerative Features of Adipose Tissue for Osteoarthritis Treatment in a Rabbit Model: Enzymatic Digestion Versus Mechanical Disruption"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3338-5747","authenticated-orcid":false,"given":"Giovanna","family":"Desando","sequence":"first","affiliation":[{"name":"Laboratorio RAMSES, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5168-3599","authenticated-orcid":false,"given":"Isabella","family":"Bartolotti","sequence":"additional","affiliation":[{"name":"Laboratorio RAMSES, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Martini","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical and Surgical Studies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-5969","authenticated-orcid":false,"given":"Gianluca","family":"Giavaresi","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical and Surgical Studies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"Nicoli Aldini","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical and Surgical Studies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Fini","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical and Surgical Studies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Roffi","sequence":"additional","affiliation":[{"name":"Applied and Translational Research Center, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Perdisa","sequence":"additional","affiliation":[{"name":"Hip and knee replacement Department, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Filardo","sequence":"additional","affiliation":[{"name":"Applied and Translational Research Center, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta","family":"Kon","sequence":"additional","affiliation":[{"name":"Humanitas University Department of Biomedical Sciences, Humanitas Clinical and Research Center, 20121 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunella","family":"Grigolo","sequence":"additional","affiliation":[{"name":"Laboratorio RAMSES, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/j.joca.2014.07.015","article-title":"Current and future impact of osteoarthritis on health care: A population-based study with projections to year 2032","volume":"22","author":"Turkiewicz","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Andrzejewska, A., Lukomska, B., and Janowski, M. (2019). Concise Review: Mesenchymal Stem Cells: From Roots to Boots. Stem Cells.","DOI":"10.1002\/stem.3016"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/1479-5876-9-181","article-title":"Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue-derived mesenchymal stem cells","volume":"9","author":"Ra","year":"2011","journal-title":"J. Transl. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jgm.3002","article-title":"Intra-articular injection of autologous adipose-derived mesenchymal stem cells in the treatment of knee osteoarthritis","volume":"20","author":"Spasovski","year":"2018","journal-title":"J. Gene Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1634\/stemcells.2006-0228","article-title":"Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease","volume":"24","author":"Lamana","year":"2006","journal-title":"Stem Cells"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/jcp.25651","article-title":"Increased chondrogenic potential of mesenchymal cells from adipose tissue versus bone marrow-derived cells in osteoarthritic in vitro models","volume":"232","author":"Pagani","year":"2017","journal-title":"J. Cell Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/scrt19","article-title":"Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells","volume":"1","author":"Gimble","year":"2010","journal-title":"Stem Cell Res. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"R22","DOI":"10.1186\/ar4156","article-title":"Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model","volume":"15","author":"Desando","year":"2013","journal-title":"Arthritis. Res. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1161\/01.CIR.0000121425.42966.F1","article-title":"Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells","volume":"109","author":"Rehman","year":"2004","journal-title":"Circulation"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1365-2141.2005.05409.x","article-title":"Immunomodulatory effect of human adipose tissue-derived adult stem cells: Comparison with bone marrow mesenchymal stem cells","volume":"129","author":"Puissant","year":"2005","journal-title":"Br. J. Haematol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cmet.2013.08.003","article-title":"Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration","volume":"18","author":"Lee","year":"2013","journal-title":"Cell Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1517\/14712598.2012.721763","article-title":"Mimicking the functional niche of adipose-derived stem cells for regenerative medicine","volume":"12","author":"Kaewsuwan","year":"2012","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nri2528","article-title":"Trophic macrophages in development and disease","volume":"9","author":"Pollard","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nri3071","article-title":"Macrophage-Mediated Inflammation in Metabolic Disease","volume":"11","author":"Chawla","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev-pathol-011110-130138","article-title":"Alternative Macrophage Activation and Metabolism","volume":"6","author":"Odegaard","year":"2011","journal-title":"Annu. Rev. Path."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: In vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jcyt.2013.02.006","article-title":"Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal\/ stem cells: A joint statement of the International Federation for Adipose Therapeutics (IFATS) and Science and the International Society for Cellular Therapy (ISCT)","volume":"15","author":"Bourin","year":"2013","journal-title":"Cytotherapy"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-017-0318-z","article-title":"Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopaedic applications","volume":"24","author":"Pak","year":"2017","journal-title":"J. Biomed. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Pak, J., Lee, J.H., Pak, N., Pak, Y., Park, K., Jeon, J.H., and Jeong, B.C. (2018). Cartilage Regeneration in Humans with Adipose Tissue-Derived Stem Cells and Adipose Stromal Vascular Fraction Cells: Updated Status. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19072146"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40064-015-1509-2","article-title":"Mechanical versus enzymatic isolation of stromal vascular fraction cells from adipose tissue","volume":"4","author":"Aronowitz","year":"2015","journal-title":"Springerplus"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.jcyt.2013.04.001","article-title":"A non-enzymatic method for isolating human adipose tissue-derived stromal stem cells","volume":"15","author":"Shah","year":"2013","journal-title":"Cytotherapy"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13619-015-0020-0","article-title":"Enzymatic and non-enzymatic isolation systems for adipose tissue-derived cells: Current state of the art","volume":"4","author":"Oberbauer","year":"2015","journal-title":"Cell Regen."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-017-0598-y","article-title":"Adipose tissue-derived stromal vascular fraction in regenerative medicine: A brief review on biology and translation","volume":"8","author":"Bora","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1182\/blood-2010-10-311464","article-title":"Engineered cell homing","volume":"118","author":"Sarkar","year":"2011","journal-title":"Blood"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Su, P., Tian, Y., Yang, C., Ma, X., Wang, X., Pei, J., and Qian, A. (2018). Mesenchymal Stem Cell Migration during Bone Formation and Bone Diseases Therapy. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082343"},{"key":"ref_26","first-page":"678063","article-title":"Biodistribution of mesenchymal stem\/stromal cells in a preclinical setting","volume":"2013","year":"2013","journal-title":"Stem Cells Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/ten.tec.2017.0336","article-title":"Short-Term Homing of Hyaluronan-Primed Cells: Therapeutic Implications for Osteoarthritis Treatment","volume":"24","author":"Desando","year":"2018","journal-title":"Tissue Eng. Part C Methods."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1634\/stemcells.2006-0589","article-title":"Concise Review: Adipose Tissue-Derived Stromal Cells-Basic and Clinical Implications for Novel Cell-Based Therapies","volume":"25","year":"2007","journal-title":"Stem Cells"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"597652","DOI":"10.1155\/2015\/597652","article-title":"Adipose-Derived Mesenchymal Stem Cells for the Treatment of Articular Cartilage: A Systematic Review on Preclinical and Clinical Evidence","volume":"2015","author":"Perdisa","year":"2015","journal-title":"Stem Cells Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1387\/ijdb.082663jd","article-title":"Genetic and epigenetic instability of human bone marrow mesenchymal stem cells expanded in autologous serum or fetal bovine serum","volume":"52","author":"Dahl","year":"2008","journal-title":"Int. J. Dev. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmed.2018.00118","article-title":"Considering Cell Therapy product \u201cGood Manufacturing practice\u201d Status","volume":"5","author":"Bedford","year":"2018","journal-title":"Front. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1002\/stem.2847","article-title":"Concise Review: Using Fat to Fight Disease: A Systematic Review of Nonhomologous Adipose-Derived Stromal\/Stem Cell Therapies","volume":"36","author":"Bateman","year":"2018","journal-title":"Stem Cells"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40634-017-0108-2","article-title":"Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis","volume":"4","author":"Russo","year":"2017","journal-title":"J. Exp. Orthop."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/jor.23471","article-title":"Chemokines and inflammation in osteoarthritis: Insights from patients and animal models","volume":"35","author":"Scanzello","year":"2017","journal-title":"J. Orthop. Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Cattaneo, G., De Caro, A., Napoli, F., Chiapale, D., Trada, P., and Camera, A. (2018). Micro-fragmented adipose tissue injection associated with arthroscopic procedures in patients with symptomatic knee osteoarthritis. BMC Musculoskelet Disord., 19.","DOI":"10.1186\/s12891-018-2105-8"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"bcr2018224426","DOI":"10.1136\/bcr-2018-224426","article-title":"Micro-fragmented adipose tissue for treatment of knee osteoarthritis with Baker\u2019s cyst: A case study","volume":"2018","author":"Arthurs","year":"2018","journal-title":"BMJ Case Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s13256-018-1776-y","article-title":"Ankylosing spondylitis, chronic fatigue and depression improved after stromal vascular fraction treatment for osteoarthritis: A case report","volume":"12","author":"Bright","year":"2018","journal-title":"J. Med. Case Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s40778-016-0053-5","article-title":"Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems\u00ae Technology Development","volume":"2","author":"Tremolada","year":"2016","journal-title":"Curr. Stem Cell Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.3727\/096368912X657855","article-title":"A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild mechanical forces from human lipoaspirates","volume":"22","author":"Bianchi","year":"2013","journal-title":"Cell Transplant."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/sctm.18-0051","article-title":"Higher pericyte content and secretory activity of micro fragmented human adipose tissue compared to enzymatically derived stromal vascular fraction","volume":"7","author":"Vezzani","year":"2018","journal-title":"Stem Cells Transl. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1002\/jcp.27307","article-title":"Effect of microfragmented adipose tissue on osteoarthritic synovial macrophage factors","volume":"234","author":"Paolella","year":"2018","journal-title":"J. Cell Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1089\/scd.2014.0071","article-title":"Isolation of adipose-derived stromal cells without enzymatic treatment: Expansion, phenotypical, and functional characterization","volume":"23","author":"Busser","year":"2014","journal-title":"Stem Cells Dev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/iep.12111","article-title":"Double labelling of human umbilical cord mesenchymal stem cells with Gd-DTPA and PKH26 and the influence on biological characteristics of hUCMSCs","volume":"96","author":"Shuai","year":"2015","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s13075-017-1318-9","article-title":"Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity","volume":"19","author":"Wang","year":"2017","journal-title":"Arthritis. Res. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/BOR.0b013e3282ba5693","article-title":"Hypoxia and osteoarthritis: How chondrocytes survive hypoxic environments","volume":"19","author":"Pfander","year":"2007","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Nava, S., Sordi, V., Pascucci, L., Tremolada, C., Ciusani, E., Zeira, O., Cadei, M., Soldati, G., Pessina, A., and Parati, E. (2019). Long-lasting anti-inflammatory activity of human micro-fragmented adipose tissue. Stem Cells Int., 5901479.","DOI":"10.1155\/2019\/5901479"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bone.2012.02.012","article-title":"The role of synovitis in osteoarthritis pathogenesis","volume":"51","author":"Scanzello","year":"2012","journal-title":"Bone"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/art.37908","article-title":"Adipose-derived mesenchymal stem cells exert anti-inflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2","volume":"65","author":"Manferdini","year":"2013","journal-title":"Arthritis. Rheum."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.scr.2013.05.008","article-title":"Adipose mesenchymal stem cells protect chondrocytes from degeneration associated with osteoarthritis","volume":"11","author":"Maumus","year":"2013","journal-title":"Stem Cell Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/sctm.18-0020","article-title":"Intra-articular administration of autologous micro fragmented adipose tissue in dogs with spontaneous osteoarthritis: Safety, feasibility and clinical outcomes","volume":"7","author":"Zeira","year":"2018","journal-title":"Stem Cells Int. Med."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Hudetz, D., Bori\u0107, I., Rod, E., Jele\u010d, \u017d., Radi\u0107, A., Vrdoljak, T., Skelin, A., Lauc, G., Trbojevi\u0107-Akma\u010di\u0107, I., and Ple\u010dko, M. (2017). The effects of Intra-articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis. Genes, 8.","DOI":"10.3390\/genes8100270"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1051\/sicotj\/2017029","article-title":"Arthroscopic treatment of chondral defects in the hip: AMIC, MACI, micro fragmented adipose tissue transplantation (MATT)and other options","volume":"3","author":"Jannelli","year":"2017","journal-title":"SICOT J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.joca.2017.01.011","article-title":"Adipose stromal cells mediated switching of the pro-inflammatory profile of M1-like macrophages is facilitated by PGE2: In vitro evaluation","volume":"25","author":"Manferdini","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1002\/stem.2689","article-title":"Immunomodulatory Effects of Adipose Stromal Vascular Fraction Cells Promote Alternative Activation Macrophages to Repair Tissue Damage","volume":"35","author":"Bowles","year":"2017","journal-title":"Stem Cells"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1726743","DOI":"10.1155\/2019\/1726743","article-title":"Pretreatment with G-CSF Could Enhance the Antifibrotic Effect of BM-MSCs on Pulmonary Fibrosis","volume":"2019","author":"Zhao","year":"2019","journal-title":"Stem Cells Int."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1063-4584(05)80318-8","article-title":"Characterization of a model of osteoarthritis in the rabbit knee","volume":"4","author":"Yoshioka","year":"1996","journal-title":"Osteoarthr. Cartil."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/j.joca.2010.05.029","article-title":"The OARSI histopathology initiative\u2014Recommendations for histological assessments of osteoarthritis in the rabbit","volume":"18","author":"Laverty","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/jor.20869","article-title":"Meniscus structure in human, sheep, and rabbit for animal models of meniscus repair","volume":"27","author":"Chevrier","year":"2009","journal-title":"J. Orthop. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.joca.2011.05.008","article-title":"Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis","volume":"19","author":"Pauli","year":"2011","journal-title":"Osteoarthr. Cartil."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/11\/2636\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:54:21Z","timestamp":1760187261000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/11\/2636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,29]]},"references-count":59,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,6]]}},"alternative-id":["ijms20112636"],"URL":"https:\/\/doi.org\/10.3390\/ijms20112636","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,29]]}}}