{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:44:50Z","timestamp":1790685890341,"version":"4.1.0"},"reference-count":87,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FEDER, Fondo de Investigaci\u00f3n Sanitaria, Instituto de Salud Carlos III","award":["CP 14\/00219"],"award-info":[{"award-number":["CP 14\/00219"]}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["ERC-2016-StG 715322-EndoMitTalk"],"award-info":[{"award-number":["ERC-2016-StG 715322-EndoMitTalk"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FEDER, Instituto de Salud Carlos III","award":["FIS16\/188"],"award-info":[{"award-number":["FIS16\/188"]}]},{"name":"Atracci\u00f3n de Talento Investigador, Comunidad de Madrid\/ Universidad Aut\u00f3noma de Madrid","award":["2017-T2\/BMD-5766"],"award-info":[{"award-number":["2017-T2\/BMD-5766"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are cell-derived membranous structures that were originally catalogued as a way of releasing cellular waste products. Since the discovery of their function in intercellular communication as carriers of proteins, lipids, and DNA and RNA molecules, numerous therapeutic approaches have focused on the use of EVs, in part because of their minimized risk compared to cell-based therapies. The skin is the organ with the largest surface in the body. Besides the importance of its body barrier function, much attention has been paid to the skin in regenerative medicine because of its cosmetic aspect, which is closely related to disorders affecting pigmentation and the presence or absence of hair follicles. The use of exosomes in therapeutic approaches for cutaneous wound healing has been reported and is briefly reviewed here. However, less attention has been paid to emerging interest in the potential capacity of EVs as modulators of hair follicle dynamics. Hair follicles are skin appendices that mainly comprise an epidermal and a mesenchymal component, with the former including a major reservoir of epithelial stem cells but also melanocytes and other cell types. Hair follicles continuously cycle, undergoing consecutive phases of resting, growing, and regression. Many biomolecules carried by EVs have been involved in the control of the hair follicle cycle and stem cell function. Thus, investigating the role of either naturally produced or therapeutically delivered EVs as signaling vehicles potentially involved in skin homeostasis and hair cycling may be an important step in the attempt to design future strategies towards the efficient treatment of several skin disorders.<\/jats:p>","DOI":"10.3390\/ijms20112758","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T03:38:01Z","timestamp":1559792281000},"page":"2758","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0817-1627","authenticated-orcid":false,"given":"Elisa","family":"Carrasco","sequence":"first","affiliation":[{"name":"Immunometabolism and Inflammation Laboratory, Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular Severo Ochoa (CBMSO) Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma, 28049 Madrid, Spain"},{"name":"Department of Molecular Biology, Faculty of Sciences, Universidad Aut\u00f3noma de Madrid (UAM), 28049 Madrid, Spain"},{"name":"Regulation of Cellular Homeostasis Laboratory, Area of Rare and Genetically Based Diseases, Instituto de Investigaci\u00f3n Hospital 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8043-7314","authenticated-orcid":false,"given":"Gonzalo","family":"Soto-Heredero","sequence":"additional","affiliation":[{"name":"Immunometabolism and Inflammation Laboratory, Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular Severo Ochoa (CBMSO) Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma, 28049 Madrid, Spain"},{"name":"Department of Molecular Biology, Faculty of Sciences, Universidad Aut\u00f3noma de Madrid (UAM), 28049 Madrid, Spain"},{"name":"Regulation of Cellular Homeostasis Laboratory, Area of Rare and Genetically Based Diseases, Instituto de Investigaci\u00f3n Hospital 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Mittelbrunn","sequence":"additional","affiliation":[{"name":"Immunometabolism and Inflammation Laboratory, Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular Severo Ochoa (CBMSO) Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma, 28049 Madrid, Spain"},{"name":"Department of Molecular Biology, Faculty of Sciences, Universidad Aut\u00f3noma de Madrid (UAM), 28049 Madrid, Spain"},{"name":"Regulation of Cellular Homeostasis Laboratory, Area of Rare and Genetically Based Diseases, Instituto de Investigaci\u00f3n Hospital 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/sj.jid.5700715","article-title":"Tissue Engineering for Cutaneous Wounds","volume":"127","author":"Clark","year":"2007","journal-title":"J. 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