{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T10:42:27Z","timestamp":1777113747739,"version":"3.51.4"},"reference-count":143,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T00:00:00Z","timestamp":1559952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U010184750301"],"award-info":[{"award-number":["U010184750301"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Parathyroid hormone-related protein (PTHrP), with isoforms ranging from 139 to 173 amino acids, has long been implicated in the development and regulation of multiple tissues, including that of the skeleton, via paracrine and autocrine signaling. PTHrP is also known as a potent mediator of cancer-induced bone disease, contributing to a vicious cycle between tumor cells and the bone microenvironment that drives the formation and progression of metastatic lesions. The abundance of roles ascribed to PTHrP have largely been attributed to the N-terminal 1\u201336 amino acid region, however, activities for mid-region and C-terminal products as well as additional shorter N-terminal species have also been described. Studies of the protein sequence have indicated that PTHrP is susceptible to post-translational proteolytic cleavage by multiple classes of proteases with emerging evidence pointing to novel functional roles for these PTHrP products in regulating cell behavior in homeostatic and pathological contexts. As a consequence, PTHrP products are also being explored as potential biomarkers of disease. Taken together, our enhanced understanding of the post-translational regulation of PTHrP bioactivity could assist in developing new therapeutic approaches that can effectively treat skeletal malignancies.<\/jats:p>","DOI":"10.3390\/ijms20112814","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T03:16:51Z","timestamp":1560136611000},"page":"2814","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Proteolytic Regulation of Parathyroid Hormone-Related Protein: Functional Implications for Skeletal Malignancy"],"prefix":"10.3390","volume":"20","author":[{"given":"Jeremy","family":"Frieling","sequence":"first","affiliation":[{"name":"Tumor Biology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conor","family":"Lynch","sequence":"additional","affiliation":[{"name":"Tumor Biology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.3616618","article-title":"A parathyroid hormone-related protein implicated in malignant hypercalcemia: Cloning and expression","volume":"237","author":"Suva","year":"1987","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1093\/clinchem\/38.11.2171","article-title":"Parathyroid hormone-related protein: Structure, function, and measurement","volume":"38","author":"Burtis","year":"1992","journal-title":"Clin. Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/jbmr.1617","article-title":"Twenty-five years of PTHrP progress: From cancer hormone to multifunctional cytokine","volume":"27","author":"McCauley","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1152\/physrev.00031.2015","article-title":"Parathyroid hormone-related protein, its regulation of cartilage and bone development, and role in treating bone diseases","volume":"96","author":"Martin","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1152\/physrev.1996.76.1.127","article-title":"Defining the roles of parathyroid hormone-related protein in normal physiology","volume":"76","author":"Philbrick","year":"1996","journal-title":"Physiol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1210\/endo.137.7.8770894","article-title":"The human PTH2 receptor: Binding and signal transduction properties of the stably expressed recombinant receptor","volume":"137","author":"Behar","year":"1996","journal-title":"Endocrinology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"17033","DOI":"10.1074\/jbc.274.24.17033","article-title":"Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(ii) bridges between helices iii and vi block activation","volume":"274","author":"Sheikh","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1073\/pnas.89.7.2732","article-title":"Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both camp and inositol trisphosphates and increases intracellular free calcium","volume":"89","author":"Juppner","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1124\/jpet.112.199752","article-title":"Parathyroid hormone (PTH) and PTH-related peptide domains contributing to activation of different PTH receptor-mediated signaling pathways","volume":"345","author":"Cupp","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1677\/JOE-10-0227","article-title":"Role of PTH1r internalization in osteoblasts and bone mass using a phosphorylation-deficient knock-in mouse model","volume":"207","author":"Datta","year":"2010","journal-title":"J. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1359\/jbmr.2003.18.8.1453","article-title":"Regulation of parathyroid hormone-stimulated phospholipase d in umr-106 cells by calcium, map kinase, and small g proteins","volume":"18","author":"Singh","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1210\/en.2004-1283","article-title":"G alpha12\/g alpha13 subunits of heterotrimeric g proteins mediate parathyroid hormone activation of phospholipase d in umr-106 osteoblastic cells","volume":"146","author":"Singh","year":"2005","journal-title":"Endocrinology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1210\/endo.140.1.6456","article-title":"Parathyroid hormone (PTH)-(1-34), (Nle(8,18),tyr34) PTH-(3-34) amide, PTH-(1-31) amide, and PTH-related peptide-(1-34) stimulate phosphatidylcholine hydrolysis in umr-106 osteoblastic cells: Comparison with effects of phorbol 12,13-dibutyrate","volume":"140","author":"Singh","year":"1999","journal-title":"Endocrinology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1210\/en.2007-0343","article-title":"Beta-arrestin-dependent parathyroid hormone-stimulated extracellular signal-regulated kinase activation and parathyroid hormone type 1 receptor internalization","volume":"148","author":"Sneddon","year":"2007","journal-title":"Endocrinology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"10856","DOI":"10.1074\/jbc.M513380200","article-title":"Distinct beta-arrestin- and g protein-dependent pathways for parathyroid hormone receptor-stimulated erk1\/2 activation","volume":"281","author":"Chen","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"11281","DOI":"10.1074\/jbc.M413393200","article-title":"Parathyroid hormone receptor trafficking contributes to the activation of extracellular signal-regulated kinases but is not required for regulation of camp signaling","volume":"280","author":"Syme","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S1097-2765(02)00727-X","article-title":"Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta","volume":"10","author":"Cingolani","year":"2002","journal-title":"Mol. Cell"},{"key":"ref_18","first-page":"E832","article-title":"Processing of pro-PTHrP by the prohormone convertase, furin: Effect on biological activity","volume":"268","author":"Liu","year":"1995","journal-title":"Am. J. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/BF01218424","article-title":"Production of parathyroid hormone and parathyroid-hormone-related protein by breast cancer cells in culture","volume":"119","author":"Francini","year":"1993","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1210\/mend-2-12-1230","article-title":"Expression of messenger ribonucleic acids encoding a parathyroid hormone-like peptide in normal human and animal tissues with abnormal expression in human parathyroid adenomas","volume":"2","author":"Ikeda","year":"1988","journal-title":"Mol. Endocrinol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1128\/jvi.67.10.6087-6095.1993","article-title":"Transactivation of the p2 promoter of parathyroid hormone-related protein by human t-cell lymphotropic virus type i tax1: Evidence for the involvement of transcription factor ets1","volume":"67","author":"Dittmer","year":"1993","journal-title":"J. Virol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1074\/jbc.272.8.4953","article-title":"Interaction of human t-cell lymphotropic virus type i tax, ets1, and sp1 in transactivation of the PTHrP p2 promoter","volume":"272","author":"Dittmer","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0303-7207(99)00151-3","article-title":"Regulation of parathyroid hormone-related protein gene expression in murine keratinocytes by e1a isoforms: A role for basal promoter and ets-1 site","volume":"156","author":"Foley","year":"1999","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"10901","DOI":"10.1074\/jbc.273.18.10901","article-title":"A negative vitamin d response DNA element in the human parathyroid hormone-related peptide gene binds to vitamin d receptor along with ku antigen to mediate negative gene regulation by vitamin d","volume":"273","author":"Nishishita","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0303-7207(97)00239-6","article-title":"Differential regulation of the parathyroid hormone-related protein gene p1 and p3 promoters by camp","volume":"138","author":"Chilco","year":"1998","journal-title":"Mol. Cell Endocrinol"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/bj3070159","article-title":"Epidermal growth factor-stimulated parathyroid hormone-related protein expression involves increased gene transcription and mrna stability","volume":"307","author":"Heath","year":"1995","journal-title":"Biochem. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1677\/joe.0.1810179","article-title":"Regulation of parathyroid hormone-related protein gene expression by epidermal growth factor-family ligands in primary human keratinocytes","volume":"181","author":"Cho","year":"2004","journal-title":"J. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1158\/0008-5472.CAN-10-2993","article-title":"Tgf-beta promotion of gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical hedgehog signaling","volume":"71","author":"Johnson","year":"2011","journal-title":"Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s10549-007-9748-8","article-title":"Amphiregulin-egfr signaling regulates PTHrP gene expression in breast cancer cells","volume":"110","author":"Gilmore","year":"2008","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0303-7207(94)90250-X","article-title":"Transforming growth factor-beta1 regulates steady-state PTH\/PTHrP receptor mrna levels and PTHrP binding in ros 17\/2.8 osteosarcoma cells","volume":"101","author":"McCauley","year":"1994","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1210\/endo.134.6.8194469","article-title":"Effects of transforming growth factor-beta on parathyroid hormone-related protein production and ribonucleic acid expression by a squamous carcinoma cell line in vitro","volume":"134","author":"Merryman","year":"1994","journal-title":"Endocrinology"},{"key":"ref_32","first-page":"747","article-title":"Mir-141-3p suppresses proliferation and promotes apoptosis by targeting gli2 in osteosarcoma cells","volume":"39","author":"Wang","year":"2018","journal-title":"Oncol Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1101\/gad.8.3.277","article-title":"Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene","volume":"8","author":"Karaplis","year":"1994","journal-title":"Genes Dev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1242\/dev.125.7.1285","article-title":"Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development","volume":"125","author":"Wysolmerski","year":"1998","journal-title":"Development"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"11846","DOI":"10.1073\/pnas.95.20.11846","article-title":"Parathyroid hormone-related protein is required for tooth eruption","volume":"95","author":"Philbrick","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1046\/j.1523-1747.1998.00428.x","article-title":"PTHrP regulates epidermal differentiation in adult mice","volume":"111","author":"Foley","year":"1998","journal-title":"J. Invest. Dermatol"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1006\/dbio.1996.0104","article-title":"Haploinsufficiency of parathyroid hormone-related peptide (PTHrP) results in abnormal postnatal bone development","volume":"175","author":"Amizuka","year":"1996","journal-title":"Dev. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1172\/JCI6629","article-title":"Ablation of the PTHrP gene or the PTH\/PTHrP receptor gene leads to distinct abnormalities in bone development","volume":"104","author":"Lanske","year":"1999","journal-title":"J. Clin. Invest."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1126\/science.273.5275.613","article-title":"Regulation of rate of cartilage differentiation by indian hedgehog and PTH-related protein","volume":"273","author":"Vortkamp","year":"1996","journal-title":"Science"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1172\/JCI26239","article-title":"Osteoblast-derived PTHrP is a physiological regulator of bone formation","volume":"115","author":"Martin","year":"2005","journal-title":"J. Clin. Invest."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1210\/jc.2009-0233","article-title":"Parathyroid hormone-related protein for the treatment of postmenopausal osteoporosis: Defining the maximal tolerable dose","volume":"95","author":"Horwitz","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1210\/jc.2002-021122","article-title":"Short-term, high-dose parathyroid hormone-related protein as a skeletal anabolic agent for the treatment of postmenopausal osteoporosis","volume":"88","author":"Horwitz","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1359\/jbmr.2000.15.8.1517","article-title":"Six-month daily administration of parathyroid hormone and parathyroid hormone-related protein peptides to adult ovariectomized rats markedly enhances bone mass and biomechanical properties: A comparison of human parathyroid hormone 1-34, parathyroid hormone-related protein 1-36, and sdz-parathyroid hormone 893","volume":"15","author":"Stewart","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1001\/jama.2016.11136","article-title":"Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: A randomized clinical trial","volume":"316","author":"Miller","year":"2016","journal-title":"JAMA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1210\/jc.2014-3718","article-title":"Effects of abaloparatide, a human parathyroid hormone-related peptide analog, on bone mineral density in postmenopausal women with osteoporosis","volume":"100","author":"Leder","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.maturitas.2016.12.003","article-title":"Abaloparatide: Recombinant human PTHrP (1-34) anabolic therapy for osteoporosis","volume":"97","author":"Chew","year":"2017","journal-title":"Maturitas"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/s00223-018-0450-0","article-title":"Abaloparatide is an effective treatment option for postmenopausal osteoporosis: Review of the number needed to treat compared with teriparatide","volume":"103","author":"Reginster","year":"2018","journal-title":"Calcif. Tissue Int."},{"key":"ref_48","first-page":"7710","article-title":"Immunohistochemical localization of parathyroid hormone-related protein in human breast cancer","volume":"50","author":"Southby","year":"1990","journal-title":"Cancer Res."},{"key":"ref_49","first-page":"3059","article-title":"Localization of parathyroid hormone-related protein in breast cancer metastases: Increased incidence in bone compared with other sites","volume":"51","author":"Powell","year":"1991","journal-title":"Cancer Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF00666208","article-title":"Osteolytic bone metastasis in breast cancer","volume":"32","author":"Yoneda","year":"1994","journal-title":"Breast Cancer Research and Treatment"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/283669a0","article-title":"Osteoclasts derived from haematopoietic stem cells","volume":"283","author":"Ash","year":"1980","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1172\/JCI118947","article-title":"Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis","volume":"98","author":"Guise","year":"1996","journal-title":"J. Clin. Invest."},{"key":"ref_53","first-page":"855","article-title":"Ras activation of human prostate epithelial cells induces overexpression of parathyroid hormone-related peptide","volume":"3","author":"Kremer","year":"1997","journal-title":"Clin. Cancer Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1002\/ijc.23602","article-title":"Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesions","volume":"123","author":"Liao","year":"2008","journal-title":"Int. J. Cancer"},{"key":"ref_55","first-page":"40","article-title":"Parathyroid hormone-related protein as a prohormone: Posttranslational processing and receptor interactions","volume":"15","author":"Orloff","year":"1994","journal-title":"Endocr Rev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"18236","DOI":"10.1016\/S0021-9258(19)37178-9","article-title":"Parathyroid hormone-related protein. Evidence for secretion of a novel mid-region fragment by three different cell types","volume":"267","author":"Soifer","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1006\/bbrc.2001.5249","article-title":"Proteolysis of proPTHrP(1-141) by \"prohormone thiol protease\" at multibasic residues generates PTHrP-related peptides: Implications for PTHrP peptide production in lung cancer cells","volume":"285","author":"Hook","year":"2001","journal-title":"Biochem. Biophys Res. Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1172\/JCI24918","article-title":"Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34","volume":"115","author":"Miao","year":"2005","journal-title":"J. Clin. Invest."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"19374","DOI":"10.1074\/jbc.M108913200","article-title":"Parathyroid hormone and parathyroid hormone-related protein exert both pro- and anti-apoptotic effects in mesenchymal cells","volume":"277","author":"Chen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1210\/en.2002-220818","article-title":"Minireview: Parathyroid hormone-related protein as an intracrine factor--trafficking mechanisms and functional consequences","volume":"144","author":"Stewart","year":"2003","journal-title":"Endocrinology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/sj.bjp.0703830","article-title":"A n-terminal PTHrP peptide fragment void of a PTH\/PTHrP-receptor binding domain activates cardiac et(a) receptors","volume":"132","author":"Schluter","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Frieling, J.S., Shay, G., Izumi, V., Aherne, S.T., Saul, R.G., Budzevich, M., Koomen, J., and Lynch, C.C. (2017). Matrix metalloproteinase processing of PTHrP yields a selective regulator of osteogenesis, PTHrP1-17. Oncogene.","DOI":"10.1038\/onc.2017.70"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0022-5347(01)65919-6","article-title":"Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: Inactivation of PTHrP-stimulated camp accumulation in mouse osteoblasts","volume":"156","author":"Cramer","year":"1996","journal-title":"J. Urol"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1359\/jbmr.2000.15.7.1266","article-title":"Cellular localization of neprilysin in mouse bone tissue and putative role in hydrolysis of osteogenic peptides","volume":"15","author":"Ruchon","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"ref_65","first-page":"308","article-title":"Tumor-bone cellular interactions in skeletal metastases","volume":"4","author":"Chirgwin","year":"2004","journal-title":"J. Musculoskelet Neuronal. Interact."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/BF00296214","article-title":"Synthetic parathyroid hormone-like protein (1-74) is anabolic for bone in vivo","volume":"51","author":"Weir","year":"1992","journal-title":"Calcif. Tissue Int."},{"key":"ref_67","first-page":"317","article-title":"A high abundance midregion species of parathyroid hormone-related protein: Immunological and chromatographic characterization in plasma","volume":"78","author":"Burtis","year":"1994","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1113\/expphysiol.1989.sp003303","article-title":"Stimulation of ovine placental calcium transport by purified natural and recombinant parathyroid hormone-related protein (PTHrP) preparations","volume":"74","author":"Abbas","year":"1989","journal-title":"Q J. Exp. Physiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0959-8049(94)00451-A","article-title":"Parathyroid hormone-related protein (PTHrP) in breast cancer and benign breast tissue","volume":"31A","author":"Edwards","year":"1995","journal-title":"Eur. J. Cancer"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1677\/joe.0.1420217","article-title":"Parathyroid hormone-related protein in human term placenta and membranes","volume":"142","author":"Bowden","year":"1994","journal-title":"J. Endocrinol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF03165025","article-title":"Circulating forms of immunoreactive parathyroid hormone-related protein for identifying patients with humoral hypercalcemia of malignancy: A comparative study with C-terminal(109-141)- and N-terminal(1-86)-region-specific PTHrP radioassay","volume":"8","author":"Suehiro","year":"1994","journal-title":"Ann. Nucl. Med."},{"key":"ref_72","first-page":"1610","article-title":"Effects of parathyroid hormone-related protein on osteogenic and adipogenic differentiation of human mesenchymal stem cells","volume":"18","author":"Zhang","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1365-2265.1994.tb03021.x","article-title":"Expression and processing of parathyroid hormone-related protein in a pancreatic endocrine cell tumour associated with hypercalcaemia","volume":"40","author":"Ratcliffe","year":"1994","journal-title":"Clin. Endocrinol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1158\/1055-9965.EPI-12-1318-T","article-title":"Identification of PTHrP(12-48) as a plasma biomarker associated with breast cancer bone metastasis","volume":"22","author":"Washam","year":"2013","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/jbmr.3142","article-title":"PTHrP(12-48) modulates the bone marrow microenvironment and suppresses human osteoclast differentiation and lifespan","volume":"32","author":"Kamalakar","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1113\/expphysiol.1990.sp003437","article-title":"Stimulation of ovine placental transport of calcium and magnesium by mid-molecule fragments of human parathyroid hormone-related protein","volume":"75","author":"Care","year":"1990","journal-title":"Exp. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"L12","DOI":"10.1152\/ajplung.00308.2001","article-title":"Parathyroid hormone-related protein-(38-64) regulates lung cell proliferation after silica injury","volume":"283","author":"Hastings","year":"2002","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1359\/jbmr.2001.16.12.2173","article-title":"Midregion parathyroid hormone-related protein inhibits growth and invasion in vitro and tumorigenesis in vivo of human breast cancer cells","volume":"16","author":"Luparello","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10549-007-9816-0","article-title":"Midregion PTHrP regulates rip1 and caspase expression in mda-mb231 breast cancer cells","volume":"111","author":"Luparello","year":"2008","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"24371","DOI":"10.1074\/jbc.271.40.24371","article-title":"Structural and physiologic characterization of the mid-region secretory species of parathyroid hormone-related protein","volume":"271","author":"Wu","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1677\/joe.0.1750517","article-title":"Parathyroid hormone-related peptide (38-94) amide stimulates atp-dependent calcium transport in the basal plasma membrane of the human syncytiotrophoblast","volume":"175","author":"Strid","year":"2002","journal-title":"J. Endocrinol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Philbrick, W. (2001). Parathyroid hormone-related protein: Gene structure, biosynthesis, metabolism, and regulation. The Parathyroids, Academic Press.","DOI":"10.1016\/B978-012098651-4\/50005-5"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1242\/jcs.00472","article-title":"PTHrP [67-86] regulates the expression of stress proteins in breast cancer cells inducing modifications in urokinase-plasminogen activator and mmp-1 expression 5","volume":"116","author":"Luparello","year":"2003","journal-title":"J. Cell Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"15233","DOI":"10.1073\/pnas.93.26.15233","article-title":"Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH\/PTHrP receptor","volume":"93","author":"Kovacs","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1165\/rcmb.2002-0314OC","article-title":"Proapoptotic effects of parathyroid hormone-related protein in type ii pneumocytes","volume":"29","author":"Hastings","year":"2003","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s002239900359","article-title":"PTHrP(107-111) inhibits in vivo resorption that was stimulated by PTHrP(1-34) when applied intermittently to neonatal mice","volume":"61","author":"Lewinson","year":"1997","journal-title":"Calcif. Tissue Int."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1210\/endo.136.3.7867592","article-title":"Carboxyl-terminal peptides from parathyroid hormone-related protein stimulate osteoclast-like cell formation","volume":"136","author":"Kaji","year":"1995","journal-title":"Endocrinology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1210\/endo-129-6-3424","article-title":"A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]","volume":"129","author":"Fenton","year":"1991","journal-title":"Endocrinology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0014-5793(02)03164-2","article-title":"The cooh-terminus of parathyroid hormone-related protein (PTHrP) interacts with beta-arrestin 1b","volume":"527","author":"Conlan","year":"2002","journal-title":"FEBS Lett"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1056\/NEJM199004193221603","article-title":"Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer","volume":"322","author":"Burtis","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"14078","DOI":"10.1074\/jbc.270.23.14078","article-title":"Cell type-specific secretion of parathyroid hormone-related protein via the regulated versus the constitutive secretory pathway","volume":"270","author":"Plawner","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1210\/endo.142.2.7944","article-title":"Nuclear forms of parathyroid hormone-related peptide are translated from non-aug start sites downstream from the initiator methionine","volume":"142","author":"Nguyen","year":"2001","journal-title":"Endocrinology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1074\/jbc.274.11.7391","article-title":"Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha","volume":"274","author":"Lam","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1128\/MCB.19.2.1210","article-title":"The arginine-rich domains present in human immunodeficiency virus type 1 tat and rev function as direct importin beta-dependent nuclear localization signals","volume":"19","author":"Truant","year":"1999","journal-title":"Mol. Cell Biol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Gu, Z., Liu, Y., Zhang, Y., Jin, S., Chen, Q., Goltzman, D., Karaplis, A., and Miao, D. (2012). Absence of PTHrP nuclear localization and carboxyl terminus sequences leads to abnormal brain development and function. PLoS One, 7.","DOI":"10.1371\/journal.pone.0041542"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.1041550102","article-title":"Long-term culture of disaggregated rat osteoclasts: Inhibition of bone resorption and reduction of osteoclast-like cell number by calcitonin and PTHrP[107-139]","volume":"155","author":"Fenton","year":"1993","journal-title":"J. Cell Physiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1210\/endo.138.3.4990","article-title":"Parathyroid hormone-related protein-(107-139) inhibits bone resorption in vivo","volume":"138","author":"Cornish","year":"1997","journal-title":"Endocrinology"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1002\/jcp.22902","article-title":"Comparison of the skeletal effects induced by daily administration of PTHrP (1-36) and PTHrP (107-139) to ovariectomized mice","volume":"227","author":"Lozano","year":"2012","journal-title":"J. Cell Physiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1210\/jc.2014-4250","article-title":"PTHrP-mediated hypercalcemia: Causes and survival in 138 patients","volume":"100","author":"Donovan","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"28382","DOI":"10.1074\/jbc.M109.022905","article-title":"Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides","volume":"284","author":"Pioszak","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S1043-2760(01)00409-X","article-title":"Molecular properties of the PTH\/PTHrP receptor","volume":"12","author":"Gardella","year":"2001","journal-title":"Trends Endocrinol Metab"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1746-1561.1995.tb03377.x","article-title":"Methodology","volume":"65","author":"Errecart","year":"1995","journal-title":"J. Sch. Health"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/(SICI)1097-4652(199702)170:2<209::AID-JCP13>3.0.CO;2-C","article-title":"Antiproliferative effect of the c-terminal fragments of parathyroid hormone-related protein, PTHrP-(107-111) and (107-139), on osteoblastic osteosarcoma cells","volume":"170","author":"Valin","year":"1997","journal-title":"J. Cell Physiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/jcp.1041580317","article-title":"C-terminal fragments of parathyroid hormone-related protein, PTHrP-(107-111) and (107-139), and the n-terminal PTHrP-(1-40) fragment stimulate membrane-associated protein kinase c activity in rat spleen lymphocytes","volume":"158","author":"Whitfield","year":"1994","journal-title":"J. Cell Physiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1681\/ASN.V1161085","article-title":"C-terminal parathyroid hormone-related protein increases vascular endothelial growth factor in human osteoblastic cells","volume":"11","author":"Esbrit","year":"2000","journal-title":"J. Am. Soc. Nephrol"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1042\/bj3550707","article-title":"Characterization of phex endopeptidase catalytic activity: Identification of parathyroid-hormone-related peptide107-139 as a substrate and osteocalcin, ppi and phosphate as inhibitors","volume":"355","author":"Boileau","year":"2001","journal-title":"Biochem. J."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Mohammad, K.S., and Guise, T.A. (2003). Mechanisms of osteoblastic metastases: Role of endothelin-1. Clin. Orthop. Relat. Res., S67\u2013S74.","DOI":"10.1097\/01.blo.0000093047.96273.4e"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.peptides.2005.03.017","article-title":"PTHrP fragments 1-16 and 1-23 do not bind to either the eta or the etb endothelin receptors","volume":"26","author":"Langlois","year":"2005","journal-title":"Peptides"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1210\/mend.16.2.0775","article-title":"Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules","volume":"16","author":"Lam","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"30433","DOI":"10.1074\/jbc.R800035200","article-title":"Proteases: Multifunctional enzymes in life and disease","volume":"283","author":"Bond","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.devcel.2010.01.003","article-title":"A new dress code for mmps: Cleavage optional","volume":"18","author":"Fingleton","year":"2010","journal-title":"Dev. Cell"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm858","article-title":"Protease degradomics: A new challenge for proteomics","volume":"3","author":"Overall","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nrd2092","article-title":"Targeting proteases: Successes, failures and future prospects","volume":"5","author":"Turk","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Fortelny, N., Cox, J.H., Kappelhoff, R., Starr, A.E., Lange, P.F., Pavlidis, P., and Overall, C.M. (2014). Network analyses reveal pervasive functional regulation between proteases in the human protease web. PLoS Biol., 12.","DOI":"10.1371\/journal.pbio.1001869"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.bbamcr.2017.08.004","article-title":"Overview of transcriptomic analysis of all human proteases, non-proteolytic homologs and inhibitors: Organ, tissue and ovarian cancer cell line expression profiling of the human protease degradome by the clip-chip DNA microarray","volume":"1864","author":"Kappelhoff","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"9517","DOI":"10.1074\/jbc.270.16.9517","article-title":"Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin. A mass spectrometric study","volume":"270","author":"Hendy","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrd3699","article-title":"The biology and therapeutic targeting of the proprotein convertases","volume":"11","author":"Seidah","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_118","first-page":"91","article-title":"Arg21 is the preferred kexin cleavage site in parathyroid-hormone-related protein","volume":"229","author":"Brenner","year":"1995","journal-title":"Eur J. Biochem."},{"key":"ref_119","first-page":"322","article-title":"some physico-chemical characteristics of \" -seminoprotein\", an antigenic component specific for human seminal plasma. Forensic immunological study of body fluids and secretion. Vii","volume":"25","author":"Hara","year":"1971","journal-title":"Nihon Hoigaku Zasshi"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1200\/JCO.2003.02.083","article-title":"Biology of prostate-specific antigen","volume":"21","author":"Balk","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Mattsson, J.M., Ravela, S., Hekim, C., Jonsson, M., Malm, J., Narvanen, A., Stenman, U.H., and Koistinen, H. (2014). Proteolytic activity of prostate-specific antigen (psa) towards protein substrates and effect of peptides stimulating psa activity. PLoS One, 9.","DOI":"10.1371\/journal.pone.0107819"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"526341","DOI":"10.1155\/2014\/526341","article-title":"Kallikreins as biomarkers for prostate cancer","volume":"2014","author":"Hong","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_123","first-page":"1089","article-title":"Prostate-specific antigen, a serine protease, facilitates human prostate cancer cell invasion","volume":"1","author":"Webber","year":"1995","journal-title":"Clin. Cancer Res."},{"key":"ref_124","first-page":"1046","article-title":"Prostate-specific antigen (psa) is an insulin-like growth factor binding protein-3 protease found in seminal plasma","volume":"75","author":"Cohen","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_125","first-page":"229","article-title":"Serum insulin-like growth factor-binding protein-2 (igfbp-2) is increased and igfbp-3 is decreased in patients with prostate cancer: Correlation with serum prostate-specific antigen","volume":"77","author":"Kanety","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/pros.20531","article-title":"Does psa play a role as a promoting agent during the initiation and\/or progression of prostate cancer?","volume":"67","author":"Williams","year":"2007","journal-title":"Prostate"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0090-4295(96)00182-3","article-title":"Alteration of the hormonal bioactivity of parathyroid hormone-related protein (PTHrP) as a result of limited proteolysis by prostate-specific antigen","volume":"48","author":"Iwamura","year":"1996","journal-title":"Urology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0009-9120(94)90015-9","article-title":"Immunoreactive prostate-specific antigen levels in female and male breast tumors and its association with steroid hormone receptors and patient age","volume":"27","author":"Yu","year":"1994","journal-title":"Clin. Biochem."},{"key":"ref_129","first-page":"25","article-title":"Immunocytochemical detection of prostate-specific antigen (psa) in skin adnexal and breast tissues and tumors","volume":"33","author":"Papotti","year":"1989","journal-title":"Basic Appl Histochem"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1016\/S0962-8924(01)82222-4","article-title":"The many faces of metalloproteases: Cell growth, invasion, angiogenesis and metastasis","volume":"11","author":"Chang","year":"2001","journal-title":"Trends Cell Biol."},{"key":"ref_131","first-page":"87","article-title":"Neutral endopeptidase 24.11: Structure, inhibition, and experimental and clinical pharmacology","volume":"45","author":"Roques","year":"1993","journal-title":"Pharmacol Rev."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1096\/fasebj.11.5.9141502","article-title":"Mammalian membrane metallopeptidases: Nep, ece, kell, and pex","volume":"11","author":"Turner","year":"1997","journal-title":"FASEB J."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/stem.592","article-title":"Concise review: Neutral endopeptidase (cd10): A multifaceted environment actor in stem cells, physiological mechanisms, and cancer","volume":"29","author":"Besancon","year":"2011","journal-title":"Stem Cells"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","article-title":"Structure and function of matrix metalloproteinases and timps","volume":"69","author":"Nagase","year":"2006","journal-title":"Cardiovasc Res."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Thiolloy, S., Edwards, J.R., Fingleton, B., Rifkin, D.B., Matrisian, L.M., and Lynch, C.C. (2012). An osteoblast-derived proteinase controls tumor cell survival via tgf-beta activation in the bone microenvironment. PLoS One, 7.","DOI":"10.1371\/journal.pone.0029862"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1158\/1541-7786.MCR-09-0445","article-title":"Osteoclast-derived matrix metalloproteinase-9 directly affects angiogenesis in the prostate tumor-bone microenvironment","volume":"8","author":"Johnson","year":"2010","journal-title":"Mol. Cancer Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ccr.2005.04.013","article-title":"Mmp-7 promotes prostate cancer-induced osteolysis via the solubilization of rankl","volume":"7","author":"Lynch","year":"2005","journal-title":"Cancer Cell"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1677\/jme.0.0310609","article-title":"Parathyroid hormone (PTH) secretion, PTH mrna and calcium-sensing receptor mrna expression in equine parathyroid cells, and effects of interleukin (il)-1, il-6, and tumor necrosis factor-alpha on equine parathyroid cell function","volume":"31","author":"Toribio","year":"2003","journal-title":"J. Mol. Endocrinol"},{"key":"ref_139","unstructured":"(2019, June 05). The human protein atlas. Available online: https:\/\/www.proteinatlas.org\/ENSG00000140564-FURIN\/tissue\/parathyroid+gland."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/pro.5560070401","article-title":"Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes","volume":"7","author":"Khan","year":"1998","journal-title":"Protein Sci."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1210\/endo.139.4.5941","article-title":"Effects of parathyroid hormone (PTH) and PTH-related peptide on expressions of matrix metalloproteinase-2, -3, and -9 in growth plate chondrocyte cultures","volume":"139","author":"Satakeda","year":"1998","journal-title":"Endocrinology"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1515\/hsz-2012-0249","article-title":"Activation profiles of human kallikrein-related peptidases by matrix metalloproteinases","volume":"394","author":"Yoon","year":"2013","journal-title":"Biol. Chem."},{"key":"ref_143","first-page":"106","article-title":"Abaloparatide","volume":"13","author":"Gonnelli","year":"2016","journal-title":"Clin. Cases Miner. Bone Metab."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/11\/2814\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:57:06Z","timestamp":1760187426000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/11\/2814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,8]]},"references-count":143,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,6]]}},"alternative-id":["ijms20112814"],"URL":"https:\/\/doi.org\/10.3390\/ijms20112814","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,8]]}}}