{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:19:49Z","timestamp":1777645189217,"version":"3.51.4"},"reference-count":54,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babes\u201d University of Medicine and Pharmacy of Timisoara","award":["\u201cVictor Babes\u201d University of Medicine and Pharmacy of Timisoara"],"award-info":[{"award-number":["\u201cVictor Babes\u201d University of Medicine and Pharmacy of Timisoara"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Maslinic acid is a pentacyclic triterpene with a plethora of biological activities, including anti-inflammatory, antioxidant, antimicrobial, cardioprotective, and antitumor effects. New derivatives with improved properties and broad-spectrum activity can be obtained following structural changes of the compound. The present study was aimed to characterize a benzylamide derivative of maslinic acid\u2014benzyl (2\u03b1, 3\u03b2) 2,3-diacetoxy-olean\u221212-en-28-amide (EM2)\u2014with respect to the anti-angiogenic and anti-inflammatory effects in two in vivo experimental models. Consequently, the compound showed good tolerability and lack of irritation in the chorioallantoic membrane assay with no impairment of the normal angiogenic process during the tested stages of development. In the acute ear inflammation murine model, application of EM2 induced a mild anti-inflammatory effect that was potentiated by the association with zinc chloride (ZnCl2). A decrease in dermal thickness of mice ears was observed when EM2 and ZnCl2 were applied separately or in combination. Moreover, hyalinization of the dermis appeared only when EM2 was associated with ZnCl2, strongly suggesting the role of their combination in wound healing.<\/jats:p>","DOI":"10.3390\/ijms20112828","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T11:39:47Z","timestamp":1560166787000},"page":"2828","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Assessment of the Antiangiogenic and Anti-Inflammatory Properties of a Maslinic Acid Derivative and its Potentiation using Zinc Chloride"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2223-5228","authenticated-orcid":false,"given":"Ioana Zinuca","family":"Pavel","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 2, Eftimie Murgu Sq., Timi\u015foara 300041, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7911-290X","authenticated-orcid":false,"given":"Rene","family":"Csuk","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina","family":"Danciu","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 2, Eftimie Murgu Sq., Timi\u015foara 300041, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefana","family":"Avram","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 2, Eftimie Murgu Sq., Timi\u015foara 300041, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5755-179X","authenticated-orcid":false,"given":"Flavia","family":"Baderca","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology, Faculty of Medicine, \"Victor Babe\u015f\" University of Medicine and Pharmacy, 2, Eftimie Murgu Sq., Timi\u015foara 300041, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Cioca","sequence":"additional","affiliation":[{"name":"Department of Pathology, CFR Clinical Hospital, 13\u221215, Tudor Vladimirescu, Timi\u015foara 300173, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2631-7028","authenticated-orcid":false,"given":"Elena-Alina","family":"Moac\u0103","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Faculty of Pharmacy, \"Victor Babe\u015f\" University of Medicine and Pharmacy, 2, Eftimie Murgu Sq., Timi\u015foara 300041, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciprian-Valentin","family":"Mihali","sequence":"additional","affiliation":[{"name":"\u201cGeorge Emil Palade\u201d Electron Microscopy Center, Institute of Life Sciences, Faculty of Medicine, \u201cVasile Goldi\u0219\u201d Western University of Arad, 86, Liviu Rebreanu St., Arad 310414, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2295-1926","authenticated-orcid":false,"given":"Iulia","family":"Pinzaru","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Faculty of Pharmacy, \"Victor Babe\u015f\" University of Medicine and Pharmacy, 2, Eftimie Murgu Sq., Timi\u015foara 300041, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danina Mirela","family":"Muntean","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences - Pathophysiology, Faculty of Medicine, \"Victor Babe\u015f\" University of Medicine and Pharmacy, 2, Eftimie Murgu Sq., Timi\u015foara 300041, Romania"},{"name":"Center for Translational Research and Systems Medicine, \"Victor Babe\u015f\" University of Medicine and Pharmacy, 2, Eftimie Murgu Sq.,Timi\u015foara 300041, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Adriana","family":"Dehelean","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Faculty of Pharmacy, \"Victor Babe\u015f\" University of Medicine and Pharmacy, 2, Eftimie Murgu Sq., Timi\u015foara 300041, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"627375","DOI":"10.1155\/2013\/627375","article-title":"New Perspectives on How to Discover Drugs from Herbal Medicines: CAM\u2019s Outstanding Contribution to Modern Therapeutics","volume":"2013","author":"Pan","year":"2013","journal-title":"Evid. 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