{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:39:59Z","timestamp":1792190399965,"version":"4.4.0"},"reference-count":162,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,6,16]],"date-time":"2019-06-16T00:00:00Z","timestamp":1560643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007300","name":"China Medical University","doi-asserted-by":"publisher","award":["CMU107-S-37"],"award-info":[{"award-number":["CMU107-S-37"]}],"id":[{"id":"10.13039\/501100007300","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and Technology","award":["MOST 106-2314-B-039-003-MY2"],"award-info":[{"award-number":["MOST 106-2314-B-039-003-MY2"]}]},{"name":"Ministry of Science and Technology","award":["MOST 107-2314-B-468 -007"],"award-info":[{"award-number":["MOST 107-2314-B-468 -007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Oral submucous fibrosis (OSF) is characterized by abnormal collagen deposition. It is a precancerous disorder and transforms into a malignant tumor in 1.5\u201315% of all cases. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. All of these greatly interfere with patient quality of life. The present review introduces OSF from a molecular perspective and summarizes what is known about its underlying mechanisms, diagnostic biomarkers, and therapeutic interventions. In addition to the aggressive treatment of OSF, its prevention is also important. Future research should, therefore, focus on improving the oral health literacy of the patients susceptible to OSF.<\/jats:p>","DOI":"10.3390\/ijms20122940","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T03:24:41Z","timestamp":1560741881000},"page":"2940","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":239,"title":["Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy"],"prefix":"10.3390","volume":"20","author":[{"given":"Yin-Hwa","family":"Shih","sequence":"first","affiliation":[{"name":"Department of Healthcare Administration, Asia University, Taichung 41354, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Tissue Bank, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan"},{"name":"Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan"},{"name":"Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan"},{"name":"Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzong-Ming","family":"Shieh","sequence":"additional","affiliation":[{"name":"Department of Dental Hygiene, College of Health Care, China Medical University, Taichung 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2558-2209","authenticated-orcid":false,"given":"Yu-Hsin","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/ijc.28754","article-title":"Potentially malignant disorders of the oral cavity: Current practice and future directions in the clinic and laboratory","volume":"136","author":"Dionne","year":"2015","journal-title":"Int. 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