{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:02:21Z","timestamp":1790510541352,"version":"4.1.0"},"reference-count":107,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2015SHM58M_004"],"award-info":[{"award-number":["2015SHM58M_004"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["Departments of Excellence - 2017 - legge 232\/2016 - art.1, commi 314\u2013337 awarded to Dept. of Science - University Roma Tre - Rome - Italy for 2018\u20132022"],"award-info":[{"award-number":["Departments of Excellence - 2017 - legge 232\/2016 - art.1, commi 314\u2013337 awarded to Dept. of Science - University Roma Tre - Rome - Italy for 2018\u20132022"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The mevalonate (MVA)\/cholesterol pathway is crucial for central nervous system (CNS) development and function and consequently, any dysfunction of this fundamental metabolic pathway is likely to provoke pathologic changes in the brain. Mutations in genes directly involved in MVA\/cholesterol metabolism cause a range of diseases, many of which present neurologic and psychiatric symptoms. This raises the question whether other diseases presenting similar symptoms are related albeit indirectly to the MVA\/cholesterol pathway. Here, we summarized the current literature suggesting links between MVA\/cholesterol dysregulation and specific diseases, namely autism spectrum disorder and Rett syndrome.<\/jats:p>","DOI":"10.3390\/ijms20133317","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T03:01:31Z","timestamp":1562554891000},"page":"3317","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Loss of Mevalonate\/Cholesterol Homeostasis in the Brain: A Focus on Autism Spectrum Disorder and Rett Syndrome"],"prefix":"10.3390","volume":"20","author":[{"given":"Marco","family":"Segatto","sequence":"first","affiliation":[{"name":"Department of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, 86090 Pesche (IS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Tonini","sequence":"additional","affiliation":[{"name":"Department of Science, University Roma Tre, Viale Marconi, 446, 00146 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank W.","family":"Pfrieger","sequence":"additional","affiliation":[{"name":"Institute of Cellular and Integrative Neurosciences (INCI) CNRS UPR 3212, Universit\u00e9 de Strasbourg, 5, rue Blaise Pascal, 67084 Strasbourg Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Trezza","sequence":"additional","affiliation":[{"name":"Department of Science, University Roma Tre, Viale Marconi, 446, 00146 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2511-6168","authenticated-orcid":false,"given":"Valentina","family":"Pallottini","sequence":"additional","affiliation":[{"name":"Department of Science, University Roma Tre, Viale Marconi, 446, 00146 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1194\/jlr.R400004-JLR200","article-title":"Thematic review series: Brain Lipids. 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