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The exclusive and specific target of the toxin is the voltage-gated sodium channels of the insect, resulting in fast excitatory paralysis and even death. Because of its strict toxic selectivity and high bioactivity, AaIT has been widely used in experiments exploring pest bio-control. Recombinant expression of AaIT in a baculovirus or a fungus can increase their virulence to insect pests and diseases vectors. Likewise, transgenic plants expressing AaIT have notable anti-insect activity. AaIT is an efficient toxin and has great potential to be used in the development of commercial insecticides.<\/jats:p>","DOI":"10.3390\/ijms20143467","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T02:23:16Z","timestamp":1563243796000},"page":"3467","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Application of the Scorpion Neurotoxin AaIT against Insect Pests"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0901-7661","authenticated-orcid":false,"given":"Sheng-Qun","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, Southern Medical University, Guangzhou, Guangdong Province 510515, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, Southern Medical University, Guangzhou, Guangdong Province 510515, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Shanghai Medical School of Fudan University, Shanghai 200011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, Southern Medical University, Guangzhou, Guangdong Province 510515, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9345-8218","authenticated-orcid":false,"given":"Hong-Juan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, Southern Medical University, Guangzhou, Guangdong Province 510515, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.cropro.2013.10.022","article-title":"Crop losses and the economic impact of insect pests on Brazilian agriculture","volume":"56","author":"Oliveira","year":"2014","journal-title":"Crop. 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