{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:46:58Z","timestamp":1787028418421,"version":"build-2736575974"},"reference-count":37,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["AN321\/2-1"],"award-info":[{"award-number":["AN321\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHW577\/8-1"],"award-info":[{"award-number":["SCHW577\/8-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R03MH094834"],"award-info":[{"award-number":["R03MH094834"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R03DA033491"],"award-info":[{"award-number":["R03DA033491"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Patterns of spontaneous electric activity in the cerebral cortex change upon administration of benzodiazepines. Here we are testing the hypothesis that the prototypical benzodiazepine, diazepam, affects spectral power density in the low (20\u201350 Hz) and high (50\u201390 Hz) \u03b3-band by targeting GABAA receptors harboring \u03b11- and \u03b12-subunits. Local field potentials (LFPs) and action potentials were recorded in the barrel cortex of wild type mice and two mutant strains in which the drug exclusively acted via GABAA receptors containing either \u03b11- (DZ\u03b11-mice) or \u03b12-subunits (DZ\u03b12-mice). In wild type mice, diazepam enhanced low \u03b3-power. This effect was also evident in DZ\u03b12-mice, while diazepam decreased low \u03b3-power in DZ\u03b11-mice. Diazepam increased correlated local LFP-activity in wild type animals and DZ\u03b12- but not in DZ\u03b11-mice. In all genotypes, spectral power density in the high \u03b3-range and multi-unit action potential activity declined upon diazepam administration. We conclude that diazepam modifies low \u03b3-power in opposing ways via \u03b11- and \u03b12-GABAA receptors. The drug\u2019s boosting effect involves \u03b12-receptors and an increase in local intra-cortical synchrony. Furthermore, it is important to make a distinction between high- and low \u03b3-power when evaluating the effects of drugs that target GABAA receptors.<\/jats:p>","DOI":"10.3390\/ijms20143486","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T02:44:03Z","timestamp":1563331443000},"page":"3486","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effects of Diazepam on Low-Frequency and High-Frequency Electrocortical \u03b3-Power Mediated by \u03b11- and \u03b12-GABAA Receptors"],"prefix":"10.3390","volume":"20","author":[{"given":"Julian I.","family":"Hofmann","sequence":"first","affiliation":[{"name":"Werner Reichardt Center for Integrative Neuroscience, Eberhard-Karls-University T\u00fcbingen, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Werner Reichardt Center for Integrative Neuroscience, Eberhard-Karls-University T\u00fcbingen, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-4746","authenticated-orcid":false,"given":"Uwe","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champain, Urbana, IL 61802-6178 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Antkowiak","sequence":"additional","affiliation":[{"name":"Werner Reichardt Center for Integrative Neuroscience, Eberhard-Karls-University T\u00fcbingen, 72076 T\u00fcbingen, Germany"},{"name":"Department of Anesthesiology and Intensive Care, Experimental Anesthesiology Section, Eberhard-Karls-University T\u00fcbingen, 72072 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrd3502","article-title":"Beyond classical benzodiazepines: Novel therapeutic potential of GABAA receptor subtypes","volume":"10","author":"Rudolph","year":"2011","journal-title":"Nat. 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