{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:26:56Z","timestamp":1790630816091,"version":"4.1.0"},"reference-count":110,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T00:00:00Z","timestamp":1563667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001675","name":"International Brain Research Organization","doi-asserted-by":"publisher","award":["Return Home Fellowship 2018"],"award-info":[{"award-number":["Return Home Fellowship 2018"]}],"id":[{"id":"10.13039\/501100001675","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sphingolipids (SL) modulate several cellular processes including cell death, proliferation and autophagy. The conversion of sphingomyelin (SM) to ceramide and the balance between ceramide and sphingosine-1-phosphate (S1P), also known as the SL rheostat, have been associated with oxidative stress and neurodegeneration. Research in the last decade has focused on the possibility of targeting the SL metabolism as a therapeutic option; and SL levels in biofluids, including serum, plasma, and cerebrospinal fluid (CSF), have been measured in several neurodegenerative diseases with the aim of finding a diagnostic or prognostic marker. Previous reviews focused on results from diseases such as Alzheimer\u2019s Disease (AD), evaluated total SL or species levels in human biofluids, post-mortem tissues and\/or animal models. However, a comprehensive review of SL alterations comparing results from several neurodegenerative diseases is lacking. The present work compiles data from circulating sphingolipidomic studies and attempts to elucidate a possible connection between certain SL species and neurodegeneration processes. Furthermore, the effects of ceramide species according to their acyl-chain length in cellular pathways such as apoptosis and proliferation are discussed in order to understand the impact of the level alteration in specific species. Finally, enzymatic regulations and the possible influence of insulin resistance in the level alteration of SL are evaluated.<\/jats:p>","DOI":"10.3390\/ijms20143564","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T02:55:37Z","timestamp":1563764137000},"page":"3564","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Alteration of Sphingolipids in Biofluids: Implications for Neurodegenerative Diseases"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7009-2743","authenticated-orcid":false,"given":"Luciana M.","family":"Pujol-Lereis","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n y Desarrollo en Inmunolog\u00eda y Enfermedades Infecciosas (CIDIE-CONICET), X5016DHK C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1126\/science.1174621","article-title":"Lipid rafts as a membrane-organizing principle","volume":"327","author":"Lingwood","year":"2010","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"170069","DOI":"10.1098\/rsob.170069","article-title":"Sphingolipids: Membrane microdomains in brain development, function and neurological diseases","volume":"7","author":"Olsen","year":"2017","journal-title":"Open Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrm2329","article-title":"Principles of bioactive lipid signalling: Lessons from sphingolipids","volume":"9","author":"Hannun","year":"2008","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cbpb.2012.05.006","article-title":"The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: Oxidative stress and the seesaw of cell survival and death","volume":"163","author":"Williams","year":"2012","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/j.1476-5381.2009.00281.x","article-title":"Sphingolipids in inflammation: Pathological implications and potential therapeutic targets","volume":"158","author":"Nixon","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0962-8924(00)01830-4","article-title":"Ceramide as a second messenger: Sticky solutions to sticky problems","volume":"10","author":"Venkataraman","year":"2000","journal-title":"Trends Cell Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s12035-009-8096-6","article-title":"Deregulated sphingolipid metabolism and membrane organization in neurodegenerative disorders","volume":"41","author":"Piccinini","year":"2010","journal-title":"Mol. Neurobiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/jnr.23763","article-title":"How membrane dysfunction influences neuronal survival pathways in sphingolipid storage disorders","volume":"94","author":"Bongarzone","year":"2016","journal-title":"J. Neurosci. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/jnr.23753","article-title":"Synaptic failure: The achilles tendon of sphingolipidoses","volume":"94","author":"Bongarzone","year":"2016","journal-title":"J. Neurosci. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jns.2008.12.010","article-title":"Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death","volume":"278","author":"Jana","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1016\/j.bbamem.2006.08.009","article-title":"Ceramides and other bioactive sphingolipid backbones in health and disease: Lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy","volume":"1758","author":"Zheng","year":"2006","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1042\/BJ20111626","article-title":"Ceramide synthases at the centre of sphingolipid metabolism and biology","volume":"441","author":"Mullen","year":"2012","journal-title":"Biochem. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.chemphyslip.2015.07.026","article-title":"Ceramide synthases in biomedical research","volume":"197","author":"Cingolani","year":"2016","journal-title":"Chem. Phys. Lipids"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1101\/gr.8.12.1259","article-title":"Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human","volume":"8","author":"Jiang","year":"1998","journal-title":"Genome Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1074\/jbc.M707386200","article-title":"Characterization of ceramide synthase 2: Tissue distribution, substrate specificity, and inhibition by sphingosine-1-phosphate","volume":"283","author":"Laviad","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1074\/jbc.M110.164392","article-title":"Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis","volume":"286","author":"Novgorodov","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00418-007-0344-0","article-title":"Differential expression of (dihydro)ceramide synthases in mouse brain: Oligodendrocyte-specific expression of CerS2\/Lass2","volume":"129","author":"Becker","year":"2008","journal-title":"Histochem. Cell Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1111\/ejn.13260","article-title":"Defective ceramide synthases in mice cause reduced amplitudes in electroretinograms and altered sphingolipid composition in retina and cornea","volume":"44","author":"Bruggen","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"35642","DOI":"10.1074\/jbc.M205211200","article-title":"Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells","volume":"277","author":"Venkataraman","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"33931","DOI":"10.1074\/jbc.M608092200","article-title":"Necessary role for the lag1p motif in (dihydro)ceramide synthase activity","volume":"281","author":"Spassieva","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1158\/1535-7163.MCT-06-0558","article-title":"Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas","volume":"6","author":"Senkal","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1194\/jlr.M009142","article-title":"Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism","volume":"52","author":"Mullen","year":"2011","journal-title":"J. Lipid Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"10922","DOI":"10.1074\/jbc.M610157200","article-title":"Alterations of ceramide\/sphingosine-1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells","volume":"282","author":"Baran","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1096\/fj.07-8621com","article-title":"Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1","volume":"21","author":"Song","year":"2007","journal-title":"Faseb J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1042\/BJ20050291","article-title":"Mammalian Lass6 and its related family members regulate synthesis of specific ceramides","volume":"390","author":"Mizutani","year":"2005","journal-title":"Biochem. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"41888","DOI":"10.1074\/jbc.M112.413500","article-title":"Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes","volume":"287","author":"Ginkel","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1194\/jlr.M800158-JLR200","article-title":"2-Hydroxy-ceramide synthesis by ceramide synthase family: Enzymatic basis for the preference of FA chain length","volume":"49","author":"Mizutani","year":"2008","journal-title":"J. Lipid Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/hmg\/ddr494","article-title":"Loss of ceramide synthase 3 causes lethal skin barrier disruption","volume":"21","author":"Jennemann","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"37083","DOI":"10.1074\/jbc.M307554200","article-title":"Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast","volume":"278","author":"Guillas","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"10902","DOI":"10.1074\/jbc.M109.077594","article-title":"A critical role for ceramide synthase 2 in liver homeostasis: I. Alterations in lipid metabolic pathways","volume":"285","author":"Park","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1042\/BJ20060379","article-title":"LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity","volume":"398","author":"Mizutani","year":"2006","journal-title":"Biochem. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"43452","DOI":"10.1074\/jbc.M307104200","article-title":"Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors","volume":"278","author":"Riebeling","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1042\/BJ20131242","article-title":"Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia","volume":"461","author":"Ebel","year":"2014","journal-title":"Biochem. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"33735","DOI":"10.1074\/jbc.M506485200","article-title":"LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor","volume":"280","author":"Lahiri","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6989","DOI":"10.1074\/jbc.M115.691212","article-title":"Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity","volume":"291","author":"Gosejacob","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"21433","DOI":"10.1074\/jbc.M113.479907","article-title":"Inactivation of ceramide synthase 6 in mice results in an altered sphingolipid metabolism and behavioral abnormalities","volume":"288","author":"Ebel","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0014-5793(02)03482-8","article-title":"Sphingomyelinases: Enzymology and membrane activity","volume":"531","author":"Alonso","year":"2002","journal-title":"FEBS Lett."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1515\/hsz-2015-0109","article-title":"Secretory sphingomyelinase in health and disease","volume":"396","author":"Kornhuber","year":"2015","journal-title":"Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/ajh.23535","article-title":"Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis","volume":"88","author":"Jenkins","year":"2013","journal-title":"Am. J. Hematol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.1111\/febs.12559","article-title":"Glycosphingolipids: Synthesis and functions","volume":"280","author":"Capasso","year":"2013","journal-title":"FEBS J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1194\/jlr.R026682","article-title":"Role of sulfatide in normal and pathological cells and tissues","volume":"53","author":"Takahashi","year":"2012","journal-title":"J. Lipid Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1016\/j.febslet.2015.09.018","article-title":"Ganglioside GM3 as a gatekeeper of obesity-associated insulin resistance: Evidence and mechanisms","volume":"589","author":"Lipina","year":"2015","journal-title":"FEBS Lett."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"525","DOI":"10.2217\/clp.12.59","article-title":"Could plasma sphingolipids be diagnostic or prognostic biomarkers for Alzheimer\u2019s disease?","volume":"7","author":"Mielke","year":"2012","journal-title":"Clin. Lipidol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neurobiolaging.2008.03.011","article-title":"Serum sphingomyelins and ceramides are early predictors of memory impairment","volume":"31","author":"Mielke","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"ref_45","first-page":"43","article-title":"Plasma sphingolipid changes with autopsy-confirmed Lewy body or Alzheimer\u2019s pathology","volume":"3","author":"Savica","year":"2016","journal-title":"Alzheimers Dement."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1194\/jlr.M033506","article-title":"Shorthand notation for lipid structures derived from mass spectrometry","volume":"54","author":"Liebisch","year":"2013","journal-title":"J. Lipid Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Han, X., Rozen, S., Boyle, S.H., Hellegers, C., Cheng, H., Burke, J.R., Welsh-Bohmer, K.A., Doraiswamy, P.M., and Kaddurah-Daouk, R. (2011). Metabolomics in early Alzheimer\u2019s disease: Identification of altered plasma sphingolipidome using shotgun lipidomics. PLOS ONE, 6.","DOI":"10.1371\/journal.pone.0021643"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"809","DOI":"10.3233\/JAD-160645","article-title":"Association between plasma ceramides and phosphatidylcholines and hippocampal brain volume in late onset Alzheimer\u2019s disease","volume":"60","author":"Kim","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Mielke, M.M., Maetzler, W., Haughey, N.J., Bandaru, V.V., Savica, R., Deuschle, C., Gasser, T., Hauser, A.K., Graber-Sultan, S., and Schleicher, E. (2013). Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson\u2019s disease and associated with cognitive impairment: A pilot study. PLOS ONE, 8.","DOI":"10.1371\/journal.pone.0073094"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1093\/brain\/awu139","article-title":"Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics","volume":"137","author":"Vidaurre","year":"2014","journal-title":"Brain"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Pujol-Lereis, L.M., Liebisch, G., Schick, T., Lin, Y., Grassmann, F., Uchida, K., Zipfel, P.F., Fauser, S., Skerka, C., and Weber, B.H.F. (2018). Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration. PLOS ONE, 13.","DOI":"10.1371\/journal.pone.0200739"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.neuroscience.2004.08.056","article-title":"Astroglial expression of ceramide in Alzheimer\u2019s disease brains: A role during neuronal apoptosis","volume":"130","author":"Satoi","year":"2005","journal-title":"Neuroscience"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"31756","DOI":"10.1038\/s41598-018-31756-0","article-title":"Particular CSF sphingolipid patterns identify iNPH and AD patients","volume":"8","author":"Torretta","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Stoessel, D., Schulte, C., Teixeira Dos Santos, M.C., Scheller, D., Rebollo-Mesa, I., Deuschle, C., Walther, D., Schauer, N., Berg, D., and Nogueira da Costa, A. (2018). Promising metabolite profiles in the plasma and CSF of early clinical Parkinson\u2019s disease. Front. Aging Neurosci., 10.","DOI":"10.3389\/fnagi.2018.00051"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"21497","DOI":"10.1038\/s41598-018-21497-5","article-title":"Enhanced release of acid sphingomyelinase-enriched exosomes generates a lipidomics signature in CSF of Multiple Sclerosis patients","volume":"8","author":"Pieragostino","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3109\/17482968.2011.619197","article-title":"Biochemical alterations associated with ALS","volume":"13","author":"Lawton","year":"2012","journal-title":"Amyotroph. Lateral Scler."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"a004762","DOI":"10.1101\/cshperspect.a004762","article-title":"Distribution and functions of sterols and sphingolipids","volume":"3","author":"Hannich","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuron.2006.09.018","article-title":"ALS: A disease of motor neurons and their nonneuronal neighbors","volume":"52","author":"Cleveland","year":"2006","journal-title":"Neuron"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5345","DOI":"10.12659\/MSM.904399","article-title":"High performance liquid chromatography-mass spectrometry (LC-MS) based quantitative lipidomics study of ganglioside-NANA-3 plasma to establish its association with Parkinson\u2019s disease patients","volume":"23","author":"Zhang","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13024-015-0010-2","article-title":"Selective loss of glucocerebrosidase activity in sporadic Parkinson\u2019s disease and dementia with Lewy bodies","volume":"10","author":"Chiasserini","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1212\/WNL.0b013e318264e380","article-title":"Serum ceramides increase the risk of Alzheimer disease: The Women\u2019s Health and Aging Study II","volume":"79","author":"Mielke","year":"2012","journal-title":"Neurology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3233\/JAD-160925","article-title":"The association between plasma ceramides and sphingomyelins and risk of Alzheimer\u2019s disease differs by sex and APOE in the Baltimore Longitudinal Study of Aging","volume":"60","author":"Mielke","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1039\/C5RA19349D","article-title":"Discovery of serum metabolites for diagnosis of progression of mild cognitive impairment to Alzheimer\u2019s disease using an optimized metabolomics method","volume":"6","author":"Liang","year":"2016","journal-title":"RSC Advances"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nri2974","article-title":"The outs and the ins of sphingosine-1-phosphate in immunity","volume":"11","author":"Spiegel","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1471-4159.2002.00997.x","article-title":"Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer\u2019s disease: Potential role in disease pathogenesis","volume":"82","author":"Han","year":"2002","journal-title":"J. Neurochem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1074\/jbc.M111.274142","article-title":"Comparative lipidomic analysis of mouse and human brain with Alzheimer disease","volume":"287","author":"Chan","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1073\/pnas.0305799101","article-title":"Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer\u2019s disease","volume":"101","author":"Cutler","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.nbd.2014.01.010","article-title":"Ceramides and sphingomyelinases in senile plaques","volume":"65","author":"Panchal","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/mds.25729","article-title":"Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson\u2019s disease","volume":"29","author":"Abbott","year":"2014","journal-title":"Mov. Disord."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s12017-010-8114-x","article-title":"The role of the ceramide acyl chain length in neurodegeneration: Involvement of ceramide synthases","volume":"12","author":"Futerman","year":"2010","journal-title":"Neuromol. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"33549","DOI":"10.1074\/jbc.M109.031971","article-title":"Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas","volume":"284","author":"Imgrund","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1471-4159.1970.tb00547.x","article-title":"Lipids and proteins in multiple sclerosis white matter","volume":"17","author":"Gerstl","year":"1970","journal-title":"J. Neurochem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"11718","DOI":"10.3390\/ijms130911718","article-title":"Environmental risk factors for multiple sclerosis: A review with a focus on molecular mechanisms","volume":"13","author":"Lucas","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Astarita, G., Jung, K.-M., Vasilevko, V., DiPatrizio, N.V., Martin, S.K., Cribbs, D.H., Head, E., Cotman, C.W., and Piomelli, D. (2011). Elevated stearoyl-CoA Desaturase in Brains of Patients with Alzheimer\u2019s disease. PLOS ONE, 6.","DOI":"10.1371\/journal.pone.0024777"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/alzrt103","article-title":"Lipidomics of Alzheimer\u2019s disease: Current status","volume":"4","author":"Wood","year":"2012","journal-title":"Alzheimers Res. Ther."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1189\/jlb.0806529","article-title":"De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis","volume":"81","author":"Seumois","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"27879","DOI":"10.1074\/jbc.M503002200","article-title":"Roles for C16-ceramide and sphingosine-1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha","volume":"280","author":"Osawa","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/978-1-4614-0631-0_70","article-title":"Ceramide signaling in retinal degeneration","volume":"723","author":"Chen","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"7485","DOI":"10.1073\/pnas.1804266115","article-title":"Traceless synthesis of ceramides in living cells reveals saturation-dependent apoptotic effects","volume":"115","author":"Rudd","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.plipres.2011.11.001","article-title":"Chain length-specific properties of ceramides","volume":"51","author":"Grosch","year":"2012","journal-title":"Prog. Lipid Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.cellsig.2010.04.006","article-title":"Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells","volume":"22","author":"Mesicek","year":"2010","journal-title":"Cell. Signal."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0006-3495(96)79341-4","article-title":"Phase behavior of stratum corneum lipids in mixed Langmuir-Blodgett monolayers","volume":"71","author":"Demel","year":"1996","journal-title":"Biophys. J."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"11818","DOI":"10.1074\/jbc.M109.078121","article-title":"The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis","volume":"285","author":"Siskind","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3389\/fpsyt.2018.00496","article-title":"Chronic psychosocial stress in mice is associated with increased acid sphingomyelinase activity in liver and serum and with hepatic C16:0-ceramide accumulation","volume":"9","author":"Reichel","year":"2018","journal-title":"Front. Psychiatry"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"35706","DOI":"10.1074\/jbc.M110.125609","article-title":"Regulated secretion of acid sphingomyelinase: Implications for selectivity of ceramide formation","volume":"285","author":"Jenkins","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.bbalip.2012.04.008","article-title":"A shift in sphingolipid composition from C24 to C16 increases susceptibility to apoptosis in HeLa cells","volume":"1821","author":"Sassa","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1042\/BJ20090699","article-title":"Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response","volume":"424","author":"Spassieva","year":"2009","journal-title":"Biochem. J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1073\/pnas.1522071113","article-title":"Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency","volume":"113","author":"Spassieva","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","article-title":"Mechanisms of insulin action and insulin resistance","volume":"98","author":"Petersen","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.cmet.2014.08.002","article-title":"Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance","volume":"20","author":"Turpin","year":"2014","journal-title":"Cell Metab."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2337\/db08-1228","article-title":"Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance","volume":"58","author":"Haus","year":"2009","journal-title":"Diabetes"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.2337\/diabetes.53.5.1215","article-title":"Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle","volume":"53","author":"Straczkowski","year":"2004","journal-title":"Diabetes"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2337\/db09-0988","article-title":"Insulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide content","volume":"59","author":"Coen","year":"2010","journal-title":"Diabetes"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"352","DOI":"10.2337\/db12-1427","article-title":"Plasma ceramides target skeletal muscle in type 2 diabetes","volume":"62","author":"Kirwan","year":"2013","journal-title":"Diabetes"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1194\/jlr.M081398","article-title":"Genetic, dietary, and sex-specific regulation of hepatic ceramides and the relationship between hepatic ceramides and IR","volume":"59","author":"Norheim","year":"2018","journal-title":"J. Lipid Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0079-6123(06)53007-9","article-title":"The selfish brain: Competition for energy resources","volume":"153","author":"Fehm","year":"2006","journal-title":"Prog. Brain Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.nbd.2014.09.001","article-title":"Insulin resistance in Alzheimer\u2019s disease","volume":"72","author":"Dineley","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1001\/archneurol.2009.27","article-title":"The role of metabolic disorders in Alzheimer disease and vascular dementia: Two roads converged","volume":"66","author":"Craft","year":"2009","journal-title":"Arch. Neurol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.preteyeres.2010.09.001","article-title":"Dietary hyperglycemia, glycemic index and metabolic retinal diseases","volume":"30","author":"Chiu","year":"2011","journal-title":"Prog. Retin. Eye. Res."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Chen, X., Rong, S.S., Xu, Q., Tang, F.Y., Liu, Y., Gu, H., Tam, P.O., Chen, L.J., Brelen, M.E., and Pang, C.P. (2014). Diabetes mellitus and risk of age-related macular degeneration: A systematic review and meta-analysis. PLOS ONE, 9.","DOI":"10.1371\/journal.pone.0108196"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.exer.2018.11.020","article-title":"Endogenous insulin signaling in the RPE contributes to the maintenance of rod photoreceptor function in diabetes","volume":"180","author":"Tarchick","year":"2018","journal-title":"Exp. Eye Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e1214","DOI":"10.1038\/cddis.2014.178","article-title":"Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium","volume":"5","author":"Leontieva","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Ch\u00e1vez, G., Pe\u00f1a-Rangel, M.T., Riesgo-Escovar, J.R., Mart\u00ednez-Mart\u00ednez, A., and Salceda, R. (2012). Insulin stimulated-glucose transporter Glut 4 is expressed in the retina. PLOS ONE, 7.","DOI":"10.1371\/journal.pone.0052959"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1210\/endo.133.2.8344201","article-title":"Characterization of glucose transporter isoforms in the adult and developing human eye","volume":"133","author":"Mantych","year":"1993","journal-title":"Endocrinology"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"L\u00f6tsch, J., Thrun, M., Lerch, F., Brunkhorst, R., Schiffmann, S., Thomas, D., Tegder, I., Geisslinger, G., and Ultsch, A. (2017). Machine-learned data structures of lipid marker serum concentrations in multiple sclerosis patients differ from those in healthy subjects. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18061217"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fpsyt.2019.00041","article-title":"A data science-based analysis points at distinct patterns of lipid mediator plasma concentrations in patients with dementia","volume":"10","author":"Gurke","year":"2019","journal-title":"Front. Psychiatry"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"14884","DOI":"10.1038\/s41598-018-33077-8","article-title":"Machine-learning based lipid mediator serum concentration patterns allow identification of multiple sclerosis patients with high accuracy","volume":"8","author":"Schiffmann","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1161\/01.RES.0000185327.45463.A8","article-title":"Novel role of lactosylceramide in vascular endothelial growth factor-mediated angiogenesis in human endothelial cells","volume":"97","author":"Rajesh","year":"2005","journal-title":"Circ. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e23700","DOI":"10.4161\/onci.23700","article-title":"Inhibition of tumor angiogenesis by globotriaosylceramide immunotargeting","volume":"2","author":"Desselle","year":"2013","journal-title":"Oncoimmunology"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.neurobiolaging.2007.07.024","article-title":"ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer\u2019s but not normal brain","volume":"30","author":"Bandaru","year":"2009","journal-title":"Neurobiol. Aging"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/14\/3564\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:07:58Z","timestamp":1760188078000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/14\/3564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,21]]},"references-count":110,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2019,7]]}},"alternative-id":["ijms20143564"],"URL":"https:\/\/doi.org\/10.3390\/ijms20143564","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,21]]}}}