{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T16:59:01Z","timestamp":1793465941323,"version":"4.5.0"},"reference-count":187,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Leukotrienes (LTs) are lipid mediators that play pivotal roles in acute and chronic inflammation and allergic diseases. They exert their biological effects by binding to specific G-protein-coupled receptors. Each LT receptor subtype exhibits unique functions and expression patterns. LTs play roles in various allergic diseases, including asthma (neutrophilic asthma and aspirin-sensitive asthma), allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and anaphylaxis. This review summarizes the biology of LTs and their receptors, recent developments in the area of anti-LT strategies (in settings such as ongoing clinical studies), and prospects for future therapeutic applications.<\/jats:p>","DOI":"10.3390\/ijms20143580","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T11:07:28Z","timestamp":1563793648000},"page":"3580","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":149,"title":["The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders"],"prefix":"10.3390","volume":"20","author":[{"given":"Airi","family":"Jo-Watanabe","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Juntendo University School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0270-5744","authenticated-orcid":false,"given":"Toshiaki","family":"Okuno","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Juntendo University School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5219-1553","authenticated-orcid":false,"given":"Takehiko","family":"Yokomizo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Juntendo University School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.pharmtox.011008.145616","article-title":"Lipid mediators in health and disease: Enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation","volume":"49","author":"Shimizu","year":"2009","journal-title":"Annu. 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